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| 1 | Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk显示文摘AIM: To investigate the role that single nucleotide polymorphisms (SNPs) in the promoter of the tumour necrosis factor-alpha (TNF-α) gene play in the risk of inflammatory bowel diseases (IBDs) in a New Zealand population, in the context of international studies. METHODS: DNA samples from 388 patients with Crohn's disease (CD), 405 ulcerative colitis (UC), 27 indeterminate colitis (IC) and 201 randomly selected controls, from Canterbury, New Zealand were screened for 3 common polymorphisms in the TNF-α receptor: -238 G→A, -308 G→A and -857C→T, using a TaqmanR assay. A meta-analysis was performed on the data obtained on these polymorphisms combined with that from other published studies. RESULTS: Individuals carrying the -308 G/A allele had a significantly (OR = 1.91, χ2 = 17.36, P < 0.0001) increased risk of pancolitis, and a 1.57-fold increased risk (OR = 1.57, χ2 = 4.34, P = 0.037) of requiring a bowel resection in UC. Carrying the -857 C/T variant decreased the risk of ileocolonic CD (OR = 0.56, χ2 =4.32, P = 0.037), and the need for a bowel resection (OR = 0.59, χ2 = 4.85, P = 0.028). The risk of UC was reduced in individuals who were smokers at diagnosis, (OR = 0.48, χ2 = 4.86, P = 0.028). CONCLUSION: TNF-α is a key cytokine known to play a role in inflammatory response, and the locus for the gene is found in the IBD3 region on chromosome 6p21, known to be associated with an increased risk for IBD. The -308 G/A SNP in the TNF-α promoter is functional, and may account in part for the increased UC risk associated with the IBD3 genomic region. The -857 C/T SNP may decrease IBD risk in certain groups. Pharmaco- or nutrigenomic approaches may be desir- able for individuals with such affected genotypes. | Lynnette R Ferguson Claudia Huebner Ivonne Petermann Richard B Gearry Murray L Barclay Pieter Demmers Alan McCulloch Dug Yeo Han | 2008 | World Journal of Gastroenterology2008，14，29： | 7 |
| 2 | Extrusion of metal powders显示文摘 | Ferguson B L | 1991 | International Materials Reviews1991，36，2： | 1 |
| 3 | The effect of competition on recov- ery strategies 显示文摘 | Ferguson M Toktay L B | 2006 | Production and Operations Management2006，15，3： | 1 |
| 4 | The Effect of Competition on Recovery Strategies 显示文摘 | Ferguson M Toktay L B | 2006 | Production and Operations Management2006，15，3： | 1 |
| 5 | The effect of competition on recovery strategies显示文摘 | Ferguson M Toktay L B | 2006 | Product and Operations Management2006，15，3： | 1 |
| 6 | The Effect of Competition on Recovery Management显示文摘 | Ferguson M E Toktay L B | 2006 | Production and Operations Management2006，15，3： | 1 |
| 7 | The effect of competition on recovery strategies 显示文摘 | Ferguson M Toktay L B | 2006 | Production and Operations Management2006，15，3： | 1 |
| 8 | The effect of competition on recovery strategies 显示文摘 | Ferguson M E Toktay L B | 2006 | Production and Operations Management2006，15，3： | 1 |
| 9 | The effect of competition on recovery strategies显示文摘 | Ferguson M Toktay L B | 2006 | Product and Operations Management2006，15，3： | 1 |
| 10 | Is leasing greener than selling? 显示文摘 | Agrawal V V Ferguson M Toktay L B | 2012 | Management Science2012，58，3： | 1 |
| 11 | Is leasing greener than selling? 显示文摘 | Agrawal Vishal V Ferguson M Toktay L B | 2011 | Management Science2011，57，10： | 1 |
| 12 | Relicensing as a Secondary Market Strategy显示文摘 | Oraiopoulos N Ferguson M E Toktay L B | 2012 | Management Science2012，58，5： | 1 |
| 13 | Relicensing as a secondary market strategy显示文摘 | Oraiopoulos N Ferguson M E Toktay L B | 2012 | Management Science2012，58，5： | 1 |
| 14 | Analysis of alkylphenol ethoxylate metabolites in the aquatic environment using liquid chromatography - electrospray spectrometry 显示文摘 | Ferguson P L Charles R I Bruce J B | 2000 | Analytical Chemistry2000，72，18： | 1 |
| 15 | Acute effects of fentanyl on breathing pattern in anaesthetized subjects显示文摘 | FERGUSON L M DRUMMOND G B | | 0，，03： | 1 |
| 16 | The effect of time off feed prior to slaughter on muscle glycogen metabolism and rate of pH decline in three different muscles of stimulated and non-stimulated sheep carcasses显示文摘 | Daly B L Gardner G E Ferguson D M Thompson J M | | 0，，11： | 1 |
| 17 | The effects of body size ob the acid-base and metabolite status in the white muscle of rainbow trout before and after exhaustive exercise 显示文摘 | Ferguson P A Kieffer J D Tufts B L | 1993 | J Exp Biol1993，180，： | 1 |
| 18 | Relicensingas a secondary market strategy显示文摘 | Oraiopoulos N Ferguson M E Toktay L B | 2012 | Management Science2012，58，5： | 1 |
| 19 | The effect of competition on recovery strategies显示文摘 | Ferguson M Toktay L B | | 0，，03： | 1 |
| 20 | Seed number and calcium concentration of ‘Braeburn’ apple fruit显示文摘 | Ferguson I B Watkins C B | 1996 | J Hort Sci1996，71，2： | 1 |
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