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| 1 | 冠状动脉内影像学临床应用专家共识(第一部分):对冠状动脉介入治疗的指导与优化显示文摘欧洲心血管介入协会(EAPCI)专家组系统总结了血管内超声(IVUS)和光学相干断层成像(OCT)这两种血管内影像学检查临床应用指征的现有证据,提供了关于IVUS和OCT指导经皮冠状动脉介入治疗(PCI)的应用价值,并明确了最可能从腔内影像学指导的介入治疗中获得临床收益的患者或病变类型,同时详细论述了PCI前如何使用IVUS或OCT优化支架尺寸(支架长度和直径)和手术策略的选择。此外,专家推荐对支架失败(支架内再狭窄或支架内血栓形成)的患者应常规进行冠状动脉内影像学检查,并首选OCT。最后,重点论述了IVUS和OCT在指导PCI和评估支架失败两个方面的优势和局限性,并对未来需要深入研究的领域进行了展望。 | Lorenz Raber Gary S Mintz Konstantinos C Koskinas Thomas W Johnson Niels R Holm Yoshinubo Onuma Maria D Radu Michael Joner Bo Yu Haibo Jia Nicolas Meneveau Jose M.de la Torre Hemandez Javier Escaned Jonathan Hill Francesco Prati Antonio Colombo Carlo di Mario Evelyn Regar Davide Capodanno William Wijns Robert A Byme Giulio Guagliumi | 2019 | 中华心血管病杂志2019，47，1： | 17 |
| 2 | Evidence based medicine and surgical approaches for colon cancer: Evidences, benefits and limitations of the laparoscopic vs open resection显示文摘AIM:To report a meta-analysis of the studies that compared the laparoscopic with the open approach for colon cancer resection.METHODS:Forty-seven manuscripts were reviewed,33 of which employed for meta-analysis according to the PRISMA guidelines.The results were differentiated according to the study design(prospective randomized trials vs case-control series)and according to the tu-mor’s location.Outcome measures included:(1)shortterm results(operating times,blood losses,bowel function recovery,post-operative pain,return to the oral intake,complications and hospital stay);(2)oncological adequateness(number of nodes harvested in the surgical specimens);and(3)long-term results(including the survivals’rates and incidence of incisional hernias)and(4)costs.RESULTS:Meta-analysis of trials provided evidences in support of the laparoscopic procedures for a several short-term outcomes including:a lower blood loss,an earlier recovery of the bowel function,an earlier return to the oral intake,a shorter hospital stay and a lower morbidity rate.Opposite the operating time has been confirmed shorter in open surgery.The same trend has been reported investigating case-control series and cancer by sites,even though there are some concerns regarding the power of the studies in this latter field due to the small number of trials and the small sample of patients enrolled.The two approaches were comparable regarding the mean number of nodes harvested and long-term results,even though these variables were documented reviewing the literature but were not computable for meta-analysis.The analysis of the costs documented lower costs for the open surgery,however just few studies investigated the incidence of postoperative hernias.CONCLUSION:Laparoscopy is superior for the majority of short-term results.Future studies should better differentiate these approaches on the basis of tumors’location and the post-operative hernias. | Laura Lorenzon Marco La Torre Vincenzo Ziparo Francesco Montebelli Paolo Mercantini Genoveffa Balducci Mario Ferri | 2014 | World Journal of Gastroenterology2014，20，13： | 8 |
| 3 | Pathophysiology, clinical features and radiological findings of differentiation syndrome/all-trans-retinoic acid syndrome显示文摘In acute promyelocytic leukemia, differentiation thera-py based on all-trans-retinoic acid can be complicated by the development of a differentiation syndrome(DS). DS is a life-threatening complication, characterized by respiratory distress, unexplained fever, weight gain, interstitial lung infiltrates, pleural or pericardial effusions, hypotension and acute renal failure. The diagnosis of DS is made on clinical