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| 1 | 微小RNA-1和微小RNA-29b对急性心肌梗死后不良心室重塑的诊断和预后价值显示文摘已知微小RNA(microRNAs,miRs)在急性心肌梗死(acute myocardial infarction,AMI)临床前期模型中可发挥纤维化和抗纤维化作用。为了评估miR-1,miR-21,miR-29b和miR-92a能否作为患者发生AMI后不良心室重塑(adverse ventricular remodeling,AVR)的循环生物标志物, | 刘莉 叶鹏 Grabmaier U Clauss S Gross L Klier I Franz WM Steinbeck G Wakili R Theiss HD Brenner C | 2017 | 中华高血压杂志2017，25，7： | 17 |
| 2 | Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity显示文摘Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds.Control of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic strategies.Here we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound healing.Solute sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in vitro.This further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo cultures.In a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the skin.This is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation profile.For in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one week.Their immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound healing.The sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure. | Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta Torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.Simon Vera Hintze Sandra Franz | 2021 | Bioactive Materials2021，6，12： | 7 |
| 3 | Soil boron fertilization:The role of nutrient sources and rootstocks in citrus production显示文摘Boron(B) is a key element for citrus production, especially in tropical regions, where the nutrient availability is commonly low in the soil. In addition, information about doses, fertilizer sources, methods of application, and particularly, differential nutrient demand of scion/rootstock combinations are required for efficient fertilization of commercial groves. In a non-irrigated sweet orange orchard(cv. Natal), grafted onto Rangpur lime, Swingle citrumelo or Sunki mandarin, we studied the application of two sources of B: boric acid(17% B, soluble in water) and ulexite(12% B, partially soluble in water) at four levels of supply(control without B, and soil application of 2, 4 and 6 kg ha^(-1) yr^(-1) of B). The experiment was carried out for three years(2004-2006). Boron availability in the soil and concentration in the leaves, as well as the fruit yield and quality of trees were evaluated. Soil B extracted with hot water and total leaf B positively correlated with doses of the nutrient applied to the trees. Levels of B in the soil and in the leaves did not vary with fertilizer sources. Fruit yield of trees grafted onto Rangpur lime and Swingle citrumelo was more responsive to B doses than those grafted onto Sunki mandarin. The maximum fruit yield of trees grafted onto Swingle was obtained with 3.2 kg ha^(-1) yr^(-1) of B, and leaf B level of 280 mg kg^(-1) that point out to a highest demand for B when this combination was compared with other rootstocks. Furthermore, fertilization with B did not affect the quality of fruits, but correlated with B and potassium(K) concentrations in the leaves. These results also support that the current recommendations for levels of B in leaves should be revisited. | Dirceu Mattos Jr Franz W R Hippler Rodrigo M Boaretto Eduardo S Stuchi Jose A Quaggio | 2017 | Journal of Integrative Agriculture2017，16，7： | 5 |
