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| 1 | Transboundary hydrological effects of hydropower dam construction on the Lancang River显示文摘 | HE Daming FENG Yan GAN Shu Darrin Magee YOU Weihong | 2006 | Chinese Science Bulletin2006，51，B11： | 13 |
| 2 | Sedimentary Characteristics and Model of Gravity Flow Depositional System for the First Member of Upper Miocene Huangliu Formation in Dongfang Area, Yinggehai Basin, Northwestern South China Sea显示文摘The gravity flow deposit were mainly developed in the lowstand systems tract(LST) of the first member of Upper Miocene Huangliu Formation(Ehl1) in Dongfang area, Yinggehai Basin, has become a valuable target for gas exploration and production. The gravity flow sedimentary characteristics of lithofacies associations, sedimentary texture, seismic facies and logging facies were described in detail on the basis of integrated analysis of cores, logging and seismic data. The sedimentary microfacies types composed of neritic sandbar, continental shelf mud, main channel, bifurcated or cross-cutting distributary channel, overspill, and natural levee are revealed under the constraint of high resolution sequence stratigraphic framework in the Ehl1. The gravity flow deposit system in the LST is divided into three evolution stages corresponding to periods of three parasequence sets. The gravity flow deposit was induced in the early LST, expanded rapidly in the middle LST and decreased slightly in the late LST. But its developing scale decreased sharply in the transgression systems tract(TST) and finally vanished in the highstand systems tract(HST). This spatial evolution rule is constrained by the integrated function of sediments supply of the Vietnam Blue River in the LST, the development of local gradient change in sea floor(micro-topography, i.e., flexure slope break), and the fall in relative sea level. On the basics of the deep study of the coupling relationship among the three main control factors, the sedimentary model is established as an optimal component of 'source-channel-sink' for shallow marine turbidite submarine fan. | Ming Sun Hua Wang Jihua Liao Huajun Gan Jun Xiao Jinfeng Ren Shu'e Zhao | 2014 | Journal of Earth Science2014，25，3： | 9 |
| 3 | Advances in research of the mid-deep South China Sea circulation显示文摘The South China Sea(SCS)is a large marginal sea connecting the Indian and Pacific oceans.Under the factors of monsoons,strait transport,and varied bathymetry,the SCS presents a three-layer structure and strong diapycnal mixing which is far greater than that in the open ocean.Theoretical analysis and observations reveal that internal tides,internal solitary waves,and strong winds are the sources of the strong mixing in the northern SCS.A major consequence of the strong mixing is an active mid-deep circulation system.This system promotes exchange of water between the SCS and adjacent oceans,and also regulates the upper layer of wind-driven circulation,making the 3 dimensional SCS circulation clearly different from that in other tropical and subtropical marginal seas.The mass transport capacity of the mid-deep circulation has a substantial impact on marine sedimentation,the biogeochemical cycle,and other processes in the SCS.This paper summarizes the recent advances in middeep sea circulation dynamics of the SCS,and discusses the opportunities and challenges in this area. | Dongxiao WANG Qiang WANG Shuqun CAI Xiaodong SHANG Shiqiu PENG Yeqiang SHU Jingen XIAO Xiaohui XIE Zhiwei ZHANG Zhiqiang LIU Jian LAN Dake CHEN Huijie XUE Guihua WANG Jianping GAN Xinong XIE Rui ZHANG Hui CHEN Qingxuan YANG | 2019 | Science China Earth Sciences2019，62，12： | 8 |
| 4 | Two new secoiridoid glycosides from the roots of Picrorhiza scrophulariiflora显示文摘从 Picrorhiza scrophulariiflora 的根,二新 secoiridoid glycosides,命名 picrosecosides 我和 II (1, 2 ) 被孤立。他们的结构根据化学药品和 spectropic 证据被阐明。 | Lian Chun Zou Tong Fei Zhu Shu Cai Gan Da Cheng Wang Yu Zhang Xu Ming Deng | 2008 | Chinese Chemical Letters2008，19，10： | 8 |
