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| 1 | Diagnosis and surgical management of breast cancer metastatic to the spine显示文摘Breast cancer is the most common malignancy and the second leading cause of death in Western women. Breast cancer most commonly metastasizes to the bone and has a particular affinity with the spine, accounting for 2/3 of osseous metastases discovered. With significant improvements in cancer therapies, the number of patients at risk for symptomatic spinal metastases is likely to increase. Patients may suffer from intractable pain and neurological dysfunction, negatively influencing their quality of life. Timely diagnosis of patients is crucial and has been aided by several breakthrough advances in imaging techniques which aid in detection, staging, and follow-up of bone metastases. Breast metastases are usually responsive to hormonal therapy and pharmacologic interventions, but skeletal metastases often require surgical intervention. The treatments are palliative but goals include the preserving or restoring neurologic function, ensuring spinal stability, and relieving pain. Advances in surgical techniques and instrumentation have allowed more effective decompres-sion and stabilization of the spine, and with the support of recent evidence the trend has shifted towards using more advanced surgical options in appropriately selected patients. In this review, the clinical presentation, diagnosis, patient selection, and surgical management of breast cancer metastatic to the spine are discussed. | Derek G Ju Alp Yurter Ziya L Gokaslan Daniel M Sciubba | 2014 | World Journal of Clinical Oncology2014，5，3： | 4 |
| 2 | One-year experience in the retinopathy of prematurity: frequency and risk factors, short-term results and follow-up显示文摘· AIM: As a result of the increase in premature births and the advances in neonatal intensive care, retinopathy of prematurity (ROP) remains one of the most important causes of childhood blindness worldwide. The main factors in the development of ROP are gestational age, birth weight and oxygen therapy. ROP continues to gain importance due to the increasing survival rates of more immature babies. · METHODS: Between January 2007 and October 2008, 203 premature infants treated at the Neonatal Intensive Care Unit (NNICU) were prospectively enrolled and the relationship between known risk factors and the occurance of ROP was studied. · RESULTS: ROP in various stages developed in 86 cases (42.4%). Statistically significant correlations were found between the development of ROP and birth weight (P < 0.0001) gestational age (P <0.0001), oxygen treatment and its duration (P <0.0001 and P =0.002), mechanical ventilation (MV) and its duration (P =0,0001 and P =0.0001), apnea(P = 0.001), intraventricular hemorrhage (IVH) (P =0.046), sepsis (P =0.0001), use of erythropoietin (EPO) (P =0.003), the number of blood transfusions and frequency (P =0.0001 and P =0.0001), surfactant application (P =0.0001), the presence of patent ductus arteriosus (PDA) (P =0.001) or bronchopu- lmonary dysplasia (BPD) (P =0.0001). No significant correlations were found between the occurance of ROP and maternal pre-eclampsia (P =0.293), multiple pregnancy (P = 0.218), or hyperbilirubinemia (P =0.494). Severity of ROP was related significantly with birth weight (P =0.0001), but no significant correlation between severity of ROP and gestational age was present. · CONCLUSION: Early description and reduction of the risk factors related with the occurance of ROP with the help of routine screening programs may warrant the prevention of visual loss, however early ophthalmic diagnosis and treatment are still mandatory to provide better visual rehabilitation. · | Sariaydin Mehmet Atlihan Fusun Calkavur Sebnem Olukman Ozgur Ercan Gulten Ozturk Arif Taylan Kaya Kilic Fatma Gokaslan Filiz Altinyaprak Derya Malatyali Rana | 2011 | International Journal of Ophthalmology(English edition)2011，4，6： | 2 |
