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851篇 您的检索式：作者名="Gonzalez I"

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	题名	作者	年代	出处	被引量
1	Immunotherapy and immunoescape in colorectal cancer显示文摘Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma.	Guillermo Mazzolini Oihana Murillo Catalina Atorrasagasti Juan Dubrot Iigo Tirapu Miguel Rizzo Ainhoa Arina Carlos Alfaro Arantza Azpilicueta Carmen Berasain José L Perez-Gracia Alvaro Gonzalez Ignacio Melero	2007	World Journal of Gastroenterology2007，13，44：	4
2	Cooperation between TGEV structural proteins in the in vitro induction of virus-specific antibodies显示文摘	Anton I M Gonzalez S Bollido M J	1996	Virus Res1996，46，12：	1
3	Determination of food authenticity by enzyme-linked immunosorbent assay (ELISA)显示文摘	ASENSIO L GONZALEZ I GARCIA T	2008	Food Control2008，19，1：	1
4	Intermediate affinity interleukin - 2 receptor mediates survival via a phosphatidylinositol 3 - kinase - dependent pathway 显示文摘	Gonzalez - Garcia A Merida I Martinez - AC	1997	J Biol Chem1997，272，10：	1
5	Attenuating lymphocyte activity:the crystal structure of the BTLA-HVEM complex显示文摘	Compaan DM Gonzalez LC Tom I	2005	J Biol Chem2005，280，39：	1
6	Pillared clays: Catalytic evaluation in heavy oil cracking using a micreactivity test显示文摘	Gonzalez F Pesquera Benito I	1999	Applied Catalysis A:General1999，181，：	1
7	HOLSR:a hierarchical proactive routing mechanism for mobile Ad Hoc networks显示文摘	Gonzalez L V Ying Ge Lamont I	2005	IEEE Communications Magazine2005，，：	1
8	TaqMan real-time PCR for the detection and quantitation of pork in meat mixtures 显示文摘	Rodriguez M A Garcia T Gonzalez I	2005	Meat Science2005，70，：	1
9	Cyclooxygenase-2(COX-2) inhibition+ decetaxel(TXT) in recurrent non-small cell lung cancer(NSCLC):preliminary result of a phase II trial(THD-0054)显示文摘	Csiki I Dang T Gonzalez A	2003	Preceedings of ASCO2003，21，：	1
10	Simultaneous nutrients and carbon removal during pretreated swine slurry degradation in a tubular biofilm photobioreactor 显示文摘	de Godos I Gonzalez C Becares E	2009	Applied Microbiology and Biotechnology2009，82，1：	1
11	hnmobi- lization of candida rugosa lipase on bentonite modified with benzyhriethylammonium chloride 显示文摘	RAMOS M D GOMEZ G I G GONZALEZ N S	2014	Journal of Molecular Catalysis B : Enzymatic2014，，99：	1
12	Systematic behavior of electro-optic ehromophore photostability 显示文摘	Gonzalez G A Canva M Stegeman G I	2000	Opt Lett2000，25，5：	1
13	Real-time TaqMan PCR for quantitative detection of cows' milk in ewes' milk mixtures 显示文摘	IApez C Gonzalez I Fajardo V	2007	International Dairy Journal2007，17，7：	1
14	A resource - based analysis of the fac- tors determining a firm~ R&D activities 显示文摘	CANTO J G D GONZALEZ I S	1999	Research Policy1999，28，：	1
15	Dosimetric characterization of a new preparation of BaSOa activated by Eu ions显示文摘	GONZALEZ P R FURETTA C CALVO B E GASO M I CRUZ-ZARAGOZA E	2007	Nucl Instrum Meth B2007，260，：	1
16	Forensic analysis of buildings affected by mining subsidence 显示文摘	GAYARRE F ALVAREZ-FERNANDEZ M I GONZALEZ NICIEZA C	2010	Engineering Failure Analysis2010，17，1：	1
17	Intermediate affinity Interleukin-2receptor mediates survival via a phophatidylinositol-3-ki-nase-dependent pathway显示文摘	Gonzalez Garcia A Merida I Martinez A	1997	Biol Chem1997，272，10：	1
18	Changes in regional blood-flow distribution and oxygen-supply during hypoxia in conscious rats显示文摘	Kuwahira I Gonzalez NC Heisler N	1993	J Appl Physiol1993，74，1：	1
19	First record of L-quebrachitol in Allophylus edulis (Sapindaceae) 显示文摘	Diaz M Gonzalez A Castro-Gamboa I	2008	Carbohy Res2008，343，：	1
20	Spontaneous vesicle imidasoline compounds显示文摘	Gonzalez Y I Stjemdahl M Dsnino D Kaler E W	2004	Langmuir2004，20，17：	1

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