| 4 | 急性缺血性卒中的机械取栓治疗:ESO、ESMINT、ESNR和EAN共同支持的2014/2015 ESO-卡罗林斯卡卒中更新会议共识声明显示文摘这份卒中后机械取栓治疗共识声明的原始版本于2014年11月16—18日在斯德哥尔摩召开的欧洲卒中组织(European Stroke Organisation, ESO)-卡罗林斯卡卒中更新会议期间得到批准。根据会议安排,在2015年利用新的临床试验数据对该声明进行了更新。2015年2月,在瑞士伯尔尼召开的ESO冬季培训会期间组织了面对面会议对共识声明进行修订,然后通过电子邮件交换意见,最终版本得到各学会的认可。推荐意见与原始版本一致,证据等级更新到2015年2月20日为止,在2015年5月15日获得确认。ESO-卡罗林斯卡卒中更新会议的目的在于总结卒中治疗研究的最新进展并探讨如何将这些最新研究结果应用于临床实践。共识会议选择了一些议题进行讨论,与会者草拟一份共识声明并进行讨论。该声明接受了ESO指南委员会的指导。这份共识声明包括对急性卒中后机械取栓治疗的推荐意见,得到欧洲卒中组织ESO、欧洲神经微创治疗学会(European Society of Minimally Invasive Neurological Therapy, ESMINT)、欧洲神经放射学学会(European Society of Neuroradiology, ESNR)和欧洲神经病学学会(European Academy of Neurology, EAN)的支持。 | Nils Wahlgren Tiago Moreira Patrik Michel Thorsten Steiner Olav Jansen Christophe Cognard Heinrich P Mattle Wim van Zwam Staffan Holmin Turgut Tatlisumak Jesper Petersson Valeria Caso Werner Hacke Mikael Mazighi Marcel Arnold Urs Fischer Istvan Szikora Laurent Pierot Jens Fiehler Jan Gralla Franz Fazekas Kennedy R Lees 高洁 徐格林 | 2016 | 国际脑血管病杂志2016，24，1： | 5 |
| 5 | Management of the Open Abdomen: From Initial Operation to Definitive Closure显示文摘 | Vargo Daniel Richardson J David Campbell Andre Chang Michael Fabian Timothy Franz Michael Kaplan Mark Moore Frederick Reed R Lawrence Scott Bradford Silverman Ronald | 2009 | The American Surgeon2009，，11： | 2 |
| 6 | Nephropathy in diabetes 显示文摘 | Molitch M E DeFronzo R A Franz M J | 2004 | Diabetes Care2004，27，1： | 2 |
| 7 | Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration显示文摘 | Joanna M Wardlaw Eric E Smith Geert J Biessels Charlotte Cordonnier Franz Fazekas Richard Frayne Richard I Lindley John T O’Brien Frederik Barkhof Oscar R Benavente Sandra E Black Carol Brayne Monique Breteler Hugues Chabriat Charles DeCarli Frank-Erik de | 2013 | Lancet Neurology2013，，8： | 2 |
| 8 | Kyphoplasty for treatment of osteoporotic vertebral fractures: a prospective non-randomized study 显示文摘 | Berlemann U Franz T Orler R | 2004 | Eur spine2004，13，： | 1 |
| 9 | Left ventricular hypertrophy:a pressure – independent cardiovascular risk factor显示文摘 | FRANZ H M KETELHUT R | 1993 | J Cardiovase Pharmacol1993，22，1： | 1 |
| 10 | Electrical remodelling of the human atrium: Similar effects in patients with chronic atrial fibrillation and atrial flutter 显示文摘 | FRANZ M R KARASIK P L LI C | 1997 | J Am Coll Cardiol1997，30，： | 1 |
| 11 | A Systematic Study on the Stability of Selected Polymer Antioxidants in EU Offical Aqueous and Alternative Food Simulants Using HPLC显示文摘 | DEMERTZIS P G FRANZ R | 1998 | Food Addit Contam1998，15，1： | 1 |
| 12 | Kyphoplasty for treament of osteoporotic vertebral fractures:a prospective non-randomized study显示文摘 | Franz T Orler R | 2004 | Eur Spine J2004，13，6： | 1 |
| 13 | Kyphoplasty for treatment of osteoporotic vertebral fractures:a prospeetive non-randomized study显示文摘 | Franz T Orler R | 2004 | Eur J Spine2004，13，6： | 1 |
| 14 | Location and characterization of the antigenic portion of the FMDV immunization protein显示文摘 | Strohmaier K Franze R Adman K H | 1982 | J Gen Virol1982，59，： | 1 |
| 15 | Kyphoplasty for treatment of osteoporotic vertebral fractures: a prospective non-randomized study显示文摘 | Berlemann U Franz T Orler R | 2004 | Eur Spine J2004，13，6： | 1 |
| 16 | The Application of a Predictive Migration Model for Evaluating the Compliance of Plastic Materials with European Food Regulations显示文摘 | BANER A BRANDSCH J FRANZ R | 1996 | Food Additives and Contaminants1996，13，5： | 1 |
| 17 | Automatic vertical welding and its industrial applications 显示文摘 | Franz R J Wooding W H | 1963 | Welding J1963，42，6： | 1 |
| 18 | Location and characterisation of the antigenic portion of the FMDV immunizing protein显示文摘 | Strohmaier K Franze R Adam K H | 1982 | J Gen Virol1982，59，2： | 1 |
| 19 | Geostatistical tools for modeling and interpreting ecological spatial dependence 显示文摘 | Rossi R E Mulla D J Gjournel A Franz E H | 1992 | Ecological Monographs1992，62，： | 1 |
| 20 | Composition and density model of the continental crust at an active continental margin- The Central Andes between 21° and 27° S 显示文摘 | Lucassen F Becchio R Harmon R Kasemann S Franz G Trumbull R Wilke H-G Romer R L Dulski P | 2001 | Tectono-physics2001，341，14： | 1 |
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