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| 1 | Matched-pair analysis of postoperative morbidity and mortality for pancreaticogastrostomy and pancreaticojejunostomy using mattress sutures in soft pancreatic tissue remnants显示文摘BACKGROUND:After pancreaticoduodenectomy,the incidence of postoperative pancreatic fistula remains high,especially in patients with 'soft' pancreatic tissue remnants.No 'gold standard' surgical technique for pancreaticoenteric anastomosis has been established.This study aimed to compare the postoperative morbidity and mortality of pancreaticogastrostomy and pancreaticojejunostomy for 'soft' pancreatic tissue remnants using modified mattress sutures.METHODS:Seventy-five patients who had undergone pancreaticogastrostomy and 75 who had undergone pancreaticojejunostomy after pancreaticoduodenectomy between 2002 and 2008 were retrospectively compared using matched-pair analysis.A modified mattress suture technique was used for the pancreaticoenteric anastomosis.Patients with an underlying 'hard' pancreatic tissue remnant,as in chronic pancreatitis,were excluded.Both groups were homogeneous for age,gender,and underlying disease.Postoperative morbidity,mortality,and preoperative and operative data were analyzed.RESULTS:There were no significant differences between the groups for the incidence of postoperative pancreatic fistula (10.7% in both).Postoperative morbidity and mortality,median operation time,median length of hospital stay,intraoperative blood loss,and the amount of intraoperatively transfused erythrocyte concentrates also did not significantly differ between the groups.Patient age >65 years (P=0.017),operation time >350minutes (P=0.001),and intraoperative transfusion of erythrocyte concentrates (P=0.038) were identified as risk factors for postoperative morbidity.CONCLUSIONS:Our results showed no significant differences between the groups in the pancreaticogastrostomy and pancreaticojejunostomy anastomosis techniques using mattress sutures for 'soft' pancreatic tissue remnants.In our experience,the mattress sutures are safe and simple to use,and pancreaticogastrostomy in particular is feasible and easy to learn,with good endoscopic accessibility to the anastomosis region.However,the location of the anastomosis and the surgical technique need to be individually evaluated to further reduce the incidence of postoperative pancreatic fistula. | Fritz Klein Marcus Bahra Matthias Glanemann Wladimir Faber Peter Warnick Andreas Andreou Safak Gül Dietmar Jacob | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，1： | 9 |
| 2 | High Hepatic SCD1 Activity Is Associated with Low Liver Fat Content in Healthy Subjects under a Lipogenic Diet显示文摘 | Günther Silbernagel Marketa Kovarova Alexander Cegan Jürgen Machann Fritz Schick Rainer Lehmann Hans-Ulrich H?ring Norbert Stefan Erwin Schleicher Andreas Fritsche Andreas Peter | 2012 | The Journal of Clinical Endocrinology & Metabolism2012，，12： | 3 |
