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| 1 | Patent foramen ovale closure reduces recurrent stroke risk in cryptogenic stroke:A systematic review and metaanalysis of randomized controlled trials显示文摘AIM To investigate if patent foramen ovale(PFO) closure device reduces the risk of recurrent stroke in patients with cryptogenic stroke.METHODS We searched five databases-Pub Med,EMBASE,Cochrane,CINAHL and Web-of-Science and clinicaltrials.gov from January 2000 to September 2017 for randomized trials comparing PFO closure to medical therapy in cryptogenic stroke.Heterogeneity was determined using Cochrane's Q statistics.Random effects model was used.RESULTS Five randomized controlled trials with 3440 patients were included in the analysis.Mean follow-up was 50 ± 20 mo.PFO closure was associated with a 41% reduction in incidence of recurrent strokes when compared to medical therapy alone in patients with cryptogenic stroke [risk ratio(RR): 0.59,95%CI: 0.40-0.87,P = 0.008].Atrial fibrillation was higher with device closure when compared to medical therapy alone(RR: 4.97,95%CI: 2.22-11.11,P < 0.001).There was no difference between the two groups with respect to all-cause mortality,major bleeding or adverse events.CONCLUSION PFO device closure in appropriately selected patients with moderate to severe right-to-left shunt and/or atrial septal aneurysm shows benefit with respect to recurrent strokes,particularly in younger patients.Further studies are essential to evaluate the impact of higher incidence of atrial fibrillation seen with the PFO closure device on long-term mortality and stroke rates. | Mahesh Anantha-Narayanan Dixitha Anugula Gladwin Das | 2018 | World Journal of Cardiology2018，10，6： | 8 |
| 2 | 生理学和治疗学中的硝酸根-亚硝酸根-一氧化氮通路显示文摘以前认为无机的硝酸根和亚硝酸根阴离子是内源一氧化氮代谢的无活性最终产物。然而,近年研究显示这些所谓的无活性阴离子在体内通过再循环生成一氧化氮,区别于经典的L-精氨酸-一氧化氮合酶通路,是另一条重要的替代的一氧化氮源,特别在缺氧状态时。本文讨论了硝酸根-亚硝酸根-一氧化氮通路非常重要的生物功能,强调了那些提示硝酸盐和亚硝酸盐在一些病理条件下具潜在治疗作用的研究,例如在心肌梗死、卒中、全身和肺动脉高压症及胃溃疡等。 | Lunderg JO Weitzberg E Gladwin M 李颖 黄世杰 | 2008 | 国际药学研究杂志2008，35，3： | 3 |
| 3 | Nitrite Regulates Hypoxic Vasodilation via Myoglobin-Dependent Nitric Oxide Generation显示文摘 | Matthias Totzeck Ulrike B. Hendgen-Cotta Peter Luedike Michael Berenbrink Johann P. Klare Heinz-Juergen Steinhoff Dominik Semmler Sruti Shiva Daryl Williams Anja Kipar Mark T. Gladwin Juergen Schrader Malte Kelm Andrew R. Cossins Tienush Rassaf | 2012 | Circulation2012，，3： | 2 |
| 4 | Nitrite Anion Provides Potent Cytoprotective and Antiapoptotic Effects as Adjunctive Therapy to Reperfusion for Acute Myocardial Infarction显示文摘 | Felix M. Gonzalez Sruti Shiva Pamela S. Vincent Lorna A. Ringwood Li-Yueh Hsu Yuen Yi Hon Anthony H. Aletras Richard O. Cannon Mark T. Gladwin Andrew E. Arai | 2008 | Circulation2008，，23： | 2 |
| 5 | Hemoglobin and the paracrine and endocrine functions of nitric oxide显示文摘 | Schechter AN Gladwin MT | 2003 | N Engl J Med2003，348，： | 1 |
| 6 | Updated Clinical Classification of Pulmonary Hypertension显示文摘 | Gérald Simonneau Ivan M. Robbins Maurice Beghetti Richard N. Channick Marion Delcroix Christopher P. Denton C. Gregory Elliott Sean P. Gaine Mark T. Gladwin Zhi-Cheng Jing Michael J. Krowka David Langleben Norifumi Nakanishi Rogério Souza | 2009 | Journal of the American College of Cardiology2009，，1： | 1 |
| 7 | The hydrogen highway to reperfusion therapy显示文摘 | Wood KC Gladwin MT | 2007 | Nature medicine2007，13，： | 1 |
| 8 | Storage lesio- n: role of red blood cell breakdown显示文摘 | Kim-Sha-prro B Lee J Gladwin MT | 2011 | Transfusion2011，51，2： | 1 |
| 9 | Poverty, Biodiversity and institutions in forest-agriculture ecotones in the western ghats and eastern himalaya ranges of india 显示文摘 | Kamaljit S B Gladwin J Siddappa S | 2007 | Agriculture Ecosystems and Environment2007，121，： | 1 |
| 10 | Anelastic degradation of acoustic pulses in rocks显示文摘 | Gladwin M T Stacey F D | 1974 | Physics of the Earth and Planetary Interiors1974，8，4： | 1 |
| 11 | The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics显示文摘 | Lundberg JO Weitzberg E Gladwin MT | 2008 | Nat Rev Drug Discov2008，7，： | 1 |
| 12 | Friction and seismic attenuation in rocks显示文摘 | Winkler K E Nur A Gladwin M | 1979 | Nature1979，277，： | 1 |
| 13 | A slow earthquake sequence on the San Andreas fault 显示文摘 | Linde A T Gladwin M T Johnston M J S | 1996 | Nature1996，383，： | 1 |
| 14 | Unraveling the reactions of nitric oxide, nitrite, and hemoglobin in physiology and therapeutics 显示文摘 | Kim-Shapiro DB Schechter AN Gladwin MT | 2006 | Arterioscler Thromb Vasc Biol2006，26，4： | 1 |
| 15 | The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics显示文摘 | LUNDBERG J O WEITZBERG E GLADWIN MT | 2008 | Nat Rev Drug Discov2008，7，： | 1 |
| 16 | Ultrasonic stress monitoring in underground mining 显示文摘 | Gladwin M T | 1982 | Int J Rock Mech Min Sci1982，19，： | 1 |
| 17 | Hemoglobin and the paracrine and endocrine functions of nitric oxide显示文摘 | Schechter AN Gladwin MT | 2003 | N Engl J Med2003，348，： | 1 |
| 18 | Nitrate-nitrite-nitric oxide pathway in pulmonary arterial hypertension therapeutics 显示文摘 | Sparacino-Watkins CE Lai YC Gladwin MT | 2012 | Circulation2012，125，： | 1 |
| 19 | Shifting Paradigms for Sustainable Development:Implications for Management Theory and Research显示文摘 | Gladwin Kennelly Krame T | 1995 | Academy of Management Review1995，20，4： | 1 |
| 20 | Tidal calibration of borehole strain metrics removing the effects of small-scale inhomogeneity显示文摘 | Hart R H G Gladwin M T Gwyther R L | 1996 | J G R1996，101，25： | 1 |
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