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| 1 | Moringa oleifera:A review on nutritive importance and its medicinal application显示文摘Moringa oleifera,native to India,grows in the tropical and subtropical regions of the world.It is commonly known as‘drumstick tree’or‘horseradish tree’.Moringa can withstand both severe drought and mild frost conditions and hence widely cultivated across the world.With its high nutritive values,every part of the tree is suitable for either nutritional or commercial purposes.The leaves are rich in minerals,vitamins and other essential phytochemicals.Extracts from the leaves are used to treat malnutrition,augment breast milk in lactating mothers.It is used as potential antioxidant,anticancer,anti-inflammatory,antidiabetic and antimicrobial agent.M.oleifera seed,a natural coagulant is extensively used in water treatment.The scientific effort of this research provides insights on the use of moringa as a cure for diabetes and cancer and fortification of moringa in commercial products.This review explores the use of moringa across disciplines for its medicinal value and deals with cultivation,nutrition,commercial and prominent pharmacological properties of this“Miracle Tree”. | Lakshmipriya Gopalakrishnan Kruthi Doriya Devarai Santhosh Kumar | 2016 | Food Science and Human Wellness2016，5，2： | 36 |
| 2 | Cranial polyneuropathy associated with vertebrobasilar dolichoectasia显示文摘 | Madhugiri VS Roopesh Kumar VR Gopalakrishnan MS | 2012 | Clin Neurol Neurosurg2012，114，： | 1 |
| 3 | A spectral finite element for wave propagation and structural diagnostic analysis of composite beam with transverse crack 显示文摘 | KUMAR D S MAHAPATRA D R GOPALAKRISHNAN S | 2004 | Finite Elements in Analysis and Design2004，40，1314： | 1 |
| 4 | Optimizing biohydrogen production from mushroom cultivation waste using anaerobic mixed cultures显示文摘 | Chyi-How Lay I-Yuan Sung Gopalakrishnan Kumar Chen-Yeon Chu Chin-Chao Chen Chiu-Yue Lin | 2012 | International Journal of Hydrogen Energy2012，，21： | 1 |
| 5 | Metabolic syndrome inpsoriatic arthritis patients:A cross-sectional study 显示文摘 | Sharma A Gopalakrishnan D Kumar R | 2013 | Int J RheumDis2013，16，6： | 1 |
| 6 | Seedinocula for biohydrogen production from biodiesel solid residues显示文摘 | Gopalakrishnan Kumar Lay ChyiHow Chu ChenYeon | 2012 | International Journal of Hydrogen Energy2012，37，15： | 1 |
| 7 | Vesicovaginal fistu- la: An update显示文摘 | Kumar S Kekre N S Gopalakrishnan G | 2007 | Indian J Urol2007，23，： | 1 |
| 8 | Surgical Management of Rectourethral Fistula显示文摘 | Gaurav Gupta Santosh Kumar Nitin S. Kekre Ganesh Gopalakrishnan | 2008 | Urology2008，，2： | 1 |
| 9 | Molecular basis of fluoride toxicities:Beyond benefits and implications in human disorders显示文摘Detrimental impacts of fluoride have become a global concern for several decades.Despite its beneficial role which is restricted only in skeletal tissues,deleterious effects are also observed in soft tissues and systems.The generation of enhanced oxidative stress is the commencement of excess fluoride exposure which may lead to cell death.Fluoride causes cell death through autophagy via Beclin 1 and mTOR signaling pathways.Beside these,several or-gan specific anomalies through different signaling pathways have been documented.Mitochon-drial dysfunction,DNA damage,autophagy and apoptosis are the damaging outcomes in case of hepatic disorders.Urinary concentration defects and cell cycle arrest have been reported in renal tissues.Abnormal immune response has been characterized in the cardiac system.Cogni-tive dysfunction,neurodegenerative condition and learning impairment have also been observed.Altered steroidogenesis,gametogenic abnormalities,epigenetic alterations and birth defect are the major reprotoxic conclusions.Abnormal immune responses,altered immu-nogenic proliferation,differentiation as well as altered ratio of immune cells are well-defined anomalies in the immune system.Though the mechanistic approach of fluoride toxicity in phys-iological systems is common,it follows different signaling cascades.This review emphasizes diverse signaling pathways which are the targets of overexposed fluoride. | Priyankar Pal Niraj Kumar Jha Debankur Pal Saurabh Kumar Jha Uttpal Anand Abilash Valsala Gopalakrishnan Abhijit Dey Prabir Kumar Mukhopadhyay | 2023 | Genes & Diseases2023，10，4： | 1 |
