|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Alcohol,nutrition and liver cancer:Role of Toll-like receptor signaling显示文摘This article reviews the evidence that ties the development of hepatocellular carcinoma (HCC) to the natural immune pro-inflammatory response to chronic liver disease, with a focus on the role of Toll-like receptor (TLR) signaling as the mechanism of liver stem cell/progenitor transformation to HCC. Two exemplary models of this phenomenon are reviewed in detail. One model applies chronic ethanol/lipopolysaccharide feeding to the activated TLR4 signaling pathway. The other applies chronic feeding of a carcinogenic drug, in which TLR2 and 4 signaling pathways are activated. In the drug-induced model, two major methyl donors, S-adenosylmethionine and betaine, prevent the upregulation of the TLR signaling pathways and abrogate the stem cell/progenitor proliferation response when fed with the carcinogenic drug. This observation supports a nutritional approach to liver cancer prevention and treatment. The observation that upregulation of the TLR signaling pathways leads to liver tumor formation gives evidence to the popular concept that the chronic pro-inflammatory response is an important mechanism of liver oncogenesis. It provides a nutritional approach, which could prevent HCC from developing in many chronic liver diseases. | Samuel W French Joan Oliva Barbara A French Fawzia Bardag-Gorce | 2010 | World Journal of Gastroenterology2010，16，11： | 11 |
| 2 | Impaired CTLA-4 responses in COPD are associated with systemic inflammation显示文摘 | Dino BA Tan Sonia Fernandez PatriciaPrice Martyn A French Philip J Thompson Yuben P Moodley | 2014 | Cellular & Molecular Immunology2014，11，6： | 3 |
| 3 | Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury显示文摘AIM To investigate the hypothesis that exposure to guanidinoacetate(GAA, a potent methyl-group consumer) either alone or combined with ethanol intake for a prolonged period of time would cause more advanced liver pathology thus identifying methylation defects as the initiator and stimulator for progressive liver damage.METHODS Adult male Wistar rats were fed the control or ethanolLieber De Carli diet in the absence or presence of GAA supplementation. At the end of 6 wk of the feeding regimen, various biochemical and histological analyses were conducted. RESULTS Contrary to our expectations, we observed that GAA treatment alone resulted in a histologically normal liver without evidence of hepatosteatosis despite persistence of some abnormal biochemical parameters. This protection could result from the generation of creatine from the ingested GAA. Ethanol treatment for 6 wk exhibited changes in liver methionine metabolism and persistence of histological and biochemical defects as reported before. Further, when the rats were fed the GAA-supplemented ethanol diet, similar histological and biochemical changes as observed after 2 wk of combined treatment, including inflammation, macroand micro-vesicular steatosis and a marked decrease in the methylation index were noted. In addition, rats on the combined treatment exhibited increased liver toxicity and even early fibrotic changes in a subset of animals in this group. The worsening liver pathology could be related to the profound reduction in the hepatic methylation index, an increased accumulation of GAA and the inability of creatine generated to exert its hepato-protective effects in the setting of ethanol.CONCLUSION To conclude, prolonged exposure to a methyl consumer superimposed on chronic ethanol consumption causes persistent and pronounced liver damage. | Natalia A Osna Dan Feng Murali Ganesan Priya F Maillacheruvu David J Orlicky Samuel W French Dean J Tuma Kusum K Kharbanda | 2016 | World Journal of Gastroenterology2016，22，38： | 2 |
| 4 | Polycrystalline silicon strain sensors 显示文摘 | French P J Evans A G R | 1985 | Sensors and Actuators A1985，7，： | 2 |
| 5 | Does it still have a role in infertility treatment? 显示文摘 | FRENCH D B DESAI N R ABARWAL A Varicocele repair | 2008 | Curr Opin Obstet Gynecol2008，20，3： | 1 |
| 6 | Conductive education evaluated:fu-ture directions显示文摘 | French L Nommensen A | 1992 | Aust Occup Ther J1992，39，： | 1 |
| 7 | Galvanic porous silicon formation without external contacts显示文摘 | ASHRUF C M A FRENCH P J BRESSERS P M M C | 1999 | Sensors and Actuators A1999，74，13： | 1 |
| 8 | Nonlinear mechanisms for gain adaptation in locust photoreceptors显示文摘 | / Pece A E C French A S Korenberg M J | 1990 | Biophys J1990，57，11： | 1 |
| 9 | The role of information inepilepsy显示文摘 | Vezzani A French J Bartfai T | 2011 | Nat Rev Neurol2011，7，1： | 1 |
| 10 | Mesenchymal stromal cells: facilitators of successful transplantation? 显示文摘 | English K French A Wood KJ | 2010 | Cell Stem Cell2010，7，4： | 1 |
| 11 | Adjunctive perampanel forrefractory partial-onset seizures : randomized phase III study 304显示文摘 | French J A Krauss G L Biton V | 2012 | Neurology2012，79，6： | 1 |
| 12 | A compar-ison of instruments and laboratories used to measure milk urea nitrogen in bulk-tank samples显示文摘 | KOHN R A FRENCH K R RUSSEK-COHEN E | 2004 | J Dairy Sci2004，87，6： | 1 |
| 13 | Transport of genistein-7-glucoside by human intestinal Caco-2 cells: poteintial role for MRP2 显示文摘 | Wells U K French K L Walgren R A | 1999 | Res Comm Mole Pathol Pharm1999，103，1： | 1 |
| 14 | The role of inflammation in epilepsy显示文摘 | Vezzani A French J Bartfai T | 2011 | Nat Rev Neurol2011，，7： | 1 |
| 15 | The role of inflammation in epilepsy显示文摘 | Vezzani A French J Bartfai T | 2011 | Nat Rev Neurol2011，7，1： | 1 |
| 16 | What do hospital consultants value about their jobs? A discrete choice experiment显示文摘 | Ubach C Scott A French F | | 0，，326： | 1 |
| 17 | A lateral field excited liquid acoustic wave sensor显示文摘 | Hu Y H French L A Vetelino J.F | | 0，，： | 1 |
| 18 | The role of inflammation in epilepsy显示文摘 | Vezzani A French J Bartfai T | 2011 | Nat Rev Neurol2011，7，1： | 1 |
| 19 | Rumen and milk oddand branched-chain fatty acid proportions are minimally influenced by ruminal vola- tile fatty acid infusions 显示文摘 | FRENCH E A BERTICS S J ARMENTANO L E | 2012 | Journal of Dairy Science2012，95，4： | 1 |
| 20 | Comparison of analytical methods and the influence of milk components on milk urea nitrogen显示文摘 | PETERSON A B FRENCH K R RUSSEK-COHEN E | 2004 | J Dairy Sci2004，87，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员