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| 1 | Artemisinin, the Magic Drug Discovered from Traditional Chinese Medicine显示文摘Artemisinin and its derivatives represent the most important and influential class of drugs in the fight against malaria. Since the discovery of artemisinin in the early 1970s, the global community has made great strides in characterizing and understanding this remarkable phytochemical and its unique chemical and pharmacological properties. Today, even as artemisinin continues to serve as the foundation for antimalarial therapy, numerous challenges have surfaced in the continued application and development of this family of drugs. These challenges include the emergence of delayed treatment responses to artemisinins in malaria and efforts to apply artemisinins for non-malarial indications. Here, we provide an overview of the story of artemisinin in terms of its past, present, and future. In particular, we comment on the current understanding of the mechanism of action (MOA) of artemisinins, and emphasize the importance of relating mechanistic studies to therapeutic outcomes, both in malarial and non-malarial contexts. | Jigang Wang Chengchao Xu Yin Kwan Wong Yujie Li Fulong Liao Tingliang Jiang Youyou Tu | 2019 | Engineering2019，5，1： | 16 |
| 2 | Effect of hydrophilic silica nanoparticles on hydrate formation: Insight from the experimental study显示文摘Invasion of drilling fluid into natural gas hydrate deposits during drilling might damage the reservoir,induce hydrate dissociation and then cause wellbore instability and distortion of the data from well logging. Adding nanoparticles into drilling fluid is an effective method in reducing the invasion of drilling fluid and enhancing borehole stability. However, the addition of nanoparticles might also introduce hydrate formation risk in borehole because they can act as the 'seeds' for hydrate nucleation. This paper presents an experimental study of the effect of hydrophilic silica nanoparticle on gas hydrate formation in a dynamic methane/liquid-water system. In the experiment, the ultrapure water with and without1.0 wt%–6.0 wt% concentrations of silica nanoparticles, grain sizes of 20 and 50 nm, were pressurized by methane gas under varied conditions of temperature and pressure. The induction time, the gas consumption, and the average rate of gas consumption in the system were measured and compared to those in ultrapure water. The results show that a concentration of 4.0 wt% hydrophilic SiO_2 particles with a grain size of 50 nm has a relatively strong inhibition effect on hydrate formation when the initial experimental condition is 5.0 °C and 5.0 MPa. Compared to ultrapure water, the hydrophilic nano-SiO_2 fluid increases the induction time for hydrate formation by 194% and decreases the amount and average rate of hydrate formation by 10% and 17%, respectively. This inhibition effect may be attributed to the hydrophilicity,amount and aggregation of silica nanoparticle according to the results of water activity and zeta potential measurements. Our work also elucidates hydrophilic, instead of hydrophobic, nanoparticles can be added to the drilling fluid to maintain wellbore stability and to protect the hydrate reservoir from drilling mud damage, because they exhibit certain degree of hydrate inhibition which can reduce the risk of hydrate reformation and aggregation during gas hydrate or deep water drilling if their concentration can be controlled properly. | Ren Wang Tianle Liu Fulong Ning Wenjia Ou Ling Zhang Zhen Wang Li Peng Jiaxin Sun Zhichao Liu Tianshu Li Huicui Sun Guosheng Jiang | 2019 | Journal of Energy Chemistry2019，28，3： | 12 |
| 3 | A Grid Interface Current Control Strategy for DC Microgrids显示文摘In this paper,a grid interface current control strategy is presented for a DC microgrid,which aims to reduce the disturbance from PV generation and the load variation to the main grid without a grid interface converter.The grid interface current is directly controlled by a battery DC-DC converter within the DC microgrid.Based on a comprehensive analysis of the battery DC-DC converter and interface current control,the control system has been mathematically modelled.This enabled two transfer functions to be derived that reflect the dynamic response of the inductor current to the duty cycle variation(inner loop),and the dynamic response of the grid interface current to the inductor current variation(outer loop).Experimental study has been done to assess the effectiveness of the proposed control strategy.The experimental results indicate that the proposed control strategy has a good performance to control the grid interface current without an interface converter,regardless the variations of both PV and the load conditions. | Muhannad Alshareef Zhengyu Lin Fulong Li Fei Wang | 2021 | CES Transactions on Electrical Machines and Systems2021，5，3： | 8 |
