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| 1 | Wireless capsule endoscopy and proximal small bowel lesions in Crohn’s disease显示文摘AIM: To investigate the prevalence of proximal small bowel (SB) lesions detected by wireless capsule endoscopy (WCE) in Crohn's disease (CD). METHODS: WCE was performed in 64 patients: 32 with CD of the distal ileum, and 32 controls with iron-deficiency anemia (IDA) or diarrhea. WCE was performed using the Given SB-WCE, followed by small intestine contrast ultrasonography (SICUS). Findings compatible with CD by using WCE included erosions, aphthoid or deep ulcers, and strictures/stenosis. RESULTS: WCE detected proximal SB lesions in 16/32 (50%) patients (14 aphthoid ulcers, 2 deep ulcers, one stricture), which appeared not to be related to clinical parameters [epigastric pain, age, smoking, non-steroidalanti-inflammatory drugs (NSAIDs), IDA]. Among patients with proximal SB lesions, 6 (37%) were smokers, 3 (19%) NSAID users, 3 (19%) had epigastric pain and 4 (25%) had IDA. SICUS detected proximal SB lesions in 3/32 patients (19%) also showing lesions with WCE. No correlations were observed between proximal SB lesions assessed by WCE or by SICUS (χ2 = 1.5, P = 0.2). CONCLUSION: The use of WCE allows the detection of previously unknown upper SB lesions in a high proportion of patients with a previous diagnosis of CD involving the distal ileum. | Carmelina Petruzziello Sara Onali Emma Calabrese Francesca Zorzi Marta Ascolani Giovanna Condino Elisabetta Lolli Paola Naccarato Francesco Pallone Livia Biancone | 2010 | World Journal of Gastroenterology2010，16，26： | 7 |
| 2 | Small intestine contrast ultrasonography vs computed tomography enteroclysis for assessing ileal Crohn's disease显示文摘AIM:To compare computed tomography enteroclysis(CTE) vs small intestine contrast ultrasonography(SICUS) for assessing small bowel lesions in Crohn's disease(CD),when using surgical pathology as gold standard.METHODS:From January 2007 to July 2008,15 eligible patients undergoing elective resection of the distal ileum and coecum(or right colon) were prospectively enrolled.All patients were under follow-up.The study population included 6 males and 9 females,with a median age of 44 years(range:18-80 years).Inclusion criteria:(1) certain diagnosis of small bowel requiring elective ileo-colonic resection;(2) age between 18-80 years;(3) elective surgery in our Surgical Unit;and(4) written informed consent.SICUS and CTE were performed ≤ 3 mo before surgery,followed by surgical pathology.The following small bowel lesions were blindly reported by one sonologist,radiologist,surgeon and histolopathologist:disease site,extent,strictures,abscesses,fistulae,small bowel dilation.Comparison between findings at SICUS,CTE,surgical specimens and histological examination was made by assessing the specificity,sensitivity and accuracy of each technique,when using surgical findings as gold standard.RESULTS:Among the 15 patients enrolled,CTE was not feasible in 2 patients,due to urgent surgery in one patients and to low compliance in the second patient,refusing to perform CTE due to the discomfort related to the naso-jejunal tube.The analysis for comparing CTE vs SICUS findings was therefore performed in 13 out of the 15 CD patients enrolled.Differently from CTE,SICUS was feasible in all the 15 patients enrolled.No complications were observed when using SICUS or CTE.Surgical pathology findings in the tested population included:small bowel stricture in 13 patients,small bowel dilation above ileal stricture in 10 patients,abdominal abscesses in 2 patients,enteric fistulae in 5 patients,lymphnodes enlargement(> 1 cm) in 7 patients and mesenteric enlargement in 9 patients.In order to compare findings by using SICUS,CTE,histology and surgery,characteristics of the small bowel lesions observed in CD each patient were blindly reported in the same form by one gastroenterologistsonologist,radiologist,surgeon and anatomopathologist.At surgery,lesions related to CD were detected in the distal ileum in all 13 patients,also visualized