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| 1 | CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells显示文摘In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until today.Angiotensin-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike protein.Although ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the lung.Considering the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its infection.Here,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike protein.The loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 amplification.Expression of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular fragment.Viral loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type mice.Interestingly,virions are observed in lymphocytes of lung tissue from a COVID-19 patient.Human T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by Meplazumab.Furthermore,CD147 mediates virus entering host cells by endocytosis.Together,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19. | Ke Wang Wei Chen Zheng Zhang Yongqiang Deng Jian-Qi Lian Peng Du Ding Wei Yang Zhang Xiu-Xuan Sun Li Gong Xu Yang Lei He Lei Zhang Zhiwei Yang Jie-Jie Geng Ruo Chen Hai Zhang Bin Wang Yu-Meng Zhu Gang Nan Jian-Li Jiang Ling Li Jiao Wu Peng Lin Wan Huang Liangzhi Xie Zhao-Hui Zheng Kui Zhang Jin-Lin Miao Hong-Yong Cui Min Huang Jun Zhang Ling Fu Xiang-Min Yang Zhongpeng Zhao Shihui Sun Hongjing Gu Zhe Wang Chun-Fu Wang Yacheng Lu Ying-Ying Liu Qing-Yi Wang Huijie Bian Ping Zhu Zhi-Nan Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 9 |
| 2 | Area and volume ratios for prediction of visual outcome in idiopathic macular hole显示文摘AIM:To predict the visual outcome in patients undergoing macular hole surgery by two novel three-dimensional morphological parameters on optical coherence tomography(OCT): area ratio factor(ARF) and volume ratio factor(VRF).METHODS: A clinical case series was conducted,including 54 eyes of 54 patients with an idiopathic macular hole(IMH). Each patient had an OCT examination before and after surgery. Morphological parameters of the macular hole,such as minimum diameter,base diameter,and height were measured. Then,the macular hole index(MHI),tractional hole index(THI),and hole form factor(HFF) were calculated. Meanwhile,novel postoperative macular hole(MH) factors,ARF and VRF were calculated by three-dimensional morphology. Bivariate correlations were performed to acquire asymptotic significance values between the steady best corrected visual acuity(BCVA) after surgery and 2D/3D arguments of MH by the Pearson method with two-tailed test. All significant factors were analyzed by the receiver operating characteristic(ROC) curve analysis of SPSS software which were responsible for vision recovery. ROC curves analyses were performed to further discuss the different parameters on the prediction of visual outcome.RESULTS: The mean and standard deviation values of patients' age,symptoms duration,and follow-up time were 64.8±8.9y(range: 28-81),18.6±11.5d(range: 2-60),and 11.4±0.4mo(range: 6-24),respectively. Steady-postBCVA analyzed with bivariate correlations was found to be significantly correlated with base diameter(r=0.521,P<0.001),minimum diameter(r=0.514,P<0.001),MHI(r=-0.531,P<0.001),THI(r=-0.386,P=0.004),HFF(r=-0.508,P<0.001),and ARF(r=-0.532,P<0.001). Other characteristic parameters such as age,duration of surgery,height,diameter hole index,and VRF were not statistically significant with steady-post-BCVA. According to area under the curve(AUC) values,values of ARF,MHI,HFF,minimum diameter,THI,and base diameter are 0.806,0.772,0.750,0.705,0.690,and 0.686,respectively. However,Steady-post-BCVA analysis with bivariate correlations for VRF was no statistical significance. Results of ROC curve analysis indicated that the MHI value,HFF,and ARF was greater than 0.427,1.027 and 1.558 respectively which could correlate with better visual acuity.CONCLUSION: Compared with MHI and HFF,ARF could effectively express three-dimensional characteristics of macular hole and achieve better sensitivity and specificity. Thus,ARF could be the most effective parameter to predict the visual outcome in macular hole surgery. | Xing-Yun Geng Hui-Qun Wu Jie-Hui Jiang Kui Jiang Jun Zhu Yi Xu Jian-Cheng Dong Zhuang-Zhi Yan | 2017 | International Journal of Ophthalmology(English edition)2017，10，8： | 8 |
