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| 1 | Total pancreatectomy and islet autotransplantation: A decade nationwide analysis显示文摘AIM: To investigate outcomes and predictors of inhospital morbidity and mortality after total pancreatectomy(TP) and islet autotransplantation. METHODS: The nationwide inpatient sample(NIS) database was used to identify patients who underwent TP and islet autotransplantation(IAT) between 2002-2012 in the United States. Variables of interest were inherent variables of NIS database which included demographic data(age, sex, and race), comorbidities(such as diabetes mellitus, hypertension, and deficiency anemia), and admission type(elective vs nonelective). The primary endpoints were mortality and postoperative complications according to the ICD-9 diagnosis codes which were reported as the second to 25 th diagnosis of patients in the database. Risk adjusted analysis was performed to investigate morbidity predictors. Multivariate regression analysis was used to identify predictors of in-hospital morbidity.RESULTS: We evaluated a total of 923 patients who underwent IAT after pancreatectomy during 2002-2012. Among them, there were 754 patients who had TP + IAT. The most common indication ofsurgery was chronic pancreatitis(86%) followed by acute pancreatitis(12%). The number of patients undergoing TP + IAT annually significantly increased during the 11 years of study from 53 cases in 2002 to 155 cases in 2012. Overall mortality and morbidity of patients were 0% and 57.8 %, respectively. Postsurgical hypoinsulinemia was reported in 42.3% of patients, indicating that 57.7% of patients were insulin independent during hospitalization. Predictors of inhospital morbidity were obesity [adjusted odds ratio(AOR): 3.02, P = 0.01], fluid and electrolyte disorders(AOR: 2.71, P < 0.01), alcohol abuse(AOR: 2.63, P < 0.01), and weight loss(AOR: 2.43, P < 0.01). CONCLUSION: TP + IAT is a safe procedure with no mortality, acceptable morbidity, and achieved high rate of early insulin independence. Obesity is the most significant predictor of in-hospital morbidity. | Reza Fazlalizadeh Zhobin Moghadamyeghaneh Aram N Demirjian David K Imagawa Clarence E Foster Jonathan R Lakey Michael J Stamos Hirohito Ichii | 2016 | World Journal of Transplantation2016，6，1： | 9 |
| 2 | Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis显示文摘Cementum is critical for anchoring the insertion of periodontal ligament fibers to the tooth root. Several aspects of cementogenesis remain unclear, including differences between acellular cementum and cellular cementum, and between cementum and bone.Biomineralization is regulated by the ratio of inorganic phosphate(Pi) to mineral inhibitor pyrophosphate(PPi), where local Piand PPi concentrations are controlled by phosphatases including tissue-nonspecific alkaline phosphatase(TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1(NPP1). The focus of this study was to define the roles of these phosphatases in cementogenesis. TNAP was associated with earliest cementoblasts near forming acellular and cellular cementum. With loss of TNAP in the Alpl null mouse, acellular cementum was inhibited, while cellular cementum production increased, albeit as hypomineralized cementoid. In contrast, NPP1 was detected in cementoblasts after acellular cementum formation, and at low levels around cellular cementum. Loss of NPP1 in the Enpp1 null mouse increased acellular cementum, with little effect on cellular cementum.Developmental patterns were recapitulated in a mouse model for acellular cementum regeneration, with early TNAP expression and later NPP1 expression. In vitro, cementoblasts expressed Alpl gene/protein early, whereas Enpp1 gene/protein expression was significantly induced only under mineralization conditions. These patterns were confirmed in human teeth, including widespread TNAP, and NPP1 restricted to cementoblasts lining acellular cementum. These studies suggest that early TNAP expression creates a low PPienvironment promoting acellular cementum initiation, while later NPP1 expression increases PPi, restricting acellular cementum apposition. Alterations in PPihave little effect on cellular cementum formation, though matrix mineralization is affected. | Laura E Zweifler Mudita K Patel Francisco H Nociti Jr Helen F Wimer Jose L Milln Martha J Somerman Brian L Foster | 2015 | International Journal of Oral Science2015，7，1： | 5 |
