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| 1 | DNA-guided hepatitis B treatment,viral load is essential,but not sufficient显示文摘Hepatitis B virus(HBV) infection is a global public health problem that concerns 350 million people worldwide.Individuals with chronic hepatitis B(CHB) are at increased risk of developing liver cirrhosis,hepaticde-compensation a nd hepatocellular carcinoma.To maintain undetectable viral load reduces chronic infection complications.There is no treatment that eradicates HBV infection.Current drugs are expensive,are associated with adverse events,and are of limited efficacy.Current guidelines try to standardize the clinical practice.Nevertheless,controversy remains about management of asymptomatic patients with CHB who are hepatitis B e antigen(HBeAg)-positive with normal alanine aminotransferase,and what is the cut-off value of viral load to distinguish HBeAg-negative CHB patients and inactive carriers.We discuss in detail why DNA level alone is not sufficient to begin treatment of CHB. | Rafael Bárcena Marugán Silvia García Garzón | 2009 | World Journal of Gastroenterology2009，15，4： | 8 |
| 2 | Persistent hepatitis C virus (HCV) infection impairs HCV‐specific cytotoxic T cell reactivity through Mcl‐1/Bim imbalance due to CD127 down‐regulation显示文摘 | J. R. Larrubia M. U. Lokhande S. García‐Garzón J. Miquel A. González‐Praetorius T. Parra‐Cid E. Sanz‐de‐Villalobos | 2012 | Journal of Viral Hepatitis2012，，2： | 3 |
| 3 | Comparison of lipid extraction methods for the microalgae Acutodesmus obliquus显示文摘Microalgae are widely used in the pharmaceutical and energy industries,therefore the conditions for their cultivation and extraction methods play an important role in the profiling and acquisition of lipids.The efficiency of lipid extraction from microalgae has attracted great interest from industry because of the wide variety of lipids and amounts that can be obtained.Acutodesmus obliquus(Scenedesmus obliquus UTEX 393)was used in this study.It was cultivated in Bold 3N medium modified with 75%nitrogen at 25℃,pH 6.8,125 r/min and a photoperiod of 18/6 h and illuminated with white light provided by a Light-Emitting Diode Surface Mount Device extensions(LED SMD)with an intensity of 1200μE/(m^(2)·s).The cells were stained with the Red Nile(RN)technique to indicate lipid production.Four extraction methods were compared,classical,microwave(MW),Soxhlet,and ultrasound(US),using the same solvent proportions(hexane:chloroform:methanol=1:2:3).All samples were analyzed with Fourier Transform Infrared Spectroscopy(FTIR)and Gas Chromatography coupled to Mass Spectrometry(GC-MS).The results showed:1)lipid production detected by RN was consistent with microalgal growth;2)the MW technique was the best extraction method,according to the statistical analysis through Randomized Complete Block(RCB)design and performance of 4.6%;and 3)the presence of saturated and unsaturated acids was indicated by FTIR spectra.GC-MS was able to identify palmitic and linoleic acids as the likely major constituents of the sample. | Diana Ximena Hurtado Claudia Lorena Garzón-Castro Jhon Cortés-Romero Edisson Tello Camacho | 2018 | International Journal of Agricultural and Biological Engineering2018，11，5： | 2 |
| 4 | Dendritic cells genetically engineered to express IL-10 induce long-lasting antigen-specific tolerance in experimental asthma显示文摘 | Henry E Desmet CJ Garze V | 2008 | J Immunol2008，181，： | 1 |
| 5 | Medial prefrontal cortex receives input from dorsal raphe nucleus neurons targeted by hypocre-tin1/orexin A-containing axons显示文摘 | Cid-Pellitero E D Garzón M | 2011 | Neuroscience2011，13，172： | 1 |
| 6 | Influence of temperature and dietary-protein supplementation eitherwith free or coated lysine on the fractional protein-turnover rates in thewhite muscle of carp显示文摘 | M. de la Higuera A. Garzón M.C. Hidalgo J. Peragón G. Cardenete J.A. Lupiá?ez | 1998 | Fish Physiology and Biochemistry1998，，1： | 1 |
| 7 | Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche显示文摘 | Ahmed Mohyeldin Tomás Garzón-Muvdi Alfredo Qui?ones-Hinojosa | 2010 | Cell Stem Cell2010，，2： | 1 |
| 8 | The pathologic cascade of cerebrovascular lesions in SHRSP:is erythrocyte accumulation an early phase?显示文摘 | Schreiber S Bueche CZ Garz C | 2012 | J Cereb Blood Flow Metab2012，32，： | 1 |
| 9 | Persistent hepatitis C virus (HCV) infection impairs HCV‐specific cytotoxic T cell reactivity through Mcl‐1/Bim imbalance due to CD127 down‐regulation显示文摘 | J. R. Larrubia M. U. Lokhande S. García‐Garzón J. Miquel A. González‐Praetorius T. Parra‐Cid E. Sanz‐de‐Villalobos | 2012 | Journal of Viral Hepatitis2012，，2： | 1 |
| 10 | Blood brain barrier breakdown as the starting point of cerebral small vessel disease?-New insights from a rat model显示文摘 | Schreiber S Bueche CZ Garz C | 2013 | Exp Transl Stroke Med2013，5，： | 1 |
| 11 | EBSD texture analysis of a high temperature gas nitrided duplex stainless steel显示文摘 | Garz'on C M Tschiptschin A P | 2006 | Materials Science and Engineering A2006，441，： | 1 |
| 12 | Effect of Wet-Dry Cycles on the Bond Behavior of Concrete Elements Strengthened with NSM CFRP Laminate Strips显示文摘 | Garzón-Roca J Sena-Cruz J M Fernandes P | 2015 | Composite Structures2015，132，： | 1 |
| 13 | Hyperactivity induced in rats by long-term isolation:further studies on a new animal model for detection of antidepressants显示文摘 | GARZN J DEL R(I)O J | 1981 | Eur J Pharmacol1981，74，4： | 1 |
| 14 | Strong water-mediated friction asymmetry and surface dynamics of zwitterionic solids at ambient conditions:L-alanine as a case study显示文摘 | Segura J.J Verdaguer A Garzón L Barrena E. Ocal C. Fraxedas J | | 0，，12： | 1 |
| 15 | Glove perforation in surgery and protective effect of double gloves 显示文摘 | DE CASTRO-PERAZA M GARZ N-RODR GUEZ E RODR GUEZ- P REZ V | 2010 | Enferm Clin2010，20，2： | 1 |
| 16 | The long-term fertilization experiments in Halle (Saale), Germany-introduction and survey显示文摘 | Merbach W Garz J Schliephake W | 2000 | Journal of Plant Nutrition and Soil Science2000，163，： | 1 |
| 17 | The properties of polymer blendsofβ-modification of polypropylene and an elastomer显示文摘 | VARGA J GARZG | 1990 | Angew Makromol Chem1990，180，： | 1 |
| 18 | The influence of copper on corrorosions and passivation of iron-chromium alloys Part Ⅱ Surface analytical examinations显示文摘 | Postrach B Garz I Strehblow H H | 1994 | Mater Corros1994，45，： | 1 |
| 19 | A mathematical model of the growth plate显示文摘 | Garz ó n-Alvarado DA | | 0，，05： | 1 |
| 20 | Oxygen in stem cell biology: a critical component of the stem cell niche显示文摘 | Mohyeldin A Garzón-Muvdi T Qui?ones-Hinojosa A | 2010 | Cell Stem Cell2010，7，2： | 1 |
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