| 3 | A User-Centric Data Secure Creation Scheme in Cloud Computing显示文摘Due to the use of the cloud computing technology,the ownership is separated from the administration of the data in cloud and the shared data might be migrated between different clouds,which would bring new challenges to data secure creation,especially for the data privacy protection.We propose a User-centric data secure creation scheme(UCDSC) for the security requirements of resource owners in cloud.In this scheme,a data owner first divides the users into different domains.The data owner encrypts data and defines different secure managing policies for the data according to domains.To encrypt the data in UCDSC,we present an algorithm based on Access control conditions proxy re-encryption(ACC-PRE),which is proved to be master secret secure and Chosen-ciphertext attack(CCA) secure in random oracle model.We give the application protocols and make the comparisons between some existing approaches and UCDSC. | SU Mang LI Fenghua SHI Guozhen GENG Kui XIONG Jinbo | 2016 | Chinese Journal of Electronics2016，25，4： | 7 |
| 4 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 5 | Structural basis for the recognition of Asef by adenomatous polyposis coli显示文摘Adenomatous polyposis coli (APC ) 通过激活刺激 APC 的 guanine 核苷酸交换因素调整房间房间粘附和房间移植(GEF;Asef ) ,它通常是通过在它的 Src 相同之间的绑定的 autoinhibited 3 (SH3 ) 并且 Dbl 相同(DH ) 领域。激活 APC 的 Asef 刺激小 GTPase Cdc42,它导致减少的房间房间坚持和提高的房间移植。在 colorectal 癌症,组成地截断了 APC 激活 Asef 并且支持癌症房间移植和 angiogenesis。这里,我们报导人的 APC/Asef 建筑群的水晶结构。我们发现 APC 的犰狳重复域使用一条高度保存的表面沟认出 Asef 的 APC 有约束力的区域(ABR ) ,哪个在绑定之上戏剧性地改变到 APC 的符合构造。为复杂形成的 APC 和 Asef 上的关键残余被变异,他们的重要性被绑定和活动试金表明。有 autoinhibited Asef 的 APC/Asef 建筑群的结构的重迭建议在 APC 和 Asef 之间的绑定可能创造在 Asef-DH 领域和 APC 之间的位的碰撞,它可能在刺激它的 GEF 活动的 Asef 导致一个 conformational 变化。我们的结构因此阐明由 APC 的 Asef 识别的分子的机制,以及对癌症为药品的干预提供一个潜在的目标。 | Zhenyi Zhang Leyi Chen Lei Gao Kui Lin Liang Zhu Yang Lu Xiaoshan Shi Yuan Gao Jing Zhou Ping Xu Jian Zhang Geng Wu | 2012 | Cell Research2012，22，2： | 5 |
| 6 | A new pyrrolidone derivative from Pistacia chinensis显示文摘新 N-phenyl-pyrrolidone 衍生物从 Pistacia 脊骨被孤立是 Bunge。它的结构作为 4-hydroxy-5-(2-oxo-1-pyrrolidinyl ) 被阐明安息香的酸的、命名 pistaciamide 根据 1D-NMR,系, HMQC 和 HMBC 分光镜的技术。 | Jian Jun Liu Chang An Geng Xi Kui Liu | 2008 | Chinese Chemical Letters2008，19，1： | 4 |
| 7 | The association between retinal vasculature changes and stroke:a literature review and Meta-analysis显示文摘● AIM: To determine the association between retinal vasculature changes and stroke. ● METHODS: MEDLINE and EMBASE were searched for relevant human studies to September 2015 that investigated the association between retinal vasculature changes and the prevalence or incidence of stroke; the studies were independently examined for their qualities. Data on clinical characteristics and calculated summary odds ratios(ORs) were extracted for associations between retinal microvascular abnormalities and stroke, including stroke subtypes where possible, and adjusted for key variables. ● RESULTS: Nine cases were included in the study comprising 20 659 patients, 1178 of whom were stroke patients. The retinal microvascular morphological markers used were hemorrhage, microaneurysm, vessel caliber, arteriovenous nicking, and fractal dimension. OR of retinal arteriole narrowing and retinal arteriovenous nicking and stroke was 1.42 and 1.91, respectively, indicating that a smallcaliber retinal arteriole and retinal arteriovenous nicking were associated with stroke. OR of retinal hemorrhage and retinal microaneurysm and stroke was 3.21 and 3.83, respectively, indicating that retinal microvascular lesions were highly associated with stroke. Results also showed that retinal fractal dimension reduction was associated with stroke(OR: 2.28 for arteriole network, OR: 1.80 for venular network). ● CONCLUSION: Retinal vasculature changes have a specific relationship to stroke, which is promising evidence for the prediction of stroke using computerized retinal vessel analysis. | Hui-Qun Wu Huan Wu Li-Li Shi Li-Yuan Yu Li-Yuan Wang Ya-Lan Chen Jin-Song Geng Jian Shi Kui Jiang Jian-Cheng Dong | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 4 |