by both SICUS and CTE in all 13 patients.Ileal lesions > 10 cm length were detected at surgery in all the 13 CD patients,confirmed by SICUS and CTE in the same 12 out of the 13 patients.When using surgical findings as a gold standard,SICUS and CTE showed the exactly same sensitivity,specificity and accuracy for detecting the presence of small bowel fistulae(accuracy 77% for both) and abscesses(accuracy 85% for both).In the tested CD population,SICUS and CTE were also quite comparable in terms of accuracy for detecting the presence of small bowel strictures(92% vs 100%),small bowel fistulae(77% for both) and small bowel dilation(85% vs 82%).CONCLUSION:In our study population,CTE and the non-invasive and radiation-free SICUS showed a comparable high accuracy for assessing small bowel lesions in CD. | Sara Onali Emma Calabrese Carmelina Petruzziello Francesca Zorzi Giuseppe Sica Roberto Fiori Marta Ascolani Elisabetta Lolli Giovanna Condino Giampiero Palmieri Giovanni Simonetti Francesco Pallone Livia Biancone | 2012 | World Journal of Gastroenterology2012，18，42： | 5 |
| 3 | Understanding individual mobility patterns from urban sensing data: A mobile phone trace example显示文摘 | Francesco Calabrese Mi Diao Giusy Di Lorenzo Joseph Ferreira Carlo Ratti | 2013 | Transportation Research Part C2013，，： | 1 |
| 4 | A family study of asymptomatic small bowel Crohn’s disease显示文摘 | Livia Biancone Emma Calabrese Carmelina Petruzziello Alessandra Capanna Francesca Zorzi Sara Onali Giovanna Condino Elisabetta Lolli Cinzia Ciccacci Paola Borgiani Francesco Pallone | 2013 | Digestive and Liver Disease2013，，： | 1 |
| 5 | Fistulizing pattern in Crohn’s disease and pancolitis in ulcerative colitis are independent risk factors for cancer: A single-center cohort study显示文摘 | Livia Biancone Sara Zuzzi Micaela Ranieri Carmelina Petruzziello Emma Calabrese Sara Onali Marta Ascolani Francesca Zorzi Giovanna Condino Simona Iacobelli Francesco Pallone | 2011 | Journal of Crohn’s and Colitis2011，，5： | 1 |
| 6 | Early stage gastric diffuse large B-cell lymphomas: results of a randomised trial comparing chemotherapy alone versus chemotherapy + involved field radiotherapy显示文摘 | Giovanni Martinelli Federica Gigli Liliana Calabrese Pier Francesco Ferrucci Emanuele Zucca Cristiano Crosta Giancarlo Pruneri Lorenzo Preda Gaia Piperno Mary Gospodarowicz Francesco Cavalli Henry Moreno Gomez | 2009 | Leukemia & Lymphoma2009，，6： | 1 |
| 7 | Frequency, Pattern, and Risk Factors of Postoperative Recurrence of Crohn’s Disease After Resection Different from Ileo-Colonic显示文摘 | Sara Onali Carmelina Petruzziello Emma Calabrese Giovanna Condino Francesca Zorzi Giuseppe Sigismondo Sica Francesco Pallone Livia Biancone | 2009 | Journal of Gastrointestinal Surgery2009，，2： | 1 |
| 8 | Anti-TNF-alpha treatments and obstructive symptoms in Crohn’s Disease: A prospective study显示文摘 | Giovanna Condino Emma Calabrese Francesca Zorzi Sara Onali Elisabetta Lolli Fabiola De Biasio Marta Ascolani Francesco Pallone Livia Biancone | 2012 | Digestive and Liver Disease2012，，： | 1 |
| 9 | Ultrasound of the Small Bowel in Crohn’s Disease显示文摘 | Emma Calabrese Francesca Zorzi Francesco Pallone Christoph Gasche | 2012 | International Journal of Inflammation2012，，： | 1 |
| 10 | Digital foot- printing: uncovering tourists with user-generated content显示文摘 | Fabien Girardin Josep Blat Francesco Calabrese | 2008 | IEEE Pervasive Computing2008，7，4： | 1 |
| 11 | Accuracy of Small-Intestine Contrast Ultrasonography, Compared With Computed Tomography Enteroclysis, in Characterizing Lesions in Patients With Crohn’s Disease显示文摘 | Emma Calabrese Francesca Zorzi Sara Onali Elisa Stasi Roberto Fiori Simonetta Prencipe Antonino Bella Carmelina Petruzziello Giovanna Condino Elisabetta Lolli Giovanni Simonetti Livia Biancone Francesco Pallone | 2013 | Clinical Gastroenterology and Hepatology2013，，8： | 1 |
