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| 1 | Undrained shear strength evaluation for hydrate-bearing sediment overlying strata in the Shenhu area, northern South China Sea显示文摘The undrained shear strength of shallow strata is a critical parameter for safety design in deep-water operations.In situ piezocone penetration tests(CPTU) and laboratory experiments are performed at Site W18-19 in the Shenhu area, northern South China Sea, where China's first marine hydrate exploitation operation is due to be located. The validation of the undrained shear strength prediction model based on CPTU parameters. Different laboratory tests, including pocket penetrometer, torvane, miniature vane and unconsolidated undrained triaxial tests, are employed to solve empirical cone coefficients by statistical and mathematical methods. Finally, an optimized model is proposed to describe the longitudinal distribution of undrained shear strength in calcareous clay strata in the Shenhu area. Research results reveal that average empirical cone coefficients based on total cone resistance, effective resistance, and excess-pore pressure are 13.8, 4.2 and 14.4, respectively. The undrained shear strength prediction model shows a good fit with the laboratory results only within specific intervals based on their compaction degree and gas-bearing conditions. The optimized prediction model in piecewise function format can be used to describe the longitudinal distribution of the undrained shear strength for calcareous clay within all depth intervals from the mud-line to the upper boundary of hydrate-bearing sediments(HBS). The optimized prediction result indicates that the effective cone resistance model is suitable for very soft to firm calcareous clays,the excess-pore pressure model can depict the undrained shear strength for firm to very stiff but gas-free clays,while the total cone resistance model is advantageous for evaluating the undrained shear strength for very stiff and gassy clays. The optimized model in piecewise function format can considerably improve the adaptability of empirical models for calcareous clay in the Shenhu area. These results are significant for safety evaluations of proposed hydrate exploitation projects. | Yanlong Li Gaowei Hu Nengyou Wu Changling Liu Qiang Chen Chen'an Li | 2019 | Acta Oceanologica Sinica2019，38，3： | 12 |
| 2 | Experimental studies on the P-T stability conditions and influencing factors of gas hydrate in different systems显示文摘The P-T stability conditions of gas hydrate in different systems (i.e., solution, silica sand, and marine sediment) were studied using multi-step decomposition method with our experimental equipment. The effects of different ions with various concentrations and sediment grains on the P-T stability conditions of gas hydrate were investigated. The results show that different ions have different influences on the phase equilibrium of gas hydrate. However, the influence of ions is in a similar trend: the larger the concentration, the bigger the P-T curve shifts to the left. For the silica sand, the influence of pore capillarity of coarse particles (> 460 μm) can be negligible. The P-T curve measured in coarse silica is in agreement with that in pure water. However, the influence of pore capillarity of fine particles (< 35 μm) is significant. The maximum reduction value of temperature is 1.5 K for methane hydrate under stable state. The sediment from the South China Sea significantly affects the P-T stability conditions of methane hydrate, with an average reduction value of 1.9 K within the experimental conditions. This is mainly the result of both the pore water salinity and the pore capillarity of sediment. Because the pore water salinity is keeping diluted by the fresh water released from hydrate dissociation, the measured P-T stability points fall on different P-T curves with the decreasing salinity. | LIU ChangLing YE YuGuang SUN ShiCai CHEN Qiang MENG QingGuo HU GaoWei | 2013 | Science China Earth Sciences2013，56，4： | 11 |