| 5 | Impacts of different drying strategies on drying characteristics,the retention of bio-active ingredient and colour changes of dried Roselle显示文摘The drying kinetics of Roselle(Hibiscus sabdariffa L) of variety Terengganu(UMKL-1) and the quality attribution of Roselle were studied. The experiments were conducted using four different drying methods, including solar greenhouse drying(SD), solar greenhouse with intermittent heat pump drying(SIHP), hot air drying(HA) and heat pump drying(HP). Among the four drying methods, HP achieved the highest drying rate at a range from0.054 g H_2 O·(g DM)^(-1) ·min^(-1) to 0.212 g H_2 O·(g DM)^(-1)·min^(-1) while SD had the lowest drying rate, measured at 0.042 g H_2 O·(g DM)^(-1)·min^(-1).The analysis on colour kinetics revealed that there is no significant colour loss(p > 0.05) observed from HP's dried Roselle. Greater amount of flavonoid compounds i.e. protocatechuic acid was found in SD and SIHP dried finished product whereas HP's dried Roselle contains higher percentage of catechin as compared to other drying methods. | Thing Chai Tham Mei Xiang Ng Shu Hui Gan Lee Suan Chua Ramlan Aziz Luqman Chuah Abdullah Sze Pheng Ong Nyuk Ling Chin Chung Lim Law | 2018 | Chinese Journal of Chemical Engineering2018，26，2： | 7 |
| 6 | Establishment and functional characterization of the reversibly immortalized mouse glomerular podocytes(imPODs)显示文摘Glomerular podocytes are highly specialized epithelial cells and play an essential role in establishing the selective permeability of the glomerular filtration barrier of kidney.Maintaining the viability and structural integrity of podocytes is critical to the clinical management of glomerular diseases,which requires a thorough understanding of podocyte cell biology.As mature podocytes lose proliferative capacity,a conditionally SV40 mutant tsA58-immortalized mouse podocyte line(designated as tsPC)was established from the Immortomouse over 20 years ago.However,the utility of the tsPC cells is hampered by the practical inconvenience of culturing these cells.In this study,we establish a user-friendly and reversibly-immortalized mouse podocyte line(designated as imPOD),on the basis of the tsPC cells by stably expressing the wildtype SV40 T-antigen,which is flanked with FRT sites.We show the imPOD cells exhibit long-term high proliferative activity,which can be effectively reversed by FLP recombinase.The imPOD cells express most podocyte-related markers,including WT-1,Nephrin,Tubulin and Vinculin,but not differentiation marker Synaptopodin.The imPOD cells do not form tumor-like masses in vivo.We further demonstrate that TGFb1 induces a podocyte injury-like response in the FLP-reverted imPOD cells by suppressing the expression of slit diaphragm-associated proteins P-Cadherin and ZO-1 and upregulating the expression of mesenchymal markers,a-SMA,Vimentin and Nestin,as well as fibrogenic factors CTGF and Col1a1.Collectively,our results strongly demonstrate that the newly engineered im-POD cells should be a valuable tool to study podocyte biology both under normal and under pathological conditions. | Xinyi Yu Liqun Chen Ke Wu Shujuan Yan Ruyi Zhang Chen Zhao Zongyue Zeng Yi Shu Shifeng Huang Jiayan Lei Xiaojuan Ji Chengfu Yuan Linghuan Zhang Yixiao Feng Wei Liu Bo Huang Bo Zhang Wenping Luo Xi Wang Bo Liu Rex C.Haydon Hue H.Luu Tong-Chuan He Hua Gan | 2018 | Genes & Diseases2018，5，2： | 5 |
| 7 | Contaminant removal from low-concentration polluted river water by the bio-rack wetlands显示文摘The bio-rack is a new approach for treating low-concentration polluted river water in wetland systems.A comparative study of the efficiency of contaminant removal between four plant species in bio-rack wetlands and between a bio-rack system and control system was conducted on a small-scale (500 mm length × 400 mm width × 400 mm height) to evaluate the decontamination effects of four different wetland plants.There was generally a significant difference in the removal of total nitrogen (TN),ammonia nitrogen (NH 3-N) and total phosphorus (TP),but no significant difference in the removal of permanganate index (COD Mn) between the bio-rack wetland and control system.Bio-rack wetland planted with Thalia dealbata had higher nutrient removal rates than wetlands