| 8 | Prevalence and Years of Life Lost due to Disability from Dental Caries among Children and Adolescents in Western China,1990-2015显示文摘Objective To analyze the prevalence and years lived with disability(YLD) from dental caries among children and adolescents and the time trends over the past two decades in Sichuan province,the largest province in west China.Methods Based on the Global Burden of Disease Study 2015(GBD2015),which systematically assessed the epidemiological characteristics of major diseases and their transitions by country and region from 1990 to 2015,we extracted the estimated results for China.We then used the Bayesian meta-regression method to estimate the sex-and age-specific prevalences and YLDs from dental caries among children and adolescents under 15 years old in Sichuan province and compared them with global and national indicators for the same period.Results In 2015,there were almost 6 million cases of dental caries in children and adolescents(aged<15 years) in Sichuan province,accounting for 6% of the total cases in China.For children under 5 years,the prevalence of deciduous caries was 55.9%,and the YLDs value was 10.8 per 100,000,while it was 24.3% and 5.1 per 100,000 respectively among 5- to 14-year-olds;for those aged 5 to 14 years,the prevalence of permanent caries was 21.5%,and the YLDs value was 11.5 per 100,000.From 1990 to 2015,the prevalence of dental caries for children under 5 years increased substantially,by 16.2%,and the YLDs increased by 8.7%.Among those aged 5 to 14 years,the prevalence increased and the YLDs decreased.Conclusion Dental caries remains a huge health burden in Western China.In contrast to the global and national data,the trend has increased rapidly over the past 25 years in this region.This work provides suggestions for the prevention and control for oral health in China with the policy of two-child. | WANG Zhuo DENG Ying LIU Shi Wei HE Jun JI Kui ZENG Xin Ying YANG Shu Juan XU Xin Yin LUO Yu ZHOU Mai Geng ZHANG Jian Xin | 2017 | Biomedical and Environmental Sciences2017，30，10： | 3 |
| 9 | Effect of Nao Yikang on choline acetyltransferase and caspase-3 brain expression in a rat model of Alzheimer's disease显示文摘BACKGROUND: The main components of the traditional Chinese medicine compound Nao Yikanghave been shown to possibly alleviate neural damage.OBJECTIVE: To observe the effects of Nao Yikang on expression of choline acetyltransferase(ChAT) and caspase-3 in the rat brains of an experimental Alzheimer's disease (AD) model, and toinvestigate the mechanisms of potential neuroprotective effects.DESIGN, TIME AND SETTING: A randomized, controlled experiment was performed at theDepartment of Pathophysiology, Medical School of Nantong University between November 2006and December 2007.MATERIALS: The main active components of Nao Yikang were as follows: prepared polygonummultiflorum, Rhizoma anemarrhenae, and Rhizoma acori tatarinowii. Nao Yikang granules wereprepared by Nantong Hospital of Traditional Chinese Medicine. Ibotenic acid (IBO) was purchasedfrom Sigma-Aldrich, USA, ChAT goat anti-rat antibody from Chemicon, USA, and cleaved caspase-3rabbit anti-rat (Asp175) (5A1) antibody from Cell Signaling, USA.METHODS: A total of 60 male, Sprague Dawley rats (2 months old) were randomly assigned to 6groups: sham-surgery, model, Nao Yikang 1.73, 3.45, 6.90 g/kg per day, and piracetam, with 10 ratsin each group. Bilateral infusions of 5 μg IBO into the nucleus basalis of Meynert were performedwith Hamilton syringe and stereotaxic apparatus for AD model establishment. For the sham-surgerygroup, rats received 1 μL saline in the identical stereotaxic position. From the second day, NaoYikang groups were administrated 1.73, 3.45, and 6.90 g/kg per day Nao Yikang, respectively, whilethe piracetam group received 0.04 g/mL piracetam, the model group received 0.5% sodiumcarboxymethyl cellulose, and the sham-surgery group received normal saline. Rats wereintragastrically administered 1 mL/100 g daily for 28 consecutive days.MAIN OUTCOME MEASURES: Following treatment of the various solutions for 28 days, Westernblot was utilized to observe ChAT expression in the frontal cortex of AD