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| 1 | A systematic study on efficiency enhancements in phosphorescent green, red and blue microcavity organic light emitting devices显示文摘A systematic study has been conducted on microcavity organic light emitting diodes(OLEDs)based on green,red and blue phosphorescent emitters to elucidate the microcavity effects for different color emitters.We found that the luminance output is determined by the reflectivity of the semitransparent electrode and the photopic response of the green,red and blue emitters.While the luminance enhancements of blue and red phosphorescent microcavity devices are small,a current efficiency as high as 224 cd A21 is obtained in the green phosphorescent microcavity OLEDs. | Chaoyu Xiang Wonhoe Koo Franky So Hisahiro Sasabe Junji Kido | 2013 | Light(Science & Applications)2013，2，1： | 12 |
| 2 | Abnormal subchondral bone remodeling and its association with articular cartilage degradation in knees of type 2 diabetes patients显示文摘Type 2 diabetes(T2 D) is associated with systemic abnormal bone remodeling and bone loss. Meanwhile,abnormal subchondral bone remodeling induces cartilage degradation, resulting in osteoarthritis(OA).Accordingly, we investigated alterations in subchondral bone remodeling, microstructure and strength in knees from T2 D patients and their association with cartilage degradation. Tibial plateaus were collected from knee OA patients undergoing total knee arthroplasty and divided into non-diabetic(n = 70) and diabetes(n = 51) groups. Tibial plateaus were also collected from cadaver donors(n = 20) and used as controls.Subchondral bone microstructure was assessed using micro-computed tomography. Bone strength was evaluated by micro-finite-element analysis. Cartilage degradation was estimated using histology. The expression of tartrate-resistant acidic phosphatase(TRAP), osterix, and osteocalcin were calculated using immunohistochemistry. Osteoarthritis Research Society International(OARSI) scores of lateral tibial plateau did not differ between non-diabetic and diabetes groups, while higher OARSI scores on medial side were detected in diabetes group. Lower bone volume fraction and trabecular number and higher structure model index were found on both sides in diabetes group. These microstructural alterations translated into lower elastic modulus in diabetes group. Moreover, diabetes group had a larger number of TRAP^+ osteoclasts and lower number of Osterix^+ osteoprogenitors and Osteocalcin^+ osteoblasts. T2 D knees are characterized by abnormal subchondral bone remodeling and microstructural and mechanical impairments, which were associated with exacerbated cartilage degradation. In regions with intact cartilage the underlying bone still had abnormal remodeling in diabetes group, suggesting that abnormal bone remodeling may contribute to the early pathogenesis of T2 D-associated knee OA. | Yan Chen Yong-Can Huang Chun Hoi Yan Kwong Yuen Chiu Qingjun Wei Jingmin Zhao X Edward Guo Frankie Leung William W Lu | 2017 | Bone Research2017，5，4： | 10 |