planted with other species.Plant fine-root (root diameter 3 mm) biomass rather than total plant biomass was related to nutrient removal efficiency.The study suggested that the nutrient removal rates are influenced by plant species,and high fine-root biomass is an important factor in selecting highly effective wetland plants for a bio-rack system.According to the mass balance,the TN and TP removal were in the range of 61.03-73.27 g/m2 and 4.14-5.20 g/m2 in four bio-rack wetlands during the whole operational period.The N and P removal by plant uptake constituted 34.9%-43.81% of the mass N removal and 62.05%-74.81% of the mass P removal.The study showed that the nitrification/denitrification process and plant uptake process are major removal pathways for TN,while plant uptake is an effective removal pathway for TP. | Ji Wang Lanying Zhang Shaoyong Lu Xiangcan Jint Shu Gan | 2012 | Journal of Environmental Sciences2012，24，6： | 4 |
| 8 | A Novel Airborne 3D Laser Point Cloud Hole Repair Algorithm Considering Topographic Features显示文摘Hole repair processing is an important part of point cloud data processing in airborne 3-dimensional(3D)laser scanning technology.Due to the fragmentation and irregularity of the surface morphology,when applying the 3D laser scanning technology to mountain mapping,the conventional mathematical cloud-based point cloud hole repair method is not ideal in practical applications.In order to solve this problem,we propose to repair the valley and ridge line first,and then repair the point cloud hole.The main technical steps of the method include the following points:First,the valley and ridge feature lines are extracted by the GIS slope analysis method;Then,the valley and ridge line missing from the hole are repaired by the mathematical interpolation method,and the repaired results are edited and inserted to the original point cloud;Finally,the traditional repair method is used to repair the point cloud hole whose valley line and ridge line have been repaired.Three experiments were designed and implemented in the east bank of the Xiaobaini River to test the performance of the proposed method.The results showed that compared with the direct point cloud hole repair method in Geomagic Studio software,the average repair accuracy of the proposed method,in the 16 m buffer zone of valley line and ridge line,is increased from 56.31 cm to 31.49 cm.The repair performance is significantly improved. | Zan ZHU Shu GAN Jianqi WANG Nijia QIAN | 2020 | Journal of Geodesy and Geoinformation Science2020，3，3： | 4 |
| 9 | A new anti-diabetic sesquiterpenoid from Acorus calamus显示文摘新 sesquiterpenoid, 1,5-guaiane-4,10-diol-6-one (1 ) ,从 Acorus 省藤属的植物的根茎的 70% EtOH 摘录被孤立。结构在分光镜的方法上被决定,特别 2D NMR 技术。1 的绝对配置被它的 ECD 光谱的 TDDFT 量化学药品计算证实。在 HepG2 房间的一个调停胰岛素的葡萄糖消费模型上加重 1 项显示出的有希望的反糖尿病的活动。 | Chang Xin Zhou Di Qiao You You Yan Hao Shu Wu Jian Xia Mo Li She Gan | 2012 | Chinese Chemical Letters2012，23，10： | 3 |
| 10 | Allogeneic hematopoietic stem cell transplantation for patients with acute leukemia显示文摘Objective: The purposes of this study were to assess the efficacy of allogeneic hematopoietic stem cell transplantation (HSCT) for acute leukemia (AL) and analyze the factors affecting the prognosis of these patients. Methods: The clinical and follow-up data of 93 AL patients (median age, 30 years) undergoing allogeneic HSCT in Xiangya Hospital over the past 12 years were collected, and the potential factors affecting the efficacy and prognosis of allogeneic HSCT patients were determined. Results: Hematopoietic reconstitution was achieved in 90 patients. At the last follow-up, the incidences of severe acute graft versus host disease (aGvHD) and extensive chronic GvHD (cGvHD) were 14.0% and 20.0%, the 3-year cumulative incidence of transplantation related mortality (TRM) and relapse rate were 16.8%±6.1% and 21.3%±6.7%, and the estimated 3-year overall survival (OS) and disease-free survival (DFS) of the patients were 64.6%±5.4% and 56.5%±5.5%, respectively. Univariate analysis indicated that age older than 40 years, HLA mismatch, and severe lung infection within the first 100 days after