rats, andimmunohistochemistry was applied to quantify caspase-3-positive cells in the frontal cortex.RESULTS: ChAT protein expression significantly decreased in the model group (P < 0.01), howevercaspase-3 expression was significantly elevated (P < 0.01) compared with the sham-surgery group.Compared with the model group, ChAT protein expression increased in the Nao Yikang 1.73 g/kgper day, 3.45 g/kg per day, 6.90 g/kg per day groups, and the piracetam group (P < 0.05 or P < 0.01)and the number of caspase-3-positive cells decreased in the Nao Yikang 3.45 g/kg per day and6.90 g/kg per day groups (P < 0.01). However, there was no change in the number ofcaspase-3-positive cells in the 3.45 g/kg per day group.CONCLUSION: The traditional Chinese medicine compound Nao Yikangincreased ChAT proteinexpression and suppressed caspase-3 expression in the frontal cortex in a dose-dependent manner. | Jinsong Geng Hengjian Ni Jiancheng Dong Kui Jiang Ailing Zhou Yae Hu | 2009 | Neural Regeneration Research2009，4，12： | 3 |
| 10 | Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial显示文摘Recent evidence suggests that CD147 serves as a novel receptor for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection.Blocking CD147 via anti-CD147 antibody could suppress the in vitro SARS-CoV-2 replication.Meplazumab is a humanized anti-CD147 IgG_(2) monoclonal antibody,which may effectively prevent SARS-CoV-2 infection in coronavirus disease 2019(COVID-19)patients.Here,we conducted a randomized,double-blinded,placebo-controlled phase 1 trial to evaluate the safety,tolerability,and pharmacokinetics of meplazumab in healthy subjects,and an open-labeled,concurrent controlled add-on exploratory phase 2 study to determine the efficacy in COVID-19 patients.In phase 1 study,59 subjects were enrolled and assigned to eight cohorts,and no serious treatment-emergent adverse event(TEAE)or TEAE grade≥3 was observed.The serum and peripheral blood Cmax and area under the curve showed non-linear pharmacokinetic characteristics.No obvious relation between the incidence or titer of positive anti-drug antibody and dosage was observed in each cohort.The biodistribution study indicated that meplazumab reached lung tissue and maintained>14 days stable with the lung tissue/cardiac blood-pool ratio ranging from 0.41 to 0.32.In the exploratory phase 2 study,17 COVID-19 patients were enrolled,and 11 hospitalized patients were involved as concurrent control.The meplazumab treatment significantly improved the discharged(P=0.005)and case severity(P=0.021),and reduced the time to virus negative(P=0.045)in comparison to the control group.These results show a sound safety and tolerance of meplazumab in healthy volunteers and suggest that meplazumab could accelerate the recovery of patients from COVID-19 pneumonia with a favorable safety profile. | Huijie Bian Zhao-Hui Zheng Ding Wei Aidong Wen Zheng Zhang Jian-Qi Lian Wen-Zhen Kang Chun-Qiu Hao Jing Wang Rong-Hua Xie Ke Dong Jie-Lai Xia Jin-Lin Miao Wen Kang Guoquan Li Di Zhang Mingru Zhang Xiu-Xuan Sun Likun Ding Kui Zhang Junfeng Jia Jin Ding Zhiqin Li Yanyan Jia Lin-Na Liu Zhe Zhang Zhao-Wei Gao Hong Du Na Yao Qing Wang Ke Wang Jie-Jie Geng Bin Wang Ting Guo Ruo Chen Yu-Meng Zhu Li-Juan Wang Qian He Rui-Rui Yao Ying Shi Xiang-Min Yang Jian-Sheng Zhou Yi-Nan Ma Ya-Tao Wang Xue Liang Fei Huo Zhe Wang Yang Zhang Xu Yang Ye Zhang Lu-Hua Gao Ling Wang Xiao-Chun Chen Hao Tang Shuang-Shuang Liu Qing-Yi Wang Zhi-Nan Chen Ping Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 11 | Interoperative fundus image and report sharing in compliance with integrating the healthcare enterprise conformance and web access to digital imaging and communication in medicine persistent object protocol显示文摘AIM:To address issues in interoperability between different fundus image systems,we proposed a web eyepicture archiving and communication system(PACS)framework in conformance with digital imaging and communication in medicine(DICOM)and health level 7(HL7)protocol to realize fundus images and reports sharing and communication through internet.METHODS:Firstly,a telemedicine-based eye care work flow was established based on integrating the healthcare enterprise(IHE)Eye Care technical framework.Then,a