| 3 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 4 | Effect of rapamycin on hepatic osteodystrophy in rats with portasystemic shunting显示文摘瞄准:如果与推延的 portasystemic 有关的 T 房间激活通过 RANKL 依赖的小径引起调停骨破折的骨头损失,学习。如果用 rapamycin 的 T 房间抑制将在老鼠免于骨头损失,我们也调查了。方法:推延的 Portasystemic 在男 Sprague-Dawley 老鼠和 rapamycin 被执行 0.1 mg/kg 被管饲法为 15 wk 管理。老鼠收到了 powderized 食物并且补加喂在骨头作文上阻止营养不良的效果。重量获得和生长在推延的动物在外科以后被恢复。在结束,骨头周转和量的骨头组织学的生物化学的参数被估计。T 房间激活,煽动性的 cytokine 生产,和 RANKL 依赖的小径的标记被测量。另外, IGF-1 和性腺机能减退的角色被调查。结果:推延的 Portasystemic 引起了是 RANKL 独立人士的低周转骨质疏松症。包括 IL-1, IL-6 和 TNFalpha,骨头再吞 cytokine 层次没在浆液和 TNFalpha 被增加, RANKL 表示不起来在 PBMC 调整了。推延的 Portasystemic 增加了传播 CD8+T 房间人口。Rapamycin 减少了传播 CD8+T 房间人口,增加了 CD8+CD25+T 规章的房间人口并且改进了骨头周转的所有参数。结论:推延的 portasystemic 引起的骨质疏松症可以被 rapamycin 部分在肝的骨营养不良的老鼠模型改善。 | Schalk W van der Merwe Maria M Conradie Robert Bond Brenda J Olivier Elongo Fritz Martin Nieuwoudt Rhena Delport Tomas Slavik Gert Engelbrecht Del Kahn Enid G Shephard Maritha J Kotze Nico P de Villiers Stephen Hough | 2006 | World Journal of Gastroenterology2006，12，28： | 2 |
| 5 | Eine quantitative bestimmung der SiH-und Si-Phenyl-Gruppe 显示文摘 | FRITZ V G BURDT H | 1962 | Zeitschriff fur anorganische und allgemeine Chemie1962，317，： | 1 |
| 6 | Phenetic Diversity of Alkaliphilic Bacillus Strains:Proposal for Nine New Species显示文摘 | Nielsen P Fritze D Priest F G | 1995 | Microbiology1995，141，： | 1 |
| 7 | The Amino-Acid Sequence of Bovine Glutathione Peroxidase显示文摘 | Wolfgang A. GüNZLER Gerd J. STEFFENS Adelbert GROSSMANN Sung-Man A. KIM Fritz ?TTING Albrecht WENDEL Leopold FLOHé | 2009 | Hoppe-Seyler′s Zeitschrift für physiologische Chemie2009，，1： | 1 |
| 8 | Separation of trace metal complexes for analysis of samples of high salt content by inductively coupled plasma mass spectrometry显示文摘 | Michael R Plantz James S Fritz Fred G | 1989 | Anal Chem1989，61，2： | 1 |
| 9 | Crosslinking of LLDPE and VLDPE via graft-po lymerized vinyltrimethoxysilane显示文摘 | Fritz H G | 1990 | Plast Rubb and Comp Proc Appl1990，13，： | 1 |
| 10 | Phosphorylafion of the DNA repair protein APE/REF21 by CKII affects redox regulation of AP-1 显示文摘 | FRITZ G KAINA B | 1999 | Oncogene1999，18，4： | 1 |
| 11 | Seasonal chemical and isotopic variations of soil CO2 at Trout Creek,Outario显示文摘 | REARDON E J ALLISON G B FRITZ P | 1979 | Journal of Hydrology1979，43，1： | 1 |
| 12 | Casein kinase Ⅱ is elevated in solid human tumors and rapidly proliferating nonneoplastic tissues显示文摘 | Munstermann U Fritz G Seitz G | 1990 | Eur J Biochem1990，189，2： | 1 |
| 13 | The isotopic composition of secondary dolomites显示文摘 | Fritz P smith D G W | 1970 | Geochimica et Cosmochimica Acta1970，34，： | 1 |
| 14 | Impedance spectroscopy of porin and gramicidin pores reconstituted into supported lipid bilayers on indium-tin-oxide electrodes显示文摘 | STEFAN G PETER N FRITZ J | 1998 | Langrnuir1998，14，： | 1 |
| 15 | The effect of mild hypothermia on plasma fentanyl concentration and biotransformation in juvenile pigs显示文摘 | Fritz H G Holzmayr M Walter B | 2005 | Anesth Analg2005，100，4： | 1 |
| 16 | HMGB1 conveys immunosuppressive characteristics on regulatory and conventional T cells显示文摘 | Wild CA Bergmann C Fritz G | 2012 | Int Immunol2012，24，8： | 1 |
| 17 | Anaerobic oxidization ofmethane in a minerotrophic peatland : enrichment of nitrite-dependent methane-oxidizing bacteria 显示文摘 | ZHU Baoli VAN DIJK G FRITZ C | 2012 | Applied andEnvironmental Microbiology2012，78，24： | 1 |
| 18 | Binding of S100 pro- teins to RAGE: an update 显示文摘 | Leclerc E Fritz G Vetter SW | 2009 | Biochim Biophys Acta2009，1793，6： | 1 |
| 19 | Binding of S100 proteins to RAGE: an update 显示文摘 | Leclerc E Fritz G Vetter SW | 2009 | Biochim Biophys Acta2009，1793，6： | 1 |
| 20 | S - 100 proteins:structure, functions and pathology 显示文摘 | Heizmann C W Fritz G Schafer B W | 2002 | Front Biosci2002，7，： | 1 |
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