transplantation were risk factors for severe aGvHD, age older than 40 years, HLA mismatch, severe lung infection within the first 100 days after transplantation, and severe aGvHD were risk factors for TRM, high-risk AL and lack of cGvHD were risk factors for relapse (all P<0.05). Survival estimation showed that HLA mismatch, severe lung infection occurring within the first 100 days post-transplantation, high-risk AL severe aGvHD and lack of cGvHD were risk factors associated with poor prognosis (all P<0.05). Further multivariate analyses revealed that severe lung infection within the first 100 days post-transplantation, severe aGvHD and lack of cGvHD were independent risk factors for unfavorable outcomes (all P<0.05). Conclusions: Allogeneic HSCT can improve the DFS of AL patients, and severe lung infection within the first 100 days post-transplantation, severe aGvHD and lack of cGvHD are independent risk factors affecting the prognosis. | Yan Chen Yajing Xu Gan Fu Yi Liu Jie Peng Bin Fu Xiaoyu Yuan Hongya Xin Yan Zhu Qun He Dengshu Wu Yigang Shu Xiaolin Li Xielan Zhao Fangping Chen | 2013 | Chinese Journal of Cancer Research2013，25，4： | 3 |
| 11 | Linkages of transboundary water allocation and its eco-thresholds with international laws显示文摘 | FENG Yan HE Daming GAN Shu GU Ying | 2006 | Chinese Science Bulletin2006，51，B11： | 3 |
| 12 | Methodology for fish biodiversity monitoring with environmental DNA metabarcoding:The primers,databases and bioinformatic pipelines显示文摘Environmental DNA(eDNA)originates from cellular material shed by organisms into aquatic or terrestrial environments and can be sampled and monitored using metabarcoding technology,which is revolutionizing fish biodiversity monitoring.Several reviews concerning fish eDNA have focused on standard sampling methods and its applications,though a systematic review focused on marker genes,databases,and bioinformatic pipelines has not yet been published.Here,we present a comprehensive literature review of studies applying metabarcoding technology to fish eDNA for the purpose of fish biodiversity monitoring.We systematically provide the available universal primers used to amplify barcoding sequences from fish eDNA,and then discuss reference barcoding databases,relevant bioinformatic analyses,as well as developed pipelines.The performances of universal primers and their relevant reference databases are summarized.Combined use of multiple primer pairs targeted for more than one gene marker(e.g.,12S,16S,Cytb,COI),and use of both local and public databases are recommended as approaches to improve the sensitivity and reliability of fish eDNA analyses.We also compare the effectiveness of eDNA metabarcoding to traditional approaches for monitoring fish biodiversity and highlight challenges and future perspectives associated with this new tool.Ultimately,we advocate for greater incorporation of eDNA analysis into fish biodiversity assessments to assist environmental managers. | Fan Xiong Lu Shu Honghui Zeng Xiaoni Gan Shunping He Zuogang Peng | 2022 | Water Biology and Security2022，1，1： | 3 |
| 13 | Experimental studies on ozonation of ethylenethiourea显示文摘The experimental study on ozonation of ethylenethiourea(ETU) is conducted.The reaction of gas-phase ETU with 0.63 × 10-6 mol/L ozone is carried out in a 200-L reaction chamber.The secondary organic aerosol(SOA) resulted from the ozonation of gas-phase ETU is observed with a scanning mobility particle size(SMPS).The rapid exponential growth of SOA reveals that the atmospheric lifetime of ETU vapor towards ozone reaction is less than four days.The ozonation of dry ETU particles,ETU-contained water droplets and ETU aqueous solution is investigated with a vacuum ultraviolet photoionization aerosol time-of-flight mass spectrometer(VUVATOFMS).The formation of 2-imidazoline is observed in the ozonation of dry ETU particles and ETU-contained water droplets.The formation of 2-imidazoline and ethylenerea is observed in the ozonation of ETU aqueous solution. | Xinyu Dong Junwang Meng Bo Yang Yang Zhang Jie Gan XiShu Jinian Shu | 2011 | Journal of Environmental Sciences2011，23，1： | 2 |
