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| 1 | Immune-modulating therapy in acute pancreatitis:Fact or fiction显示文摘Acute pancreatitis(AP) is one of the most common diseases of the gastrointestinal tract,bearing significant morbidity and mortality worldwide.Current treatment of AP remains unspecific and supportive and is mainly targeted to aggressively prevent systemic complications and organ failure by intensive care.As acute pancreatitis shares an indistinguishable profile of inflammation with sepsis,therapeutic approaches have turned towards modulating the systemic inflammatory response.Targets,among others,have included pro- and antiinflammatory modulators,cytokines,chemokines,immune cells,adhesive molecules and platelets.Even though,initial results in experimental models have been encouraging,clinical implementation of immuneregulating therapies in acute pancreatitis has had a slow progress.Main reasons include difficulty in clinical translation of experimental data,poor understanding of inflammatory response time-course,flaws in experimental designs,need for multimodal approaches and commercial drawbacks.Whether immune-modulation in acute pancreatitis remains a fact or just fiction remains to be seen in the future. | Karolina Akinosoglou Charalambos Gogos | 2014 | World Journal of Gastroenterology2014，20，41： | 17 |
| 2 | Serum cytokine profile in patients with hepatitis B e antigen-negative chronic active hepatitis B and inactive hepatitis B virus carriers显示文摘An insufficient cellular immune response seems to be critical for the immunopathogenesis of chronic hepatitis B virus infection.We have previously demonstrated no differences of T-lymphocyte subsets in blood between inactive hepatitis B s antigen(HBsAg) carriers and patients with HBeAg-negative chronic active hepatitis B.This study investigated the peripheral blood cytokine profile in patients with HBeAg-negative chronic active hepatitis B infection(Group A,n = 21) and inactive HBsAg carriers(Group B,n = 13).Serum cytokines [interferon(IFN)-γ,tumor necrosis factor-α,interleukin(IL)-1b,IL-4,IL-12,IL-10,IL-2,IL-5,IL-8] were analyzed by using flow cytometry.Patients with chronic active disease presented with significantly decreased levels of IFN-γ and IL-10 compared to inac-tive carriers(P = 0.048 and P = 0.008,respectively).In HBeAg-negative chronic active hepatitis B patients,a significant negative correlation of IFN-γ levels with serum hepatitis B viral load was noted(P = 0.021).In conclusion,patients with HBeAg-negative chronic active hepatitis B and HBsAg inactive carriers display a different cytokine profile.Decreased Th1 response observed in patients with chronic active hepatitis B could be implicated in the persistence of virus replication and ongoing progression of liver disease. | Dimitra Dimitropoulou Marina Karakantza Georgios L Theodorou Lydia Leonidou Stelios F Assimakopoulos Athanasia Mouzaki Charalambos A Gogos | 2013 | World Journal of Gastrointestinal Pathophysiology2013，4，1： | 13 |
| 3 | A new type of ERGIC–ERES membrane contact mediated by TMED9 and SEC12 is required for autophagosome biogenesis显示文摘Under stress,the endomembrane system undergoes reorganization to support autophagosome biogenesis,which is a central step in autophagy.How the endomembrane system remodels has been poorly understood.Here we identify a new type of membrane contact formed between the ER-Golgi intermediate compartment(ERGIC)and the ER-exit site(ERES)in the ER-Golgi system,which is essential for promoting autophagosome biogenesis induced by different stress stimuli.The ERGIC-ERES contact is established by the interaction between TMED9 and SEC12 which generates a short distance opposition(as close as 2-5 nm)between the two compartments.The tight membrane contact allows the ERES-located SEC12 to transactivate COPII assembly on the ERGIC.In addition,a portion of SEC12 also relocates to the ERGIC.Through both mechanisms,the ERGIC-ERES contact promotes formation of the ERGIC-derived COPII vesicle,a membrane precursor of the autophagosome.The ERGIC-ERES contact is physically and functionally different from the TFG-mediated ERGIC-ERES adjunction involved in secretory protein transport,and therefore defines a unique endomembrane structure generated upon stress conditions for autophagic membrane formation. | Shulin Li Rui Yan Jialu Xu Shiqun Zhao Xinyu Ma Qiming Sun Min Zhang Ying Li Jun-Jie Gogo Liu Liangyi Chen Sai Li Ke Xu Liang Ge | 2022 | Cell Research2022，32，2： | 3 |