| 3 | Mechanical Properties of Methane Hydrate-Bearing Interlayered Sediments显示文摘The complex distribution of gas hydrate in sediments makes understanding the mechanical properties of hydrate-bearing sediments a challenging task.The mechanical behaviors of hydrate-bearing interlayered sediments are still poorly known.A series of triaxial shearing tests were conducted to investigate the strength parameters and deformation properties of methane hydrate-bearing interlayered sediments at the effective pressure of 1 MPa.The results indicate that the stress-strain curves of hydrate-bearing interlayered sediments are significantly different from that of hydrate-bearing sediments.The peak strength,Young's modulus,initial yielding modulus,and failure mode are deeply affected by the methane hydrate distribution.The failure behaviors and mechanism of strain softening and hardening patterns of the interlayered specimens are more complicated than those of the integrated specimens.This study compares the different mechanical behaviors between integrated and interlayered specimens containing gas hydrate,which can serve as a reference for the prediction and analysis of the deformation behaviors of natural gas hydrate reservoirs. | DONG Lin LI Yanlong LIU Changling LIAO Hualin CHEN Guoqi CHEN Qiang LIU Lele HU Gaowei | 2019 | Journal of Ocean University of China2019，18，6： | 11 |
| 4 | Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2显示文摘Host cellular receptors play key roles in the determination of virus tropism and pathogenesis.However,little is known about SARS-CoV-2 host receptors with the exception of ACE2.Furthermore,ACE2 alone cannot explain the multi-organ tropism of SARS-CoV-2 nor the clinical differences between SARS-CoV-2 and SARS-CoV,suggesting the involvement of other receptor(s).Here,we performed genomic receptor profiling to screen 5054 human membrane proteins individually for interaction with the SARS-CoV-2 capsid spike(S)protein.Twelve proteins,including ACE2,ASGR1,and KREMEN1,were identified with diverse S-binding affinities and patterns.ASGR1 or KREMEN1 is sufficient for the entry of SARS-CoV-2 but not SARS-CoV in vitro and in vivo.SARS-CoV-2 utilizes distinct ACE2/ASGR1/KREMEN1(ASK)receptor combinations to enter different cell types,and the expression of ASK together displays a markedly stronger correlation with virus susceptibility than that of any individual receptor at both the cell and tissue levels.The cocktail of ASK-related neutralizing antibodies provides the most substantial blockage of SARS-CoV-2 infection in human lung organoids when compared to individual antibodies.Our study revealed an interacting host receptome of SARS-CoV-2,and identified ASGR1 and KREMEN1 as alternative functional receptors that play essential roles in ACE2-independent virus entry,providing insight into SARS-CoV-2 tropism and pathogenesis,as well as a community resource and potential therapeutic strategies for further COVID-19 investigations. | Yunqing Gu Jun Cao Xinyu Zhang Hai Gao Yuyan Wang Jia Wang Juan He Xiaoyi Jiang Jinlan Zhang Guanghui Shen Jie Yang Xichen Zheng Gaowei Hu Yuanfei Zhu Shujuan Du Yunkai Zhu Rong Zhang Jianqing Xu Fei Lan Di Qu Guoliang Xu Yun Zhao Dong Gao Youhua Xie Min Luo Zhigang Lu | 2022 | Cell Research2022，32，1： | 8 |
| 5 | Influence of foraminifera on formation and occurrence characteristics of natural gas hydrates in fine-grained sediments from Shenhu area, South China Sea显示文摘Marine gas hydrates accumulate primarily in coarse-grained, high-permeability layers; however, highly saturated natural gas hydrates have been discovered in the fine-grained sediments of Shenhu area, South China Sea(SCS). This may be explained by key factors, such as the great abundance of foraminifera shells. In this paper, by analyzing the SCS foraminifera structure and performing hydrate formation experiments in the foraminifera shells, the contribution of foraminifera to hydrate accumulation in the SCS was investigated from a microscopic point of view. Simulations of hydrate formation were carried out in both pure SCS foraminifera shells and the host sediments. Pore structures in typical foraminifera were studied by use of micro-focus X-ray computed tomography(CT) and scanning electron microscopy(SEM). Hydrate growth and occurrence characteristics in the foraminifera shells were observed in-situ. The results showed that the presence of foraminifera significantly enhanced the effective porosity of the SCS sediments. Moreover, while the hydrates grew preferentially in the chambers of the coarse-grained foraminifera by adhering to the inner walls of the foraminifera shells, no apparent hydrate accumulation was observed in the fine-grained or argillaceous matrix. These findings provide a basis for further studies on the accumulation mechanism of hydrates and physical properties of hydrate reservoir in the South China Sea. | LI ChengFeng HU GaoWei ZHANG Wei YE YuGuang LIU ChangLing LI Qing SUN JianYe | 2016 | Science China Earth Sciences2016，59，11： | 7 |