| 4 | An Investigation of Optimal Machine Learning Methods for the Prediction of ROTI显示文摘The rate of the total electron content(TEC)change index(ROTI)can be regarded as an effective indicator of the level of ionospheric scintillation,in particular in low and high latitude regions.An accurate prediction of the ROTI is essential to reduce the impact of the ionospheric scintillation on earth observation systems,such as the global navigation satellite systems.However,it is difficult to predict the ROTI with high accuracy because of the complexity of the ionosphere.In this study,advanced machine learning methods have been investigated for ROTI prediction over a station at high-latitude in Canada.These methods are used to predict the ROTI in the next 5 minutes using the data derived from the past 15 minutes at the same location.Experimental results show that the method of the bidirectional gated recurrent unit network(BGRU)outperforms the other six approaches tested in the research.It is also confirmed that the RMSEs of the predicted ROTI using the BGRU method in all four seasons of 2017 are less than 0.05 TECU/min.It is demonstrated that the BGRU method exhibits a high level of robustness in dealing with abrupt solar activities. | Fulong XU Zishen LI Kefei ZHANG Ningbo WANG Suqin WU Andong HU Lucas Holden | 2020 | Journal of Geodesy and Geoinformation Science2020，3，2： | 7 |
| 5 | Independent Component Analysis and Graph Theoretical Analysis in Patients with Narcolepsy显示文摘The present study was aimed to evaluate restingstate functional connectivity and topological properties of brain networks in narcolepsy patients compared with healthy controls.Resting-state fMRI was performed in 26 adult narcolepsy patients and 30 matched healthy controls.MRI data were first analyzed by group independent component analysis,then a graph theoretical method was applied to evaluate the topological properties in the whole brain.Small-world network parameters and nodal topological properties were measured.Altered topological properties in brain areas between groups were selected as regionof-interest seeds,then the functional connectivity among these seeds was compared between groups.Partial correlation analysis was performed to evaluate the relationship between the severity of sleepiness and functional connectivity or topological properties in the narcolepsy patients.Twenty-one independent components out of 48 were obtained.Compared with healthy controls,the narcolepsy patients exhibited significantly decreased functional connectivity within the executive and salience networks,along with increased functional connectivity in the bilateral frontal lobes within the executive network.There were no differences in small-world network properties between patients and controls.The altered brain areas in nodal topological properties between groups were mainly in the inferior frontal cortex,basal ganglia,anterior cingulate,sensory cortex,supplementary motor cortex,and visual cortex.In the partial correlation analysis,nodal topological properties in the putamen,anterior cingulate,and sensory cortex as well as functional connectivity between these regions were correlated with the severity of sleepiness(sleep latency,REM sleep latency,and Epworth sleepiness score)among narcolepsy patients.Altered connectivity within the executive and salience networks was found in narcolepsy patients.Functional connection changes between the left frontal cortex and left caudate nucleus may be one of the parameters describing the severity of narcolepsy.Changes in the nodal topological properties in the left putamen and left posterior cingulate,changes in functional connectivity between the left supplementary motor area and right occipital as well as in functional connectivity between the left anterior cingulate gyrus and bilateral postcentral gyrus can be considered as a specific indicator for evaluating the severity of narcolepsy. | Fulong Xiao Chao Lu Dianjiang Zhao Qihong Zou Liyue Xu Jing Li Jun Zhang Fang Han | 2019 | Neuroscience Bulletin2019，35，4： | 7 |