browser/server architecture eye-PACS system was established in conformance with the web access to DICOM persistent object(WADO)protocol,which contains three tiers.RESULTS:In any client system installed with web browser,clinicians could log in the eye-PACS to observe fundus images and reports.Multipurpose internet mail extensions(MIME)type of a structured report is saved as pdf/html with reference link to relevant fundus image using the WADO syntax could provide enough information for clinicians.Some functions provided by open-source Oviyam could be used to query,zoom,move,measure,view OICOM fundus images.CONCLUSION:Such web eye-PACS in compliance to WADO protocol could be used to store and communicate fundus images and reports,therefore is of great significance for teleophthalmology. | Hui-Qun Wu Zheng-Min Lv Xing-Yun Geng Kui Jiang Le-Min Tang Guo-Min Zhou Jian-Cheng Dong | 2013 | International Journal of Ophthalmology(English edition)2013，6，6： | 2 |
| 12 | Building Distributed Web GIS: A Mobile Agent Based Approach显示文摘The diversity of GISs and the wide spread availability of WWW have led to an increasing amount of research on integrating a variety of heterogeneous and autonomous GISs in a cooperative environment to construct a new generation of GIS characterizing in open architecture, distributed computation, interoperability, and extensibility. Our on going research project MADGIS (Mobile Agent based Distributed Geographic Information System) is reported, in which we propose the architecture of MADGIS to meet the requirements of integrating distributed GIS applications under Internet environment. We first describe the architecture of MADGIS, and detailed discussions focusing on the structure of client site, server site and mobile agent in MADGIS. Then we explore key techniques for MADGIS implementation. | jhguan@wtusm.edu.cn Guan Ji hong 1 , Zhou Shui geng 2 , Bian Fu ling 3, Meng Ling kui 3 1. School of Computer, Wuhan University, Wuhan 430072, China 2. State Key Laboratory of Software Engineering, Wuhan University, Wuhan 430072, Chin | 2001 | Wuhan University Journal of Natural Sciences2001，6，Z1： | 2 |
| 13 | Targeting PI3K/Akt signal transduction for cancer therapy显示文摘The phosphatidylinositol 3-kinase(PI3K)/Akt pathway plays a crucial role in various cellular processes and is aberrantly activated in cancers,contributing to the occurrenee and progression of tumors.Examining the upstream and downstream nodes of this pathway could allow full elucidation of its function.Based on accumulating evidenee,strategies targeting major components of the pathway might provide new in sights for can cer drug discovery.Researchers have explored the use of some in hibitors targeti ng this pathway to block survival pathways.However,because oncogenic PI3K pathway activation occurs through various mechanisms,the clinical efficacies of these inhibitors are limited.Moreover,pathway activation is accompanied by the development of therapeutic resista nee.Therefore,strategies involvi ng pathway in hibitors and other can cer treatments in combinati on might solve the therapeutic dilemma.In this review,we discuss the roles of the PI3K/Akt pathway in various cancer phenotypes,review the current statuses of different PI3K/Akt in hibitors,and in troduce combi nation therapies con sisti ng of signaling in hibitors and conven tional cancer therapies.The information presented herein suggests that cascading inhibitors of the PI3K/Akt signaling pathway,either alone or in combi nation with other therapies,are the most effective treatment strategy for can cer. | Yan He Miao Miao Sun Guo Geng Zhang Jing Yang Kui Sheng Chen Wen Wen Xu Bin Li | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 2 |