| 4 | A rare etiology of post-endoscopic retrograde cholangiopancreatography pneumoperitoneum显示文摘Major complications of endoscopic retrograde cholangiopancreatography (ERCP) include pancreatitis, hemorrhage, cholangitis, and duodenal perforation. The occurrence of free air in the peritoneal cavity post- ERCP is a rare event (< 1%), which is usually the result of duodenal or ductal perforation related to therapeutic ERCP with sphincterotomy. We describe for the first time a different aetiology of pneumoperitoneum, in an 84-year-old woman with pancreatic cancer and a large hepatic metastasis, after ERCP with common bile duct stent deployment. Our patient developed, pneumoperitoneum due to air leakage from rupture of intrahepatic bile ducts and Glisson’s capsule in the area of a peripheral large hepatic metastasis. The potential mechanism underlying this complication might be post- ERCP pneumobilia and increased pressure of intrahepatic bile ducts leading to rupture of intrahepatic bile ducts in the liver metastatic mass owing to neoplastic tissue friability. This case indicates the need for close clinical and radiological observation of patients with hepatic masses (primary or metastatic) subjected to ERCP. In such patients, avoidance of excessive air insufflation during ERCP and/or placement of a nasogastric tube for bowel decompression immediately after ERCP might be a reasonable strategy to prevent such unusual complications. | Stelios F Assimakopoulos Konstantinos C Thomopoulos Sofia Giali Christos Triantos Dimitrios Siagris Charalambos Gogos | 2008 | World Journal of Gastroenterology2008，14，18： | 2 |
| 5 | A case of ischemic hepatitis显示文摘 | Gogos C Tsiamita M | 2004 | Sleep Breath2004，8，3： | 1 |
| 6 | Pro-versus anti-inflammatory cytokine predfile in patients with severe sepsis:a market for prognosis and future the rapeutic options显示文摘 | Gogos CA Drosou E Bassaris HP | 2000 | J Infect Dis2000，181，2： | 1 |
| 7 | Systemic inflammation after drug-eluting stent placement显示文摘 | Gogo PB Schneider DJ Watkins MW | 2005 | J Thromb Thrombolysis2005，19，2： | 1 |
| 8 | Interaction of a water mist with a buoyant methane diffusion flame显示文摘 | Downie B Polymeropoulos C Gogos G | 1995 | Fire Safety Journal1995，24，4： | 1 |
| 9 | Comparative Effects of Cip- rofloxacin and Ceftazidime on Cytokine Production in Patients with Se- vere Sepsis Caused by Gram - Negative Bacteria 显示文摘 | Gogos CA Skoutelis A Lekkou A | 2004 | Antimicrob A- gents Chemother2004，48，8： | 1 |
| 10 | Modeling madness in mice:one piece ata time显示文摘 | Arguello P A Gogos J A | 2006 | Neuron2006，52，1： | 1 |
| 11 | Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: A marker for prognosis and future therapeutic options 显示文摘 | Gogos CA Droson E Basseris HP | 2000 | J Infect Dis2000，181，： | 1 |
| 12 | Systemic inflammation after drug-eluting stent placement 显示文摘 | Gogo PB Jr Schneider D J Watkins MW | 2005 | J Thromb Thmmbolysis2005，19，2： | 1 |
| 13 | Pro- versus anti -inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic op- tions 显示文摘 | Gogos CA Drosou E Bassaris HP | 2000 | J Infect Dis2000，181，1： | 1 |
| 14 | Systemic inflammation after drug-eluting stent placement显示文摘 | Gogo PB Jr Schneider DJ Watkins MW | 2005 | J Thromb Thrombolysis2005，19，2： | 1 |
| 15 | Different pain scores in single transum bilical incision laparoscopic cholecystectomy versus classic laparoscopic cholecystecto my: a randomized controlled trial显示文摘 | Tsimoyiannis EC Tsimogiannis KE Pappas - Gogos G | 2010 | Surg Endosc2010，24，8： | 1 |
| 16 | A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings显示文摘 | Andrea Gogos Alyssa M. Sbisa Jeehae Sun Andrew Gibbons Madhara Udawela Brian Dean Haifei Shi | 2015 | International Journal of Endocrinology2015，，： | 1 |
| 17 | Comparative Effects of Cipro- floxacin and Ceftazidime on Cytokine Production in Patients with Se- vere Sepsis Caused by Gram - Negative Bacteria 显示文摘 | CA Gogos A Skoutelis A Lekkou E | 2004 | Antimicrob A- gents Chemother2004，48，8： | 1 |
| 18 | Identification of sequence variants andan alysis of the role of the catechol-Omethyl-transferase gene in schizophrenia susceptibility显示文摘 | Karayiorgou M Gogos JA Galke BL | 1998 | Biol Psychiatry1998，43，： | 1 |
| 19 | Pro-versus antiinflammatoIy cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic options 显示文摘 | Gogos cA Dmsou E Bassaris HP | 2000 | J Infect Dis2000，181，1： | 1 |
| 20 | Early alterations of the innate and adaptive immune statuses in sepsis according to the type of underlying infection显示文摘 | Gogos C Kotsaki A Pelekanou A | 2010 | Critical Care2010，14，3： | 1 |
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