| 6 | Thermal performances of non-equidistant helical-coil phase change accumulator for latent heat storage显示文摘Helical-coil is a common structure of heat exchanger unit in phase change heat accumulator and usually has the equal coil pitch between adjacent coils.Its thermal performances Thus,could be improved by improving the uniformity was of unit the phase change material(PCM)temperature distribution.flow a novel non-equidistant helical-coil made structure heat proposed area in this study.Its coil pitch match decreased along the direction of heat transfer fluid,which the exchange in that volume increase to the decreasing temperature difference between was the heat transfer and fluid and PCM.The structure was optimized using numerical simulation.helical-coil temperature An heat experimental accumulator system was developed the experiment results indicated latent the proposed non-equidistant uniformity more effective than equidistant helical-coil for heat storage.The of the distribution was also confirmed by simulation results. | ZHANG GaoWei HU Peng LIU MingHou | 2017 | Science China(Technological Sciences)2017，60，5： | 5 |
| 7 | Retraction Note to:SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion显示文摘The authors have retracted this article1.After the publication of this article,it came to the authors attention that in order to support the conclusions of the study,the authors should have used primary T cells instead of T-cell lines.In addition,there are concerns that the flow cytometry methodology applied here was flawed.These points resulted in the conclusions being considered invalid. | Xinling Wang Wei Xu Gaowei Hu Shuai Xia Zhiping Sun Zezhong Liu Youhua Xie Rong Zhang Shibo Jiang Lu Lu | 2020 | Cellular & Molecular Immunology2020，17，8： | 5 |
| 8 | Characteristics of authigenic pyrite and its sulfur isotopes influenced by methane seep at Core A, Site 79 of the middle Okinawa Trough显示文摘The anaerobic oxidation of methane(AOM) has strongly developed at Core A, Site 79 of the middle Okinawa Trough, East China Sea, and a large amount of authigenic pyrite is preserved in the surface sediment. In this study, we analyze the characteristics of the authigenic pyrite and its sulfur isotopic values. The authigenic pyrite is stripy and tubular, and there were foraminifera compartments filled with pyrite. The pyrite is extracted using chromium reduction, and the values of ? 34 S are found to lie between ?41.20‰ and 8.92‰ V-CDT. The bulk pyrite tends to be more enriched in 34 S with increasing depth. Particularly, the ? 34 S value of the pyrite lies between ?32.73‰ and ?41.20‰ V-CDT above 278 cmbsf, but it quickly increases below this depth(?21.49‰–8.92‰ V-CDT). At the same time, the total sulfur content of the pyrite shows an abrupt increase above 100 cmbsf but is otherwise stable between 1.04% and 0.55% below 100 cmbsf. The stable and negative values of ? 34 S and the decreasing values of total sulfur above 278 cmbsf indicate reduced AOM activities in 17.18–5.3 ka. In addition, the increasing ? 34 S and pyrite content indicate strong AOM development and methane seep below 278 cmbsf in 18.8–17.18 ka. In particular, the highest positive value of ? 34 S occurring in 18.78 ka indicates the most intense AOM activity. The shallow sulfate-methane interface(SMI) and high methane flux below marine sediments also strongly support this activity. | WANG Meng CAI Feng LI Qing LIANG Jie YAN GuiJing DONG Gang WANG Feng SHAO HeBin HU GaoWei | 2015 | Science China Earth Sciences2015，58，12： | 4 |
| 9 | Geochemical constraints on the methane seep activity in western slope of the middle Okinawa Trough, the East China Sea显示文摘Anaerobic oxidation of methane and sulfate reduction was studied in the pore waters of four cores at two stations of the middle Okinawa Trough. Pore water vertical distributions of sulfate, methane, sulfide, total alkalinity, ammonium, and phosphate were determined in this study. Our results show strong linear sulfate concentration gradients of 6.83 mmol/L m?1 in Core A and 5.96 mmol/L m?1 in Core C, which were collected from two stations. Concurrent variations of methane, total alkalinity and hydrogen sulfide all exhibit steep increases with depth at both cores, which indicate active methane seep activities around two stations. Pore water ammonium and phosphate concentrations reveal minor influences of organic matter degradation on sulfate reduction at two stations. Sulfate methane interface(SMI) was extrapolated from linear sulfate profiles in methane seep cores. Shallower SMI depths(A: 4.9 mbsf; C: 5.4 mbsf) indicate strong methane fluxes and active anaerobic oxidation of methane in the underlying sediments. | LI Qing CAI Feng LIANG Jie SHAO HeBin DONG Gang WANG Feng YANG ChuanSheng HU GaoWei | 2015 | Science China Earth Sciences2015，58，6： | 3 |
