|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Diabetic nephropathy:Is it time yet for routine kidney biopsy?显示文摘Diabetic nephropathy(DN)is one of the most important long-term complications of diabetes.Patients with diabetes and chronic kidney disease have an increased risk of all-cause mortality,cardiovascular mortality,and kidney failure.The clinical diagnosis of DN depends on the detection of microalbuminuria.This usually occurs after the first five years from the onset of diabetes,and predictors of DN development and progression are being studied but are not yet implemented into clinical practice.Diagnostic tests are useful tools to recognize onset,progression and response to therapeutic interventions.Microalbuminuria is an indicator of DN,and it is considered the only noninvasive marker of early onset.However,up to now there is no diagnostic tool that can predict which patients will develop DN before any damage is present.Pathological renal injury is hard to predict only with clinical and laboratory findings.An accurate estimate of damage in DN can only be achieved by the histological analysis of tissue samples.At the present time,renal biopsy is indicated on patients with diabetes under the suspicion of the presence of nephropathies other than DN.Results from renal biopsies in patients with diabetes had made possible the classification of renal biopsies in three major groups associated with different prognostic features:diabetic nephropathy,non-diabetic renal disease(NDRD),and a superimposed non-diabetic condition on underlying diabetic nephropathy.In patients with type 2 diabetes with a higher degree of suspicion for NDRD,it is granted the need of a renal biopsy.It is important to identify and differentiate these pathologies at an early stage in order to prevent progression and potential complications.Therefore,a more extensive use of biopsy is advisable. | Maria L Gonzalez Suarez David B Thomas Laura Barisoni Alessia Fornoni | 2013 | World Journal of Diabetes2013，4，6： | 29 |
| 2 | New insights into renal lipid dysmetabolism in diabetic kidney disease显示文摘Lipid dysmetabolism is one of the main features of diabetes mellitus and manifests by dyslipidemia as well as the ectopic accumulation of lipids in various tissues and organs,including the kidney.Research suggests that impaired cholesterol metabolism,increased lipid uptake or synthesis,increased fatty acid oxidation,lipid droplet accumulation and an imbalance in biologically active sphingolipids(such as ceramide,ceramide-1-phosphate and sphingosine-1-phosphate)contribute to the development of diabetic kidney disease(DKD).Currently,the literature suggests that both quality and quantity of lipids are associated with DKD and contribute to increased reactive oxygen species production,oxidative stress,inflammation,or cell death.Therefore,control of renal lipid dysmetabolism is a very important therapeutic goal,which needs to be archived.This article will review some of the recent advances leading to a better understanding of the mechanisms of dyslipidemia and the role of particular lipids and sphingolipids in DKD. | Alla Mitrofanova George Burke Sandra Merscher Alessia Fornoni | 2021 | World Journal of Diabetes2021，12，5： | 5 |
| 3 | Role of inflammation in diabetic nephropathy显示文摘 | Fornoni A Ijaz A Tejada T | 2008 | Curr diabetes Rev2008，4，1： | 1 |
| 4 | Role of inflammation in diabetic nephropathy显示文摘 | Fornoni A Ijaz A Tejada T | | 0，，01： | 1 |
| 5 | Role of inflammation in diabetic nephropathy显示文摘 | Fornoni A ljaz A Tejada L | 2008 | Currdiabetes Rev2008，4，1： | 1 |
| 6 | Ecological and evolutionary implications of plant tolerance to herbivory 显示文摘 | FORNONI J | 2011 | Functional Ecology2011，25，： | 1 |
| 7 | Podocytopathy in diabetes: a metabolic and endocrine disorder显示文摘 | Diez-Sampedro A Lenz O Fornoni A | 2011 | Am J Kidney Dis2011，58，4： | 1 |
| 8 | Variation in arbuscular mycorrhizal fungi colonization modifies the expression of tolerance to above-ground defoliation 显示文摘 | GARRIDO E BENNETT A E FORNONI J | 2010 | Journal of Ecology2010，98，： | 1 |
| 9 | Roleofinflammation in diabetic nephrop-athy 显示文摘 | Fornoni A Ijaz A Tejada T | 2008 | Curt diabetes Rev2008，4，1： | 1 |
| 10 | Podocytopathy in diabetes:a metabolic and endocrine disorder显示文摘 | Diez-Sampedro A Lenz O Fornoni A | 2011 | Am J Kidney Dis2011，58，： | 1 |
| 11 | Role of inflammation in diabetic nephropathy显示文摘 | Fornoni A Ijaz A Tejada T | 2008 | Curr Diabetes Rev2008，4，1： | 1 |
| 12 | Upregulation of type I collagen by TGF-beta in mesangial cells is blocked by PPARgamma ac- tivation显示文摘 | Fornoni A Elliot S J Guan Y | 2002 | Am J Physiol Renal Physiology2002，282，4： | 1 |
| 13 | Inhibition of c-jun N terminal kinase (JNK) improves functional beta cell mass in human islets and leads to AKT and glycogen synthase kinase-3 ( GSK-3 ) phosphorylation显示文摘 | Fornoni A Pileggi A Molano RD | 2008 | Diabetologia2008，51，2： | 1 |
| 14 | Rituximab targets podocytes in recurrent focal segmental glomerulosclerosis显示文摘 | Fornoni A Sageshima J Wei C | 2011 | Sci Transl Med2011，3，85： | 1 |
| 15 | Abatacept in B7-1-positive proteinuric kidney disease显示文摘 | Yu CC Fornoni A Weins A | 2013 | N Engl J Med2013，369，25： | 1 |
| 16 | Role ofinflammtion in diabetic nephropathy 显示文摘 | Fornoni A Ijaz A Tejada T | 2008 | Curt Diabetes Rev2008，4，1： | 1 |
| 17 | Role of inflammation in dia-betic nephropathy显示文摘 | Fornoni A Ijaz A Tejada T | 2008 | Curr Diabetes Rev2008，4，1： | 1 |
| 18 | Proteinuria, the podoeyte, and insulin resistance显示文摘 | Fornoni A | 2010 | N Engl J Med2010，363，21： | 1 |
| 19 | Renin-angiotensin system blockade and diabetes: moving the adipose organ from the periphery to the center显示文摘 | Lenz O Fornoni A | 2008 | Kidney Int2008，74，7： | 1 |
| 20 | Upregulation of type Ⅰ collagen by TGF-β in mesangial cells is blocked by PPARγactivation显示文摘 | Zheng F Fornoni A Elliot SJ | 2002 | Am J Physiol Renal Physiol2002，282，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员