| 3 | Helicobacterpylori virulence factors in duodenal ulceration:A primary cause or a secondary infection causing chronicity显示文摘感染不看十二指肠的溃疡的成比例地的高流行的来自有 Helicobacter pylori (H pylori ) 的高流行的国家的报告,建议 H pylori 不能是十二指肠的溃疡的一个原发性原因的可能性。这差异可能被变化在不同人口在毒力因素的流行解释,这被提出了。这篇论文的目的是决定出版文学是否支持这可能性。相关文学与 H pylori 感染和毒力因素的高、低的流行为国家独立被考察并且分析。尽管 H pylori 的剧毒的紧张是,更经常显著地与 H pylori 感染的低流行在国家比没有疾病与十二指肠溃疡在病人介绍在人口,在在十二指肠溃疡之间的毒力因素的流行没有差别,非-在许多国家的溃疡消化不良或正常题目,在两 H pylori 感染并且毒力因素的流行高的地方。在这些国家,毒力因素的存在不是预兆的临床的结果。为了在国家解释在毒力因素和十二指肠溃疡之间的协会,在 H pylori 流行是低的的地方,仅仅二份报纸被发现那几乎别把小支持给建议的平常的模型,也就是没有他们,有毒力因素的有机体是比那些更可能的开始十二指肠溃疡。我们提供建议毒力因素是更可能的防碍以前生产的溃疡愈合的一个其他的假设。毒力因素的存在仅仅在 H pylori 的流行是低的国家与十二指肠溃疡的流行相关。有很小的证据,毒力因素开始十二指肠的溃疡,但是他们可能与溃疡的失败有关愈合。 | FrankI Tovey Michael Hobsley John Holton | 2006 | World Journal of Gastroenterology2006，12，1： | 6 |
| 4 | Profiles and removal efficiency of polycyclic aromatic hydrocarbons by two different types of sewage treatment plants in Hong Kong显示文摘Sewage discharge could be a major source of polycyclic aromatic hydrocarbons(PAHs) in the coastal waters. Stonecutters Island and Shatin Sewage Treatment Works(SCISTW and STSTW)in Hong Kong, adopted chemically enhanced primary treatment and biological treatment,respectively. This study aimed at(1) determining the removal efficiencies of PAHs,(2) comparing the capabilities in removing PAHs, and(3) characterizing the profile of each individual PAHs, in the two sewage treatment plants(STPs). Quantification of 16 PAHs was conducted by a Gas Chromatography. The concentrations of total PAHs decreased gradually along the treatment processes(from 301 ± 255 and 307 ± 217 ng/L to 14.9 ± 12.1 and 63.3 ± 54.1 ng/L in STSTW and SCISTW, respectively). It was noted that STSTW was more capable in removing total PAHs than SCISTW with average total removal efficiency 94.4% ± 4.12% vs. 79.2% ± 7.48%(p < 0.05). The removal of PAHs was probably due to sorption in particular matter, confirmed by the higher distribution coefficient of individual and total PAHs in solid samples(dewatered sludge contained92.5% and 74.7% of total PAHs in SCISTW and STSTW, respectively) than liquid samples(final effluent-total contained 7.53% and 25.3% of total PAHs in STSTW and SCISTW, respectively).Despite the impressive capability of STSTW and SCISTW in removing PAHs, there was still a considerable amount of total PAHs(1.85 and 39.3 kg/year, respectively for the two STPs) being discharged into Hong Kong coastal waters, which would be an environmental concern. | Yu Bon Man Ka Lai Chow Zhang Cheng Wing Yin Mo Yung Hau Chan James Chung Wah Lam Frankie Tat Kwong Lau Wing Cheong Fung Ming Hung Wong | 2017 | Journal of Environmental Sciences2017，29，3： | 5 |
| 5 | 锁定加压钢板治疗人工关节假体周围骨折显示文摘目的 介绍一种采用锁定加压钢板螺钉 (L CP)固定人工关节周围骨折的方法。方法 为一例髋关节假体远端周围螺旋骨折 ,采用 12孔长锁定加压钢板于外侧固定。近折端 6孔 ,其中 5孔用锁定螺钉作单侧骨皮质固定 ,最末孔用 4 .5 m m螺钉固定 ;远折端 4孔 ,作双侧骨皮质固定 ,中间骨折区域 2孔空出 ,以免干扰骨折愈合。结果 术后 3天开始行髋膝关节功能锻炼 ,1周后下地站立锻炼 ,2周患肢部分负重训练。术后 X线片示骨折复位固定良好 ,假体柄周围无松动迹象。术后 3个月复查 X线片示骨折愈合无畸形 ,假体无松动 ;6个月随访 ,患肢无疼痛、肌萎缩 ,功能恢复正常。结论 L CP用于处理关节假体周围骨折时方法简便 ,剥离范围小 ,对局部组织创伤小 ,有利于骨折的愈合 。 | Frankie Leung 项舟 | 2002 | 中国修复重建外科杂志2002，16，2： | 4 |
| 6 | Arthroscopic assessment of soft tissue injuries in comminuted intra-articular fractures of the distal radius显示文摘Objective To diagnose and evaluate soft tissue injuries in intra-articular fractures of the distal radius using arthroscopy.Methods Twenty young patients with displaced intra-articular fractures of distal radius were recruited in this prospective study.Three AO C2 and 17 C3 fractures were included.After arthroscopic examination fractures of distal radius were treated by external fixation with limited internal fixation or open plate