| 10 | Diagnosis and conserva-tive treatment of tubercular rectoprostatic fistula显示文摘 | Kumar S Kekre NS Gopalakrishnan G | 2006 | Ann R Coll Surg Engl2006，88，1： | 1 |
| 11 | 用微卫星标记评估红尾鲃的种群结构(英文)显示文摘本文检测了三种鲤科鱼的 1 6对微卫星引物在红尾中的适用性 ,其中 6对引物可以成功扩增 ,且 5个位点具有多态性。对采自两条不同河流的标本 ,通过检测这些多态微卫星位点的遗传变异情况 ,评估了它们在红尾种群结构分析的适合性。结果显示这 5个多态位点在上述两个样本中的平均表观杂合度分别是 0 2 93和0 4 71。 | Achamveettil GOPALAKRISHNAN Kochikkaran Kunjumohammed MUSAMMILU Peringady Mohammed ABDUL MUNEER Kuldeep Kumar LAL Dhurendra KAPOOR Alphis Geethanand PONNIAH Vindhya MOHINDRA | 2004 | 动物学报2004，50，4： | 1 |
| 12 | Oxidative stress and mitochondrial transfer:A new dimension towards ocular diseases显示文摘Ocular cells like,retinal pigment epithelium(RPE)is a highly specialized pigmented monolayer of post-mitotic cells,which is located in the posterior segment of the eye between neuro sensory retina and vascular choroid.It functions as a selective barrier and nourishes retinal visual cells.As a result of high-level oxygen consumption of retinal cells,RPE cells are vulnerable to chronic oxidative stress and an increased level of reactive oxygen species(ROS)generated from mitochondria.These oxidative stress and ROS generation in retinal cells lead to RPE degeneration.Various sources including mtDNA damage could be an important factor of oxidative stress in RPE.Gene therapy and mitochondrial transfer studies are emerging fields in ocular disease research.For retinal degenerative diseases stem cell-based transplantation methods are developed from basic research to preclinical and clinical trials.Translational research contributions of gene and cell therapy would be a new strategy to prevent,treat and cure various ocular diseases.This review focuses on the effect of oxidative stress in ocular cell degeneration and recent translational researches on retinal degenerative diseases to cure blindness. | Mohana Devi Subramaniam Mahalaxmi Iyer Aswathy P.Nair Dhivya Venkatesan Sinnakaruppan Mathavan Nimmisha Eruppakotte Soumya Kizhakkillach Manoj kumar Chandran Ayan Roy Abilash Valsala Gopalakrishnan Balachandar Vellingiri | 2022 | Genes & Diseases2022，9，3： | 1 |
| 13 | Thermal vibration analysis of monolayer graphene embedded in elastic medium based on nonlocal continuum mechanics 显示文摘 | KUMAR T J P NARENDAR S GOPALAKRISHNAN S | 2013 | Composite Structures2013，100，1： | 1 |
| 14 | Nitrogen stress induced changes in the marine cyanobacterium oscillatoria willei; BDU 130511 显示文摘 | Sushanta Kumar Saha Lakshmanan Uma Gopalakrishnan Sabramanian | 2003 | FEMS Microbiology Ecology2003，45，： | 1 |
| 15 | Anticancer activity of the ethanolic extract of Crateva nurvala bark against testosterone and MNU-induced prostate cancer in rats显示文摘AIM: In the present study the anticancer activity of the ethanolic extract of Crateva nurvala bark was evaluated against testosterone and N-methyl-N-nitrosourea (MNU)-induced prostate cancer in male Wistar rats. METHODS: Prostate cancer was induced in rats by the injection of testosterone for 3 d followed by injection of the chemical carcinogen MNU for 1 week. The prostate cancer-induced rats were treated with the ethanolic extract of C. nurvala bark, and testosterone injection was also continued through the experimental period of 4 months. Biochemical estimations including prostatic acid phosphatase, lipid peroxidation, enzymic antioxidants and non-enzymic antioxidants activity were done in the prostate and seminal vesicle tissue homogenate. RESULTS: There was a significant increase in the level of acid phosphatase and lipid peroxidation in prostate cancer-induced rats, and after treatment with C. nurvala extract a significant decrease in the level of acid phosphatase lipid peroxidation were observed. The enzymic and non-enzymic antioxidants were decreased in the prostate cancer induced group and after treatment they were restored to near normal values. Histopathological examination showed significant changes such as hyperplastic prostatic acini and malignant proliferation of ductal epithelial cells in the prostate and seminal vesicle of carcinogen induced rats. After treatment with C. nurvala extract normal and flow-dilated ducts and acini with regular epithelial lining were observed in the prostate and partially hyperplastic and partially flattered epithelium were observed in seminal vesicles. CONCLUSION: The ethanolic extract of C. nurvala has significant anticancer activity evaluated by in an in vivo model. | Dugganaboyana GURU KUMAR Vijayakumar PARVATHI Periasamy MEENAKSHI Muthaiyan Ahalliya RATHI Velliyur Kanniappan GOPALAKRISHNAN | 2012 | 中国天然药物2012，10，5： | 1 |
