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| 1 | 曲马多治疗糖尿病性神经疼痛的双盲随机试验显示文摘目的 :本研究旨在评价曲马多治疗糖尿病性神经痛的有效性和安全性。背景 :糖尿病性神经痛是糖尿病患者的主要症状 ,其治疗和其他的末梢神经病变一样 ,不能令人满意。曲马多是作用于中枢的镇痛剂 ,用于治疗中到重度疼痛。方法 :多中心、门诊病例、随机、双盲、安慰剂做对照、设置平行组的研究 ,包括清洗期 (在此期间停用所有镇痛剂 )和一个为期 42天的双盲治疗期。总共有 1 31名患糖尿病性神经痛的患者按每日 4次接受了曲马多 (n =65)或看上去与曲马多相同的安慰剂胶囊治疗 (n =66)。 42天的治疗结束后或治疗中断后比较曲马多组和安慰剂组平均疼痛强度评分作出主要有效性分析 ;次要有效性分析为疼痛缓解率评分和根据日常活动和睡眠状况作出的对生活质量的评估。结果 :曲马多平均剂量为 2 1 0mg/天 ,治疗糖尿病性神经痛较安慰剂有显著疗效 (P≤ 0 .0 0 1 )。曲马多组患者生理(P =0 .0 2 )和社会功能 (P =0 .0 4 )的评分显著优于安慰剂组。未发现对睡眠有显著治疗作用。曲马多最常见的不良反应是恶心 ,便秘 ,头疼和嗜睡。结论 | Harati Y Gooch C Swenson M Green D Raskin P Donofrio P Cornblath D Sachdeo R Siu CO Kamin M | 2001 | 中国疼痛医学杂志2001，7，1： | 2 |
| 2 | Acute ischaemic stroke interventions: large vessel occlusion and beyond显示文摘Care for acute ischaemic stroke is one of the most rapidly evolving fields due to the robust outcomes achieved by mechanical thrombectomy.Large vessel occlusion(LVO)accounts for up to 38%of acute ischaemic stroke and comes with devastating outcomes for patients,families and society in the pre-intervention era.A paradigm shift and a breakthrough brought mechanical thrombectomy back into the spotlight for acute ischaemic stroke;this was because five randomised controlled trials from several countries concluded that mechanical thrombectomy for acute stroke offered overwhelming benefits.This review article will present a comprehensive overview of LVO management,techniques and devices used,and the future of stroke therapy.In addition,we review our institution experience of mechanical thrombectomy for posterior and distal circulation occlusion. | Ahmad Sweid Batoul Hammoud Sunidhi Ramesh Daniella Wong Tyler D Alexander Joshua Harrison Weinberg Maureen Deprince Jaime Dougherty Dimitri Jean-Mickael Maamari Stavropoula Tjoumakaris Hekmat Zarzour Michael R Gooch Nabeel Herial Victor Romo David M Hasan Robert H Rosenwasser Pascal Jabbour | 2020 | Stroke & Vascular Neurology2020，5，1： | 2 |
| 3 | Noninvasive dectection of endothelial dysfunction in children and adults at risk of atherosclerosis显示文摘 | Celermajer D S Sorensen K E Gooch V M | 1992 | Lancet1992，340，： | 1 |
| 4 | Color transfer between images显示文摘 | Reinhard E Ashikhmin M Gooch B | 2001 | IEEE Computer Graphics and Applications2001，21，5： | 1 |
| 5 | Maintenance of the long-term effectiveness of tramadol in treatment of the pain of diabetic neuropathy显示文摘 | Gooch C Swenson M | 2000 | J Diabetes Complication2000，14，2： | 1 |
| 6 | Color transfer between images显示文摘 | Reinhard E Ashikhmin M Gooch B | 2001 | IEEE Computer Graphics and Applications2001，21，5： | 1 |
| 7 | Color transfer between images 显示文摘 | Reinhard E Ashikhmin M Gooch B | 2001 | IEEE Computer Graphics and Applications2001，21，5： | 1 |
| 8 | Doubleblind randomized trial of tramal for the pain of diabetic neuropathy显示文摘 | Harati Y Gooch C Swenson M | 1998 | Neurology1998，50，： | 1 |
| 9 | The synthesis and cha-racterization of LiFeAs and NaFeAs显示文摘 | ChuC W Chen F Gooch M | 2009 | Physica C2009，469，912： | 1 |
| 10 | Color trausfer hetween images 显示文摘 | Reinhard E Ashikmin M Gooch B | 2001 | IEEE Computer Graphies and Applications2001，21，5： | 1 |
| 11 | Color transfer between images显示文摘 | Reinhard E Ashikhmin M Gooch B | 2001 | IEEE Computer Graphics and Applications2001，21，5： | 1 |
| 12 | Color transfer between images显示文摘 | Reinhard E Ashikhmin M Gooch B | 2001 | IEEE Computer Graphics and Appli- cations2001，21，5： | 1 |
| 13 | Double blind randomized trial of tramadol for the treatment of the pain of diabetic neuropathy显示文摘 | HARATO Y GOOCH C SWENSON M | 1998 | Neurology1998，50，： | 1 |
| 14 | Noninvasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis显示文摘 | Celermajer D S Sorensen K E Gooch V M | 1992 | Lancet1992，340，8828： | 1 |
| 15 | Color transfer between images显示文摘 | Reinhard M Ashikhmin M Gooch B | 2001 | IEEE Computer Graphics and Applications2001，21，5： | 1 |
| 16 | Non-invasive detection of endo thelial dysfunction in children and adults at risk of atherosclero sis显示文摘 | Celermajer D S Sorensen K E Gooch V M Spiegelhalter D J Miller O I Sullivan I D | 1992 | Lancet1992，340，： | 1 |
| 17 | Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis显示文摘 | Celermajer D S Sorensen K E Gooch V M | 1992 | Lancet1992，340，8828： | 1 |
| 18 | Color transfer between images显示文摘 | Reinhard E Adhikhmin M Gooch B | 2001 | IEEE Computer Graphics and Applications2001，21，5： | 1 |
| 19 | Failure prediction in automatically generated digital elevation models显示文摘 | GOOCH M J CHANDLER J H | 2001 | Computer & Geosciences2001，，27： | 1 |
| 20 | Non invasive dectection of endothelial dysfunction in children and adults at risk of atherosclerosis显示文摘 | CELERMAJER D S SORENSEN K E GOOCH V M | 1992 | Lancet1992，340，： | 1 |
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