| 12 | Ileal lesions in patients with ulcerative colitis after ileo-rectal anastomosis:Relationship with colonic metaplasia显示文摘AIM:To assess whether in ulcerative colitis (UC) patients with ileo-rectal anastomosis (IRA), ileal lesions may develop in the neo-terminal-ileum and their possible relation with phenotypic changes towards colonic epithelium. METHODS: A total of 19 patients with IRA under regular follow up were enrolled, including 11 UC and 8 controls (6 Crohn’s disease, CD; 1 familial adenomatous polyposis, FAP; 1 colon cancer, colon K). Ileal lesions were identifi ed by ileoscopy with biopsies taken from the ileum (involved and uninvolved) and from the rectal stump. Staining included HE and immunohistochemistry using monoclonal antibodies against colonic epithelial protein CEP (Das-1) and human tropomyosin isoform 5, hTM5 (CG3). Possible relation between development of colonic metaplasia and ileal lesions was investigated.RESULTS: Stenosing adenocarcinoma of the rectal stump was detected in 1 UC patient. The neo-terminal ileum was therefore investigated in 10/11 UC patients. Ileal ulcers were detected in 7/10 UC, associated with colonic metaplasia in 4/7 (57.1%) and Das-1 and CG3 reactivity in 3/4 UC. In controls, recurrence occurred in 4/6 CD, associated with colonic metaplasia in 3/4 and reactivity with Das-1 and CG3 in 2/3. CONCLUSION: Present fi ndings suggest that in UC, ileal lesions associated with changes towards colonic epithelium may develop also after IRA. Changes of the ileal content after colectomy may contribute to the development of colonic metaplasia, leading to ileal lesions both in the pouch and in the neo-terminal ileum after IRA. | Livia Biancone Emma Calabrese Giampiero Palmieri Carmelina Petruzziello Sara Onali Giuseppe Sigismondo Sica Marta Cossignani Giovanna Condino Kiron Moy Das Francesco Pallone | 2008 | World Journal of Gastroenterology2008，14，34： | 1 |
| 13 | Au,Pd and maghemite nanofunctionalized hydroxyapatite scaffolds for bone regeneration显示文摘Nanotechnology plays a key role in the development of innovative scaffolds for bone tissue engineering(BTE)allowing the incorporation of nanomaterials able to improve cell proliferation and differentiation.In this study,Mg-HA-Coll type I scaffolds(Mg-HA-based scaffolds)were nanofunctionalized with gold nanorods(Au NRs),palladium nanoparticles(Pd NPs)and maghemite nanoparticles(MAG NPs).Nanofunctionalized Mg-HA-based scaffolds(NF-HA-Ss)were tested for their ability to promote both the proliferation and the differentiation of adipose-derived mesenchymal stem cells(hADSCs).Results clearly highlight that MAG nanofunctionalization substantially improves cell proliferation up to 70% compared with the control(Mg-HA-based scaffold),whereas both Au NRs and Pd NPs nanofunctionalization induce a cell growth inhibition of 94% and 89%,respectively.Similar evidences were found for the osteoinductive properties showing relevant calcium deposits(25% higher than the control)for MAG nanofunctionalization,while a decreasing of cell differentiation(20% lower than the control)for both Au NRs and Pd NPs derivatization.These results are in agreement with previous studies that found cytotoxic effects for both Pd NPs and Au NRs.The excellent improvement of both osteoconductivity and osteoinductivity of the MAG NF-HA-S could be attributed to the high intrinsic magnetic field of superparamagnetic MAG NPs.These findings may pave the way for the development of innovative nanostructured scaffolds for BTE. | Giovanna Calabrese Salvatore Petralia Claudia Fabbi Stefano Forte Domenico Franco Salvatore Guglielmino Emanuela Esposito Salvatore Cuzzocrea Francesco Traina Sabrina Conoci | 2020 | Regenerative Biomaterials2020，7，5： | 1 |
| 14 | Impact of Primary Coronary Angioplasty Delay on Myocardial Salvage, Infarct Size, and Microvascular Damage in Patients With ST-Segment Elevation Myocardial Infarction显示文摘 | Marco Francone Chiara Bucciarelli-Ducci Iacopo Carbone Emanuele Canali Raffaele Scardala Francesca A. Calabrese Gennaro Sardella Massimo Mancone Carlo Catalano Francesco Fedele Roberto Passariello Jan Bogaert Luciano Agati | 2009 | Journal of the American College of Cardiology2009，，23： | 1 |
