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| 1 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 2 | Correlations between esophageal diseases and manometric length: A study of 617 patients 显示文摘 | Awad ZT Watson P Filipi CJ | 1999 | J Gastrointest Surg1999，3，5： | 1 |
| 3 | Climatic and anthropogenic influence on the stable isotope record from bulk carbonates and ostracodes in Lake Neuchatel,Switzerland,during the last two millennia显示文摘 | Lambert P Hunziker J Kübler B Bernasconi S | 1999 | J Paleolimnol1999，21，： | 1 |
| 4 | Structural and pathologi cal effect of synthesis of hepatitis B virus large envelope polypeptide in transgenic mice显示文摘 | Chisari FV Filipi P Bunas J | 1987 | Proc Natl Acad Sci USA1987，84，19： | 1 |
| 5 | Structural and pathological effect of synthesis of hepatitis B virus large envelope polypeptide in transgenic mice 显示文摘 | Chisari FV Filipi P Bunas J | 1987 | Proc Natl Acad Sci USA1987，84，19： | 1 |
| 6 | Influence of shoulder geometry on microstructure anti mechanical properties of friction stir wehled 6082 aluminium alloy 显示文摘 | Scialpi A De Filipis L A C Cavaliere P | 2007 | Materials and Design2007，28，4： | 1 |
| 7 | Focused directed evolution of β-glucosidases: theoretical versus real effectiveness of a minimal working setup and simple robust screening 显示文摘 | Mazura P Filipi T Soucek P Brzobohaty B | 2011 | Carbohydr Res2011，346，2： | 1 |
| 8 | Correlations between esophageal diseases and manometric length: a study of 617 patients 显示文摘 | Awad ZT Watson P Filipi CJ | 1999 | J Gastrointest Surg1999，3，5： | 1 |
| 9 | Interaction between juvenile hormone, 20-hydroxyecdysone, corpus cardiacumallatum complex,and the overies in regulating vitellogenin levels in the housefly, Musca dornestica 显示文摘 | Adams T S Filipi P A | 1988 | J Insect Physiol1988，34，： | 1 |
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