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| 1 | Nonalcoholic steatohepatitis in Asian Indians is neither associated with iron overload nor with HFE gene mutations显示文摘AIM: The pathogenesis of occurrence of liver inflammation and fibrosis in patients with nonalcoholic steatohepatitis (NASH) is not completely understood. Other than insulin resistance, iron abnormalities have been thought to be one of the triggering factors. Therefore, our aim was to study the role of iron abnormalities and HFE gene mutations in patients with NASH.METHODS: Thirty-one patients of NASH diagnosed on the basis of clinical examination biochemistry, ultrasonography and liver biopsy (n = 14) were included in the study. Serum iron parameters (n = 23) (iron, ferritin, total iron-binding capacity and transferrin saturation), Peris' iron staining on liver biopsies (n = 14) and HFE gene mutations (C282Y and H63D) (n = 16) were studied in these patients. The association between iron staining, necroinflammatory activity and fibrosis stage on liver biopsies was also determined.RESULTS: Elevated serum iron, ferritin and transferrin saturation above 55% were observed in 4.3% of patients.On histology, 71% of the patients had negative iron staining,21.4% had 1+ staining, 7.2% had 2+ staining and none had 3+ or 4+ staining. There was no association between the degree of iron staining and necroinflammatory activity (P = 0.55) and fibrosis stage (P = 0.09) on histology. None of the patients had C282Y HFE gene mutation and four patients (25%) were found to be heterozygotes for H63D gene mutation.CONCLUSION: Our study does not favor iron overload and HFE gene mutations as major factors in the pathogenesis of NASH in Asian Indians. | Ajay Duseja Reena Das Mohit Nanda Ashim Das Gurjeewan Garewal Yogesh Chawla | 2005 | World Journal of Gastroenterology2005，11，3： | 9 |
| 2 | Frequency of primary iron overload and HFE gene mutations (C282Y,H63D and S65C) in chronic liver disease patients in north India显示文摘AIM:To identify the frequency of iron overload and study the three mutations in the HFE gene (C282Y,H63D,and S65C) in patients with chronic liver disorders (CLD) and controls. METHODS:To identify patients with iron overload (transferrin saturation > 45% in females and > 50% in males and serum ferritin > 1000 ng/mL) we evaluated 236 patients with CLD,including 59 with non-alcoholic steatohepatitis (NASH),22 with alcoholic liver disease (ALD),19 of cirrhosis due to viruses (HBV,HCV),and 136 with cryptogenic cirrhosis. Mutations of the HFE gene were analyzed by PCR-RE. hundred controls were screened for iron status and the mutations. RESULTS:Seventeen patients with CLD showed evidence of iron overload. Fifteen cases of iron overload had cryptogenic cirrhosis and two had ALD. None of the controls showed iron overload. We did not find any individual with 282Y or 65C either in the cases or in the controls. The prevalence of H63D heterozygosity was 12% in normal individuals,14.8% in 236 patients (16.9% in NASH,13.6% in ALD,26.3% in viral and 12.5% in cryptogenic cirrhosis) and the overall prevalence was 13.98%. Only two of the 17 patients with primary iron overload were heterozygous for H63D. One patient with NASH and one normal individual who were homozygous for H63D showed no iron overload.CONCLUSION:Primary iron overload in Indians is nonHFE type,which is different from that in Europeans and further molecular studies are required to determine the defect in various iron regulatory genes. | Barjinderjit Kaur Dhillon Reena Das Gurjeewan Garewal Yogesh Chawla RK Dhiman Ashim Das Ajay Duseja GR Chandak | 2007 | World Journal of Gastroenterology2007，13，21： | 5 |
| 3 | Bile acids as carcinogens in human gastrointestinal cancers显示文摘 | H. Bernstein C. Bernstein C.M. Payne K. Dvorakova H. Garewal | 2004 | Mutation Research-Reviews in Mutation Research2004，，1： | 2 |
| 4 | The difference in colon polyp size before and after removal显示文摘 | Thomas G. Morales Richard E. Sampliner Harinder S. Garewal M.Brian Fennerty Mikel Aickin | 1996 | Gastrointestinal Endoscopy1996，，1： | 2 |
| 5 | The incidence of adenocarinoma in Barrett's esophagns: aprospective of 170 patients followed 4 - 8 yeeas显示文摘 | Drewitz DJ Sampliner RE Garewal HS | 1997 | Am J Gastroenterol1997，92，： | 1 |
| 6 | Antioxidants and the prevention of coro-nary heart disease显示文摘 | Hoffman RM Garewal HS | 1995 | Arch Electronm Med1995，155，3： | 1 |
| 7 | Non-erosive reflux disease (NERD) -acid reflux and symptom patterns 显示文摘 | Matrinez SD Malagon IB Garewal HS | 2003 | Aliment Pharmacol Ther2003，17，4： | 1 |
| 8 | A bile acids-induced apoptosis assay for colon cancer risk and associated quality control studies 显示文摘 | BERNSTEIN C BERNSTEIN H GAREWAL H | 1999 | Cancer Res1999，59，： | 1 |
| 9 | Non-erosive reflux disease (NERD)--acid reflux and symptom patterns 显示文摘 | Martinez SD Malagon IB Garewal HS | 2003 | Aliment Pharmacol Ther2003，17，4： | 1 |
| 10 | A bile acid-induced apoptosis assay for colon cancer risk and associated quality control studies显示文摘 | Bernstein C Bernstein H Garewal H | 1999 | Cancer Res1999，59，10： | 1 |
| 11 | Non-erosive reflux disease(NERD)-acid reflux and symptom patterns显示文摘 | Martinez SD Malagon IB Garewal HS | | 0，，： | 1 |
| 12 | Influence of beta-carotene on immune functions显示文摘 | R H Prabhala L M Braune H S Garewal R R Watson | 1993 | Ann N Y Acad Sci1993，691，12： | 1 |
| 13 | Non-erosivereflux disease(NERD)acid reflux and symptom patterns显示文摘 | Martinez SD Malagon IB Garewal HS et at | | 0，，04： | 1 |
| 14 | Non-erosive reflux disease(NERD)一acid reflux and symptom patterns显示文摘 | Martinez SD Malagon IB Garewal HS | 2003 | Aliment Pharmacol Ther2003，17，4： | 1 |
| 15 | Non erosive reflux disease (NERD) acid reflux and sympotom patterms显示文摘 | Martinez SD Malagon B Garewal H at al | 2003 | Aliment Pharmacol Ther2003，17，： | 1 |
| 16 | Automated reticulocyte response is a good predictor of bone-marrow recovery in pediatric malignancies显示文摘 | Das R Rawal A Garewal G | 2006 | Pediatr Hematol 0ncol2006，23，4： | 1 |
| 17 | American Society of Clinical Oncology Technology Assessment:ehemotherapy sensitivity and resistance assays显示文摘 | Schrag D Garewal HS Burstein HJ | 2004 | J Clin Oncol2004，22，17： | 1 |
| 18 | Non-erosive reflux disease (NERD) -acid reflux and symptmn pattern显示文摘 | Martinez SD Malagon IB Garewal HS | 2003 | Aliment Pharmacol Ther2003，17，4： | 1 |
| 19 | Nonerosive reflux disease (NERD) - acid reflux and symptom patterns 显示文摘 | Martinez S D Malagon I B Garewal H S | 2003 | Aliment Pharmacol Ther2003，17，： | 1 |
| 20 | Subclavian artery dissection and triple infarction of the nervous system 显示文摘 | Garewal M Selhorst JB | 2005 | Arch Neurol2005，62，12： | 1 |
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