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| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | UVB light regulates expression of antioxidants and inflammatory mediators in human corneal epithelial cells显示文摘 | Black AT Gordon MK Heck DE Gallo MA Laskin DL Laskin JD | | 0，，07： | 1 |
| 3 | The efficacy of antifibrinolytics in the reduction of blood loss during complex adult reconstructive spine surgery显示文摘 | Urban MK Beckman J Gordon M | | 0，，10： | 1 |
| 4 | Postoperative prophylactic administration of beta-adrenergic blockers in patients at rick for myocardial ischemia显示文摘 | Markowitz SM Gordon MA | 2000 | Aneath Analg2000，90，6： | 1 |
| 5 | A rapid,simplified procedure for simultaneous assay of norepinephrine,dopamine and 5-hytroxytry-ptamine from discrete brain area显示文摘 | Shellenberger MK Gordon JK | 1971 | Anal Biochem1971，39，： | 1 |
| 6 | Regulation of TREM ex- pression in hepatic macrophages and endothelial cells during acute en- dotoxemia显示文摘 | Chen LC Laskin JO Gordon MK LaskJn DL | 2008 | Fxp Mol Pathol2008，84，2： | 1 |
| 7 | Non-suicidal self-injuryamong adolescents : diagnostic correlates and relation to suicideattempts 显示文摘 | Nock MK Joiner TE Gordon KH | 2006 | Psychiat Res2006，144，1： | 1 |
| 8 | Relationship between social factors and pituitary - adrenocortical activity in female rhesus monkeys (Macaca mulatta)显示文摘 | Gust DA Gordon TP Hambright MK Wilson ME 1993 | 1993 | Horm Behav1993，27，3： | 1 |
| 9 | Dynamics of mash1 expression in vitro and in vivo suggest a nonstem cell site of mash1 action in the olfactory receptor neuron lineage显示文摘 | Gordon MK Mumm JS Davis RA | 1995 | Mol Cell Neurosci1995，6，： | 1 |
| 10 | Stimulation of matrix metalloproteinase producti-on by recombinant extracellular matrix metalloproteinase inducer from transfeeted Chinese hamster ovary cells显示文摘 | Guo H Zucker S Gordon MK | 1997 | J Biol Chem1997，272，： | 1 |
| 11 | Sulfur mustard induces an endoplasmic reticulum stress response in the mouse ear vesicant model显示文摘 | Chang YC Wang JD Svoboda KK Casillas RP Laskin JD Gordon MK | 2013 | Toxicol Appl Pharmacol2013，268，2： | 1 |
| 12 | Preferential expression of matrix metallopreteinase-9 in mouse skin after sulfur mustard exposure显示文摘 | Shakarjian M P Bhatt P Gordon MK | 2006 | Appl Toxicol2006，26，3： | 1 |
| 13 | Stimulation of matrix metalloproteinase production by recombinan extracelluar matrix metalloproteinase inducer from transfected Chinese hamster ovary cells 显示文摘 | Zucker S Gordon MK | 1997 | J Biol Chem1997，272，1： | 1 |
| 14 | Regulation of TREM expression in hepatic maerophages and endothelial cells during acute endotoxemia 显示文摘 | Chen LC Laskin J D Gordon MK | 2008 | Exp Mol Pathol2008，84，2： | 1 |
| 15 | Stimulation of matrix metalloproteinase production by recombinant extracelluar matrix metalloproteinase inducer from transfected Chinese hamster ovary cells显示文摘 | Guo H Zucker S Gordon MK | 1997 | J Biol Chem1997，272，1： | 1 |
| 16 | Traumatic (or amputation) neuroma显示文摘 | Janes SM Renaut PH Gordon Mk | 2004 | ANZ Journal of Surgert2004，4，8： | 1 |
| 17 | The rapidly expanding family of human polyomaviruses: recent development in understanding their life cycle and role in human pathology显示文摘 | White MK Gordon J Khalili K | 2013 | PLoS Pathog2013，9，10： | 1 |
| 18 | Regulation of TREM expression in hepatic macrophages and endothelial cells during acute endutoxemia显示文摘 | Chen LC Laskin JD Gordon MK | 2008 | Exp Mol Patho12008，84，2： | 1 |
| 19 | The polyomavirus,JCV and its involvement in human disease显示文摘 | Khalili K Gordon J White MK | 2006 | Adv Exp Med Biol2006，577，： | 1 |
| 20 | Doxycycline hydrogels as a potential therapy for ocular vesicant injury显示文摘 | Gordon MK Desantis A Deshmukh M | 2010 | J Ocul Pharmacol T- her2010，26，5： | 1 |
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