| 3 | Apple dwarfing rootstocks exhibit an imbalance in carbohydrate allocation and reduced cell growth and metabolism显示文摘Apple dwarfing rootstocks cause earlier shoot termination and reduced root and shoot mass.To identify physiological factors responsible for rootstock-induced growth restriction,we compared vascular-enriched gene expression between two dwarfing rootstocks(‘M27’and‘M9’)and the vigorous rootstock‘M793’using RNA sequencing and quantitative reverse transcriptase PCR.Differentially expressed genes common to both dwarfing rootstocks belonged to five main biological processes:(1)primary metabolism,(2)cell wall synthesis and modification,(3)secondary metabolism,(4)hormone signalling and response and(5)redox homeostasis.Genes promoting the biosynthesis of amino acids,lipids and cell walls were downregulated in dwarfing rootstocks,whereas genes promoting the breakdown of these compounds were upregulated.The only exception to this trend was the upregulation of starch synthesis genes in dwarfing rootstocks.Non-structural carbohydrate analysis demonstrated that starch concentrations in‘M9’roots,stems and grafted‘Royal Gala’(‘RG’)scions were double that of equivalent tissues from‘RG’homo-grafted trees(‘RG’/‘RG’).Fructose and glucose concentrations were much lower in all three tissues of the‘RG’/‘M9’trees.Together,these data indicate that dwarfing rootstocks are in a state of sugar depletion and reduced cellular activity despite having large starch reserves.Another significant finding was the over-accumulation of flavonoids and the downregulation of auxin influx transporters MdAUX1 and MdLAX2 in dwarfing rootstocks.We propose that both factors reduce polar auxin transport.The results of this study contribute novel information about the physiological state of dwarfing rootstocks. | Toshi M Foster Peter A McAtee Chethi N Waite Helen L Boldingh Tony K McGhie | 2017 | Horticulture Research2017，4，1： | 4 |
| 4 | Molecular genetic investigations of the mechanism of tumourgenesis in von Hippel-Lindau disease:analysis of allele loss in VHL tumors 显示文摘 | Foster K Crossey PA Richards FM | 1994 | Hum Mol Genet1994，3，： | 2 |
| 5 | Cardiac resynchronization therapy for the treatment of heart failure in patients with intraventricular conduction delay and malignant ventricular tachyarrhythmias显示文摘 | Steven L Higgins John D Hummel Imran K Niazi Michael C Giudici Seth J Worley Leslie A Saxon John P Boehmer Michael B Higginbotham Teresa De Marco Elyse Foster Patrick G Yong | 2003 | Journal of the American College of Cardiology2003，，8： | 2 |
| 6 | Microporous gel electrolyte Li-ion battery显示文摘 | Zhang S S Xu K Foster D L | 2004 | Journal of Power Sources2004，125，1： | 1 |
| 7 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 8 | Uhrasound biom- icroscopy of anterior segment structures in normal and glau-comatous eyes 显示文摘 | Pavlin C J Harasiewicz K Foster FS | 1992 | Am JOph thamol1992，113，： | 1 |
| 9 | Chitosan-van- comysin composite biomaterial as a laser activated surgical adhesive with regional antimicrobial activity显示文摘 | Foster LJ Thomson K Marcal H | 2010 | Biomacro- molecules2010，11，12： | 1 |
| 10 | RUSLE,revided:Status,question,answers,and the future显示文摘 | Renard K G Foster G R | 1994 | Soil and water Conservation1994，49，3： | 1 |
| 11 | The effect of various electrolyte additives on reversible Li-graphite intercalation显示文摘 | Foster D L Behl W K Wolfenstine J | 2000 | J Power Sources2000，85，2： | 1 |
| 12 | RUSLE; Revised universal soil Loss equation 显示文摘 | RENARD K G FOSTER G R WEESIES G A | 1991 | Journal of Soll and Water Conservation1991，46，： | 1 |
| 13 | Impro- ving data availability through dynamic mod- el Driven Replication in Large Peer-to-Peer Communities显示文摘 | Ranganath A K Iamnitchi A Foster I | | 0，，： | 1 |
| 14 | The conundrum of traumatic colon injury显示文摘 | Fealk M Osipov R Foster K | 2004 | Am J Surg2004，188，6： | 1 |
| 15 | The serpin proteinase inhibitor9is an endogenous inhibitor of interleukin1beta- converting enzyme(caspase-1)activity in human vascular smooth muscle cells显示文摘 | YOUNG J L SUKHOVA G K FOSTER D | 2000 | J Exp Med2000，191，： | 1 |
| 16 | A History of Medical and Biological Imaging with Polyvinylidene Fluoride (PVDF) Transducers显示文摘 | Foster F S Harasiewicz K A Sherar M D | 2000 | IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control2000，47，6： | 1 |
| 17 | Policy & Practice:challenges ahead for US regional planning governance显示文摘 | FOSTER K | 2010 | Town Planning Review2010，81，5： | 1 |
| 18 | In vitro analysis of the anthelmintle axtivity of forage chicory (Cichorium intybus L) sesquiterpene laxtones against a predominatly Haemonchus contortus egg population 显示文摘 | Foster J G Cassida K A Turner K E | 2011 | Veterinary Parasitology2011，180，34： | 1 |
| 19 | Nasal ocular reflexes occur after nasal challenge with allergen 显示文摘 | Baroody EM Foster K Markarian A | 2007 | J Allergy Clin Immunol2007，119，1： | 1 |
| 20 | Revised slope length factor for the universal soil loss equation显示文摘 | McCool D K Foster G R Mutchler C K | 1989 | Transactions ofASAE1989，32，： | 1 |
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