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| 1 | Near-infrared fluorescence sentinel lymph node detection in gastric cancer: A pilot study显示文摘AIM: To investigate feasibility and accuracy of nearinfrared fluorescence imaging using indocyanine green: nanocolloid for sentinel lymph node(SLN) detection in gastric cancer.METHODS: A prospective, single-institution, phaseI feasibility trial was conducted. Patients suffering from gastric cancer and planned for gastrectomy were included. During surgery, a subserosal injection of 1.6 m L ICG:Nanocoll was administered around the tumor. NIR fluorescence imaging of the abdominal cavity was performed using the Mini-FLARE? NIR fluorescence imaging system. Lymphatic pathways and SLNs were visualized. Of every detected SLN, the corresponding lymph node station, signal-to-background ratio and histopathological diagnosis was determined. Patients underwent standard-of-care gastrectomy. Detected SLNs outside the standard dissection planes were also resected and evaluated.RESULTS: Twenty-six patients were enrolled. Four patients were excluded because distant metastases were found during surgery or due to technical failure of the injection. In 21 of the remaining 22 patients, at least 1 SLN was detected by NIR Fluorescence imaging(mean 3.1 SLNs; range 1-6). In 8 of the 21 patients, tumor-positive LNs were found. Overall accuracy of the technique was 90%(70%-99%; 95%CI), which decreased by higher p T-stage(100%, 100%, 100%, 90%, 0% for respectively Tx, T1, T2, T3, T4 tumors). All NIR-negative SLNs were completely effaced by tumor. Mean fluorescence signal-to-background ratio of SLNs was 4.4(range 1.4-19.8). In 8 of the 21 patients, SLNs outside the standard resection plane were identified, that contained malignant cells in 2 patients.CONCLUSION: This study shows successful use of ICG:Nanocoll as lymphatic tracer for SLN detection in gastric cancer. Moreover, tumor-containing LNs outside the standard dissection planes were identified. | Quirijn RJG Tummers Leonora SF Boogerd Wobbe O de Steur Floris PR Verbeek Martin C Boonstra Henricus JM Handgraaf John V Frangioni Cornelis JH van de Velde Henk H Hartgrink Alexander L Vahrmeijer | 2016 | World Journal of Gastroenterology2016，22，13： | 9 |
| 2 | Near-infrared fluorescence imaging of a solitary fibrous tumor of the pancreas using methylene blue显示文摘A 67-year-old female presented with unexplained abdominal pain. A contrast-enhanced computed tomography scan of the abdomen incidentally revealed a mass in the uncinate process of the pancreas. This mass was resected and based on histopathological findings, diagnosed as a solitary fibrous tumor (SFT) of the pancreas. A SFT is an extremely rare benign mesenchymal tumor that in 65% of cases affects the visceral pleura but can also affect extra-pleural sites. The intraoperative demarcation of pancreatic tumors, such as SFTs, can bechallenging. In this report, the first clear intraoperative identification of a SFT of the pancreas in a human was shown using near-infrared fluorescence and methylene blue. | Joost R van der Vorst Alexander L Vahrmeijer Merlijn Hutteman Tjalling Bosse Vincent THBM Smit Cornelis JH van de Velde John V Frangioni Bert A Bonsing | 2012 | World Journal of Gastrointestinal Surgery2012，4，7： | 7 |
| 3 | Sentinel Lymph Node Mapping of the Gastrointestinal Tract by Using Invisible Light显示文摘 | Edward G. Soltesz Sungjee Kim Sang-Wook Kim Rita G. Laurence Alec M. De Grand Cherie P. Parungo Lawrence H. Cohn Moungi G. Bawendi John V. Frangioni | 2006 | Annals of Surgical Oncology2006，，3： | 2 |
| 4 | Solubilization and purification of enzymatically active glutathione S - transferase ( pGEX ) fusion protein显示文摘 | FRANGIONI J V NEEL B G | 1993 | Anal Biochem1993，210，1： | 1 |
| 5 | Tighter approximated MILP formulations for unit commitment problems 显示文摘 | Antonio Frangioni Claudio Gentile Fabrizio Lacalandra | 2009 | IEEE Trans on Power Systems2009，24，1： | 1 |
| 6 | Tighter approximated MILP formulations for unit commitment problems显示文摘 | Frangioni A Gentile C Lacalandra F | 2009 | IEEE Transactions on Power Systems2009，24，1： | 1 |
| 7 | Lagrangian heuristics based on disaggregated bundle methods for hydrothermal unit commitment显示文摘 | Borghetti A Frangioni A Lacalandra F | 2003 | IEEE Transactions on Power Systems2003，18，1： | 1 |
| 8 | A multi-exchange neighborhood for minimum makespan machine scheduling problems显示文摘 | Frangioni A Necciari E ScutellaM G | 2004 | Journal of Combinational Optimization2004，8，： | 1 |
| 9 | Solubilization and purification of enzymaticaly active glutathione S-transferase (pGEX) fusion proteins 显示文摘 | Frangioni JV Neel BG | 1993 | Anal Biochem1993，210，： | 1 |
| 10 | Tighterapproximated MILP formulations for unit commitment problems显示文摘 | FRANGIONI A GENTILE C LACALANDRA F | 2009 | IEEE Trans on Power Systems2009，24，1： | 1 |
| 11 | Image - guided surgery u- sing invisible near - infrared light:fundamentals of clinical translation 显示文摘 | Gioux S Choi HS Frangioni JV | 2010 | Mol Imaging2010，9，5： | 1 |
| 12 | Perspective cuts for a class ofconvex 0-1 mixed integer programs显示文摘 | FRANGIONI A GENTILE C | 2006 | Mathematical Programming2006，106，2： | 1 |
| 13 | Intraoperative identification of esophageal sentinel lymph nodes with near - infrared fluorescence imaging显示文摘 | Parungo C P Ohnishi S Kim S W Kim S Laurence R G Soltesz E G Chen F Y Colson Y L Cohn L H Bawendi M G Frangioni J V | 2005 | The Journal of Thoracic and Cardiovascular Surgery2005，129，4： | 1 |
| 14 | In vivo tracking of stem cells for clinical trials in cardiovascular disease显示文摘 | FRANGIONI JV HAJJAR RJ | 2004 | Circulation2004，110，3： | 1 |
| 15 | In vivo near-infrared fluorescence imaging 显示文摘 | Frangioni JV | 2003 | Cur Opin Chem Biol2003，7，5： | 1 |
| 16 | In vivo tracking of stem cel s for clinical trials in cardiovascular disease显示文摘 | Frangioni JV Haj ar RJ | | 0，，21： | 1 |
| 17 | The nontransmembrane tyrosine phosphatase PTP-I B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence显示文摘 | Frangioni J V Beahm P H Shifrin V | 1992 | Cell1992，68，3： | 1 |
| 18 | Tighter approximated MILP formulations for unit commitment problems显示文摘 | FRANGIONI A GENTILE C LACALANDRA F | 2009 | IEEE Trans on Power Systems2009，24，1： | 1 |
| 19 | Lagrangian heuristic on disaggregated Buddle methods for hydrothermal unit commitment 显示文摘 | Borghetti A Frangioni A Lacalandra F | 2003 | IEEE Trans on Power Systems2003，18，1： | 1 |
| 20 | In vivo near-infrared fluorescence imaging显示文摘 | Frangioni JV | | 0，，05： | 1 |
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