| 10 | Simulation of the Accumulation Process of Biogenic Gas Hydrates in the Shenhu Area of Northern South China Sea显示文摘Objective Previous work has largely discussed the relations between sediment structures and accumulation of gas hydrates in the Shenhu area of South China Sea,but has not documented why the gas hydrates occurred at the seafloor topographic highs.Many gas hydrate exploration examples abroad also indicate that the saturation of | LIAO Jing GONG Jianming Lü Wanjun WU Nengyou YUE Baojing LUAN Xiwu HU Gaowei | 2016 | Acta Geologica Sinica(English Edition)2016，90，6： | 3 |
| 11 | Effect of Methane Gas on Acoustic Characteristics of Hydrate-Bearing Sediment–Model Analysis and Experimental Verification显示文摘Gas leakage is an important consideration in natural systems that experience gas hydrate accumulation.A number of velocity models have been created to study hydrate-bearing sediments,including the BGTL theory,the weighted equation,the Wood equation,the K-T equation,and the effective medium theory.In previous work,we regarded water as the pore fluid,which meant its density and bulk modulus values were those of water.This approach ignores the presence of gas,which results in a biased calculation of the pore fluid's bulk modulus and density.To take into account the effect of gas on the elastic wave velocity,it is necessary to recalculate the bulk modulus and density of an equivalent medium.Thus,a high-pressure reactor device for simulating leakage systems was developed to establish the relationship between wave velocity and hydrate saturation in methane-flux mode.A comparison of the values calculated by the velocity model with the experimental data obtained in this study indicates that the effective medium theory(EMT,which considers gas effects)is more applicable than other models.For hydrate saturations of 10%–30%,the result ranges between EMT-B(homogenous gas distribution)and EMT-B(patchy gas distribution).For hydrate saturations of 30%–60%,the results are similar to those of the EMT-B(homogenous gas distribution)mode,whereas hydrate saturations of 60%–70%yield results similar to those of the EMT-A mode.For hydrate saturations greater than 80%,the experimental results are similar to those of the EMT-B mode.These results have significance for hydrate exploitation in the South China Sea. | BU Qingtao HU Gaowei LIU Changling DONG Jie XING Tongju SUN Jianye LI Chengfeng MENG Qingguo | 2021 | Journal of Ocean University of China2021，20，1： | 2 |
| 12 | A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants显示文摘The current COVID-19 pandemic has heavily burdened the global public health system and may keep simmering for years.The frequent emergence of immune escape variants have spurred the search for prophylactic vaccines and therapeutic antibodies that confer broad protection against SARS-CoV-2 variants.Here we show that the bivalency of an affinity maturated fully human singledomain antibody(n3113.1-Fc)exhibits exquisite neutralizing potency against SARS-CoV-2 pseudovirus,and confers effective prophylactic and therapeutic protection against authentic SARS-CoV-2 in the host cell receptor angiotensin-converting enzyme 2(ACE2)humanized mice.The crystal structure of n3113 in complex with the receptor-binding domain(RBD)of SARS-CoV-2,combined with the cryo-EM structures of n3113 and spike ecto-domain,reveals that n3113 binds to the side surface of up-state RBD with no competition with ACE2.The binding of n3113 to this novel epitope stabilizes spike in up-state conformations but inhibits SARS-CoV-2 S mediated membrane fusion,expanding our recognition of neutralization by antibodies against SARS-CoV-2.Binding assay and pseudovirus neutralization assay show no evasion of recently prevalent SARS-CoV-2 lineages,including Alpha(B.1.1.7),Beta(B.1.351),Gamma(P.1),and Delta(B.1.617.2)for n3113.1-Fc with Y58L mutation,demonstrating the potential of n3113.1-Fc(Y58L)as a promising candidate for clinical development to treat COVID-19. | Zhenlin Yang Yulu Wang Yujia Jin Yuanfei Zhu Yanling Wu Cheng Li Yu Kong Wenping Song Xiaolong Tian Wuqiang Zhan Ailing Huang Shanshan Zhou Shuai Xia Xiaoxu Tian Chao Peng Cuicui Chen Yibing Shi Gaowei Hu Shujuan Du Yuyan Wang Youhua Xie Shibo Jiang Lu Lu Lei Sun Yuanlin Song Tianlei Ying | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 1 |