grounds and has proven to be difficult, because none of the symptoms is pathognomonic for the syndrome without any definitive diagnostic criteria. As DS can have subtle signs and symptoms at presentation but progress rapidly, end-stage DS clinical picture resembles the acute respiratory distress syndrome with extremely poor prognosis; so it is of absolute importance to be conscious of these complications and initiate therapy as soon as it was suspected. The radiologic appearance resembles the typical features of cardiogenic pulmonary edema. Diagnosis of DS remains a great skill for radiologists and haematologist but it is of an utmost importance the cooperation in suspect DS, detect the early signs of DS, examine the patients' behaviour and rapidly detect the complications. | Luciano Cardinale Francesco Asteggiano Federica Moretti Federico Torre Stefano Ulisciani Carmen Fava Giovanna Rege-Cambrin | 2014 | World Journal of Radiology2014，6，8： | 6 |
| 4 | Clinical characteristics and prognostic impact of atrial fibrillation in patients with chronic heart failure显示文摘AIM To assess the prevalence, clinical characteristics and independent prognostic impact of atrial fibrillation(AF) in chronic heart failure(CHF) patients, and the potential protective effect of disease-modifying medications, particularly beta-blockers(BB). METHODS We retrospectively reviewed the charts of patients referred to our center since January 2004, and collected all clinical information available at their first visit. We assessed mortality to the end of June 2015. We compared patients with and without AF, and assessed the association between AF and all-cause mortality by multivariate Cox regression and Kaplan-Meyer analysis, particularly accounting for ongoing treatment with BB.RESULTS A total of 903 patients were evaluated(mean age 68 ± 12 years, 73% male). Prevalence of AF was 19%, ranging from 10% to 28% in patients ≤ 60 and ≥ 77 years, respectively. Besides the older age, patients with AF had more symptoms(New York Heart Association II-III 60% vs 44%), lower prevalence of dyslipidemia(23% vs 37%), coronary artery disease(28% vs 52%) and left bundle branch block(9% vs 16%). On the contrary, they more frequently presented with an idiopathic etiology(50% vs 24%), a history of valve surgery(13% vs 4%) and received overall more devices implantation(31% vs 21%). The use of disease-modifying medications(i.e., BB and ACE inhibitors/angiotensin receptor blockers) was lower in patients with AF(72% vs 80% and 71% vs 79%, respectively), who on the contrary were more frequently treated with symptomatic and antiarrhythmic drugs including diuretics(87% vs 69%) and digoxin(51% vs 11%). At a mean follow-up of about 5 years, all-cause mortality was significantly higher in patients with AF as compared to those in sinus rhythm(SR)(45% vs 34%, P value < 0.05 for all previous comparisons). However, in a multivariate analysis including the main significant predictors of allcause mortality, the univariate relationship between AF and death(HR = 1.49, 95%CI: 1.15-1.92) became not statistically significant(HR = 0.98, 95%CI: 0.73-1.32). Nonetheless, patients with AF not receiving BB treatment were found to have the worst prognosis, followed by patients with SR not receiving BB therapy and patients with AF receiving BB therapy, who both had similarly worse survival when compared to patients with SR receiving BB therapy.CONCLUSION AF was highly prevalent and associated with older age, worse clinical presentation and underutilization of disease-modifying medications such as BB in a population of elderly patients with CHF. AF had no independent impact on mortality, but the underutilization of BB in this group of patients was associated to a worse long-term prognosis. | Lorenzo Gigli Pietro Ameri Gianmarco Secco Gabriele De Blasi Roberta Miceli Alessandra Lorenzoni Francesco Torre Francesco Chiarella Claudio Brunelli Marco Canepa | 2016 | World Journal of Cardiology2016，8，11： | 4 |
