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| 1 | Acute-on-chronic liver failure: Controversies and consensus显示文摘Acute-on-chronic liver failure(ACLF)is a poorly defined syndrome characterised by rapid clinical deterioration in patients with chronic liver disease.Consequences include high short-term morbidity,mortality,and healthcare resource utilisation.ACLF encompasses a dysregulated,systemic inflammatory response,which can precipitate extra hepatic organ failures.Common precipitants include infection,alcoholic hepatitis,and reactivation of viral hepatitis although frequently no cause is identified.Heterogenous definitions,diagnostic criteria,and treatment guidelines,have been proposed by international hepatology societies.This can result in delayed or missed diagnoses of ACLF,significant variability in clinical management,and under-estimation of disease burden.Liver transplantation may be considered but the mainstay of treatment is organ support,often in the intensive care unit.This review will provide clarity around where are the controversies and consensus in ACLF including:Epidemiology and resource utilisation,key clinical and diagnostic features,strategies for management,and research gaps. | Natalie L Y Ngu Eliza Flanagan Sally Bell Suong T Le | 2023 | World Journal of Gastroenterology2023，29，2： | 2 |
| 2 | Endomet-rial CD56+ natural killer cells in women with recurrent miscarriage:a histomorphometric study显示文摘 | CLIFFORD K FLANAGAN AM REGAN L | 1999 | Hum Reprod1999，14，11： | 1 |
| 3 | Autodirective microphone systems显示文摘 | Flanagan J L Berkeley D A Elko G W | 1991 | Acoustics1991，73，3： | 1 |
| 4 | Re- sponses of boreal conifers to climate fluctuations: indications from tree-ring widths and carbon isotope analyses显示文摘 | BROOKS J R FLANAGAN L B EHLERINGER J R | 1998 | Can J For Res1998，28，： | 1 |
| 5 | Isolation and characterization of the lignans, isolariciresinol and pinoresinol, in flaxseed meal显示文摘 | MEAGHER L P BEECHER G R FLANAGAN V P | 1999 | Journal of Agriculture and Food Chemistry1999，47，8： | 1 |
| 6 | Multiple logistic regression analysis of plasma paraquat concentrations as a predictor of outcome in 375 cases of paraquat poisoning显示文摘 | Jones L Elton R Flanagan R | | 0，，： | 1 |
| 7 | Effects of substrate stiffness on cell morphology, cytoskeletal structure and adhesion 显示文摘 | Yeung T Georges P C Flanagan L Av | 2005 | Cell Motol Cytoskel2005，60，1： | 1 |
| 8 | Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sintering显示文摘 | J M Williamsa A Adewunmi C L Flanagan | 2005 | Biomaterials2005，26，： | 1 |
| 9 | Arsenic groundwater in eastern New England:occurrence, controls and human health implications 显示文摘 | Ayotte J D Montgomery D L Flanagan S M | 2003 | Environ Sci Technol2003，37，10： | 1 |
| 10 | Historical development of glycidyl azide polymer显示文摘 | Frankel M B Grant L R Flanagan J E | 1992 | Propulsion and Power1992，8，3： | 1 |
| 11 | Haematological toxicity of drugs used in psychiatry显示文摘 | Flanagan RJ Dunk L | 2008 | Hum Psychopharmacol Clin Exp2008，23，1： | 1 |
| 12 | Apoptosis repressor with caspase recruitment do- main, a multifunctionat modulator of cell death显示文摘 | LUDWIG-GALEZOWSKA A H FLANAGAN L REHM M | 2010 | J Cell Mol Med2010，15，3： | 1 |
| 13 | foot-and-mouth disease virus from African buffalo to cattle in a wildlife area of Zimbabwe显示文摘 | Dawe P S Flanagan F O Madekurozwa R L | 1994 | Vet Rec1994，134，： | 1 |
| 14 | Seasonal and interannual variation in carbon dioxide exchange and carbon balance in a northern temperate grassland 显示文摘 | Flanagan L B Wever L A Carlson P J | 2002 | Global Change Biology2002，8，： | 1 |
| 15 | Carbon isotope composition of boreal plants: functional grouping of life forms显示文摘 | Brooks J R Flanagan L B Buchman N | 1997 | Oecologia1997，110，： | 1 |
| 16 | The influence of insulin on circulating ghrelin显示文摘 | FLANAGAN D E EVANS M L MONSOD T P | 2003 | Metab2003，284，2： | 1 |
| 17 | XIAP impairs Smac releasefrom the mitochondria during apoptosis显示文摘 | Flanagan L Sebastid J Tully L P | 2010 | Celll Death Dis2010，1，： | 1 |
| 18 | mTOR in breast cancer:differential expression in triple-negative and nontriple-negative tumors显示文摘 | Walsha S Flanagan L Quinn C | 2012 | Breast2012，21，2： | 1 |
| 19 | Environmental regulation of carbon dioxide exchange at the forest floor in a boreal black spruce ecosystem显示文摘 | Swanson R V Flanagan L B | 2001 | Agricultural and Forest Me- teorology2001，108，3： | 1 |
| 20 | Computer-steered microphone arrays for sound transduction in large rooms 显示文摘 | FLANAGAN J L | 1985 | Journal of Acoustic Society of America1985，78，： | 1 |
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