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| 1 | Molecular genetics of berry colour variation in table grape显示文摘 | Diego Lijavetzky Leonor Ruiz-García José A. Cabezas María T. Andrés Gemma Bravo Ana Ibá?ez Juan Carre?o Félix Cabello Javier Ibá?ez José M. Martínez-Zapater | 2006 | Molecular Genetics and Genomics2006，，5： | 2 |
| 2 | Stimulation of'Fuji'apple skin color by ethephon and phosphorus calcium mixed compounds inrelation to flavonoid synthesis显示文摘 | Li Z Gemma H Iwahori S | 2002 | Scientia Horticulturae2002，94，7： | 1 |
| 3 | Remifentanil provides hemodynamic stability and faster awakening time in transsphenoidal surgery显示文摘 | Gemma M Tommasino C Cozzi S | 2002 | Anesth Analg2002，94，： | 1 |
| 4 | Methylation of TFAM gene promoter in peripheral white blood cells is associated with insulin resistance in adolescents显示文摘 | Gemma C Sookoian S Dieuzeide G | | 0，，01： | 1 |
| 5 | Effect of chitosan coating on the storage of peach, Japanese pear and kiwifruit显示文摘 | Du J Gemma H Iwahori S | 1997 | J Jpn Soc Hort Sci1997，66，： | 1 |
| 6 | Relationship between ab- scisic acid content and maturation of the sweet cherry显示文摘 | KONDO S GEMMA H | 1993 | J Japan Soc Hort Sci1993，62，1： | 1 |
| 7 | Flower bud formation in Japanese pear trees under adverse conditions and effects of some growth regulators 显示文摘 | RAKNGAN J GEMMA H IWAHORI S | 1995 | Journal of Tropical Agriculture1995，39，： | 1 |
| 8 | Relationship between abscisic acid(ABA)content and maturation of the sweet cherry显示文摘 | Kondo S Gemma H | 1993 | J Jpn Soc Hortic Sci1993，62，： | 1 |
| 9 | Decreased anthocyanin biosynthesis in grape berries grown under elevated night temperature condition显示文摘 | Mori K Sugaya S Gemma H | 2005 | Scientia Horticulturae2005，105，3： | 1 |
| 10 | Decreased anthocyanin biosynthe- sis in grape berries grown under elevated night temperature con- dition显示文摘 | Mori K Sugaya S Gemma H | 2005 | Scientia Horticulturae2005，105，3： | 1 |
| 11 | Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer显示文摘Colorectal cancer(CRC)is the second leading cause of cancer-related death worldwide.The five-year survival rate of CRC patients depends on the stage at diagnosis,being higher than 80%when CRC is diagnosed in the early stages but lower than 10%when CRC is diagnosed in advanced stages.Autoantibodies against specific CRC autoantigens(tumor-associated antigens(TAAs))in the sera of patients have been widely demonstrated to aid in early diagnosis.Thus,we herein aim to identify autoantigens target of autoantibodies specific to CRC that possess a significant ability to discriminate between CRC patients and healthy individuals by means of liquid biopsy.To that end,we examined the protein content of the exosomes released by five CRC cell lines and tissue samples from CRC patients by means of immunoprecipitation coupled with mass spectrometry analysis.A total of 103 proteins were identified as potential autoantigens specific to CRC.After bioinformatics and meta-analysis,we selected 15 proteins that are more likely to be actual CRC autoantigens in order to evaluate their role in CRC prognosis by Western blot(WB)and immunohistochemistry(IHC).We found dysregulation at the protein level for 11 of these proteins in both tissue and plasma exosome samples from patients,along with an association of nine of these proteins with CRC prognosis.After validation,all but one showed a statistically significant high diagnostic ability to distinguish CRC patients and individuals with premalignant lesions from healthy individuals,either by luminescence Halotag-based beads,or by a multiplexed biosensing platform involving the use of magnetic microcarriers as solid support modified with covalently immobilized Halotag fusion proteins constructed for CRC detection.Taken together,our results highlight the usefulness of the approach defined here to identify the TAAs specific to chronic diseases;they also demonstrate that the measurement of autoantibody levels in plasma against the TAAs identified here could be integrated into a point-of-care(POC)device for CRC detection with high diagnostic ability. | Ana Montero-Calle Itziar Aranguren-Abeigon María Garranzo-Asensio Carmen Poves María Jesús Fernández-Aceñero Javier Martínez-Useros Rodrigo Sanz Jana Dziaková Javier Rodriguez-Cobos Guillermo Solís-Fernández Eloy Povedano Maria Gamella Rebeca Magnolia Torrente-Rodríguez Miren Alonso-Navarro Vivian de los Ríos J.Ignacio Casal Gemma Domínguez Ana Guzman-Aranguez Alberto Peláez-García JoséManuel Pingarrón Susana Campuzano Rodrigo Barderas | 2021 | Engineering2021，7，10： | 1 |
| 12 | Effects of chitosan coating on the storage of peach,Japanese pear and kiwifruit显示文摘 | Du J M Gemma H Iwahori S | 1997 | Journal of the Japanese Society for Horticultural Science1997，66，1： | 1 |
| 13 | Gefitinib 0ressa) sensitive lung cancer cell lines show phesphorylation of Akt without ligand stimulation 显示文摘 | NORO R GEMMA A KOSAIHIREA S | 2006 | BMC Cancer2006，6，9： | 1 |
| 14 | β-Secretase as a therapeu- tic target for Alzheimer's disease显示文摘 | Ghosh AK Gemma S Tang J | 2008 | Neurotharapeutics2008，5，3： | 1 |
| 15 | Androgen deficiency in women with hypopituitarism 显示文摘 | Karen KM Gemma S Aileen S | 2001 | J Clin Endocrinol Metab2001，86，2： | 1 |
| 16 | Remifentanil provides hemodynamic stability and faster awakening time in transsphenoidal surgery显示文摘 | Gemma M Tommasino C Cozzi S | 2002 | Anesthes Analg2002，94，： | 1 |
| 17 | Decreased anthocyanin biosynthesis in grape berries grown under elevated night temperature condition显示文摘 | Mori K Sugaya S Gemma H | 2005 | Seientia Horticuhurae2005，105，： | 1 |
| 18 | Effects of chitosan coating on the storability and on the uhrastmctural changes of 'Jonagold' apple fruit in storage显示文摘 | Du J M GEMMA H IWAHORI S | 1998 | Food Preservation Science1998，，： | 1 |
| 19 | Synthesis and bio- logical evaluation of novel allophenylnorstatine-based HIV-1 pro- tease inhibitors incorporating high affinity P2-1igands显示文摘 | GHOSH AK GEMMA S SIMONI E | 2010 | Bioorg Med Chem Lett2010，20，3： | 1 |
| 20 | Brain Perfusion Correlates of Visuoperceptual Deficits in Mild Cognitive Impairment and Mild Alzheimer’s Disease显示文摘 | Montserrat Alegret Georgina Vinyes-Junqué Mercè Boada Pablo Martínez-Lage Gemma Cuberas Ana Espinosa Isabel Roca Isabel Hernández Sergi Valero Maitée Rosende-Roca Ana Mauleón James T. Becker and Lluís Tárraga | 2010 | Journal of Alzheimer’s Disease2010，，2： | 1 |
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