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| 1 | Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”显示文摘Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, S.aureus intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure. | Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. Charles C. Lee Stephanie P. Hao Irvin Oh Chao Xie Hani A. Awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan | 2019 | Bone Research2019，7，3： | 19 |
| 2 | Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit显示文摘 | Juliana Barr Gilles L. Fraser Kathleen Puntillo E. Wesley Ely Céline Gélinas Joseph F. Dasta Judy E. Davidson John W. Devlin John P. Kress Aaron M. Joffe Douglas B. Coursin Daniel L. Herr Avery Tung Bryce R. H. Robinson Dorrie K. Fontaine Michael A. Ramsa | 2013 | Critical Care Medicine2013，，1： | 6 |
| 3 | Phase 2 trial of linifanib (ABT‐869) in patients with unresectable or metastatic hepatocellular carcinoma显示文摘 | Han Chong Toh Pei‐Jer Chen Brian I. Carr Jennifer J. Knox Sharlene Gill Peter Ansell Evelyn M. McKeegan Barry Dowell Michelle Pedersen Qin Qin Jiang Qian Frank A. Scappaticci Justin L. Ricker Dawn M. Carlson Wei Peng Yong | 2012 | Cancer2012，，2： | 4 |
| 4 | “Zero Ischemia” Partial Nephrectomy: Novel Laparoscopic and Robotic Technique显示文摘 | Inderbir S. Gill Manuel S. Eisenberg Monish Aron Andre Berger Osamu Ukimura Mukul B. Patil Vito Campese Duraiyah Thangathurai Mihir M. Desai | 2010 | European Urology2010，，1： | 3 |
| 5 | Every Minute Counts When the Renal Hilum Is Clamped During Partial Nephrectomy 显示文摘 | R. Houston Thompson Brian R. Lane Christine M. Lohse Bradley C. Leibovich Amr Fergany Igor Frank Inderbir S. Gill Michael L. Blute Steven C. Campbell | 2010 | European Urology2010，，： | 3 |
| 6 | The impact of waiting list alpha-fetoprotein changes on the outcome of liver transplant for hepatocellular carcinoma显示文摘 | Shaheed Merani Pietro Majno Norman M. Kneteman Thierry Berney Philippe Morel Gilles Mentha Christian Toso | 2011 | Journal of Hepatology2011，，4： | 3 |
| 7 | CYLD基因在Brooke-Spiegler综合征、家族性圆柱瘤和多发性家族性毛发上皮瘤中的基因突变:缺乏基因型-显型关联性 | Bowen S. Gill M. Lee D.A. J.T. Celebi 阎小宁 | 2005 | 世界核心医学期刊文摘(皮肤病学分册)2005，0，9： | 3 |
| 8 | Comparison between hepatic wedge resection and anatomic resection for colorectal liver metastases显示文摘 | Daria Zorzi M.D. John T. Mullen M.D. Eddie K. Abdalla M.D. Timothy M. Pawlik M.D. M.P.H. Axel Andres M.D. Andrea Muratore M.D. Steven A. Curley M.D. Gilles Mentha M.D. Lorenzo Capussotti M.D. Jean-Nicolas Vauthey M.D | 2006 | Journal of Gastrointestinal Surgery2006，，1： | 2 |
| 9 | Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit显示文摘 | Juliana Barr Gilles L. Fraser Kathleen Puntillo E. Wesley Ely Céline Gélinas Joseph F. Dasta Judy E. Davidson John W. Devlin John P. Kress Aaron M. Joffe Douglas B. Coursin Daniel L. Herr Avery Tung Bryce R. H. Robinson Dorrie K. Fontaine Michael A. Ramsa | 2013 | Critical Care Medicine2013，，1： | 2 |
| 10 | Surgical Management of Early-Stage Hepatocellular Carcinoma: Resection or Transplantation?显示文摘 | Emily C. Bellavance Kimberly M. Lumpkins Gilles Mentha Hugo P. Marques Lorenzo Capussotti Carlo Pulitano Pietro Majno Paulo Mira Laura Rubbia-Brandt Alessandro Ferrero Luca Aldrighetti Steven Cunningham Nadia Russolillo Benjamin Philosophe Eduardo Barroso | 2008 | Journal of Gastrointestinal Surgery2008，，10： | 2 |
| 11 | Successful anti-hepatitis C virus therapy with telaprevir in an HIV/hepatitis C virus co-infected patient with a severe recurrence of hepatitis C virus infection on the liver graft显示文摘 | Teresa M. Antonini Valerie Furlan Elina Teicher Stephanie Haim-Boukobza Mylene Sebagh Audrey Coilly Laurence Bonhomme-Faivre Gilles Peytavin Anne-Marie Roque-Afonso Daniel Vittecoq Didier Samuel Anne-Marie Taburet Jean-Charles Duclos-Vallée | 2013 | AIDS2013，，16： | 2 |
