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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Faultcurrent contribution from synchronous machine andinverter based distributed generators显示文摘 | NATTHAPHOB N GERALD T H RAJA A | 2007 | IEEE Trans onPower Delivery2007，22，1： | 1 |
| 3 | Technical basis and proposal for deriving sediment quality criteria for metals显示文摘 | Gerald T A Dominic M D T David J H | 1996 | Environmental Toxicology and Chemistry1996，15，12： | 1 |
| 4 | Recurrent hypoglycemia alters hypothalamic expression of the regulatory proteins FosB and synaptophysin显示文摘 | SALWA A NICOLE M S GERALD J T | 2008 | Am J Physiol Regul Integr Comp Physiol2008，295，： | 1 |
| 5 | Half-fourier rare MR cholangiopancreatography:Experience in 300 subjects显示文摘 | Ann SF Mary A T Gerald WC | 1998 | Radiology1998，207，1： | 1 |
| 6 | Discriminating among subgroups of borderline personality disorder: An assessment of object representation显示文摘 | Gerald T Rafael A Javier & Mima C | 2003 | The American Journal of Psychoanalysis2003，63，2： | 1 |
| 7 | Mechanisms forcing abrupt fluctuations of the Indian Ocean Summer Monsoon during the last Deglaciation 显示文摘 | Gerald G Simon T | 1997 | Quaternary Science Reviews1997，16，： | 1 |
| 8 | Biological basis for the cardiovascular consequences of COX-2 inhibition:therapeutic challenges and opportunities显示文摘 | Grosser T Fries S Fitz Gerald G A | 2006 | J Clin Invest2006，116，1： | 1 |
| 9 | A multicenter comparison of intraaortic balloon pump utilization in isolated coronary artery bypass graft surgery显示文摘 | Roger J.F Baskett Gerald T O’Connor Gregory M Hirsch William A Ghali Kathy Sabadosa Jeremy R Morton Cathy S Ross Felix Hernandez William C Nugent Stephen J Lahey Donato A Sisto Lawrence J Dacey John D Klemperer Robert E Helm Andrew Maitland | 2003 | The Annals of Thoracic Surgery2003，，6： | 1 |
| 10 | Dia-mond-Studded Helical Traveling Wave Tube显示文摘 | Dayton James A Mearini Gerald T Chen Hsiung | 2005 | IEEETransactions on Electron Device2005，52，5： | 1 |
| 11 | Developments in flame retardancy of polyester fibers 显示文摘 | Gerald T Halle William A | 2006 | TANDEC Nonwovens Conference Proceedings2006，，15： | 1 |
| 12 | An envgene derived fromaprimary human immunodeficiency virus type 1isolate confershigh in vivo replicative capacity to a chimeric simian/human im-munodeficiency virus in rhesus monkeys显示文摘 | Keith A R John T L Gerald V | 1996 | J Virology1996，70，5： | 1 |
| 13 | Developments in flame retardancy of polyester fibers 显示文摘 | Keep Gerald T Haile William A | 2006 | TANDEC Nonwovens Conference Proceedings2006，，15： | 1 |
| 14 | Some phytoehemieal, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research显示文摘 | BADUELDIN H A GERALD B MUSBAH O T | 2008 | Food and Chemical Toxicology2008，46，2： | 1 |
| 15 | Climate Data Challenges in the 21st Century显示文摘 | Jonathan T Overpeck Gerald A Meehl Sandrine Bony | 2011 | Science2011，331，： | 1 |
| 16 | WT1 regulates the expression of the major glomerular podocyte membrane protein podocalyxin显示文摘 | Palmer R E Kotsianti A Cadman B Boyd T Gerald W Haber D A | 2001 | Curr Biol2001，11，： | 1 |
| 17 | Fault current contribution from synchronous machine and inverter based distributed generators显示文摘 | Natthaphob N Gerald T H Raja A | 2007 | IEEE Transactions on Power Delivery2007，22，1： | 1 |
| 18 | A power quality index based on equipment sensitivity,cost and network vulnerability显示文摘 | Lee G J Mihaela M A Gerald T H | 2004 | IEEE Trans on Power Delivery2004，19，3： | 1 |
| 19 | Special online collection: dealing with data显示文摘 | JOUATHAN T O GERALD A M SANDRINE B | 2011 | Science2011，331，6018： | 1 |
| 20 | Diamond-Studded Helical Traveling Wave Tube显示文摘 | Dayton James A Jr Fellow Mearini Gerald T | 2005 | IEEE TRANSACTIONS on ELECTRON DEVICES2005，52，5： | 1 |
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