| 1 | Primary intestinal lymphangiectasia in an adult patient:A case report and review of literature显示文摘BACKGROUND Primary intestinal lymphangiectasia(PIL),first described in 1961,is a rare disorder of unknown etiology resulting in protein-losing enteropathy.The disease is characterized by dilatation and leakage of intestinal lymph vessels leading to hypoalbuminemia,hypogammaglobulinemia,and lymphopenia.Since the severity and location of lymph vessels being affected can vary considerably,the range of associated symptoms is wide from mild lower-limb edema to generalized edema,abdominal and/or pleural effusion,and recurrent diarrhea,among others.Although usually developing in early childhood,we present the case of a 34-yearold woman with PIL.Moreover,we performed a literature review systematically assessing clinical presentation,and provide a practical approach to facilitate diagnosis and therapy of PIL in adults.CASE SUMMARY Our patient presented with unspecific symptoms of abdominal discomfort,fatigue,nausea,and recurrent edema of the lower limbs.Interestingly,a striking collinearity of clinical symptoms with female hormone status was evident.Additionally,polyglobulia,hypoalbuminemia,hypogammaglobulinemia,and transient lymphocytopenia were evident.Due to suspicion of a bone marrow disease,an extensive diagnostic investigation was carried out excluding secondary causes of polyglobulinemia and hypoalbuminemia.The diagnosis of primary intestinal lymphangiectasia was established after 22 wk by histological analysis of biopsy samples obtained via enteroscopy.Consecutively,the patient was put on a high-protein and low-fat diet with medium-chain triglycerides supplementation leading to significant improvement of clinical symptoms until 2 years of follow-up.CONCLUSION PIL can be the reason for cryptogenic hypoalbuminemia,hypogammaglobulinemia,and lymphopenia in adulthood.Due to difficulty in correct diagnosis,treatment initiation is often delayed despite being effective and welltolerated.This leads to a significant disease burden in affected patients.PIL is increasingly been recognized in adults since the majority of case reports were published within the last 10 years,pointing towards an underestimation of the true prevalence.The association with female hormone status warrants further investigation. | Rudolf Huber Georg Semmler Alexander Mayr Felix Offner Christian Datz | 2020 | World Journal of Gastroenterology2020，26，48： | 6 |
| 2 | The quest for conditional independence in prospectivity modeling: weights-of-evidence, boost weights-of-evidence, and logistic regression显示文摘prospectivity 建模的目的是存在 T = 的有条件的概率的预言 1 或缺席 T = 给有利或禁止的预言者 B,或建设的 0 一目标 T 一二个班 T 的 0,1 分类。逻辑回归的大小写把 weights-of-evidence (WofE ) 称为的一个专辑是由于它的明显的简洁当模特儿的 prospectivity 的地质学家爱好方法。然而,当它被给目标的所有预言者的联合有条件的独立的严重数学建模假设暗示,数字简洁正在欺骗。证据的一般重量明确地被介绍它同样简单作为常规重量估计,即由数,但是别要求有条件的独立。对回归看法补足 prospectivity 上的分类看法正在建模。增加是从一套弱分类器的一个强壮的分类器的构造。从回归观点,它是仔细与逻辑回归有关。增加 weights-of-evidence (BoostWofE ) 被介绍进尽管关于弱分类器为假设建模的松驰不是,当模特儿到有条件的独立的假设的抵销违背的 prospectivity (起始) 增加的目的。在 BoostWofE 的原来的出版,制作数据集被用来验证这条途径。用它被显示出的一样的制作数据集,那 BoostWofE 不能通常补偿无论什么的缺乏的有条件的独立预言者的连续地处理的顺序。因此, BoostWofE 的宣称的特征通过反例被反驳,当理论调查结果被证实时如果预言者是指示物,包括相互作用术语的那逻辑回归能确切补偿联合有条件的独立的违背。 | Helmut SCHAEBEN Georg SEMMLER | 2016 | Frontiers of Earth Science2016，10，3： | 0 |
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