fixation.Results Triangular fibrocartilage complex(TFCC)injury was found in 18 patients(90%).Most were isolated Palmer type 1D injuries(67 %).Scapho-lunate ligament injury wa s found in two patients:one partial tear(grade Ⅱ)and one complete tear(grad e Ⅲ).Follow-ups ranged from 6 to 18 months.At the last follow-up,wrist fun ction was excellent in one patient(6%),good in eight(44%)and fair in 11(50 %).Conclusion TFCC injuries are common in intra-articular fractures of the distal radius while injuries to scapho-lunate ligament are uncommon. | Frankie Leung Paata Gudushauri Boris Fung Shew PingChow | 2006 | 中华创伤骨科杂志2006，8，3： | 4 |
| 7 | International validation of the Chinese University Prognostic Index for staging of hepatocellular carcinoma: a joint United Kingdom and Hong Kong study显示文摘The outcome of hepatocellular carcinoma(HCC) patients significantly differs between western and eastern population centers. Our group previously developed and validated the Chinese University Prognostic Index(CUPI) for the prognostication of HCC among the Asian HCC patient population. In the current study, we aimed to validate the CUPI using an international cohort of patients with HCC and to compare the CUPI to two widely used staging systems, the Barcelona Clinic Liver Cancer(BCLC) classification and the Cancer of the Liver Italian Program(CLIP). To accomplish this goal, two cohorts of patients were enrolled in the United Kingdom(UK; n = 567; 2006-2011) and Hong Kong(HK; n = 517; 2007-2012). The baseline clinical data were recorded. The performances of the CUPI, BCLC, and CLIP were compared in terms of a concordance index(C-index) and were evaluated in subgroups of patients according to treatment intent. The results revealed that the median follow-up durations of the UK and HK cohorts were 27.9 and 29.8 months, respectively. The median overall survival of the UK and HK cohorts were 22.9 and 8.6 months, respectively. The CUPI stratified the patients in both cohorts into three risk subgroups corresponding to distinct outcomes. The median overall survival of the CUPI low-, intermediate-, and high-risk subgroups were 3.15, 1.24, and 0.29 years, respectively, in the UK cohort and were 2.07, 0.32, and 0.10 years, respectively, in the HK cohort. For the patients who underwent curative treatment, the prognostic performance did not differ between the three staging systems, and all were suboptimal. For those who underwent palliative treatment, the CUPI displayed the highest C-index, indicating that this staging system was the most informative for both cohorts. In conclusion, the CUPI is applicable to both western and eastern HCC patient populations. The performances of the three staging systems differed according to treatment intent, and the CUPI was demonstrated to be optimal for those undergoing palliative treatment. A more precise staging system for early-stage disease patients is required. | Stephen L.Chan Philip J.Johnson Frankie Mo Sarah Berhane Mabel Teng Anthony W.H.Chan Ming C.Poon Paul B.S.Lai Simon Yu Anthony T.C.Chan Winnie Yeo | 2014 | Chinese Journal of Cancer2014，33，10： | 4 |
