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| 1 | Metrically measuring liver biopsy:A chronic hepatitis B and C computer-aided morphologic description显示文摘AIM: To describe a quantitative analysis method for liver biopsy sections with a machine that we have named 'Dioguardi Histological Metriser' which au- tomatically measures the residual hepatocyte mass (including hepatocytes vacuolization), inflammation, fibrosis and the loss of liver tissue tectonics. METHODS: We analysed digitised images of liver bi- opsy sections taken from 398 patients. The analysis with Dioguardi Histological Metriser was validated by comparison with semi-quantitative scoring system. RESULTS: The method provides: (1) the metrical ex- tension in two-dimensions (the plane) of the residual hepatocellular set, including the area of vacuoles pertinent to abnormal lipid accumulation; (2) the geo- metric measure of the inflammation basin, which dis- tinguishes intra-basin space and extra-basin dispersed parenchymal leukocytes; (3) the magnitude of collagen islets, (which were considered truncated fractals and classified into three degrees of magnitude); and (4) the tectonic index that quantifies alterations (disorders) in the organization of liver tissue. Dioguardi Histologi- cal Metriser machine allows to work at a speed of 0.1 mm2/s, scanning a whole section in 6-8 min.CONCLUSION: The results are the first standardized metrical evaluation of the geometric properties of the parenchyma, inflammation, fibrosis, and alterations in liver tissue tectonics of the biopsy sections. The present study confirms that biopsies are still valuable, not only for diagnosing chronic hepatitis, but also for quantifying changes in the organization and order of liver tissue structure. | Nicola Dioguardi Fabio Grizzi Barbara Fiamengo Carlo Russo | 2008 | World Journal of Gastroenterology2008，14，48： | 5 |
| 2 | Posterior heel pain associated with a calcaneal step and Achilles tendon calcification显示文摘 | Fiamengo SA Warren RF Marshall JL | | 0，，： | 1 |
| 3 | Vascular architecture:is it a helpful histopathological biomarker for hepatocellular carcinoma?显示文摘Hepatocellular carcinoma(HCC) remains one of the major public health problems throughout the world.Although originally associated with tumorigenic processes,liver angiogenesis has also been observed in the context of different liver in-flammatory,fibrotic,and ischemic conditions.Here we investigate the fractal dimension as a quantitator of non-Euclidean two-dimensional vascular geometry in a series of paired specimens of primary HCC and surrounding non-tumoral tissue,and discuss why this parameter might provide additional information regarding cancer behavior.The application of fractal geometry to the measurement of liver vascularity and the availability of a computer-aided quantitative method can eliminate errors in visual interpretation,and make it possible to obtain closer-to-reality numerals that are compulsory for any measurement process. | GRIZZI Fabio FRANCESCHINI Barbara FIAMENGO Barbara RUSSO Carlo DIOGUARDI Nicola | 2007 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2007，8，4： | 1 |
| 4 | Diagnostic value of HSP70, glypican 3, and glutamine synthetase in hepatocellular nodules in cirrhosis显示文摘 | Di Tommaso L Franchi G Park Y N Fiamengo B Destro A Morenghi E | 2007 | Hepatology2007，45，： | 1 |
| 5 | Design and syn- thesis of tricyclic cores for kinase inhibition 显示文摘 | Epps S V Fiamengo B Edmunds J | 2013 | Bioorganic & Medicinal Chemistry Letters2013，23，3： | 1 |
| 6 | Sentinel node mapping using indocyanine green and near-infrared fluo- rescence imaging technology for uterine malignancies: preliminary experience with the da vinci xi system显示文摘 | Siesto G Romano F Fiamengo B | 2016 | J Minim Invasive Gyneeol2016，23，4： | 1 |
| 7 | Benefits Sought by Citizens in Multichannel E-government Payment Services: Evidence from Italy显示文摘 | Russo C Ghezzi C M Fiamengo G | 2014 | Procedia Social and2014，109，8： | 1 |
| 8 | On Alice Munro’s Short Story Writing显示文摘Alice Munro,renowned Canadian short story writer,ingeniously explores human complexity and the transience of life in a revolutionary short story format.And she is addicted to portraying loss,death,pain,murder,and betrayal etc.,many dark sides of real life.As a female writer,she records the lives of girl and women with unsentimental eyes. | 沐永华 Janice Fiamengo | 2019 | 海外英语2019，，17： | 0 |
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