| 13 | Revision of P-wave Velocity and Thickness of Hydrate Layer in Shenhu Area, South China Sea显示文摘To revise P-wave velocity and thickness of the hydrate layer in the Shenhu area of the South China Sea, acoustic and resistivity logging curves are reanalyzed. The waterlogging phenomenon is found in the shallow sediments of five drilling wells, which causes P-wave velocity to approximate the propagation velocity of sea water(about 1500 m s-1). This also affects the identification of the hydrate layer and results in the underestimate of its thickness. In addition, because there could be about a 5 m thick velocity ramp above or below the hydrate layer as interpreted by acoustic and resistivity logging curves, the recalibrated thickness of this layer is less than the original estimated thickness. The recalibrated P-wave velocity of the hydrate layer is also higher than the original estimated velocity. For the drilling well with a relatively thin hydrate layer, the velocity ramp plays a more important role in identifying and determining the thickness of the layer. | GONG Jianming ZHANG Xunhua ZOU Changchun CHEN Qiang WANG Lichen YUAN Chunfang HU Gaowei JIANG Yubo | 2014 | Journal of Ocean University of China2014，13，5： | 1 |
| 14 | Evaluation of the Shallow Gas Hydrate Production Based on the Radial Drilling-Heat Injection-Back Fill Method显示文摘It has been evidenced that shallow gas hydrate resources are abundant in deep oceans worldwide.Their geological back-ground,occurrence,and other characteristics differ significantly from deep-seated hydrates.Because of the high risk of well construction and low production efficiency,they are difficult to be recovered by using conventional oil production methods.As a result,this paper proposes an alternative design based on a combination of radial drilling,heat injection,and backfilling methods.Multi-branch holes are used to penetrate shallow gas hydrate reservoirs to expand the depressurization area,and heat injection is utilized as a supplement to improve gas production.Geotechnical information collected from an investigation site close to the offshore production well in the South China Sea is used to assess the essential components of this plan,including well construction stability and gas production behavior.It demonstrates that the hydraulic fracturing of the 60mbsf overburden layer can be prevented by regulating the drilling fluid densities.However,the traditional well structure is unstable,and the suction anchor is advised for better mechanical performance.The gas produc-tion rate can be significantly increased by combining hot water injection and depressurization methods.Additionally,the suitable produc-tion equipment already in use is discussed. | CHEN Qiang WAN Yizhao WU Nengyou SUN Jianye WANG Jian LIU Changling LI Yanlong LI Chengfeng HU Gaowei | 2024 | Journal of Ocean University of China2024，23，1： | 0 |
| 15 | Deformation Characteristics of Hydrate-Bearing Sediments显示文摘The safe and efficient development of natural gas hydrate requires a deep understanding of the deformation behaviors of reservoirs.In this study,a series of triaxial shearing tests are carried out to investigate the deformation properties of hydrate-bearing sediments.Variations of volumetric and lateral strains versus hydrate saturation are analyzed comprehensively.Results indicate that the sediments with high hydrate saturation show dilative behaviors,which lead to strain-softening characteristics during shearing.The volumetric strain curves have a tendency to transform gradually from dilatation to compression with the increase in effective confining pressure.An easy prediction model is proposed to describe the relationship between volumetric and axial strains.The model coefficientβis the key dominating factor for the shape of volumetric strain curves and can be determined by the hydrate saturation and stress state.Moreover,a modified model is established for the calculation of lateral strain.The corresponding determination method is provided for the easy estimation of model coefficients for medium sand sediments containing hydrate.This study provides a theoretical and experimental reference for deformation estimation in natural gas hydrate development. | DONG Lin LI Yanlong ZHANG Yajuan HU Gaowei LIAO Hualin CHEN Qiang WU Nengyou | 2024 | Journal of Ocean University of China2024，23，1： | 0 |
