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| 1 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 2 | Advanced Glycation End Products in Foods and a Practical Guide to Their Reduction in the Diet显示文摘 | Jaime Uribarri Sandra Woodruff Susan Goodman Weijing Cai Xue Chen Renata Pyzik Angie Yong Gary E. Striker Helen Vlassara | 2010 | Journal of the American Dietetic Association2010，，6： | 2 |
| 3 | Factor-analytic study of the Yale Global Tic Severity Scale显示文摘 | Eric A. Storch Tanya K. Murphy Melanie Fernandez Mohan Krishnan Gary R. Geffken Ashley R. Kellgren Wayne K. Goodman | 2006 | Psychiatry Research2006，，1： | 1 |
| 4 | Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease显示文摘 | Gilbert S Omenn Gary E Goodman Mark D Thomquist | 1996 | The New England Journal of Medicine1996，334，： | 1 |
| 5 | Sleep-related problems in pediatric obsessive-compulsive disorder显示文摘 | Eric A. Storch Tanya K. Murphy Caleb W. Lack Gary R. Geffken Marni L. Jacob Wayne K. Goodman | 2007 | Journal of Anxiety Disorders2007，，5： | 1 |
| 6 | Hierarchical modeling identifies novel lung cancer susceptibility variants in inflammation pathways among 10,140 cases and 11,012 controls显示文摘 | Darren R. Brenner Paul Brennan Paolo Boffetta Christopher I. Amos Margaret R. Spitz Chu Chen Gary Goodman Joachim Heinrich Heike Bickeb?ller Albert Rosenberger Angela Risch Thomas Muley John R. McLaughlin Simone Benhamou Christine Bouchardy Juan Pablo Lew | 2013 | Human Genetics2013，，： | 1 |
| 7 | A conical-collared intramedullary stem can improve stress transfer and limit micromotion显示文摘 | Jay A. Mandell Dennis R. Carter Stuart B. Goodman David J. Schurman Gary S. Beaupré | 2004 | Clinical Biomechanics2004，，7： | 1 |
| 8 | Association of Diabetes Susceptibility Gene Calpain-10 with Pancreatic Cancer Among Smokers显示文摘 | Pui-yee Fong Megan D. Fesinmeyer Emily White Federico M. Farin Sengkeo Srinouanprachanh Zahra Afsharinejad Margaret T. Mandelson Teresa A. Brentnall Matt J. Barnett Gary E. Goodman Melissa A. Austin | 2010 | Journal of Gastrointestinal Cancer2010，，3： | 1 |
| 9 | Colorectal Chemoprevention Pilot Study (SWOG-9041), Randomized and Placebo Controlled: The Importance of Multiple Luminal Lesions显示文摘 | David Z.J. Chu Michael A. Hussey David S. Alberts Frank L. Meyskens Cecilia M. Fenoglio-Preiser Saul E. Rivkin Glenn M. Mills Jeffrey K. Giguere Charles D. Blanke Gary E. Goodman | 2011 | Clinical Colorectal Cancer2011，，4： | 1 |
| 10 | Risk factors for lung cancer and for intervention effects in CARET, the B-carotene and retinol efficacy trial显示文摘 | GILBERT S OMENN GARY E GOODMAN | 1996 | Journal of the National Cancer Institute1996，88，21： | 1 |
| 11 | Plasma Phospholipid Fatty Acids and Prostate Cancer Risk in the SELECT Trial显示文摘 | Theodore M. Brasky Amy K. Darke Xiaoling Song Catherine M. Tangen Phyllis J. Goodman Ian M. Thompson Frank L. Meyskens Gary E. Goodman Lori M. Minasian Howard L. Parnes Eric A. Klein Alan R. Kristal | 2013 | JNCI Journal of the National Cancer Institute2013，，15： | 1 |
| 12 | Adenoma Recurrences After Resection of Colorectal Carcinoma: Results From the Southwest Oncology Group 9041 Calcium Chemoprevention Pilot Study显示文摘 | David Z. J. Chu Kari Chansky David S. Alberts Frank L. Meyskens Cecilia M. Fenoglio-Preiser Saul E. Rivkin Glenn M. Mills Jeffrey K. Giguere Gary E. Goodman James L. Abbruzzese Scott M. Lippman | 2003 | Annals of Surgical Oncology2003，，8： | 1 |
| 13 | Prior Lung Disease and Risk of Lung Cancer in a Large Prospective Study显示文摘 | Alyson J. Littman Mark D. Thornquist Emily White Lisa A. Jackson Gary E. Goodman Thomas L. Vaughan | 2004 | Cancer Causes and Control2004，，8： | 1 |
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