| 3 | Total sacretomy and Galvestont rod reconstruction for malignant neoplasns显示文摘 | Gokaslan ZL Romsdahl MM Kroll SS | 1997 | J Neurosurg1997，87，5： | 1 |
| 4 | Vertebroplasty and kyphoplasty for spinal metastases显示文摘 | Chi JH Gokaslan ZL | | 0，，01： | 1 |
| 5 | Diagnosis and management of metastatic cervical spine tumors 显示文摘 | Molina CA Gokaslan ZL Sciubba DM | 2012 | Orthop Clin North Am2012，43，1： | 1 |
| 6 | Transtboracic verte brectomy for metatastic spinal tumors显示文摘 | Gokaslan ZL York JE Walsh GL | 1998 | J Neurosurg1998，89，4： | 1 |
| 7 | Fin needle as piration biopsy of the salivary glands显示文摘 | Cajulis RS Gokaslan ST Yu GH | 1997 | Acta Cyto1997，41，5： | 1 |
| 8 | Thoracolumbar spine: surgical treatment of metastatic disease 显示文摘 | FOURNEY D R GOKASLAN Z L | 2003 | Curr Opin Orthop2003，14，3： | 1 |
| 9 | Successful treatment of vancomy- cin-resistant Enterococcus meningitis with linezolid 显示文摘 | Hachem R Afif C Gokaslan Z | 2001 | Eur J Clin Mi- crobiol Infect Dis2001，20，6： | 1 |
| 10 | Spinal-pelvic fixation in patients with lumbosacral neoplasms显示文摘 | Jackson R J Gokaslan ZL | 2000 | J Ncurosurg2000，92，1： | 1 |
| 11 | Spinal instability and deformity due to neo- plastic conditions 显示文摘 | Fourney DR Gokaslan ZL | 2003 | Neurosurg Focus2003，14，1： | 1 |
| 12 | Transthoraeic vertebrectomy for metastatic spine tumors显示文摘 | Gokaslan ZL York JE Walsh GL | 1998 | J Neurosury1998，89，： | 1 |
| 13 | Delayed on set of paralysis and slowed tumor growth following in situ place ment of recombinant human bone morphogenetic protein 2 within spine tumors in a rat model of metastatic breast cancer显示文摘 | Molina C A Sarabia Estrada R Gokaslan Z L | 2012 | J Neuro surg Spine2012，16，4： | 1 |
| 14 | Cerebral Arteriojugular Oxygen Difference as an Estimate of Cerbral Blood Flow in Comatose Patients显示文摘 | Robertson C S Narayan R K Gokaslan Z L | 1989 | J lburosury1989，70，： | 1 |
| 15 | Anterior approaches to the thoracic spine in patients with cancer,indications and results显示文摘 | Walsh GL Gokaslan ZL McCutchenon IE | 1997 | Ann Thorac Surg1997，64，： | 1 |
| 16 | Transthoracic vertebrectomy for metastatic spinal tumors 显示文摘 | Gokaslan Z L York J E Walsh G L | 1998 | J Neurosurg1998，89，4： | 1 |
| 17 | Survival of patients with malignant primary osseous spinal neo- plasms: results from the Surveillance,Epidemiology,and End Results (SEER) database from 1973 to 2003 显示文摘 | Mukherjee D Chaichana KL Gokaslan ZL | 2011 | J Neurosurg Spine2011，14，2： | 1 |
| 18 | Apoptosis in the endometrium of postmenopausal women receiving tibolone显示文摘 | Gokaslan H Oktem O Durmusoglu F | 2003 | Gynecol Obstet Invest2003，6，3： | 1 |
| 19 | Differential diagnosis of smooth muscle tumors utilizing p53, pTEN and Ki- 67 expression with estrogen and progesterone receptors 显示文摘 | Gokaslan H Turkaslan H Kayak Z N | 2005 | Gynecol Obstet Invest2005，59，1： | 1 |
| 20 | Expression and localizationof 72 kDa type IV collagenase (MMP-2) in human malignantgliomas in vivo 显示文摘 | Sawaya RE Yamamoto M Gokaslan ZL | 1996 | Clin Exp Metastasis1996，14，1： | 1 |
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