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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | A new framework for complex wavelet transforms 显示文摘 | FERNANDES F A VAN SPAENDONCK R L C | 2003 | IEEE Trans Signal Processing2003，51，7： | 1 |
| 3 | Treatment of human monocytes with interleukin(IL)-18 increases TLR4 and mannose receptor expression and modulates cytokine production显示文摘 | Dias-Melicio L A Fernandes R K Golim M A | | 0，，1： | 1 |
| 4 | A new framework for complex wavelet transforms显示文摘 | FERNANDES F C A VAN SPAENDONCK R L C BURRUS C S | 2003 | IEEE Transactions on Signal Processing2003，51，7： | 1 |
| 5 | The influence of sea- sonal signals on the estimation of the tectonic motion in short continuous GPS time-series 显示文摘 | Bos M S Bastos L Fernandes R M S | 2010 | Journal of Geodynamics2010，49，3： | 1 |
| 6 | Mas deficiency in FVB/N mice produces marked changes in lipid and glycemic metabolism显示文摘 | Santos S H Fernandes L R Mario E G | 2008 | Diabetes2008，57，： | 1 |
| 7 | Universal correlation of self-diffusion coefficients of model and real fluids based on residual entropy scaling law 显示文摘 | VAZ R V MAGALHAES A L FERNANDES D L A | 2012 | Chemical Engineering Science2012，79，： | 1 |
| 8 | 肉种鸡和产蛋鸡营养中维生素的抗氧化特性研究进展显示文摘自由基与多不饱和脂肪酸反应启动一个被称为生命系统中脂质过氧化反应以及食物氧化酸败的连锁反应过程。多不饱和脂肪酸更易氧化,导致有毒产物的形成。由于胚胎组织中不饱和脂肪酸含量较高,在肉种鸡日粮中使用抗氧化剂可以改善雏鸡的氧化状态。带壳蛋被认为具有抗氧化酸败的作用,然而研究表明食用蛋中的卵黄脂质在储存时易被氧化,这种氧化受到储存时间、温度及卵黄脂肪酸不饱和程度的影响。因此有许多在蛋鸡饲料中添加抗氧化剂来保持其营养价值的试验研究。文献表明,卵黄中的VE具有抗氧化活性,对孵化期的胚胎以及初生的雏鸡均有较好的保护作用。然而这些研究均未考虑到维生素对孵化率的影响。由于经济方面的原因,维生素的实际使用量明显低于研究中的建议使用量,因此,它在胚胎中的积极作用以及雏鸡的抗氧化作用在生产中的应用价值不是很大。其他抗氧化剂如角黄素等与VE具有协同作用,然而,这些高成本的物质可能限制了它们在肉种鸡上的应用。本文综述了肉种鸡和产蛋鸡营养中的维生素(特别是VE)对胚胎组织和卵黄脂抗氧化性的影响。 | Rocha J S R Lara L J C Baiao N C Vasconcelos R J C Barbosa V M Pompeu M A Fernandes M N S 王来娣 | 2011 | 中国家禽2011，33，3： | 1 |
| 9 | Energy cost and intracyclic variation of the velocity of the centre of mass in butterfly stroke显示文摘 | BARBOSA T M KESKINEN K L FERNANDES R | 2005 | Eur J Appl Physiol2005，93，56： | 1 |
| 10 | Racial disparities in infection-related mortality at Alice Springs Hospital, Central Australia, 2000-2005显示文摘 | Einsiedel L J Fernandes L A Woodman R J | 2008 | Medical Journal of Australia2008，188，10： | 1 |
| 11 | Comparisonof grab start between elite and trained swimmers显示文摘 | Vantorre J Seifert L Fernandes R J | 2010 | International journal of sports medicine2010，31，12： | 1 |
| 12 | Kinematicalprofiling of the front crawl start 显示文摘 | Vantorre J Seifert L Fernandes R J | 2010 | Int JSports Med2010，31，1： | 1 |
| 13 | Effect of nutrient sources on yield, fruit quality and nutritional status of cucumber plants, cultivated in hydroponics 显示文摘 | Fernandes A A Martinez -H E P Oliveira -L R de et el | 2002 | Horticultura Brasileira2002，204，： | 1 |
| 14 | Scaling of velocity and temperature fluctuations in turbulent thermal convection显示文摘 | Fernandes R L J Adrian R J | | 0，，： | 1 |
| 15 | Time-dependent effects of training on cardiovascular control in sponta- neously hypertensive rats: role for brain oxidative stress and inflammation and baroreflex sensitivity显示文摘 | Masson G S Costa T S Yshii L Fernandes D C Soares P P Laurindo F R | 2014 | PLoS One2014，9，94： | 1 |
| 16 | Biomechanicalinfluence of start technique preference forelite track starters in front crawl显示文摘 | Vantorre J Seifert L Fernandes R J | 2010 | The Open SportsSciences Journal2010，3，： | 1 |
| 17 | Kine- matical profiling of the front crawl start显示文摘 | VANTORRE J SEIFERT L FERNANDES R J | 2010 | Int J Sports Med2010，31，1： | 1 |
| 18 | Eval- uation of the energy expenditure in competitive swimming strokes 显示文摘 | BARBOSA T M FERNANDES R KESKINEN K L | 2006 | Int J Sports Med2006，27，11： | 1 |
| 19 | Energy and protein requirements for maintenance and growth of Boer crossbred kids 显示文摘 | FERNANDES M H M R RESENDE K T TEDES- CHI L O | 2007 | J Anim Sci2007，85，4： | 1 |
| 20 | Determinationof the drag coefficient during the first andsecond gliding positions of the breaststroke underwaterstroke显示文摘 | Vilas-Boas J P Costa L Fernandes R J | 2010 | Journal of applied biomechanics-2010，26，3： | 1 |
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