| 16 | Experimental Examination of Velocity-Models in Estimating Gas Hydrate Saturation in Sediments显示文摘Elastic velocities(v_p and v_s)have been widely used in estimating gas hydrate saturation in void spaces of sediments.The commonly used models are empirical equations or some physically based models,such as Wyllie’s time average,Effective Medium Theory (EMT),Modified Biot-Gassmann Theory by Lee (BGTL),etc.These equations or models are selective to distinct conditions.In order to evaluate the app- | Gaowei Hu~(1,3),Yuguang Ye~(2,3),Jian Zhang~(2,3),Jiasheng Wang~1 1.Faculty of Earth Sciences,China University of Geosciences(Wuhan),Wuhan 430074,China. 2.Key Laboratory of Marine Hydrocarbon Resources and Environment Resources,the Ministry of Land and Resources,Qingdao 266071,China 3.Qingdao Institute of Marine Geology,the Ministry of Land and Resources,Qingdao 266071,China | 2009 | 地学前缘2009，16，S1： | 0 |
| 17 | RETRACTED ARTICLE:SARS-CoV-2 infects T lymphocytes through its spike protein-mediated membrane fusion显示文摘The authors have retracted this article [1]. After the publication ofthis article, it came to the authors attention that in order tosupport the conclusions of the study, the authors should haveused primary T cells instead of T cell lines. Additionally, there areconcerns that the flow cytometry methodology applied here wasflawed. These points resulted in the conclusions being consideredinvalid. | Xinling Wang Wei Xu Gaowei Hu Shuai Xia Zhiping Sun Zezhong Liu Youhua Xie Rong Zhang Shibo Jiang Lu Lu | 2023 | Cellular & Molecular Immunology2023，20，5： | 0 |
| 18 | CORRECTION:Author Correction:Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2显示文摘In the initial published version of this article,there were errors in the 5th and 6th affiliations.The correct 5th affiliation is“State Key Laboratory of Molecular Biology,Center for Excellence in Molecular Cell Science,Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Beijing,China”. | Yunqing Gu Jun Cao Xinyu Zhang Hai Gao Yuyan Wang Jia Wang Juan He Xiaoyi Jiang Jinlan Zhang Guanghui Shen Jie Yang Xichen Zheng Gaowei Hu Yuanfei Zhu Shujuan Du Yunkai Zhu Rong Zhang Jianqing Xu Fei Lan Di Qu Guoliang Xu Yun Zhao Dong Gao Youhua Xie Min Luo Zhigang Lu | 2022 | Cell Research2022，32，6： | 0 |
| 19 | Hydrate formation and distribution within unconsolidated sediment:Insights from laboratory electrical resistivity tomography显示文摘Laboratory visual detection on the hydrate accumulation process provides an effective and low-cost method to uncover hydrate accumulation mechanisms in nature.However,the spatial hydrate distribution and its dynamic evolutionary behaviors are still not fully understood due to the lack of methods and experimental systems.Toward this goal,we built a two-dimensional electrical resistivity tomography(ERT)apparatus capable of measuring spatial and temporal characteristics of hydrate-bearing porous media.Beach sand(0.05–0.85 mm)was used to form artificial methane hydrate-bearing sediment.The experiments were conducted at 1°C under excess water conditions and the ERT data were acquired and analyzed.This study demonstrates the utility of the ERT method for hydrate mapping in laboratory-scale.The results indicate that the average electrical conductivity decreases nonlinearly with the formation of the hydrate.At some special time-intervals,the average conductivity fluctuates within a certain scope.The plane conductivity fields evolve heterogeneously and the local preferential hydrate-forming positions alternate throughout the experimental duration.We speculate that the combination of hydrate formation itself and salt-removal effect plays a dominant role in the spatial and temporal hydrate distribution,as well as geophysical parameters changing behaviors during hydrate accumulation. | Yanlong Li Nengyou Wu Changling Liu Qiang Chen Fulong Ning Shuoshi Wang Gaowei Hu Deli Gao | 2022 | Acta Oceanologica Sinica2022，41，9： | 0 |
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