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| 1 | 国际卒中遗传学联盟的推荐意见(第1部分):标准化表型数据收集显示文摘与几乎所有复杂疾病一样,卒中的患病风险和临床转归也是多基因作用的[1]。探索相关基因突变有望为新型个体化治疗方法奠定基础,从而显著减少卒中对全球健康造成的毁灭性影响。为了达到足够的统计学效能以确认多个风险性等位基因,需要很大的样本量。尽管卒中是全世界范围内第二大致死病因和成年人致残的主要原因[2],但没有任何一家研究机构能独立收集到足够的样本。在认识到这一挑战之后,来自世界各地的卒中研究者们于2007年成立了国际卒中遗传学联盟( International Stroke Genetics Consortium, ISGC; http://www. strokegenetics.org),其使命是通过研究在全球多个研究机构入组的患者来识别影响卒中患病风险、临床预后和治疗效果的遗传学因素。尽管先前已取得了一些成功[3-5],仍有大量工作有待进行,这不仅是为了发现风险性等位基因从而达到卒中个体化医疗的最终目标,更是为了开发综合性卒中风险评估手段以及得到足以改变临床实践的结果[6]。根据糖尿病和冠状动脉疾病等其他复杂疾病的研究进展,为了识别与卒中相关的所有基因突变,需要100000~200000个样本。为了达到这个样本量,需要进行更为广泛的协作。 | Jennifer J. Majersik John W.Cole Jonathan Golledge Natalia S. Rost Yu-Feng Yvonne Chan M. Edip Gurol Ame G. Lindgren Daniel Woo Israel Fernandez-Cadenas Donna T. Chen Vincent Thijs Bradford B. Worrall Ayeesha Kamal Paul Bentley Joanna M. Wardlaw Ynte M. Ruigrok Thomas W.K Battey Reinhold Schmidt Joan Montaner Anne-Katrin Giese Jaume Roquer Jordi Jimenez-Conde Chaeyoung Lee Hakan Ay Juan Jose Martin 李海峰 岳耀先 徐军 | 2015 | 国际脑血管病杂志2015，23，9： | 3 |
| 2 | Profiles of serum microRNAs; miR-125b-5p and miR223-3p serve as novel biomarkers for HBV-positive hepatocellular carcinoma显示文摘 | Burcu Gurer Giray Gurol Emekdas Seda Tezcan Mahmut Ulger Mehmet Sami Serin Orhan Sezgin Engin Altintas Eyup Naci Tiftik | 2014 | Molecular Biology Reports2014，，7： | 2 |
| 3 | Kinetics of ozone decomposition: A dynamicapproach显示文摘 | Gurol Mirat D | 1982 | Environ Sci Technol1982，16，7： | 1 |
| 4 | A modified automated method for isolation of viable pancreatic islets in laboratory animals显示文摘 | Gurol AO Yillar G Kursun AO | | 0，，05： | 1 |
| 5 | Effects of linoleic acid on generalized convulsive and nonconvulsive epileptic seizures显示文摘 | Ekici F Gurol G Ates N | 2014 | Turk J Med Sci2014，44，： | 1 |
| 6 | Catalytic Decomposition of Hydrogen Peroxide on Iron Oxide: Kinetics, Mechanism, and Implications显示文摘 | Shu- Sung Lin Mirat D Gurol | 1999 | Environ Sci Technol1999，32，14： | 1 |
| 7 | Plasma β-amyloid and white matter lesions in AD,MCI,and cerebral amyloid angiopathy显示文摘 | Gurol ME Irizarry MC Smith EE | 2006 | Neurology2006，66，： | 1 |
| 8 | The effect of humic acids on nitrobenzene oxidation by ozonation and O3/UV processes 显示文摘 | Latifoglu A Gurol M D | 2003 | Water Research2003，37，8： | 1 |
| 9 | Cerebral amyloid angiopathy burden associated with leukoaraiosis: a positron emission tomography/magnetic resonance imaging study 显示文摘 | Gurol ME Viswanathan A Gidicsin C | 2013 | Ann Neurol2013，73，： | 1 |
| 10 | Catalytic decomposition of hydrogen peroxide on iron oxide:kinetics,mechanism,and implications显示文摘 | Lin S S Gurol M D | | 0，，10： | 1 |
| 11 | Chemical oxidation of chlorinated organics by hydrogen peroxide in the presence of sand显示文摘 | Joseph X Ravikumar Mirat D Gurol | | 0，，03： | 1 |
| 12 | Catalytic Decomposition of Hydrogen Peroxide on Iron Oxide: Kinetics, Mechanisms and Implications显示文摘 | Lin S S Gurol M D | 1998 | Environmental Science & Technology1998，32，10： | 1 |
| 13 | Plasma β-amyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy 显示文摘 | Gurol ME Irizarry MC Smith EE | 2006 | Neurology2006，66，： | 1 |
| 14 | Chemical oxidation by photolytic decomposition of hydrogen peroxide 显示文摘 | Liao C H Gurol M D | 1995 | Environmental Science Technology1995，29，12： | 1 |
| 15 | The types of neurological deficits might not justify withholding treatment in patients with low total National Institutes of Health Stroke Scale scores显示文摘 | Leira EC Ludwig BR Gurol ME | | 0，，： | 1 |
| 16 | Stroke unit versus neurology ward a before and after study显示文摘 | Krespi Y Gurol ME Coban O | 2003 | Neurol2003，250，11： | 1 |
| 17 | Catalytic decomposition of hydrogen peroxide on iron oxide:Kinetics, mechanism and implications 显示文摘 | Lin S S Gurol M D | 1998 | Environ Sci Tech1998，32，： | 1 |
| 18 | Total energy loss assessment for trickle lateral lines equipped with integrated in-line and on-line emitters显示文摘 | Gurol Yildirim | 2010 | Ir rig Sci2010，，28： | 1 |
| 19 | The effect of humic acids on nitrobenzene oxidation by ozonation and 3/UV processes 显示文摘 | Latifoglu A Gurol M D | 2003 | Water Research2003，37，8： | 1 |
| 20 | A comparative study of the role of eytokine polymorphisms interleukin- 10 and tumor necrosis factor alpha in susceptibility to im plant failure and chronic periodontitis显示文摘 | Gurol C Kazazoglu E Dabakoglu B | 2011 | Int J Oral Max- illofac Implants2011，26，5： | 1 |
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