| 8 | 日粮核苷酸对减少由T-2毒素和呕吐毒素诱导的鸡白细胞DNA损伤的作用显示文摘本研究旨在通过测定T-2毒素和呕吐毒素(Deoxynivalenol,DON)对脾脏白细胞DNA片段化和鸡氧化应激的影响,以评估日粮核苷酸对毒素诱导的DNA损伤的修复潜力。选用雄性肉鸡,分别饲喂添加或不加核苷酸的含有10 mg/kg的T-2毒素或呕吐毒素的饲粮。试验进行17 d后,利用'彗星'分析法(又叫单细胞凝胶电泳)检测脾脏白细胞的DNA损伤,通过测定血浆和肝脏中的丙二醛(Malondialdehyde,MDA)含量及血浆中的总抗氧化水平(Total Antioxidant Status,TAS)和谷胱甘肽过氧化物酶(Glutathione Peroxidase,GPx)含量来评判机体的脂质过氧化程度,肝毒性通过血浆中肝酶(谷丙转氨酶ALT,谷草转氨酶AST和谷氨酰转肽酶GGT)水平来评定。T-2毒素和呕吐毒素能诱导的鸡脾脏白细胞DNA的片段化,补充核苷酸只能减少T-2毒素引起损伤的程度。相比于空白对照组,饲粮中含有T-2毒素的添加或不添加核苷酸的两个处理组肉鸡的TAS和AST显著减小。饲粮中含有T-2毒素和呕吐毒素的处理组肉鸡血浆和肝脏组织中的MDA含量与对照组相比没有显著性差异。当肉鸡饲喂含有霉菌毒素的饲粮时,日粮核苷酸的补充并不影响机体MDA的生成。结果发现日粮核苷酸对削弱免疫细胞中因T-2毒素诱发的DNA损伤具有功效,这表明补充日粮核苷酸对霉菌毒素中毒的免疫系统的改善具有有益作用。 | 贺淼 张涛 Franki T Pajk T Rezar V T.Rezar A.Levart J. Salobir | 2014 | 国外畜牧学(猪与禽)2014，0，5： | 3 |
| 9 | Transcriptome and Proteome Expressions Involved in Insulin Resistance in Muscle and Activated T-Lymphocytes of Patients with Type 2 Diabetes显示文摘We analyzed the genes expressed (transcriptomes) and the proteins translated (pro-teomes) in muscle tissues and activated CD4+ and CD8+ T-lymphocytes (T-cells) of five Type 2 diabetes (T2DM) subjects using Affymetrix microarrays and mass spectrometry,and compared them with matched non-diabetic controls. Gene ex-pressions of insulin receptor (INSR),vitamin D receptor,insulin degrading enzyme,Akt,insulin receptor substrate-1 (IRS-1),IRS-2,glucose transporter 4 (GLUT4),and enzymes of the glycolytic pathway were decreased at least 50% in T2DM than in controls. However,there was greater than two-fold gene upregulation of plasma cell glycoprotein-1,tumor necrosis factor α (TNFα),and gluconeogenic enzymes in T2DM than in controls. The gene silencing for INSR or TNFα resulted in the inhibition or stimulation of GLUT4,respectively. Proteome profiles correspond-ing to molecular weights of the above translated transcriptomes showed different patterns of changes between T2DM and controls. Meanwhile,changes in tran-scriptomes and proteomes between muscle and activated T-cells of T2DM were comparable. Activated T-cells,analogous to muscle cells,expressed insulin sig-naling and glucose metabolism genes and gene products. In conclusion,T-cells and muscle in T2DM exhibited differences in expression of certain genes and gene products relative to non-diabetic controls. These alterations in transcriptomes and proteomes in T2DM may be involved in insulin resistance. | Frankie B.Stentz Abbas E.Kitabchi | 2007 | Genomics, Proteomics & Bioinformatics2007，5，3： | 3 |
| 10 | Engineered polycaprolactone–magnesium hybrid biodegradable porous scaffold for bone tissue engineering显示文摘In this paper, we describe the fabrication of a new biodegradable porous scaffold composed of polycaprolactone(PCL) and magnesium(Mg)micro-particles. The compressive modulus of PCL porous scaffold was increased to at least 150% by incorporating 29% Mg particles with the porosity of 74% using Micro-CT analysis. Surprisingly, the compressive modulus of this scaffold was further increased to at least 236% when the silane-coupled Mg particles were added. In terms of cell viability, the scaffold modified with Mg particles significantly convinced the attachment and growth of osteoblasts as compared with the pure PCL scaffold. In addition, the hybrid scaffold was able to attract the formation of apatite layer over its surface after 7 days of immersion in normal culture medium, whereas it was not observed on the pure PCL scaffold. This in vitro result indicated the enhanced bioactivity of the modified scaffold. Moreover, enhanced bone forming ability was also observed in the rat model after 3 months of implantation. Though bony in-growth was found in all the implanted