| 16 | Outcome of shock wave lithotripsy as monotherapy for large soli- tary renal stones(>2 cm in size) without stenting显示文摘 | RAJAIAN S KUMAR S GOPALAKRISHNAN G | 2010 | Indian J Urol2010，26，3： | 1 |
| 17 | Navigating the intersection of psychiatry and ophthalmology:A comprehensive review of depression and anxiety management in glaucoma patients显示文摘Glaucoma,a prevalent and debilitating eye disease,has long been associated with vision impairment and blindness.However,recent research has shed light on the often-underestimated psychological dimensions of this condition.Anxiety and depression,two pervasive psychiatric comorbidities,have been increasingly recognized among glaucoma patients.This comprehensive review aims to explore the intricate relationship between psychiatry and ophthalmology,in the context of managing depression and anxiety in glaucoma patients.By meticulously examining peer-reviewed literature,we synthesize current knowledge on the prevalence,risk factors,and underlying mechanisms of anxiety and depression in glaucoma.The evidence reveals that glaucoma patients face an elevated risk of experiencing these mood disorders.Factors such as progressive vision loss,complex medication regimens,and the fear of further visual deterioration contribute to their vulnerability.Moreover,we delve into the bidirectional relationship between glaucoma and mood disorders,shedding light on the complex interplay between ocular and emotional health.Our review investigates the implications of anxiety and depression on glaucoma management,including their potential impact on treatment adherence,disease progression,and overall quality of life.We also explore the neurobiological pathways linking glaucoma and mood disorders,providing a foundation for future research and potential therapeutic interventions.In conclusion,recognizing the psychological burden carried by glaucoma patients is essential for holistic and patient-centered care.This review underscores the pressing need for integrated approaches that bring together ophthalmological and psychiatric expertise to optimize the well-being of individuals facing the challenges of glaucoma.By addressing anxiety and depression in glaucoma care,healthcare providers can enhance the overall quality of life for these patients,ultimately leading to improved outcomes and a brighter future for those affected by this condition.This review offers valuable insight for healthcare practitioners and researchers,providing a concise overview of key topics and research in the field of managing depression and anxiety in glaucoma patients. | Prasanna Venkatesh Ramesh Arvind Kumar Morya Ashik Azad Pavithra Pannerselvam Aji Kunnath Devadas Sai Thaejesvi Gopalakrishnan Shruthy Vaishali Ramesh Ajanya K Aradhya | 2024 | World Journal of Psychiatry2024，14，3： | 0 |
| 18 | Biotechnological valorization of algal biomass:an overview显示文摘Algal biomass has significant advantages over terrestrial plants in terms of CO2 sequestration,biomass productivity,waste-water treatment along with multiple biobased products synthesis.Metabolic versatility and high carbohydrate content of microalgal biomass act as a potential alternative feedstock to fossil resources and contribute towards the biobased economy growth.Effective biomass utilization would play a key role to establish sustainable bioprocess development and technology translation to the industrial community.In this framework,the present review discusses the renewable resource potential of algal biomass and its complete utilization for multiple biobased products synthesis in a closed-loop biorefinery approach.Various methods are discussed to obtain high biomass growth and pretreatments to obtain the maximum sugars solubiliza-tion.Further,combined bioprocesses were discussed for the production of biohydrogen,biomethane,bioethanol,short-chain fatty acids(SCFA),medium-chain fatty acids(MCFA),and biopolymers in a closed-loop approach. | A.Naresh Kumar Jeong-Jun Yoon Gopalakrishnan Kumar Sang-Hyoun Kim | 2021 | Systems Microbiology and Biomanufacturing2021，1，2： | 0 |