| 15 | 轮胎形态变化的仿真技术显示文摘轮胎形态变化仿真技术可以在汽车开发的早期阶段向汽车制造商提供装配不同轮胎和轮辋型号的预测数据。这项仿真技术具有进一步应用的潜在价值。在汽车早期设计阶段,需要考虑的有关轮胎的重要问题包括:应该选择哪种规格的轮胎和轮辋,设定最佳的轮胎充气内压,如何才能通过对轮胎的改进获得接近轮胎实测值的重要性能指标,这些数据与汽车的相关性有多大?轮胎模型软件CD Tire/3D是可以在第一个实体样品出现之前用来预测轮胎性能的新软件,可以解决上述问题。 | 冯普凌 Francesco Calabrese Manfred B?cker Axel Gallrein | 2019 | 现代橡胶技术2019，45，3： | 0 |
| 16 | The cold chain and the COVID-19 pandemic:an unusual increase in histamine content in fish samples collected in Southern Italy during lockdown显示文摘Objectives:We analysed 900 samples of fresh(250)and processed(650)fish products collected in Sicily(Southern Italy)in 2020 during the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic(hereafter:COVID-19).Materials and methods:The samples were divided temporally based on four phases relating to the various restrictions imposed by the Italian government in this period.The validated method of ultrahigh-performance liquid chromatography combined with a diode array detector was then employed for the analysis.Results:The samples collected during the Phase I lockdown period and after it had ended(Phase II)revealed significant increases in the mean histamine levels:(41.89±87.58)mg/kg and(24.91±76.76)mg/kg,respectively.The 11(1.3%of the total)fresh fish samples that were identified as being non-compliant with Regulation(EC)No.2073/2005 were only found during these two periods.All the processed samples were always compliant.The histamine values decreased as the restrictions eased,achieving a mean value of(11.16±9.3)mg/kg(Phase III).Conclusions:There was an increase in the incidence offish samples that were non-compliant with Regulation(EC)No.2073/2005 compared to previous surveillance data.These results provide a first report on the effect of lockdown measures on food safety and the cold chain.Our findings must cause food safety operators to intensify their controls over fresh fish products in such periods to safeguard consumer health.Further studies are required to evaluate whether the same trend would be observed with other food contaminants. | Francesco Giuseppe Gailuzzo Gaetano Cammilleri Antonello Cicero Licia Pantano Andrea Pulvirenti Andrea Macaluso Nicola Cicero Vittorio Calabrese Vincenzo Ferrantelli | 2021 | Food Quality and Safety2021，5，4： | 0 |
| 17 | Albumin-bilirubin score in non-malignant liver diseases should be properly validated显示文摘The albumin-bilirubin(ALBI)score to assess the risk of decompensation in patients with initially compensated cirrhosis may improve their prognostic evaluation.This letter critically evaluates the research,which utilizes the ALBI score to forecast decompensation in cirrhosis patients over a three-year period.This score was initially developed to assess liver function in hepatocellular carcinoma,its prognostic utility for non-malignant liver diseases has now been explored,recognizing decompensation as a pivotal event that significantly affects patient’s survival.Some concerns regarding the methodology of this research may be raised,particularly the exclusive use of radiological diagnosis,potentially including patients without definite cirrhosis and thus skewing the decompensation risk assessment.The reported predominance of variceal bleeding as a decompensating event conflicts with established literature,that often reports ascites as the initial decompensation manifestation.The letter highlights the absence of details on esophageal varices and their management,which could introduce bias in evaluating the ALBI score's predictive power.Furthermore,the letter points out the small sample size of patients with high-risk ALBI grades,potentially compromising the score's validity in this context.We suggest prospective future research to investigate the dynamic changes in the ALBI score over time to reinforce the validity of the ALBI score as a predictor of decompensation in non-malignant liver disease. | Andrea Pasta Francesco Calabrese Maria Corina Plaz Torres Giorgia Bodini Manuele Furnari EdoardoVincenzo Savarino Vincenzo Savarino Edoardo Giovanni Giannini Elisa Marabotto | 2023 | World Journal of Gastroenterology2023，29，46： | 0 |
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