scaffolds. High volume of new bone formation could be found in the Mg/PCL hybrid scaffolds when compared to the pure PCL scaffold. Both pure PCL and Mg/PCL hybrid scaffolds were degraded after 3 months. However, no tissue inflammation was observed. In conclusion, these promising results suggested that the incorporation of Mg micro-particles into PCL porous scaffold could significantly enhance its mechanical and biological properties. This modified porous bio-scaffold may potentially apply in the surgical management of large bone defect fixation. | Hoi Man Wong Paul K.Chu Frankie K.L.Leung Kenneth M.C.Cheung Keith D.K.Luk Kelvin W.K.Yeung | 2014 | Progress in Natural Science:Materials International2014，24，5： | 3 |
| 11 | A study of circulating interleukin 10 in prognostication of unresectable hepatocellular carcinoma显示文摘 | Stephen L. Chan Frankie K. F. Mo Cesar S. C. Wong Charles M. L. Chan Linda K. S. Leung Edwin P. Hui Brigette B. Ma Anthony T. C. Chan Tony S. K. Mok Winnie Yeo | 2011 | Cancer2011，，16： | 2 |
| 12 | 访前南斯拉夫导演埃米尔·库斯图里卡显示文摘'我什么都没变'记者:塞尔维亚人……波斯尼亚人……你在《地下》中已经表现了这种撕裂之痛。在大约10年前拍摄了这部电影以来,有什么改变吗?库斯图里卡:对于我来说,什么都没变。从政治角度来看,我还是那样的观点:我感兴趣的,是人性,不是意识形态。大家可能觉得这个想法很幼稚。对我而言,却是我在所做的一切中寻找的第一位的东西。从电影角度来看,如果说有什么改变的话,就是我换了电影的类型。《地下》可以说是拉伯雷式的,有点怪诞,带有隐喻特征。《生命是个奇迹》更加接近我本人,它是一首歌谣,通过它,我试图同时探索戏剧、诗歌和喜剧三个领域。记者:《生命是个奇迹》讲述的是一对互相倾慕的情侣却没有权利相爱的故事。你更像是在莎士比亚这一边,因为这部片子让我们想到了《罗密欧和朱丽叶》,只是你的是喜剧版。 | Frankie | 2005 | 电影文学2005，，5： | 2 |
| 13 | Treatment of small-bowel fistulae in the open abdomen with topical negative-pressure therapy显示文摘 | Mathieu D’Hondt Dirk Devriendt Frank Van Rooy Franky Vansteenkiste André D’Hoore Freddy Penninckx Marc Miserez | 2011 | The American Journal of Surgery2011，，： | 2 |
| 14 | Metabolite profiling of plasma and urine from rats with TNBS‐induced acute colitis using UPLC‐ESI‐QTOF‐MS‐based metabonomics – a pilot study显示文摘 | Xiaojun Zhang Franky F. K. Choi Yan Zhou Feung P. Leung Shun Tan Shuhai Lin Hongxi Xu Wei Jia Joseph J. Y. Sung Zongwei Cai Zhaoxiang Bian | 2012 | FEBS Journal2012，，： | 2 |
| 15 | A randomized, single-blind cross-over design evaluating the effectiveness of an individually defined, targeted physical therapy approach in treatment of children with cerebral palsy 显示文摘 | FRANKI I VAN DEN BROECK C DE CAT J | 2014 | Clin Rehabi2014，28，10： | 1 |
| 16 | Distribution patterns of tree species in a Malaysian tropical rain forest显示文摘 | He F Legendre P La Frankie J V | 1997 | Journal of Vegetation Science1997，8，： | 1 |
| 17 | Glomerular hypertension enhances mesangial cell apoptosis: an in vitro study 显示文摘 | Gibbons N Franki N Reddy K | 1996 | J Am Soc Nephrol1996，7，5： | 1 |
| 18 | Chemical profiling of Radix Paeoniae evaluated by ultra perf ormance liquid chromato graphy/photo diode array/quadru poletime of flight mass spectrometry显示文摘 | Li S L Son g J Z Choi Franky F K | 2009 | J Pharm Biomed Anal2009，49，2： | 1 |
| 19 | Haar wavelets for efficient similarity search of time-series: with and without time warping显示文摘 | FRANKY K ADA W CLEMENT Y | 2003 | IEEE Transactions on Knowledge and Data Engineering2003，15，3： | 1 |
| 20 | Chemical profiling of Radix Paeoniae evaluated by ultra-performance liquid chromatography/photo-diode-array/quadrupoletime of flight mass spectrometry显示文摘 | LI Song-lin SONG Jing-zheng Franky FK | 2009 | Pharm Biomed Anal2009，49，2： | 1 |
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