| 5 | Survival after radiotherapy in gastric cancer: Systematic review and meta-analysis显示文摘 | Vincenzo Valentini Francesco Cellini Bruce D. Minsky Gian Carlo Mattiucci Mario Balducci Giuseppe D’Agostino Elisa D’Angelo Nicola Dinapoli Nicola Nicolotti Chiara Valentini Giuseppe La Torre | 2009 | Radiotherapy and Oncology2009，，2： | 4 |
| 6 | IgA nephropathy: Causes, prognosis and treatment显示文摘 | Francesco Paolo Schena Diletta Domenica Torres Giuseppina Cerrullo | 2005 | 肾脏病与透析肾移植杂志2005，14，6： | 3 |
| 7 | Impact of chronic liver disease in intensive care unit acquired pneumonia: a prospective study显示文摘 | Marta Pasquale Mariano Esperatti Ernesto Crisafulli Miquel Ferrer Gianluigi Li Bassi Mariano Rinaudo Angels Escorsell Javier Fernandez Antoni Mas Francesco Blasi Antoni Torres | 2013 | Intensive Care Medicine2013，，10： | 2 |
| 8 | Adjuvant vinorelbine plus cisplatin versus observation in patients with completely resected stage IB–IIIA non-small-cell lung cancer (Adjuvant Navelbine International Trialist Association [ANITA]): a randomised controlled trial显示文摘 | Jean-Yves Douillard Rafael Rosell Mario De Lena Francesco Carpagnano Rodryg Ramlau Jose Luis Gonzáles-Larriba Tomasz Grodzki Jose Rodrigues Pereira Alain Le Groumellec Vito Lorusso Claude Clary Antonio J Torres Jabrail Dahabreh Pierre-Jean Souquet Julio A | 2006 | Lancet Oncology2006，，9： | 2 |
| 9 | Unexpected Gallbladder Cancer after Laparoscopic Cholecystectomy for Acute Cholecystitis: A Worrisome Picture显示文摘 | Gennaro Clemente Gennaro Nuzzo Agostino Rose Ivo Giovannini Giuseppe Torre Francesco Ardito Felice Giuliante | 2012 | Journal of Gastrointestinal Surgery2012，，8： | 1 |
| 10 | A new Caucasian case of neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD): A clinical, molecular, and functional study显示文摘 | Giuseppe Fiermonte Giovanni Parisi Diego Martinelli Francesco De Leonardis Giuliano Torre Ciro Leonardo Pierri Alessia Saccari Francesco Massimo Lasorsa Angelo Vozza Ferdinando Palmieri Carlo Dionisi-Vici | 2011 | Molecular Genetics and Metabolism2011，，4： | 1 |
| 11 | Vascularized retinal pigment epithelial detachment in age-related macular degeneration: treatment and RPE tear incidence显示文摘 | Ugo Introini Ana Torres Gimeno Fabrizio Scotti Marco Setaccioli Silvia Giatsidis Francesco Bandello | 2012 | Graefe’s Archive for Clinical and Experimental Ophthalmology2012，，9： | 1 |
| 12 | Total Anorectal Reconstruction With the Artificial Bowel Sphincter: Report of Eight Cases显示文摘 | Giovanni Romano M.D. Filippo La Torre M.D. Giorgio Cutini M.D. Francesco Bianco M.D. Pasquale Esposito M.D. Alberto Montori M.D | 2003 | Diseases of the Colon & Rectum2003，，6： | 1 |
| 13 | Risk factors for community-acquired pneumonia in adults in Europe: a literature review显示文摘 | Antoni Torres Willy E Peetermans Giovanni Viegi Francesco Blasi | 2013 | Thorax2013，，11： | 1 |
