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| 1 | mRNA expression of DOK1-6 in human breast cancer显示文摘AIM:To examine the expression of downstream of tyrosine kinase(DOK)1-6 genes in normal and breast cancer tissue and correlated this with several clinicopathological and prognostic factors.METHODS:DOK1-6 m RNA extraction and reverse transcription were performed on fresh frozen breast cancer tissue samples(n = 112) and normal background breast tissue(n = 31). Tissues were collected between 1991 and 1996 at two centres and all patients underwent mastectomy and ipsilateral axillary node dissection. All tissues were randomly numbered and the details were only made known after all analyses were completed. Transcript levels of expression were determined using real-time polymerase chain reaction and analyzed against TNM stage, tumour grade and clinical outcome over a 10-year follow-up period.RESULTS:DOK-2 and DOK-6 expression decreased with increasing TNM stage. DOK-6 expression decreased with increasing Nottingham Prognostic Index(NPI) [NPI-1 vs NPI-3(mean copy number 15.4 vs 0.22, 95%CI:2.7-27.6, P = 0.018) and NPI-2 vs NPI-3(mean copy number 7.6 vs 0.22, 95%CI:0.1-14.6, P = 0.048)]. After a median follow up period of 10 years, higherlevels of DOK-2 expression were found among patients who remained disease-free compared to those who developed local or distant recurrence(mean copy number 3.94 vs 0.0000096, 95%CI:1.0-6.85, P = 0.0091), and distant recurrence(mean copy number 3.94 vs 0.0025, 95%CI:1.0-6.84, P = 0.0092). Patients who remained disease-free had higher levels of DOK-6 expression compared to those who died from breast cancer.CONCLUSION:Decreasing expression levels of DOK-2 and DOK-6 with increased breast tumour progression supports the notion that DOK-2 and DOK-6 behave as tumour suppressors in human breast cancer. | Tamara Ghanem James Bracken Abdul Kasem Wen G Jiang Kefah Mokbel | 2014 | World Journal of Clinical Oncology2014，5，2： | 3 |
| 2 | Micro-ntcchmisms ,f slow crack growth in polyethylene under constant tensile loading 显示文摘 | Plummer C J G Goldberg A Ghanem A | 2001 | Polymer2001，42，23： | 1 |
| 3 | Time-kinetic study of repigmentation in vitiligo patients by tacrolimus or pimecrolimus 显示文摘 | Lubaki LJ Ghanem G Vereecken P et al | 2010 | Arch Dermatol Res2010，302，2： | 1 |
| 4 | 查看详情显示文摘 | Naulin C Costes M Moudden Z Ghanem N Dorthe G | | 0，，： | 1 |
| 5 | Stochastic finite-element analysis of seismic soil-structure interaction 显示文摘 | Ghiocel D M Ghanem R G | 2002 | Journal of Engineer- ing Mechanics2002，128，1： | 1 |
| 6 | MR Findings in a Rare Case of Sclerosing Mesenteritis of the Mesocolon显示文摘 | Ghanem N Pache G Bley T | 2005 | Magn Reson Imaging2005，21，5： | 1 |
| 7 | Urinary excretion of epidermal-type fatty acid-binding protein and S100A7 protein in patients with cutaneous melanoma 显示文摘 | Brouard MC Saurat JH Ghanem G | 2002 | Melanoma Res2002，12，6： | 1 |
| 8 | Spectral stochastic finite-element formulation for reliability analysis显示文摘 | Ghanem R G Spanos P D | 1991 | Engineering Mechanics1991，117，10： | 1 |
| 9 | PRK and butterfly LASEK : prospective, randomized, contralateral eye comparison of epithelial healing and ocular discomfort显示文摘 | GHANEM V C SOUZA G C SOUZA D C | 2008 | J Refract Surg2008，24，6： | 1 |
| 10 | MR findings in a rate case of sclerosing mesenteritis of the mesocolon显示文摘 | Ghanem N Pache G Bley T | | 0，，： | 1 |
| 11 | Databases Deepen the Web显示文摘 | Ghanem T M Aref W G | 2004 | IEEE Computer2004，73，1： | 1 |
| 12 | Databases deepen the Web显示文摘 | GHANEM T M AREF W G | 2004 | Computer2004，37，1： | 1 |
| 13 | Expression and prognostic relevance of vascular endothelial growth factor (VEGF) and its receptor (FLT-1) in nephroblastoma 显示文摘 | Ghanem MA van-Steenbrugge G J Sudaryo MK | 2003 | J Clin Pathol2003，56，2： | 1 |
| 14 | Initial experience with 64-row cardiac CT: non-invasive visualization of coronary aftery bypass grafts 显示文摘 | Pache G Saueressig U Frydrychowicz A Foell D Ghanem N Kotter E | 2006 | Eur Heart J2006，27，2： | 1 |
| 15 | Outcomes for and risk factors associated with vancomycin-resistant Enterococcus faecalis and vancomycin-resistant Enterococcus faecium bacteremia in cancer patients显示文摘 | GHANEM G HACHEM R JIANG Y | 2007 | Infect Control Hosp Epidemiol2007，28，9： | 1 |
| 16 | Incorporation of Cu, Fe, Ag, and Au nanop- articles in mercapto-silica (MOS) and their CO2 adsorp- tion capacities 显示文摘 | Nezar H Khdary Mohamed A Ghanem Mohamed G Mera- juddine | 2014 | Joumal of C O5 Utilization2014，5，： | 1 |
| 17 | Leachate Production and Disposal of Kitchen Food Solid Waste by Dry Fermentation for Biogas Generation 显示文摘 | Ghanem Ⅲ Gu G W Zhu J F | 2001 | Renewable Energy2001，23，34： | 1 |
| 18 | Loss-of-function variants of the human melano-cortin-1 receptor gene in melanoma cells define struc-tural determinants of receptor function 显示文摘 | SANCHEZ M J OLIVARES S C GHANEM G etal | 2002 | Eur JBiochem2002，269，24： | 1 |
| 19 | Spatio-temporal Access Methods显示文摘 | Mokbel M F Ghanem T M Aref W G | 2003 | IEEE Data Engineering Bulletin2003，26，2： | 1 |
| 20 | Spectral stochastic finite-element formulation for reliability analysis显示文摘 | Ghanem R G Spanos P D | 1991 | Engineering Mechanics1991，117，10： | 1 |
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