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| 1 | Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration显示文摘 | Joanna M Wardlaw Eric E Smith Geert J Biessels Charlotte Cordonnier Franz Fazekas Richard Frayne Richard I Lindley John T O’Brien Frederik Barkhof Oscar R Benavente Sandra E Black Carol Brayne Monique Breteler Hugues Chabriat Charles DeCarli Frank-Erik de | 2013 | Lancet Neurology2013，，8： | 2 |
| 2 | Comparison of threeresearch models of portal hypertension in mice: macroscopic,histological and portal pressure evaluation 显示文摘 | Geerts AM Vanheule E Praet M | 2008 | Int J Exp Pathol2008，89，： | 1 |
| 3 | Glycosylated and unglycosylated human lactoferrins both bind iron and show identical affinities towards human lysozyme and bacterial lipopolysaccharide, but differ in their susceptibilities towards tryptic proteolysis显示文摘 | Berkel P H van Geerts M E Veen H A van | 1995 | Biochem J1995，312，1： | 1 |
| 4 | The role of hypofracttionation radiotherapy for dif- fuse intrinsic显示文摘 | Geert O R J Janssens Corrie E M Gidding Erik J Van lindert | 2009 | lnt J Radiation Oncology Biol Phys2009，73，3： | 1 |
| 5 | Molecular mechanism of anaerobic ammonium oxidation 显示文摘 | Kartal B Maalcke W J Almeida N M Cirpus I Gloerich J Wim Geerts Camp H J M O Harhangi H R Janssen-Megens E M Francoijs K-J Stunnenberg H G Keltjens J T Jetten M S M Strous M | 2011 | Nature2011，479，： | 1 |
| 6 | Nterminal stretch Arg2, Arg3, Arg4, and A rg5 of human lactoferrin is essential for binding to heparin, bacterial lipopolysaccharide, human lysozyme and DNA 显示文摘 | Geerts M E J Van Veen H A | 1997 | Biochem J1997，328，： | 1 |
| 7 | Influence of somatostatin and octreotide on liver microcirculation in an experimental mouse model of cirrhosis studied by intravital fluorescence microscopy 显示文摘 | VANHEULE E GEERTS A M REYNAERT H | 2008 | Liver International2008，28，1： | 1 |
| 8 | Glycosylated and unglycosylated human lactoferrins both bind iron and show identical affinities towards human lysozyme and bacterial lipopolysaccharide, but differ in their susceptibilities towards tryptic proteolysis显示文摘 | Berkel P H van Geerts M E Veen H A van | 1995 | Biochem J1995，312，1： | 1 |
| 9 | Characterization of recombinant human lactoferrin secreted in milk of transgenic mice显示文摘 | NUIJENS J H VAN BERKEL P H GEERTS M E | 1997 | J Biol Chem1997，272，13： | 1 |
| 10 | Challenging protein purification from anammox bacteria 显示文摘 | Cirpus I E Y Geerts W Hermans J H M | 2006 | International Journal of Biological Macromolecules2006，39，13： | 1 |
| 11 | Characterization of recombinant human lactoferrin secreted in milk of transgenic mice显示文摘 | Nuijens J H van Berkel P H C Geerts M E J | 1997 | J Biol Chem1997，272，13： | 1 |
| 12 | Challenging protein purification from anammox bacteria显示文摘 | Cirpus I E Y Geerts W Hermans J H M | | 0，，1： | 1 |
| 13 | 查看详情显示文摘 | Savage R C Mativetsky J M Orgiu E Palma M Gbabode G Geerts Y H Samori P | | 0，，： | 1 |
| 14 | Characterization of Recombinant Human Lactoferrin Secreted in Milk of Transgenic Mice显示文摘 | Nuijens J H van Berkel P H C Geerts M E J | 1997 | J Biol Chem1997，272，13： | 1 |
| 15 | Comparison of three research models of portal hypertension in mice:macroscopic,histological and portal pressure evaluation显示文摘 | GEERTS AM VANHEULE E PRAET M | 2008 | Int J Exp Pathol2008，89，1： | 1 |
| 16 | Glycosylated and unglycosylated human lactofemns both bind iron and show identical affinities towards human lysozyme and bacterial lipopolysaccharide, but differ in their susceptibilities towards tryptic proteolysis 显示文摘 | Van Berkel P H C Geerts M E J van Veen H A | 1995 | Biochem J1995，312，： | 1 |
| 17 | Prevalence of-and risk factors for work disability in Dutch patients with inflammatory bowel disease显示文摘AIM To determine the prevalence of work disability in inflammatory bowel disease(IBD), and to assess risk factors associated with work disability.METHODS For this retrospective cohort study, we retrieved clinical data from the Dutch IBD Biobank on July 2014, containing electronic patient records of 3388 IBD patients treated in the eight University Medical Centers in the Netherlands. Prevalence of work disability was assessed in 2794 IBD patients and compared with the general Dutch population. Multivariate analyses were performed for work disability(sick leave, partial and full disability) and long-term full work disability(> 80% work disability for > 2 years).RESULTS Prevalence of work