| 12 | A Prospective Multicenter Registry of Patients with Chronic Gastroesophageal Reflux Disease Receiving Transoral Incisionless Fundoplication显示文摘 | Reginald C.W. Bell Peter G. Mavrelis William E. Barnes David Dargis Bart J. Carter Kevin M. Hoddinott Robert W. Sewell Karim S. Trad Brian DaCosta Gill Glenn M. Ihde | 2012 | Journal of the American College of Surgeons2012，，6： | 2 |
| 13 | MSH1 Is a Plant Organellar DNA Binding and Thylakoid Protein under Precise Spatial Regulation to Alter Development显示文摘作为新陈代谢的中心,植物细胞器参予维护,防卫,并且发信号。MSH1 是在线粒体和质体涉及 organellar 染色体稳定性的植物特定的蛋白质。MSH1 的质体弄空在开发和 DNA methylation 引起可继承的、非基因的变化。我们从抑制衬里到亚 compartmentalize MSH1 效果的 RNAi 用半互补异种和 transgene 空的 segregants 调查了 msh1 显型。我们证明那 MSH1 表情空间地被调整,明确地在外皮和脉管的实质以内本地化到质体。蛋白质绑 DNA 并且本地化 nucleoids,而是分别和蛋白质蛋白质相互作用数据到质体和 mitochondrial 显示 MSH1 也与 thylakoid 膜联系。在上色,不能生活的压力忍耐,可变生长率,和推迟的成熟的质体 MSH1 弄空结果。从在植物的 7%-10% 的线粒体结果的弄空在叶形态学,热忍耐,和 mitochondrial 染色体稳定性改变了。MSH1 不直接在原子核以内本地化,但是质体弄空在是 MSH1 的可继承的独立人士的 flowering 时间,成熟,和生长率生产非基因的变化。MSH1 弄空在质体和 mitochondrially 改变的线的一个子集改变非光敏的氧化还原作用行为。宫外的表示生产有害效果,加重它的严格的表达式控制。解开 MSH1 效果的复杂性提供卓见进扳机植物特定, transgenerational 改编行为。 | Kamaldeep S. Virdi Yashitola Wamboldt Hardik Kundariya John D. Laurie Ido Keren K.R. Sunil Kumar Anna Block Gilles Basset Steve Luebker Christian Elowsky Philip M. Day Johnna L. Roose Terry M. Bricker Thomas Elthon Sally A. Mackenzie | 2016 | Molecular Plant2016，9，2： | 2 |
| 14 | Effect of Surgical Margin Status on Survival and Site of Recurrence After Hepatic Resection for Colorectal Metastases显示文摘 | Timothy M. Pawlik Charles R. Scoggins Daria Zorzi Eddie K. Abdalla Axel Andres Cathy Eng Steven A. Curley Evelyne M. Loyer Andrea Muratore Gilles Mentha Lorenzo Capussotti Jean-Nicolas Vauthey | 2005 | Annals of Surgery2005，，5： | 2 |
| 15 | COMPLICATIONS OF LAPAROSCOPIC PARTIAL NEPHRECTOMY IN 200 CASES显示文摘 | ANUP P. RAMANI MIHIR M. DESAI ANDREW P. STEINBERG CHRISTOPHER S. NG SIDNEY C. ABREU JIHAD H. KAOUK ANTONIO FINELLI ANDREW C. NOVICK INDERBIR S. GILL | 2005 | The Journal of Urology2005，，： | 2 |
| 16 | Development and mapping of microsatellite (SSR) markers in wheat显示文摘 | Q. J. Song J. R. Shi S. Singh E. W. Fickus J. M. Costa J. Lewis B. S. Gill R. Ward P. B. Cregan | 2005 | Theoretical and Applied Genetics2005，，3： | 2 |
| 17 | TRANSPERITONEAL VERSUS RETROPERITONEAL LAPAROSCOPIC PARTIAL NEPHRECTOMY: PATIENT SELECTION AND PERIOPERATIVE OUTCOMES显示文摘 | CHRISTOPHER S. NG INDERBIR S. GILL ANUP P. RAMANI ANDREW P. STEINBERG MASSIMILIANO SPALIVIERO SIDNEY C. ABREU JIHAD H. KAOUK MIHIR M. DESAI | 2005 | The Journal of Urology2005，，： | 2 |
| 18 | National Lipid Association recommendations for patient-centered management of dyslipidemia: Part 1 – executive summary显示文摘 | Terry A. Jacobson Matthew K. Ito Kevin C. Maki Carl E. Orringer Harold E. Bays Peter H. Jones James M. McKenney Scott M. Grundy Edward A. Gill Robert A. Wild Don P. Wilson W. Virgil Brown | 2014 | Journal of Clinical Lipidology2014，，： | 2 |
| 19 | The dynamic neutralization system for the spine: a multi-center study of a novel non-fusion system显示文摘 | Thomas M. Stoll Gilles Dubois Othmar Schwarzenbach | 2002 | European Spine Journal2002，，2： | 2 |
| 20 | Single-Port Transvesical Simple Prostatectomy: Initial Clinical Report显示文摘 | Mihir M. Desai Monish Aron David Canes Khaled Fareed Oswaldo Carmona Georges-Pascal Haber Sebastien Crouzet Juan Carlos Astigueta Roy Lopez Robert de Andrade Robert J. Stein James Ulchaker Rene Sotelo Inderbir S. Gill | 2008 | Urology2008，，5： | 1 |
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