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| 1 | Host pathogen interactions in Helicobacter pylori related gastric cancer显示文摘Helicobacter pylori (H. pylori), discovered in 1982, is a microaerophilic, spiral-shaped gram-negative bacterium that is able to colonize the human stomach. Nearly half of the world's population is infected by this pathogen. Its ability to induce gastritis, peptic ulcers, gastric cancer and mucosa-associated lymphoid tissue lymphoma has been confirmed. The susceptibility of an individual to these clinical outcomes is multifactorial and depends on H. pylori virulence, environmental factors, the genetic susceptibility of the host and the reactivity of the host immune system. Despite the host immune response, H. pylori infection can be difficult to eradicate. H. pylori is categorized as a group?Ⅰ?carcinogen since this bacterium is responsible for the highest rate of cancerrelated deaths worldwide. Early detection of cancer can be lifesaving. The 5-year survival rate for gastric cancer patients diagnosed in the early stages is nearly 90%. Gastric cancer is asymptomatic in the early stages but always progresses over time and begins to cause symptoms when untreated. In 97% of stomach cancer cases, cancer cells metastasize to other organs. H. pylori infection is responsible for nearly 60% of the intestinaltype gastric cancer cases but also influences the development of diffuse gastric cancer. The host genetic susceptibility depends on polymorphisms of genes involved in H. pylori-related inflammation and the cytokine response of gastric epithelial and immune cells. H. pylori strains differ in their ability to induce a deleterious inflammatory response. H. pylori-driven cytokines accelerate the inflammatory response and promote malignancy. Chronic H. pylori infection induces genetic instability in gastric epithelial cells and affects the DNA damage repair systems. Therefore, H. pylori infection should always be considered a pro-cancerous factor. | Magdalena Chmiela Zuzanna Karwowska Weronika Gonciarz Bujana Allushi Pawel Staczek | 2017 | World Journal of Gastroenterology2017，23，9： | 37 |
| 2 | Molecular mimicry in Helicobacter pylori infections显示文摘Gram-negative bacteria Helicobacter pylori(H. pylori) colonize gastric mucosa in humans and increase the risk of serious diseases such as gastric and duodenal ulcers, stomach cancers and mucosa associated lymphoid tissue lymphoma. The role of H. pylori infection in the pathogenesis of several extragastric diseases has been suggested including immune thrombocytopenic purpura, iron deficiency anemia, vitamin D deficiency, cardiovascular diseases,diabetes mellitus and dermatological disorders. Also neurological diseases and even lung cancer have attracted researchers concern. The relation between H. pylori infection and a growth retardation in children has also been suggested. Many mechanisms of molecular mimicry between H. pylori and the host have been proposed as a pathogen strategy to manipulate the immune system of the host in order to remain unrecognized and avoid eradication. A lot of effort has been put into the demonstration of homologous sequences between H. pylori and host compounds. However, knowledge about how often autoantibodies or autoreactive T lymphocytes induced during H. pylori infections cause pathological disorders is insufficient. This review provides data on H. pylori antigenic mimicry and possible deleterious effects due to the induction of immune response to the components common to these bacteria and the host. | magdalena chmiela weronika gonciarz | 2017 | World Journal of Gastroenterology2017，23，22： | 24 |
| 3 | Sole use of dexmedetomidine has limited utility for conscious sedation during outpatient colonoscopy 显示文摘 | Jalowiecki P Rudner R Gonciarz M | 2005 | Anesthesiology2005，103，2： | 1 |
| 4 | VEGF and metalloproteinase 2(MMP 2)expression in gastric cancer tissue显示文摘 | Robert Partyka Maciej Gonciarz Przemysiaw Jdowiecki | 2012 | Med Sci Monit2012，18，4： | 1 |
| 5 | Sole use of dexmedeto-midine has limited utility for conscious sedation during outpatient colonoscopy显示文摘 | Jalowiecki P Rudner R Gonciarz M | 2005 | Anesthesiology2005，103，2： | 1 |
| 6 | Progastrin and its products from patients with chronic viral hepatitis and liver cirrhosis显示文摘 | Konturek SJ Gonciarz M Gonciarz Z | 2003 | Scand J Gastroenterol2003，，6： | 1 |
| 7 | Sole use of dexmedetomidine has limited utility for conscious sedation during outpatient colonoscopy显示文摘 | Jalowiecki P Rudner R Gonciarz M | 2005 | Anes- thesiology2005，103，2： | 1 |
| 8 | Sole use of dexmedetomidine has limited utility for conscious sedation during outpatient colonoscopy显示文摘 | Jalowiecki P Rudner R Gonciarz M | 2005 | Anesthesiology2005，103，2： | 1 |
| 9 | Sole use of Dexmedetom idine has limited utility for conscious sedation during outpatient colonoscopy显示文摘 | JALOWIEEKI P RUDNER R GONCIARZ M | | 0，，02： | 1 |
| 10 | VEGF and metallopro-teinase 2(MMP 2)expression in gastric cancer tissue显示文摘 | Partyka R Gonciarz M Jalowiecki P | 2012 | Med SciMonit2012，18，4： | 1 |
| 11 | Sole use of dexmedetomidine has limited utility for conscious sedation during outpatient colonoscopy显示文摘 | JALOWIECKI P RUDNER R GONCIARZ M | 2005 | Anesthesiology2005，103，2： | 1 |
| 12 | Sole use of dexmedetomidine has limited utility for conscious sedation during outpatient colonoscopy 显示文摘 | Jalowiecki P Rudner R Gonciarz M | 2005 | Anesthesiology2005，13，2： | 1 |
| 13 | VEGF and metal- loproteinase-2 (MMP-2) expression in gastric cancer tissue 显示文摘 | Partyka R Gonciarz M Jalowiecki P | 2012 | Med Sei Monit2012，18，4： | 1 |
| 14 | Sole use ofdexmedetomidine has limited utility for conscious sedation duringoutpatient colonoscopy显示文摘 | Jalowiecki P Rudner R Gonciarz M | 2005 | Anesthesiology2005，103，： | 1 |
| 15 | Sole use of dexmedetomidine has limited utility for conscious sedation during outpatient colonoscopy显示文摘 | Jalowiecki P Rudner R Gonciarz M | | 0，，02： | 1 |
| 16 | Dose long-term erythropoietin therapy influence the prebalence of serum markers of hepatitis B and C in haemodialysed ruaemic patients显示文摘 | Masjasz J Wiecek A Gonciarz Z | 2004 | Pol Merkuriusz Lek2004，16，94： | 1 |
| 17 | Genetic aspects of colorectal carcinogenesis 显示文摘 | Gonciarz M Pierzchalski P Lorens K | 2004 | Wiad Lek2004，57，12： | 1 |
| 18 | Sole use of dexmedetomidine has limited utility for conscious sedation during outpatient colonoscopy显示文摘 | JALOWIECKI P RUDNER R GONCIARZ M | | 0，，02： | 1 |
| 19 | VEGF and metalloproteinase-2(MMP- 2) expression in gastric cancer tissue显示文摘 | Partyka R Gonciarz MJalowiecki P | 2012 | Med Sci Monit2012，18，4： | 1 |
| 20 | Sole use of dexmedetomidine has limited utility for conscious se- dation during outpatient colonoscopy 显示文摘 | JALOWIECKI P RUDNER R GONCIARZ M | 2005 | Anesthesiology2005，103，2： | 1 |
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