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| 1 | Neutrophil-lymphocyte ratio:A prognostic tool in patients with inhospital cardiac arrest显示文摘BACKGROUND In-hospital cardiac arrest(IHCA) portends a poor prognosis and survival to discharge rate. Prognostic markers such as interleukin-6, S-100 protein and high sensitivity C reactive protein have been studied as predictors of adverse outcomes after return of spontaneous circulation(ROSC); however; these variables are not routine laboratory tests and incur additional cost making them difficult to incorporate and less attractive in assessing patient's prognosis. The neutrophil-lymphocyte ratio(NLR) is a marker of adverse prognosis for many cardiovascular conditions and certain types of cancers and sepsis. We hypothesize that an elevated NLR is associated with poor outcomes including mortality at discharge in patients with IHCA.AIM To determine the prognostic significance of NLR in patients suffering IHCA who achieve ROSC.METHODS A retrospective study was performed on all patients who had IHCA with the advanced cardiac life support protocol administered in a large urban community United States hospital over a one-year period. Patients were divided into two groups based on their NLR value(NLR < 4.5 or NLR ≥ 4.5). This cutpoint was derived from receiving operator characteristic curve analysis(area under the curve = 0.66) and provided 73% positive predictive value, 82% sensitivity and42% specificity for predicting in-hospital death after IHCA. The primary outcome was death or discharge at 30 d, whichever came first.RESULTS We reviewed 153 patients with a mean age of 66.1 ± 16.3 years; 48% were female.In-hospital mortality occurred in 65%. The median NLR in survivors was 4.9(range 0.6-46.5) compared with 8.9(0.28-96) in non-survivors(P = 0.001). A multivariable logistic regression model demonstrated that an NLR above 4.55[odds ratio(OR) = 5.20, confidence interval(CI): 1.5-18.3, P = 0.01], older age(OR= 1.03, CI: 1.00-1.07, P = 0.05), and elevated serum lactate level(OR = 1.20, CI:1.03-1.40, P = 0.02) were independent predictors of death.CONCLUSION An NLR ≥ 4.5 may be a useful marker of increased risk of death in patients with IHCA. | Vishal H Patel Philip Vendittelli Rajat Garg Susan Szpunar Thomas LaLonde John Lee Howard Rosman Rajendra H Mehta Hussein Othman | 2019 | World Journal of Critical Care Medicine2019，8，2： | 5 |
| 2 | Elevatedlevel of interleukin-6 predicts organ failure and severedisease in patients with acute pancreatitis显示文摘 | Sathyanarayan G Garg PK Prasad H | 2007 | J Gastroen-terol Hepatol2007，22，4： | 1 |
| 3 | Compressional wave propagation in liquid and or gas saturated porous media 显示文摘 | Garg S K Nayfeh A H | 1986 | Journal of Applied Physics1986，60，9： | 1 |
| 4 | A parameter opti- mization approach to controller partitioning for integrated flight/propulsion control application显示文摘 | Schmidt P H Garg S Holowecky B R | 1993 | IEEE Transac- tions on Control Systems Technology1993，1，1： | 1 |
| 5 | Improvement in glycemic excursions with a transcutaneous,real-time continuous glucose sensor A randomized controlled trial显示文摘 | Garg S Zisser H Schwartz S | 2006 | Diabetes care2006，29，1： | 1 |
| 6 | Compressional waves in fluid-saturated elastic porous media显示文摘 | GARG S K ADNAN H NAYFEH | 1974 | Journal of Applied Physics1974，45，： | 1 |
| 7 | Nuclear factor-kappa B sup- pressive and inhibitor-kappa B stimulatory effects of tmglitazone in obese patients with type 2 diabetes : evidence of an anti-inflammato- ry action显示文摘 | Aljada A Garg R Ghanim H | 2001 | J Clin Endocrinol Metab2001，86，7： | 1 |
| 8 | Performance analysis of a hybrid photovoltaic/thermal (PV/T) collector with integrated CPC troughs显示文摘 | Garg H P Adhikari R S | 1999 | International joumal of energy research1999，23，15： | 1 |
| 9 | On the design and development of hybrid journal bearings: a review 显示文摘 | H C Garg H B Sharda V Kumar | 2006 | Tribotest2006，12，1： | 1 |
| 10 | Theoretical and experimental studies on collector/storage type solar water heater显示文摘 | H P Garg R Usha | 1982 | International Journal of Solar Energy1982，29，： | 1 |
| 11 | Optimal Power Allocation for OFDM-based Cognitive Radio with New Pri- mary Transmission Protection Criteria 显示文摘 | KANG X GARG H K LIANG Y C | 2010 | IEEE Transaction on Wireless Communication2010，9，6： | 1 |
| 12 | Nitric oxide stimulates the activity of a 72 - kDa neutral matrix metalloproteinase in cultured rat mesangial cells显示文摘 | Trachtman H Futterweit S Garg P | 1996 | Biochem Biophys Res Commun1996，218，3： | 1 |
| 13 | Maximum-likelihood detection in DWT domain image watermarking using laplacian modeling显示文摘 | Ng T M Garg H K | 2005 | Signal Processing Letters IEEE2005，12，4： | 1 |
| 14 | Dynamic interaction of railway train and bridges 显示文摘 | CHU K H GARG V K WIRIYACHAI A | 1980 | Vehicle System Dynamics1980，9，4： | 1 |
| 15 | Light -regulated overex- pression of an Arabidopsis phytochrome A gene in rice alters plant archi- tecture and increases grain yield显示文摘 | GARG A K SAWERS R J H WANG H | 2006 | Planta2006，223，4： | 1 |
| 16 | MaxiDary antral muco-cele and its relevance for maxillary simis augmentation graft-ing :A case report 显示文摘 | Garg AK Mugnolo GM Sasken H | 2000 | Int J Oral Maxillofac Implants2000，15，2： | 1 |
| 17 | Suppression of nuclear factor-kappa B and stimulation of inhibitor kappa B by troglitazone:evidence for an anti-inflammatory effect and a potential antiatherosclerotic effect in the obese显示文摘 | Ghanim H Garg R Aljada A | 2001 | J Clin Endocrinol Metab2001，86，3： | 1 |
| 18 | Impact study by various bridge models 显示文摘 | WIRIYACHAI A CHU K H GARG V K | 1982 | Earthquake Engineering & Structural Dynamics1982，10，1： | 1 |
| 19 | Nitric oxide bioac- tivity of traditional Chinese medicines used for cardio- vascular indications 显示文摘 | Tang Y Garg H Geng Y J | 2009 | Free Radic Biol Med2009，21，： | 1 |
| 20 | Spinal cord and spinal nerve root involvement (myeloradiculopathy) in tuberculous meningitis显示文摘 | GUPTA R GARG R K JAIN A MALHOTRA H S VERMA R SHARMA P K | 2015 | Medicine (Baltimore)2015，94，： | 1 |
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