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| 1 | Estimating steatosis and fibrosis: Comparison of acoustic structure quantification with established techniques显示文摘AIM:To compare ultrasound-based acoustic structure quantification(ASQ) with established non-invasive techniques for grading and staging fatty liver disease.METHODS:Type 2 diabetic patients at risk of nonalcoholic fatty liver disease(n = 50) and healthy volunteers(n = 20) were evaluated using laboratory analysis and anthropometric measurements, transient elastography(TE), controlled attenuation parameter(CAP), proton magnetic resonance spectroscopy(1H-MRS; only available for the diabetic cohort), and ASQ.ASQ parameters mode, average and focal disturbance(FD) ratio were compared with:(1) the extent of liver fibrosis estimated from TE and nonalcoholic fatty liver disease(NAFLD) fibrosis scores; and(2) the amount of steatosis, which was classified according to CAP values.RESULTS:Forty-seven diabetic patients(age 67.0±8.6 years;body mass index 29.4±4.5 kg/m2)with reliable CAP measurements and all controls(age 26.5±3.2 years;body mass index 22.0±2.7 kg/m2)were included in the analysis.All ASQ parameters showed differences between healthy controls and diabetic patients(P<0.001,respectively).The ASQ FD ratio(logarithmic)correlated with the CAP(r=-0.81,P<0.001)and 1H-MRS(r=-0.43,P=0.004)results.The FD ratio[CAP<250 d B/m:107(102-109),CAP between 250 and 300 d B/m:106(102-114);CAP between 300 and 350 d B/m:105(100-112),CAP≥350 d B/m:102(99-108)]as well as mode and average parameters,were reduced in cases with advanced steatosis(ANOVA P<0.05).However,none of the ASQ parameters showed a significant difference in patients with advanced fibrosis,as determined by TE and the NAFLD fibrosis score(P>0.08,respectively).CONCLUSION:ASQ parameters correlate with steatosis,but not with fibrosis in fatty liver disease.Steatosis estimation with ASQ should be further evaluated in biopsy-controlled studies. | Thomas Karlas Joachim Berger Nikita Garnov Franziska Lindner Harald Busse Nicolas Linder Alexander Schaudinn Bettina Relke Rima Chakaroun Michael Trltzsch Johannes Wiegand Volker Keim | 2015 | World Journal of Gastroenterology2015，21，16： | 9 |
| 2 | Hy- drolysis of Neptunium (V) at Variable Tempera- tures (10-85 ℃) 显示文摘 | Rao L Srinivasan T G Garnov A Yu | 2004 | Geoehim Cosmochim Acta2004，68，23： | 1 |
| 3 | Laser ablation and micropatterning of thin TiN coatings显示文摘 | T.V. Kononenko S.V. Garnov S.M. Pimenov V.I. Konov V. Romano B. Borsos H.P. Weber | 2000 | Applied Physics A Materials Science & Processing2000，，6： | 1 |
| 4 | Laser ablation of metals and ceramics in picosecond- nanosecond pulsewidth in the presence of different ambient atmospheres 显示文摘 | KONONENKO T V GARNOV S V KLIMENTOV S M | 1996 | Applied Surface Science1996，1996，109110： | 1 |
| 5 | Non-Invasive Assessment of Hepatic Steatosis in Patients with NAFLD Using Controlled Attenuation Parameter and ~H-MR Spectroscopy 显示文摘 | Karlas T Petroff D Garnov N | 2014 | PLos one2014，9，91： | 1 |
| 6 | Color-center generation in silicate glasses exposed to infrared femtosecond pulses显示文摘 | GABEL K GARNOV S V | 1998 | J Opt Soc Am B1998，15，1： | 1 |
| 7 | Oxidative alkaline leaching of Americium from simulated high-level nuclear waste sludges 显示文摘 | REED W A GARNOV Y A RAO L NASH K L BOND A H | 2005 | Separation Science and Technology2005，40，5： | 1 |
| 8 | Flexible add-on solution for MR image-guided interventions in a closed-bore scanner environment显示文摘 | Busse H Garnov N Thrmer G | 2010 | Magn Reson Med2010，64，3： | 1 |
| 9 | Novel technique for MR elastography of the prostate using a modified standard endorectal coil as actuator显示文摘 | Gregor Th?rmer Martin Reiss‐Zimmermann Josephin Otto Karl‐Titus Hoffmann Michael Moche Nikita Garnov Thomas Kahn Harald Busse | 2012 | J. Magn. Reson. Imaging2012，，： | 1 |
| 10 | Complexation of uranium (Ⅵ) and samarium(Ⅲ) with oxydiacetic acid: Temperature effect and coordination modes显示文摘 | Rao L Garnov A Y Jiang J | 2003 | Inorganic Chemistry2003，42，11： | 1 |
| 11 | Laser ablation and micro-patterning of thin TiN coatings显示文摘 | Kononenko T V Garnov S V Pimenov S M | 2000 | Applied Physics A:Materials Science&Processing2000，71，： | 1 |
| 12 | Deformation of block environments in underground nuclear explosions显示文摘 | GARNOV V V SPIVAK A A | 2004 | Combustion Explosion and Shock Waves2004，40，6： | 1 |
| 13 | Experimental study of temperature dependenee of reflectivity and heat capacity of steels and alloys at continuous wave Nd: YAG laser heating 显示文摘 | GARNOV S V KONOV V I | 1996 | SPIE1996，3093，： | 1 |
| 14 | Non-invasive assessment of hepatic steatosis in patients with NAFLD using controlled attenuation parameter and 1H-MR spectroscopy显示文摘 | Karlas T Petroff D Garnov N | 2014 | PLoS One2014，9，91： | 1 |
| 15 | Colorcenter generation in silicate glasses exposed to infrared femtosecond pulses显示文摘 | EFIMOV O M GABEL K GARNOV S V | 1998 | JOSA1998，15，1： | 1 |
| 16 | Diode pumped Nd : YAG laser with active Q-switching and mode locking for hole drilling 显示文摘 | SOLOKHIN S A SIROTKIN A A GARNOV S | 2011 | Laser Physics2011，21，6： | 1 |
| 17 | Laser ablation of metals and ceramics in picosecond-nanosecond pulsewidth in the presence of different ambient atmospheres显示文摘 | Kononenko T V Garnov S V Klimentov S M | 1997 | Applied Surface Science1997，，： | 1 |
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