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| 1 | Effects of resveratrol in experimental and clinical non-alcoholic fatty liver disease显示文摘The prevalence of obesity and related conditions like non-alcoholic fatty liver disease(NAFLD) is increasing worldwide and therapeutic options are limited.Alternative treatment options are therefore intensively sought after.An interesting candidate is the natural polyphenol resveratrol(RSV) that activates adenosinmonophosphate-activated protein kinase(AMPK) and silent information regulation-2 homolog 1(SIRT1).In addition,RSV has known anti-oxidant and anti-inflammatory effects.Here,we review the current evidence for RSVmediated effects on NAFLD and address the different aspects of NAFLD and non-alcoholic steatohepatitis(NASH) pathogenesis with respect to free fatty acid(FFA) flux from adipose tissue,hepatic de novo lipogenesis,inadequate FFA β-oxidation and additional intra- and extrahepatic inflammatory and oxidant hits.We review the in vivo evidence from animal studies and clinical trials.The abundance of animal studies reports a decrease in hepatic triglyceride accumulation,liver weight and a general improvement in histological fatty liver changes,along with a reduction in circulating insulin,glucose and lipid levels.Some studies document AMPK or SIRT1 activation,and modulation of relevant markers of hepatic lipogenesis,inflammation and oxidation status.However,AMPK/SIRT1-independent actions are also likely.Clinical trials are scarce and have primarily been performed with a focus on overweight/obese participants without a focus on NAFLD/NASH and histological liver changes.Future clinical studies with appropriate design are needed to clarify the true impact of RSV treatment in NAFLD/NASH patients. | Sara Heebll Karen Louise Thomsen Steen B Pedersen Hendrik Vilstrup Jacob George Henning Grnbk | 2014 | World Journal of Hepatology2014，6，4： | 11 |
| 2 | Management of blood glucose with noninsulin therapies in type 2 diabetes 显示文摘 | George CM Brujin LL Will K | 2015 | Am Fam Physician2015，92，1： | 1 |
| 3 | Analysis of protein sequence and interaction data for candidate disease gene prediction显示文摘 | George RA Liu JY Feng LL | 2006 | Nucleic Acids Res2006，34，19： | 1 |
| 4 | Helicobacter pylori negative duodenal ulcer 显示文摘 | George LL Brandle S | 1991 | Am J Gastroenterol1991，86，10： | 1 |
| 5 | Human corneal epithelial equivalents constructed on Bombyx mori silk fibroin membranes显示文摘 | Bray Ll George KA Ainscough SL | 2011 | Biomaterials2011，32，22： | 1 |
| 6 | Helicobacter pylori negative duodenal ulcer显示文摘 | George LL Brandl S | 1991 | Am J Gastroenterol1991，86，： | 1 |
| 7 | Current con-cepts of follicle-stimulating hormone receptor generegulation 显示文摘 | George JW Dille EA Heckert LL | 2011 | Biol Reprod2011，84，1： | 1 |
| 8 | Isolation of human platelet membrane microparticles from plasma and serum显示文摘 | George JN Thoi LL McManus LM | 1982 | Blood1982，60，4： | 1 |
| 9 | Helicobacter pylori negative duodenal ulcer 显示文摘 | George LL Brandle S | 1991 | Am J Gastroenterol1991，86，10： | 1 |
| 10 | Effect of inocu- lum size on detection of Candida growth by the BACTEC 9240 automated blood culture system using aerobic and anaerobic media显示文摘 | George B J Horvath LL Hospenthal DR | 2005 | J Clin Microbiol2005，43，1： | 1 |
| 11 | Helicobacter Pylori negative duodenal显示文摘 | George LL Brandl S | 1991 | Am J Gastroenterol1991，86，： | 1 |
| 12 | Detection of fif- teen species of eandida in an automated blood culture system 显示文摘 | Horvath LL George Bj' Hospenthal DR | 2007 | J Clin Mierobiol2007，45，9： | 1 |
| 13 | Do statings beneficially or adversely affect glucose homeostasis? 显示文摘 | Michael SK George LL Haralampos JM | 2010 | Current Vascular Pharmacology2010，8，： | 1 |
| 14 | Helicobacter pylori-negative duodenal ulcer 显示文摘 | Borody TJ George LL Brandl S | 1991 | Am J Gastroenterol1991，86，9： | 1 |
| 15 | Helicobacter Pylori negative duodenal ulcer显示文摘 | Borody TJ George LL Brandl S | 1991 | Am J Gastroenterol1991，86，： | 1 |
| 16 | Helicobacter pylori negative duodenal ulcer显示文摘 | Borody TJ George LL Brandl S | 1991 | Am J Gastroenterol1991，86，： | 1 |
| 17 | Effect of Resin Disinfectants-I3 and I5 on Giardia muris and Giardia Lamblia显示文摘 | George LM Louis RF Jack LL | 1983 | Appl Envinron Microbiol1983，46，5： | 1 |
| 18 | Isolation of human plate- let membrane mieroparticles from plasma and serum显示文摘 | George JN Thoi LL Mc Manus LM | 1982 | Blood1982，60，4： | 1 |
| 19 | Direct comparison of the BACTEC 9240 and BacT/ALERT 3D automated blood culture sys- tems for candida growth detection 显示文摘 | Horvath LL George B J Murray CK | 2004 | J Clin Mierobiol2004，42，1： | 1 |
| 20 | Analysis of protein sequence and interaction data for candidate disease gene prediction显示文摘 | George RA Liu JY Feng LL | 2006 | Nucleic Acids Res2006，34，19： | 1 |
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