| 14 | Interferon β-1a alone or in combination with ribavirin: A randomized trial to compare efficacy and safety in chronic hepatitis C显示文摘AIM: To compare the efficacy and safety of recombinant human IFN β-1a alone or in combination with ribavirin in treatment-na(i)ve subjects with chronic hepatitis C.METHODS: Open, randomized trial was performed in 6 Italian tertiary centers: 102 of the 108 patients screened were randomized to receive 6 MIU of recombinant human IFN β-1a subcutaneously daily for 24 wk, alone (Group 1, n = 51) or in combination with ribavirin 1 000 to 1 200 mg/d (Group 2, n = 51).RESULTS: The end-of-treatment virologic response rate was 29.4% in Group 1 and 41.2% in Group 2 (non-significant). Twenty-four weeks after stopping therapy,sustained virologic response rate was 21.6% in Group 1 and 27.4% in Group 2 (non-significant). All subjects in Group 1 completed treatment, while two subjects in Group 2 stopped therapy due to treatment-related adverse events.CONCLUSION: Recombinant human IFN β-1a, alone or in combination with ribavirin, has an excellent safety profile and, may represent an alternative for chronic hepatitis C patients who are unable to tolerate pegylated α-interferon. | Rinaldo Pellicano Antonio Craxì Piero Luigi Almasio Mario Valenza Giovanna Venezia Alfredo Alberti Silvia Boccato Luigi Demelia Orazio Sorbello Antonino Picciotto Francesco Torre Gaetano Ideo Carlo Cattaneo Mara Berrutti Mario Rizzetto | 2005 | World Journal of Gastroenterology2005，11，29： | 1 |
| 15 | Unexpected Gallbladder Cancer after Laparoscopic Cholecystectomy for Acute Cholecystitis: A Worrisome Picture显示文摘 | Gennaro Clemente Gennaro Nuzzo Agostino Rose Ivo Giovannini Giuseppe Torre Francesco Ardito Felice Giuliante | 2012 | Journal of Gastrointestinal Surgery2012，，8： | 1 |
| 16 | A Systematic Review of Resectability and Survival After Concurrent Chemoradiation in Primarily Unresectable Pancreatic Cancer显示文摘 | Alessio G. Morganti Mariangela Massaccesi Giuseppe La Torre Luciana Caravatta Adele Piscopo Rosa Tambaro Luigi Sofo Giuseppina Sallustio Marcello Ingrosso Gabriella Macchia Francesco Deodato Vincenzo Picardi Edy Ippolito Numa Cellini Vincenzo Valentini | 2010 | Annals of Surgical Oncology2010，，1： | 1 |
| 17 | Insulin-dependent diabetes mellitus affects eradication rate of Helicobacter pylori infection显示文摘 | Antonio Gasbarrini Veronica Ojetti Dario Pitocco Francesco Franceschi Marcello Candelli Elena Sanz Torre Maurizio Gabrielli Giovanni Cammarota Alessandro Armuzzi Roberto Pola Paolo Pola Giovanni Ghirlanda Giovanni Gasbarrini | 1999 | European Journal of Gastroenterology & Hepatology1999，，7： | 1 |
| 18 | Soluble β2-μ-Associated and β2-μ-Free HLA Class I Heavy Chain Serum Levels in Interferon-α Nonresponder Chronic Hepatitis C Patients. Markers of Immune Activation, and Response to Antiviral Retreatment显示文摘 | Francesco Puppo Francesco Torre Paola Contini Massimo Ghio Sabrina Brenci Renata Brizzolara Nicoletta Sinelli Nadia Campo Francesco Indiveri Antonino Picciotto | 2000 | Journal of Clinical Immunology2000，，6： | 1 |
| 19 | Beneficial Effects of Helicobacter pylori Eradication on Idiopathic Chronic Urticaria显示文摘 | Cristiana Di Campli Antonio Gasbarrini Eleonora Nucera Francesco Franceschi Veronica Ojetti Elena Sanz Torre Domenico Schiavino Paolo Pola Giampiero Patriarca Giovanni Gasbarrini | 1998 | Digestive Diseases and Sciences1998，，6： | 1 |
| 20 | Genetic Heterogeneity in Italian Families with IgA Nephropathy: Suggestive Linkage for Two Novel IgA Nephropathy Loci显示文摘 | Luigi Bisceglia Giuseppina Cerullo Paola Forabosco Diletta Domenica Torres Francesco Scolari Michele Di Perna Marina Foramitti Antonio Amoroso Sara Bertok Jürgen Floege Peter Rene Mertens Klaus Zerres Efstathios Alexopoulos Dimitrios Kirmizis Mazzucco Erm | 2006 | The American Journal of Human Genetics2006，，6： | 1 |
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