| 14 | Meplazumab in hospitalized adults with severe COVID-19(DEFLECT):a multicenter,seamless phase 2/3,randomized,third-party double-blind clinical trial显示文摘Meplazumab,a humanized CD147 antibody,has shown favourable safety and efficacy in our previous clinical studies.In DEFLECT(NCT04586153),167 patients with severe COVID-19 were enroled and randomized to receive three dosages of meplazumab and a placebo.Meplazumab at 0.12 mg/kg,compared to the placebo group,showed clinical benefits in significantly reducing mortality by 83.6%(2.4%vs.14.6%,p=0.0150),increasing the proportion of patients alive and discharged without supplemental oxygen(82.9%vs.70.7%,p=0.0337)and increasing the proportion of patients who achieved sustained clinical improvement(41.5%vs.31.7%).The response rate in the 0.2 mg/kg group was relatively increased by 16.0%compared with the placebo group(53.7%vs.46.3%).Meplazumab also reduced the viral loads and multiple cytokine levels.Compare with the placebo group,the 0.3 mg/kg significantly increased the virus negative rate by 40.6%(p=0.0363)and reduced IL-8 level(p=0.0460);the 0.2 mg/kg increased the negative conversion rate by 36.9%,and reduced IL-4(p=0.0365)and IL-8 levels(p=0.0484).In this study,the adverse events occurred at a comparable rate across the four groups,with no unexpected safety findings observed.In conclusion,meplazumab promoted COVID-19 convalescence and reduced mortality,viral load,and cytokine levels in severe COVID-19 population with good safety profile. | Huijie Bian Liang Chen Zhao-Hui Zheng Xiu-Xuan Sun Jie-Jie Geng Ruo Chen Ke Wang Xu Yang Shi-Rui Chen Si-Yu Chen Rong-Hua Xie Kui Zhang Jin-Lin Miao Jun-Feng Jia Hao Tang Shuang-Shuang Liu Hong-Wei Shi Yong Yang Xiao-Chun Chen Vinay Malhotra Nosheen Nasir Iffat Khanum Faisal Mahmood Saeed Hamid Claudio Marcel Berdun Stadnik Kengi Itinose Caroline Cândida Carvalho de Oliveira Cesar Dusilek Lucas Rivabem Adilson Joaquim Westheimer Cavalcante Suzara Souto Lopes Wladmir Faustino Saporito Fábio JoséConcilio Fucci Jesus Abraham Simon-Campos Ling Wang Lin-Na Liu Qing-Yi Wang Ding Wei Zheng Zhang Zhi-Nan Chen Ping Zhu | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 1 |
| 15 | Effect of Temperature and H<sub>2</sub>S Concentration on Corrosion of X52 Pipeline Steel in Acidic Solutions显示文摘 | Rong Shan Wang Li Kui Weng Yan Wei Zhang Jian Qiao Geng Chen Xi Du Er Wei Liu | 2013 | Materials Science Forum2013，，743： | 1 |
| 16 | Progress of super-resolution near-field structure and application in optical data storage显示文摘 | Kui ZHANG Yongyou GENG Yang WANG Yiqun WU | 2014 | Frontiers of Optoelectronics2014，7，4： | 1 |
| 17 | Raltitrexed induces mitochondrial?mediated apoptosis in SGC7901 humangastric cancer cells显示文摘 | Song Xue Ying?Xia Chen Shu?Kui Qin Ai?Zhen Yang Lin Wang Hai?Jun Xu Hai?Yun Geng | 2014 | Molecular Medicine Reports2014，，4： | 1 |
| 18 | Enzymatic Degradation of the Copolyester P(BS- co -DGS)显示文摘 | Rong Shan Wang Li Kui Weng Yan Wei Zhang Jian Qiao Geng Chen Xi Du Er Wei Liu | 2013 | Materials Science Forum2013，，743： | 1 |
| 19 | A Trustworthy Path Discovery Mechanism in Ubiquitous Networks显示文摘With the evolution of information communication technology, a large number of new applications appear, resulting in kinds of new accessing equipments to be deployed. Since the characteristics of randomness, dynamic and unpredictability of their positions, securely discovering these new equipments is one of a primary challenges to guarantee the security issues for these new applications. Traditional path discovery protocols cannot be directly borrowed and applied onto new service models due to the aforementioned inherent vulnerabilities. In this paper, we propose a Public key infrastructure-based(PKIbased) Trustworthy path discovery mechanism(TPDM),which is further implemented by trustworthy node discovery and neighbor node discovery protocols for new service models. As a result, a source node can discover a trustworthy path to the destination node and each intermediate node can also detect its neighbor nodes. Security analysis and evaluation results indicate the effectiveness and efficiency of our proposed mechanism. | GENG Kui LI Fenghua CAO Jin LI Hui CHEN Chen ZHANG Cui | 2016 | Chinese Journal of Electronics2016，25，2： | 0 |
| 20 | THE STUDY OF THE SYNTHESES OF THE DERIVATIVES OF POLYPHENYLENE AND THEIR CONDUCTIVITY显示文摘THESTUDYOFTHESYNTHESESOFTHEDERIVATIVESOFPOLYPHENYLENEANDTHEIRCONDUCTIVITY￥YinKuiLl;QingZiLIU;SanHUANG;TieFengWEN;ShangYouZHOU... | Yin Kui Ll Qing Zi LIU San HUANG Tie Feng WEN Shang You ZHOU Wei SUN Dong Geng WAN Yung qing LI(Changsha institute of Technology, Changsha 410073) | 1995 | Chinese Chemical Letters1995，6，2： | 0 |
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