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| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | Occlusion rate and complications of plastic biliary stent placement in patients undergoing neo-adjuvant chemoradiotherapy for pancreatic cancer with malignant biliary obstruction显示文摘 | Boulay BR Gardner TB Gordon SR | 2010 | J Clin Gastroenterol2010，44，6： | 1 |
| 3 | lipid concentrationsin critical illness:implications for preventing and treating endotoxemia显示文摘 | Gordon BR Parker T S Levine D M | 1996 | Crit Care Med1996，24，4： | 1 |
| 4 | Control of nasal obstruction in perennial allergic rhinitis显示文摘 | Wang DY Raza MT Gordon BR | 2004 | Curr Opin Allergy Clin Immunol2004，4，3： | 1 |
| 5 | Removal of low-density lipoproteins in patients by extracorporeal immunoadsorption显示文摘 | Saal SD Parker TS Gordon BR | 1986 | Am J Med1986，80，： | 1 |
| 6 | Prevalence of picky eatersamong infants and toddlers and their caregivers' decisinns abotlt ofh*ring a new food显示文摘 | Carruth BR Ziegler PJ Gordon A | 2004 | J Am Diet Assoc2004，，： | 1 |
| 7 | Relationship of hypolipidemia to cytokine concentrations and outcomes in critically ill surgical patients 显示文摘 | Gordon BR Parker TS Levine DM | 2001 | Crit Care Med2001，29，8： | 1 |
| 8 | Control of nasal ob struction in perennial allergic rhinitis显示文摘 | Wang DY Raza MT Gordon BR | 2004 | Curr ()pin Al- lergy Clin Immunol2004，4，3： | 1 |
| 9 | Low lipid concentrations in critical illness: implications for preventing and treating endotoxemia显示文摘 | Gordon BR Parker TS Levine DM | 1996 | Crit Care Med1996，24，4： | 1 |
| 10 | Long-termeffects of low-density lipoprotein apheresis using anautomated dextran sulfate cellulose adsorption system显示文摘 | Gordon BR Kelsey SF Dau PC | 1998 | Am J Cardiol1998，81，4： | 1 |
| 11 | Control of nasal obstruction in peren- nial allergic rhinitis 显示文摘 | Wang DY Raza MT Gordon BR | 2004 | Curr Opin Allergy Clin mmunol2004，4，： | 1 |
| 12 | The allergic march: can we prevent allergies and asthma? 显示文摘 | Gordon BR | 2011 | Otolarynt Clin North Am2011，44，76： | 1 |
| 13 | Plasmin catalyzes binding of lipoprotein(a)to immobilized fibrinogen and fibrin 显示文摘 | Gordon BR Parker TS | 1989 | Proc Natl Acad Sci USA1989，86，： | 1 |
| 14 | Low lipid concentrations in critical illness: implications for preventing and treating endotoxemia 显示文摘 | Gordon BR Parker TS Lovine DM | 1996 | Crit Care Med1996，24，4： | 1 |
| 15 | Control of nasal obstruction in perennial allergic rhinitis显示文摘 | Wang DY RazaMT Gordon BR | 2004 | Curr Opin Allergy Clin hnmuno12004，4，3： | 1 |
| 16 | Relationship of hypolipidemia to cytokine concentrations and outcomes in critically ill surgical patients 显示文摘 | Gordon BR Parker TS Levine DM | 2001 | Crit Care Med2001，29，8： | 1 |
| 17 | Control of nasal obstruction in pe- rennial allergic rhinitis 显示文摘 | Wang DY Raza MT Gordon BR | 2004 | Curr Opin Allergy Clin mmunol2004，4，： | 1 |
| 18 | Phase 1B, randomized, double-blind, dose-escalation trial of CPG 10101 in patients with chronic hepatitis C virus显示文摘 | McHutchison JG Bacon BR Gordon SC | 2007 | Hepatology2007，46，5： | 1 |
| 19 | Boceprevir for previously treated chronic HCV genotype I infection 显示文摘 | Bacon BR Gordon SC Lawitz E Marcellin P Vierling JM Zeuzem S Poordad F Goodman ZD Sings HL Boparai N Burroughs M Brass CA Albrecht JK Esteban R HCV RESPOND-2 Investigators | 2011 | N Engl J Med2011，364，13： | 1 |
| 20 | Relationship of hypolipidemia to cytokine concentrations and outcomes in critically ill surgical patients显示文摘 | Gordon BR Parker TS Levine DM | 2001 | Crit Care Med2001，29，8： | 1 |
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