| 6 | Total mesorectal excision with or without preoperative chemoradiotherapy for resectable mid/low rectal cancer: a long-term analysis of a prospective, single-center, randomized trial显示文摘Background:The preliminary results of our phase II randomized trial reported comparable functional sphincter pres-ervation rates and short-term survival outcomes between patients undergoing total mesorectal excision(TME)with or without preoperative concurrent chemoradiotherapy(CCRT).We now report the long-term results after a median follow-up of 71 months.Methods:Between March 23,2008 and August 2,2012,192 patients with T3-T4 or node-positive,resectable,mid/low rectal adenocarcinoma were randomly assigned to receive TME with or without preoperative CCRT.The following endpoints were assessed:cumulative rates of local recurrence and distant metastasis,disease-free survival(DFS),and overall survival(OS).Results:The data of 184 eligible patients were analyzed:94 patients in the TME group and 90 patients in the CCRT+TME group.In the whole cohort,the 5-year DFS and OS rates were 84.8%and 85.1%,respectively.The 5-year DFS rates were 85.2%in the CCRT+TME group and 84.3%in the TME group(P=0.969),and the 5-year OS rates were 83.5%in the CCRT+TME group and 86.5%in the TME group(P=0.719).The 5-year cumulative rates of local recur-rence were 6.3%and 5.0%(P=0.681),and the 5-year cumulative rates of distant metastasis were 15.0%and 15.7%(P=0.881)in the CCRT+TME and TME groups,respectively.No significant improvements in 5-year DFS and OS were observed with CCRT by subgroup analyses.Conclusions:Both treatment strategies yielded similar long-term outcomes.A selective policy towards preoperative CCRT is thus recommended for rectal cancer patients if high-quality TME surgery and enhanced chemotherapy can be performed. | Fulong Wang Wenhua Fan Jianhong Peng Zhenhai Lu Zhizhong Pan Liren Li Yuanhong Gao Hui Li Gong Chen Xiaojun Wu Peirong Ding Zhifan Zeng Desen Wan | 2018 | Cancer Communications2018，38，1： | 6 |
| 7 | Porphyromonas gingivalis bacteremia increases the permeability of the blood-brain barrier via the Mfsd2a/Caveolin-1 mediated transcytosis pathway显示文摘Bacteremia induced by periodontal infection is an important factor for periodontitis to threaten general health. P. gingivalis DNA/virulence factors have been found in the brain tissues from patients with Alzheimer’s disease(AD). The blood-brain barrier(BBB) is essential for keeping toxic substances from entering brain tissues. However, the effect of P. gingivalis bacteremia on BBB permeability and its underlying mechanism remains unclear. In the present study, rats were injected by tail vein with P. gingivalis three times a week for eight weeks to induce bacteremia. An in vitro BBB model infected with P. gingivalis was also established. We found that the infiltration of Evans blue dye and Albumin protein deposition in the rat brain tissues were increased in the rat brain tissues with P. gingivalis bacteremia and P. gingivalis could pass through the in vitro BBB model. Caveolae were detected after P. gingivalis infection in BMECs both in vivo and in vitro. Caveolin-1(Cav-1) expression was enhanced after P. gingivalis infection.Downregulation of Cav-1 rescued P. gingivalis-enhanced BMECs permeability. We further found P. gingivalis-gingipain could be colocalized with Cav-1 and the strong hydrogen bonding between Cav-1 and arg-specific-gingipain(RgpA) were detected.Moreover, P. gingivalis significantly inhibited the major facilitator superfamily domain containing 2a(Mfsd2a) expression. Mfsd2a overexpression reversed P. gingivalis-increased BMECs permeability and Cav-1 expression. These results revealed that Mfsd2a/Cav-1 mediated transcytosis is a key pathway governing BBB BMECs permeability induced by P. gingivalis, which may contribute to P. gingivalis/virulence factors entrance and the subsequent neurological impairments. | Shuang Lei Jian Li Jingjun Yu Fulong Li Yaping Pan Xu Chen Chunliang Ma Weidong Zhao Xiaolin Tang | 2023 | International Journal of Oral Science2023，15，1： | 3 |