| 14 | Downregulation of MEIS1 mediated by ELFN1-AS1/EZH2/DNMT3a axis promotes tumorigenesis and oxaliplatin resistance in colorectal cancer显示文摘Oxaliplatin is widely used in the frontline treatment of colorectal cancer(CRC),but an estimated 50%of patients will eventually stop responding to treatment due to acquired resistance.This study revealed that diminished MEIS1 expression was detected in CRC and harmed the survival of CRC patients.MEIS1 impaired CRC cell viabilities and tumor growth in mice and enhanced CRC cell sensitivity to oxaliplatin by preventing DNA damage repair.Mechanistically,oxaliplatin resistance following MEIS1 suppression was critically dependent on enhanced FEN1 expression.Subsequently,we confirmed that EZH2-DNMT3a was assisted by lncRNA ELFN1-AS1 in locating the promoter of MEIS1 to suppress MEIS1 transcription epigenetically.Based on the above,therapeutics targeting the role of MEIS1 in oxaliplatin resistance were developed and our results suggested that the combination of oxaliplatin with either ELFN1-AS1 ASO or EZH2 inhibitor GSK126 could largely suppress tumor growth and reverse oxaliplatin resistance.This study highlights the potential of therapeutics targeting ELFN1-AS1 and EZH2 in cell survival and oxaliplatin resistance,based on their controlling of MEIS1 expression,which deserve further verification as a prospective therapeutic strategy. | Yimin Li Yaqi Gan Jiaxin Liu Juanni Li Zhengwei Zhou Ruotong Tian Ruizheng Sun Jiaqi Liu Qing Xiao Yuanyuan Li Pengyan Lu Yulong Peng Yuqian Peng Guang Shu Gang Yin | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 2 |
| 15 | Three new diterpenoid alkaloids isolated from Aconitum brevicalcaratum显示文摘In the present study, three new aconitine-type diterpenoid alkaloids brochyponines A–C(1–3) were isolated from the roots of Aconitum brevicalcaratum. Their structures were established on the basis of extensive spectroscopic analyses(IR, HR-ESI-MS, and 1D and 2D NMR). The NMR data of salt form for compound 1 in CDCl_3 were also measured. | SHU Yan YIN Tian-Peng WANG Jia-Peng GAN Dong ZHANG Qin-Yan CAI Le DING Zhong-Tao | 2018 | Chinese Journal of Natural Medicines2018，16，11： | 2 |
| 16 | Diagnosis,treatment,and prevention of severe acute hepatitis of unknown etiology in children显示文摘Background Severe acute hepatitis of unknown etiology in children has recently exhibited a global trend of concentrated occurrence.This review aimed to summarize the current available information regarding the outbreak of severe acute hepatitis and introduce our hospital’s previous experiences with the diagnosis and treatment of severe acute hepatitis for reference.Data sources Websites including the UK Health Security Agency,European Centre for Disease Prevention and Control,CDC,WHO,and databases including PubMed/Medline,Cochrane Library,Embase and Web of Science were searched for articles on severe acute hepatitis in children.Results As of May 26,2022,a total of 650 cases have been reported in 33 countries;at least 38(6%)children required liver transplantation,and nine(1%)died.Cases are predominantly aged between 3 and 5 years old,and there are no epidemiological links among them.The common manifestations are jaundice,vomiting and pale stools.Adenovirus tested positive in most cases,and SARS-CoV-2 and other viruses were detected in a few cases,but virus particles were not found in liver tissue.Adenovirus immunohistochemistry showed immunoreactivity in the intrasinusoidal lumen from some liver samples.The hierarchical treatment includes symptomatic and supportive therapy,management of coagulation disorders and hepatic encephalopathy,artifcial liver support,and liver transplantation(approximately 6%–10%of cases require liver transplant).Conclusions The etiology of this severe acute hepatitis in children is not clear.The clinical features are severe acute hepatitis with signifcantly elevated liver enzymes.Clinicians need to be alert to children with hepatitis. | Ying‑Hu Chen Jin‑Gan Lou Zi‑Hao Yang Qing‑Jiang Chen Chun‑Zhen Hua Sheng Ye Chen‑Mei Zhang Jie Chen Zong‑Wei Huang Jin‑Dan Yu Zhi‑Gang Gao Qiang Shu | 2022 | World Journal of Pediatrics2022，18，8： | 2 |