| 19 | Bioelectrochemical system-mediated waste valorization显示文摘Bioelectrochemical systems(BESs)are a new and emerging technology in the field of fermentation technology.Electrical energy was provided externally to the microbial electrolysis cells(MECs)to generate hydrogen or value-added chemicals,including caustic,formic acid,acetic acid,and peroxide.Also,BES was designed to recover nutrients,metals or remove recalcitrant compounds.The variety of naturally existing microorganisms and enzymes act as a biocatalyst to induce poten-tial differences amid the electrodes.BESs can be performed with non-catalyzed electrodes(both anode and cathode)under favorable circumstances,unlike conventional fuel cells.In recent years,value-added chemical producing microbial electrosyn-thesis(MES)technology has intensely broadened the prospect for BES.An additional strategy includes the introduction of innovative technologies that help with the manufacturing of alternative materials for electrode preparation,ion-exchange membranes,and pioneering designs.Because of this,BES is emerging as a promising technology.This article deliberates recent signs of progress in BESs so far,focusing on their diverse applications beyond electricity generation and resulting performance. | K.Chandrasekhar A.Naresh Kumar Tirath Raj Gopalakrishnan Kumar Sang-Hyoun Kim | 2021 | Systems Microbiology and Biomanufacturing2021，1，4： | 0 |
| 20 | Unveiling the silent link:Normal-tension glaucoma's enigmatic bond with cardiac blood flow显示文摘This comprehensive review embarks on a captivating journey into the complex relationship between cardiology and normal-tension glaucoma(NTG),a condition that continues to baffle clinicians and researchers alike.NTG,characterized by optic nerve damage and visual field loss despite normal intraocular pressure,has long puzzled clinicians.One emerging perspective suggests that alterations in ocular blood flow,particularly within the optic nerve head,may play a pivotal role in its pathogenesis.While NTG shares commonalities with its high-tension counterpart,its unique pathogenesis and potential ties to cardiovascular health make it a fascinating subject of exploration.It navigates through the complex web of vascular dysregulation,blood pressure and perfusion pressure,neurovascular coupling,and oxidative stress,seeking to uncover the hidden threads that tie the heart and eyes together in NTG.This review explores into the intricate mechanisms connecting cardiovascular factors to NTG,shedding light on how cardiac dynamics can influence ocular health,particularly in cases where intraocular pressure remains within the normal range.NTG's enigmatic nature,often characterized by seemingly contradictory risk factors and clinical profiles,underscores the need for a holistic approach to patient care.Drawing parallels to cardiac health,we examine into the shared vascular terrain connecting the heart and the eyes.Cardiovascular factors,including systemic blood flow,endothelial dysfunction,and microcirculatory anomalies,may exert a profound influence on ocular perfusion,impacting the delicate balance within the optic nerve head.By elucidating the subtle clues and potential associations between cardiology and NTG,this review invites clinicians to consider a broader perspective in their evaluation and management of this elusive condition.As the understanding of these connections evolves,so too may the prospects for early diagnosis and tailored interventions,ultimately enhancing the quality of life for those living with NTG. | Prasanna Venkatesh Ramesh Arvind Kumar Morya Ajanya K Aradhya Pavithra Pannerselvam Sai Thaejesvi Gopalakrishnan Shruthy Vaishali Ramesh Aji Kunnath Devadas Navaneeth Krishna | 2024 | World Journal of Cardiology2024，16，1： | 0 |
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