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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Role of protein kinase G in growth and glutamine metabolism of Mycobacterium bovis BCG显示文摘 | Nguyen L Walburger A Houben E Koul A Muller S Morbitzer M Klebl B Ferrari G Pieters J | 2005 | J Bacteriol2005，187，16： | 1 |
| 3 | Leptin inhibits steroid biosynthesis by human granulose-lutein cells 显示文摘 | Barreca A Mastorakos G Furlini M Vottero A Ferrari B Chrousos GP Bernasconi S | 2001 | Horm Metab Res2001，33，6： | 1 |
| 4 | Influence of the impregnation order of molybdenum and cobalt in carbon-supported catalysts for hydrodeoxygenation reactions显示文摘 | Ferrari M Delmon B Grange P | | 0，，： | 1 |
| 5 | A New Series of Imidazolones:Highly Specific and Potent Nonpeptide AT1 Angiotensin II Receptor Antagonists 显示文摘 | Bemhart C A Perreaut P M Ferrari B P | 1993 | J Med Chem1993，36，22： | 1 |
| 6 | Template-impinted nanostructured swfaces for protein recognition 显示文摘 | Shi H Q Tsai W B Garrison M D Ferrari S Ratner B D | 1999 | Nature1999，398，6728： | 1 |
| 7 | Diagnosis of central precocious puberty:endocrine assessment显示文摘 | Iughetti L Predieri B Ferrari M | 2000 | J Pediatr Endocrinol Metab2000，13，1： | 1 |
| 8 | Identifying the free boundary of a stochastic, irreversible investment problem via the Bank-E1 karoui representation theorem 显示文摘 | CHIAROLLA M B FERRARI G | 2015 | SI- AM Journal on Control and Optimization2015，52，2： | 1 |
| 9 | Influence of root signals resulting from soil dehydration and high soil strength on grow of crop plants显示文摘 | Ludlow M M Sommer K L Flower D J Ferraris R So H B | 1989 | Current Topics in Plant Biochemistry and Physiology1989，8，： | 1 |
| 10 | Microcolony cultivation on a soil substrate membrane system selects for previously uncultured soil bacteria显示文摘 | FERRARI B C BINNERUP S J GILLINGS M | 2005 | Appl Environ Microbiol2005，71，12： | 1 |
| 11 | Impact of immune escape mutations on HIV-1fitness in the context of the cognate transmitted/founder genome显示文摘 | Song H Pavlicek J W Cai F Bhattacharya T Li H Iyer S S Bar K J Decker J M Goonetilleke N Liu M K Berg A Hora B Drinker M S Eudailey J Pickeral J Moody M A Ferrari G McMichael A Perelson A S Shaw G M Hahn B H Haynes B F Gao F | 2012 | Retrovirology2012，9，： | 1 |
| 12 | Influence of the Active Phase Loading in Carbon Supported Molybdenum-Cobalt Catalysts for Hydrodeoxygenation Reactions显示文摘 | Ferrari M Delmon B Grange P | 2002 | Microporous Mesoporous Mater2002，56，3： | 1 |
| 13 | Serum concentration of NSE and S-100b during LVAD in nonresuscitated patients显示文摘 | Pfeifer R Ferrari M B(o)rner A | | 0，，01： | 1 |
| 14 | Synthe- sis, characterisation, X-ray structure and biological activity of three new 5-formyluracil thiosemicarbazone complexes 显示文摘 | FERRARI M B BISCEGLIE F PELOSI G | 2001 | Inorg Biochem2001，83，2： | 1 |
| 15 | Simultaneous determination of deoxynivalenol, zearalenone, T-2 and HT-2 toxins in breakfast cereals and baby food by high-performance liquid chromatography and tandem mass spectrometry显示文摘 | ROMAGNOLI B FERRARI M BERGAMINI C | 2010 | Journal of Mass Spectrometry2010，45，9： | 1 |
| 16 | First report of races 11 and 12 of Cercospora sojina, the causal agent of soybean frogeye leaf spot,in Argentina显示文摘 | SCANDIANI M FERRI M FERRARI B | 2012 | Plant disease2012，96，7： | 1 |
| 17 | Kidney transplantation in rats : an appraisal of surgical techniques and outcome显示文摘 | SCHUMACHER M VAN VLIET B N FERRARI P | 2003 | Microsurgery2003，23，： | 1 |
| 18 | CoMo/carbon hydrodeoxygenation catalysts: influence of the hydrogen sulfide partial pressure and of the sulfidation temperature 显示文摘 | Ferrari M Bosmans S Maggi R B | 2001 | Catalysis Today2001，65，24： | 1 |
| 19 | Synthetic,spectroscopic and X-ray crystallographic studies on copper(Ⅱ) complexes with pyruvic acid and pyridoxal thiosemicarbazones显示文摘 | Ferrari M B Fava G G Leporati E | 1998 | Inorg Chim Acta1998，269，： | 1 |
| 20 | Microcolony cultivation on a soil substrate membrane system selects for previously uncultured soil bacteria显示文摘 | Ferrari B C Binnerup S J Gillings M | 2005 | Appl Environ Microbiol2005，71，12： | 1 |
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