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| 1 | Endoscopic ultrasound-guided vs endoscopic retrograde cholangiopancreatography biliary drainage for obstructed distal malignant biliary strictures: A systematic review and meta-analysis显示文摘BACKGROUND For palliation of malignant biliary obstruction(MBO), the gold-standard method of biliary drainage is endoscopic retrograde cholangiopancreatography(ERCP)with the placement of metallic stents. Endoscopic ultrasound(EUS)-guided drainage is an alternative that is typically reserved for cases of ERCP failure.Recently, however, there have been robust randomized clinical trials(RCTs)comparing EUS-guided drainage and ERCP as primary approaches to MBO.AIM To compare EUS guidance and ERCP in terms of their effectiveness and safety in palliative biliary drainage for MBO.METHODS This was a systematic review and meta-analysis, in which we searched the MEDLINE, Excerpta Medica, and Cochrane Central Register of Controlled Trials databases. Only RCTs comparing EUS and ERCP for primary drainage of MBO were eligible. All of the studies selected provided data regarding the rates of technical and clinical success, as well as the duration of the procedure, adverse events, and stent patency. We assessed the risk of biases using the Jadad score and the quality of evidence using the Grading of Recommendations Assessment,Development and Evaluation criteria.RESULTS The database searches yielded 5920 records, from which we selected 3 RCTs involving a total of 222 patients(112 submitted to EUS and 110 submitted to ERCP). In the EUS and ERCP groups, the rate of technical success was 91.96%n and 91.81%, respectively, with a risk difference(RD) of 0.00%(95%CI:-0.07, 0.07;P = 0.97; I^2 = 0%). The clinical success was 84.81% and 85.53% in the EUS and ERCP groups, respectively, with an RD of-0.01%(95%CI:-0.12, 0.10; P = 0.90; I^2 =0%). The mean difference(MD) for the duration of the procedure was-0.12%(95%CI:-8.20, 7.97; P = 0.98; I^2 = 84%). In the EUS and ERCP groups, there were14 and 25 adverse events, respectively, with an RD of-0.06%(95%CI:-0.23, 0.12; P= 0.54; I^2 = 77%). The MD for stent patency was 9.32%(95%CI:-4.53, 23.18; P =0.19; I^2 = 44%). The stent dysfunction rate was significantly lower in the EUS t group(MD =-0.22%; 95 CI:-0.35,-0.08; P = 0.001; I^2 = 0%).CONCLUSION EUS represents an interesting alternative to ERCP for MBO drainage,demonstrating lower stent dysfunction rates compared with ERCP. Technical and clinical success, duration, adverse events and patency rates were similar. | Fernanda P Logiudice Wanderlei M Bernardo Facundo Galetti Vitor M Sagae Carolina O Matsubayashi Antonio C Madruga Neto Vitor O Brunaldi Diogo T H de Moura Tomazo Franzini Spencer Cheng Sergio E Matuguma Eduardo G H de Moura | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，4： | 6 |
| 2 | Synthesis and Biological Evaluation of Some 6-Substi?tuted Purines显示文摘 | FERNANDA G B ELAINE S C MAGNUM 0 M | 2007 | EurJ of Med Chern2007，42，： | 1 |
| 3 | 显示文摘 | Lueiana cla C Fernanda M B C Viviane G T | 2008 | Polymer Bul- letin2008，61，3： | 1 |
| 4 | Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma显示文摘 | Staquicini Fernanda I Ozawa Michael G Moya Catherine A Driessen Wouter H P Barbu E Magda Nishimori Hiroyuki Soghomonyan Suren Flores Leo G Liang Xiaowen Paolillo Vincenzo Alauddin Mian M Basilion James P Furnari Frank B Bogler Oliver Lang F | 2011 | Journal of Clinical Investigation2011，，1： | 1 |
| 5 | Antimicrobial and antioxidant properties of chitosan enzymatically functionalized with flavonoids显示文摘 | Fernanda S Georg M G Vanja K | 2009 | Process Biochemistry2009，44，7： | 1 |
| 6 | Use of UHPFRC overlay to reduce stresses in orthotropic steel decks 显示文摘 | Lamine D Pierre M Fernanda G | 2013 | Journal of Constructional Steel Research2013，89，5： | 1 |
| 7 | Revealing climatic variability of the last three millennia in northwestern Iberia using pollen influx data 显示文摘 | Desprat S María Fernanda S G Loutre M F | 2003 | Earth and Planetary Science Letters2003，213，12： | 1 |
| 8 | The role of cerium in the oxidation of ethanol over SnO2 - supported molybdenum oxides 显示文摘 | Fernanda M G Paulo R S Medeiros Lucia G Appel | 2001 | Appl Catal A : General2001，208，： | 1 |
| 9 | Synthesis,characterization and evaluation of sulfonic resins as catalysts显示文摘 | Fernanda M B C Rosane R S Ailton S G | 2004 | European Polymer Journal2004，40，7： | 1 |
| 10 | Identification of human sperm proteins involved in the interaction with homologous zona pellucida 显示文摘 | Andrea L Fernanda G Carolina M | 2003 | Fertility and Sterikity2003，79，3： | 1 |
| 11 | Use of RAPD Analysis for differentiation among six enological saccharomyces strains 显示文摘 | Angela X Fernanda S Francisco M G | 2010 | Food Technol Biotechnol2010，38，1： | 1 |
| 12 | Synthesis, characterization and activity of an immobilized photocatalyst: Natural porous diatomite supported TiO2 nanoparticles 显示文摘 | WANG B FERNANDA C G SUN Z M | 2015 | J Colloid Interface Sci2015，438，： | 1 |
| 13 | The Role of Cerium in the Oxidation of Ethanol over SnO2-Supported Molybdenum Oxides显示文摘 | Goncalves Fernanda M Medeiros Paulo R S Appel Lucia G | 2001 | Applied Catalysis A:General2001，208，12： | 1 |
| 14 | Pro- duct-service systems:a literature review on integrated products and services 显示文摘 | Fernanda H B Marcelo G G F Paulo A C M | 2013 | Journal of Cleaner Produc- tion2013，47，5： | 1 |
| 15 | Antioxidant properties and fruit quality during longterm storage of ‘Rocha' pear:effects of maturity and storage conditions 显示文摘 | Filipe J P Silva M H G Fernanda F | 2010 | Journal of Food Quality2010，33，： | 1 |
| 16 | Study of composites based on polypropylene and calcium carbonate by experimental design显示文摘 | Marisa C G Rocha Antonio H M F T Silva Fernanda M B Coutinho | | 0，，08： | 1 |
| 17 | Study of composites based on polypropylene and calcium carbonate by experimental design显示文摘 | Marisa C G Rocha Antonio H M F T Silva Fernanda M B Coutinho | 2005 | Polymer Testing2005，24，8： | 1 |
| 18 | Surface modification of styrene-divinylbenzene copolymers by polyacry- lamide grafting via gamma irradiation 显示文摘 | Luciana da C Fernanda M B C Viviane G T | 2008 | Polymer Bulletin2008，61，3： | 1 |
| 19 | Kinetic and thermodynamic aspects of glucose-6- phosphate dehydro-genase activity and synthesis显示文摘 | FERNANDA G F G RIBEIRO M Z CONVERTI A | 2003 | Enzyme and Microbial Technology2003，32，1： | 1 |
| 20 | Exopolysaccharide Production by Lactobacillus Casei in Milk under Different Growth Conditions 显示文摘 | FERNANDA M GRACIELA S D G OLIVER G | 1996 | Milchwissenschaft1996，51，12： | 1 |
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