| 8 | A novel random phase-shifting digital holographic microscopy method显示文摘This paper proposes a new method that reconstructs the information of specimen by using random phase shift step in digital holographic microscopy (DHM). The principles of the method are described and discussed in detail. In practical experiment, because the phase shifter is neither perfectly linear nor calibrated, digital holograms with inaccurate phase shift step are recorded by the charge-coupled device (CCD). The phase could be accurately reconstructed from the recorded digital holograms by using the random phase-shifting algorithm, which makes up for reconstructed phase error caused by ordinary phase-shifting algorithm. The phase aberration compensation is also discussed. In order to verify the flexibility of the proposed method, numerical simulation of random phase-shifting DHM was carried out. The simulation results illustrated that the presented method is effective when the phase shift step is unknown or random in DHM. | HuiMin Xie ZhenXing Hu FuLong Dai YanJie Li PengWan Chen QingMing Zhang FengLei Huang | 2009 | Science China(Technological Sciences)2009，52，7： | 3 |
| 9 | Study of high pressure sintering behavior of CBN composites starting with CBN-Al mixtures显示文摘Cubic boron nitride(CBN) composites starting with CBN-Al mixtures were sintered on WC-16 wt%Co substrate under static high pressure of 5.0 GPa at temperatures of 800 to 1 400℃for 30 min.Vickers hardness of the sintered samples increased with increasing CBN content and the highest hardness of 32.7 GPa was achieved for the CBN-5 wt%Al specimens sintered at 1 400℃.The reactions between CBN and Al started to occur at about 900℃and the reaction products strongly depended on the Al content,sintering temperature and Co diffused from the substrates according to the x-ray diffraction(XRD) observations.The CBN composite sintered at 1 200℃from a CBN-15 wt%Al mixture showed the best cutting performance. | Li Yongjun Li Sicheng Lv Ran Qin Jiaqian Zhang Jian Wang Jianghua Wang Fulong Kou Zili He Duanwei (Institute of Atomic and Molecular Physics,Sichuan University,Chengdu 610065,China) | 2008 | 金刚石与磨料磨具工程2008，28，S1： | 3 |
| 10 | Conductor selection and economic analysis of D.R.congo–guinea±800 kV UHVDC transmission project显示文摘Africa is embracing new opportunities featured with industrialization,urbanization and regionalization.Based on co-development of‘Electricity,Mining,Metallurgy,Industry and Trade’and grids interconnection proposed by Global Energy Interconnection Development and Cooperation Organization(GEIDCO),the high-quality hydropower resource of the Congo River can be exploited in large scale under the wide-range interconnected framework of African Energy Interconnection(AEI),forging a new engine for Africa economy.The transmission distance of the Congo River hydropower reaches 6,000 km at its farthest end in North Africa,which brings forth challenges to economics of proposed projects.Under this novel continental energy interconnection scheme in Africa,economics of those projects have not yet been in detail studied.This paper has implemented China’s mature engineering experiences and analytical tools of UHVDC project planning into the AEI structure,through exploring the economic behavior of ultra-long distance UHVDC projects in the scope of conductor selection in the Congo River hydropower transmission for the first time,and has provided concerned parties with a technical and analytical results of their economics comparison.This paper has chosen the D.R.Congo-Guinea±800 kV UHVDC project as a typical example.Its preliminary system planning is introduced and three types of conductor are selected for scheme comparison.Later in this paper,the transmission loss,total investment and equivalent annual cost of the project have been calculated and analyzed.In the final part,sensitivity analysis results of the annual cost to utilization hours,transmission loss,loss tariff and construction cost has been provided. | Zhengxi Chen Chen Wang Jun Li Fulong Song Zhi Zhang | 2020 | Global Energy Interconnection2020，3，4： | 3 |