disability was higher in Crohn's disease(CD)(29%) and ulcerative colitis(UC)(19%) patients compared to the general Dutch population(7%). In all IBD patients, female sex, a lower education level, and extra-intestinal manifestations, were associated with work disability. In CD patients, an age > 40 years at diagnosis, disease duration > 15 years,smoking, surgical interventions, and anti-TNFα use were associated with work disability. In UC patients, an age > 55 years, and immunomodulator use were associated with work disability. In CD patients, a lower education level(OR = 1.62, 95%CI: 1.02-2.58), and in UC patients, disease complications(OR = 3.39, 95%CI: 1.09-10.58) were associated with long-term full work disability.CONCLUSION The prevalence of work disability in IBD patients is higher than in the general Dutch population. Early assessment of risk factors for work disability is necessary, as work disability is substantial among IBD patients. | Lieke M Spekhorst Bas Oldenburg Ad A van Bodegraven Dirk J de Jong Floris Imhann Andrea E van der Meulen-de Jong Marieke J Pierik Janneke C van der Woude Gerard Dijkstra Geert D'Haens Mark Lowenberg Rinse K Weersma Eleonora AM Festen 无 | 2017 | World Journal of Gastroenterology2017，23，46： | 1 |
| 18 | Influence of soma- tostatin and octreotide on liver microcirculation in an experimental mouse model of cirrhosisstudied by intravital fluorescence micros- copy显示文摘 | Vanheule E Geerts A M Reynaert H | 2008 | Liver Int2008，28，1： | 1 |
| 19 | Characterization of Recombinant Human Lactoferrin Secreted in Milk of Transgenic Mice显示文摘 | Nuijens J H Patrick van Berkel H C Geerts M E J | 1997 | J Biol Chem1997，272，： | 1 |
| 20 | Endovascular treatment in anterior circulation stroke beyond 6.5 hours after onset or time last seen well:results from the MR CLEAN Registry显示文摘Background Randomised controlled trials with perfusion selection have shown benefit of endovascular treatment(EVT)for ischaemic stroke between 6 and 24 hours after symptom onset or time last seen well.However,outcomes after EVT in these late window patients without perfusion imaging are largely unknown.We assessed their characteristics and outcomes in routine clinical practice.Methods The Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands Registry,a prospective,multicentre study in the Netherlands,included patients with an anterior circulation occlusion who underwent EVT between 2014 and 2017.CT perfusion was no standard imaging modality.We used adjusted ordinal logistic regression analysis to compare patients treated within versus beyond 6.5 hours after propensity score matching on age,prestroke modified Rankin Scale(mRS),National Institutes of Health Stroke Scale,Alberta Stroke Programme Early CT Score(ASPECTS),collateral status,location of occlusion and treatment with intravenous thrombolysis.Outcomes included 3-month mRS score,functional independence(defined as mRS 0-2),and death.Results Of 3264 patients who underwent EVT,106(3.2%)were treated beyond 6.5 hours(median 8.5,IQR 6.9-10.6),of whom 93(87.7%)had unknown time of stroke onset.CT perfusion was not performed in 87/106(80.2%)late window patients.Late window patients were younger(mean 67 vs 70 years,p<0.04)and had slightly lower ASPECTS(median 8 vs 9,p<0.01),but better collateral status(collateral score 2-3:68.3%vs 57.7%,p=0.03).No differences were observed in proportions of functional independence(43.3%vs 40.5%,p=0.57)or death(24.0%vs 28.9%,p=0.28).After matching,outcomes remained similar(adjusted common OR for 1 point improvement in mRS 1.04,95%CI 0.56 to 1.93).Conclusions Without the use of CT perfusion selection criteria,EVT in the 6.5-24-hour time window was not associated with poorer outcome in selected patients with favourable clinical and CT/CT angiography characteristics.randomised controlled trials with lenient inclusion criteria are needed to identify more patients who can benefit from EVT in the late window. | Luuk Dekker Esmee Venema F Anne V Pirson Charles B L M Majoie Bart J Emmer Ivo G H Jansen Maxim J H L Mulder Robin Lemmens Robert-Jan B Goldhoorn Marieke J H Wermer Jelis Boiten Geert J LycklamaàNijeholt Yvo B W E M Roos Adriaan C G M van Es Hester F Lingsma Diederik W J Dippel Wim H van Zwam Robert J van Oostenbrugge Ido R van den Wijngaard on behalf of the MR CLEAN Registry investigators | 2021 | Stroke & Vascular Neurology2021，6，4： | 1 |
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