| 17 | Hierarchically mesoporous carbon spheres coated with a single atomic Fe-N-C layer for balancing activity and mass transfer in fuel cells显示文摘Novel cost-effective fuel cells have become more attractive due to the demands for rare and expensive platinum-group metal(PGM)catalysts for mitigating the sluggish kinetics of the oxygen reduction reaction(ORR).The high-cost PGM catalyst in fuel cells can be replaced by earth-abundant transition-metalbased catalysts,that is,an Fe-N-C catalyst,which is considered one of the most promising alternatives.However,the performance of the Fe-N-C catalyst is hindered by the low catalytic activity and poor stability,which is caused by insufficient active sites and the lack of optimization of the triple-phase interface for mass transportation.Herein,a novel Fe–N–C catalyst consisting of mono-dispersed hierarchically mesoporous carbon sphere cores and single Fe atom-dispersed functional shells are presented.The synergistic effect between highly dispersed Fe-active sites and well-organized porous structures yields the combination of high ORR activity and high mass transfer performance.The half-wave potential of the catalyst in 0.1M H_(2)SO_(4) is 0.82 V versus reversible hydrogen electrode,and the peak power density is 812 mW·cm^(−2) in H_(2)–O_(2) fuel cells.Furthermore,it shows superior methanol tolerance,which is almost immune to methanol poisoning and generates up to 162 mW·cm^(−2) power density in direct methanol fuel cells. | Chengyong Shu Qiang Tan Chengwei Deng Wei Du Zhuofan Gan Yan Liu Chao Fan Hui Jin Wei Tang Xiao-dong Yang Xiaohua Yang Yuping Wu | 2022 | Carbon Energy2022，4，1： | 2 |
| 18 | Endoscopic surgical strategy of non-functional urinary bladder paraganglioma in children显示文摘 | Xiang Song-tao Wang Shu-sheng Zhou Jian-fu Gan Shu Chen Zhi-qiang | 2013 | Chinese Medical Journal2013，，5： | 1 |
| 19 | Genetic polymorphisms in the TGF- beta 1 gene and breast cancer survival: a report from the Shanghai Breast Cancer Study 显示文摘 | Shu XO Gan YT Cai Q | 2004 | Cancer Res2004，64，3： | 1 |
| 20 | Global research trends in the field of liver cirrhosis from 2011 to 2020: A visualised and bibliometric study显示文摘BACKGROUND Liver cirrhosis is the leading cause of liver-related mortality worldwide. It is currently a global health challenge.AIM This research intended to explore and analyse research trends and frontiers in this field during the last 10 years, providing new inspiration for clinical decisionmaking and scientific research.METHODS Publications on hepatic cirrhosis research were retrieved from the Web of Science Core Collection on April 4, 2021. Bibliometric visualisation was conducted through VOSviewer and CiteSpace.RESULTS The analytic research was based on original articles and reviews. A total of 7775records of hepatic cirrhosis published from 2011 to 2020 were retrieved. In the past ten years, the number of related annual publications has increased significantly, especially in the United States and China. All publications were distributed among 109 countries. The United States contributed the most(21.95%)and was consistently the leading driving force, with a solid academic reputation in this area. The University of Barcelona distributed the most related articles(177articles) and was cited the most frequently. The Journal of Hepatology ranked third in the top 10journals, which has the highest impact factor(impact factor 2019 = 20.582). Jasmohan S. Bajaj was the most productive author(72 articles). Burst keywords(e.g., sofosbuvir, burden, care, sarcopenia,chronic liver failure, human gut microbiome, and nonalcoholic fatty liver disease) and a succession of reference citation bursts have provided clues about research frontiers in recent years.CONCLUSION This study identified developing trends in the evolution of liver cirrhosis to provide new inspiration for researchers. | Pei-Ling Gan Shu Huang Xiao Pan Hui-Fang Xia Xin-Yi Zeng Wen-Sen Ren Xian Zhou Mu-Han Lv Xiao-Wei Tang | 2022 | World Journal of Gastroenterology2022，28，33： | 1 |
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