| 11 | 对可切除的中/低位直肠癌是/否进行术前放化疗的全直肠系膜切除术研究:一项前瞻性、单中心、随机试验的长期分析显示文摘背景与目的我们的Ⅱ期随机试验的初步研究结果显示,对进行全直肠系膜切除术(total mesorectal excision,TME)的患者是/否进行术前同步放化疗(concurrent chemoradiotherapy,CCRT),二者的功能性括约肌保留率和短期生存结局相近。在经过中位71个月的随访后,现报告这一长期试验的结果。方法在2008年3月23日至2012年8月2日期间,192例患有T3–T4或淋巴结阳性、可切除的中/低直肠腺癌患者被随机分为接受或不接受术前CCRT组,之后均进行TME。评估以下终点:局部复发和远处转移的累积率、无病生存(disease?free survival,DFS)和总生存(overall survival,OS)。结果对入组的184例患者资料进行分析,其中TME组有94例,CCRT+TME组有90例。在整个队列中,5年DFS和OS率分别为84.8%和85.1%。CCRT+TME组的5年DFS率为85.2%,TME组为84.3%(P=0.969);CCRT+TME组的5年OS率为83.5%,TME组为86.5%(P=0.719)。在CCRT+TME和TME组中,局部复发的5年累积率分别为6.3%和5.0%(P=0.681),远处转移的5年累积率分别为15.0%和15.7%(P=0.881)。通过亚组分析,接受CCRT未观察到5年DFS和OS的显著改善。结论两种治疗方案的长期结局相近。因此,如果可以进行高质量的TME手术和强化化疗,建议选择性地对直肠癌患者进行术前CCRT。 | Fulong Wang Wenhua Fan Jianhong Peng Zhenhai Lu Zhizhong Pan Liren Li Yuanhong Gao Hui Li Gong Chen Xiaojun Wu Peirong Ding Zhifan Zeng Desen Wan | 2019 | 癌症2019，38，5： | 2 |
| 12 | Postconditioning of stellate ganglion block improves intestinal barrier function by inhibiting autophagy in conscious rats following hemorrhagic shock and resuscitation显示文摘To the Editor:Hemorrhagic shock is a critical pathological process characterized by microcirculation dysfunction and hypoperfusion,with severe consequences of cell damage and organ dysfunction.Intestinal barrier dysfunction is a critical link of distant organ injury caused by hemorrhagic shock.Prophylactic treatment with stellate ganglion block(SGB)significantly reduces hemorrhagic shock-induced intestinal barrier damage. | Zhonghua Li Wendi Wang Qi Sun Tingjiao Suo Jiayi Zhai Huibo Du Zhen’ao Zhao Fulong Li Chunyu Niu Zigang Zhao | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 13 | Tenure-based residential segre- gation in post-reform Chinese cities: a case study of Shanghai 显示文摘 | ZHIGANG LI FULONG WU | 2008 | Transactions of the institute of British geographers2008，，3： | 1 |
| 14 | Contextualizing of Residential Mobility and Housing Choice:Evidence from Urban China显示文摘 | Siming Li Fulong Wu | 2004 | Environment and Planning A2004，36，1： | 1 |
| 15 | Research and comprehensive evaluation on delivery schemes of the Grand Inga hydropower station显示文摘Congo River has abundant hydropower resources,and large-scale cascade power stations,such as the Grand Inga,can be constructed in downstream locations.However,the fragile economic foundations of the Democratic Republic of the Congo and neighbor!ng Central African countries,and the small-scale regional power consumption market prohibit the implementation of large-scale hydro power projects.As the high-voltage,I on g-dista nee power transmission tech no logy matures,hydropower from the Grand Inga can be delivered to load centers in other regions of Africa.This study establishes a 6 dime nsional comprehe nsive assessment model using the best-worst method to evaluate large-scale,I on g-distance,cross-border power intercon necti on projects.The model is applied to evaluate all the can didate in ter-regional power delivery schemes of the Inga III hydropower station,and the evaluation results can effectively help investment institutions and policy makers in policy making and potential market targeting. | Fulong Song Xiaoxiao Yu Jun Li Yu Ni Chunyan Bian Xinchang Lv | 2020 | Global Energy Interconnection2020，3，6： | 1 |
| 16 | Tenure-based residential segregation in post-reform Chinese cities: a case study of Shanghai显示文摘 | Li Zigang Wu Fulong | 2008 | Trans- actions of the Institute of British Geographers2008，33，3： | 1 |
| 17 | Facile synthesis of Co-SBA-16 mesoporous molecular sieves with EISA method and their applications for hydroxylation of benzene显示文摘 | Yongli Dong Xinlin Zhan Xiaoyu Niu Jing Li Fulong Yuan Yujun Zhu Honggang Fu | 2014 | Microporous and Mesoporous Materials2014，，： | 1 |
| 18 | Hemorheological Investigation of Clotting by Rotational Viscometer显示文摘 | LIAO Fulong LI Wen HUANG Shen | 1987 | Clinical Hemorheo-logy1987，7，： | 1 |
| 19 | A New Bemorheological Approach for Evaluation of Antiplatelet and Anticoagulative Drugs-rotational Viscometry显示文摘 | LIAO Fulong LI Wen YIN Xiaojie | 1992 | Clinical Hemorheology1992，12，： | 1 |
| 20 | Sociospatial Differentiation;Progress and Space in Subdistricts Of Shanghai显示文摘 | Wu Fulong Li Zhigang | 2005 | Urban Geography2005，26，2： | 1 |
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