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| 1 | Molecular mechanisms of liver ischemia reperfusion injury:Insights from transgenic knockout models显示文摘Ischemia reperfusion injury is a major obstacle in liver resection and liver transplantation surgery.Understanding the mechanisms of liver ischemia reperfusion injury(IRI) and developing strategies to counteract this injury will therefore reduce acute complications in hepatic resection and transplantation,as well as expanding the potential pool of usable donor grafts.The initial liver injury is initiated by reactive oxygen species which cause direct cellular injury and also activate a cascade of molecular mediators leading to microvascular changes,increased apoptosis and acute inflammatory changes with increased hepatocyte necrosis.Some adaptive pathways are activated during reperfusion that reduce the reperfusion injury.IRI involves a complex interplay between neutrophils,natural killer T-cells cells,CD4+ T cell subtypes,cytokines,nitric oxide synthases,haem oxygenase-1,survival kinases such as the signal transducer and activator of transcription,Phosphatidylinositol 3-kinases/Akt and nuclear factor κβ pathways.Transgenic animals,particularly genetic knockout models,have become a powerful tool at elucidating mechanisms of liver ischaemia reperfusion injury and are complementary to pharmacological studies.Targeted disruption of the protein at the genetic level is more specific and maintained than pharmacological inhibitors or stimulants of the same protein.This article reviews the evidence from knockout models of liver IRI about the cellular and molecular mechanisms underlying liver IRI. | Gourab Datta Barry J Fuller Brian R Davidson | 2013 | World Journal of Gastroenterology2013，19，11： | 50 |
| 2 | Operative treatment of cervical spondylotic myelopathy显示文摘 | Rao RD Gourab K David KS | | 0，，07： | 1 |
| 3 | Operative treatment of cervical spondylotic myelopathy 显示文摘 | Rao RD Gourab K David KS | 2006 | J Bone Joint Surg Am2006，88，： | 1 |
| 4 | Diffusion heterogeneity tensor MRI (Alpha-Dti):mathematics and initial applications in spinal cord regeneration after trauma 显示文摘 | Ellingson BM Sehmit BD Gourab K | 2009 | Biomed Sci Instrum2009，45，： | 1 |
| 5 | Increased lower limb spasticity butnot strength or function following a single-dose serotonin reuptake in-hibitor in chronic stroke 显示文摘 | Gourab K Schmit BD Homby TG | 2015 | Arch Phys Med Rehabil2015，96，12： | 1 |
| 6 | Design of non-uniform circular antenna arrays using a modified invasive weed optimization algorithm显示文摘 | GOURAB G R SWAGATAM D PRITHWISH C | 2011 | IEEE Transactions on Antenns and Propagation2011，59，1： | 1 |
| 7 | Operative Treatment of Cervical Spondylotic Myelopathy 显示文摘 | Rao DR gourab K Dawid KS | 2006 | J Boen Joint Sury Am2006，88，7： | 1 |
| 8 | Operative treatment of cervical spondylotic myelopathy 显示文摘 | Rao RD Gourab K David KS | 2006 | J Bone Joint Surg Am2006，88，7： | 1 |
| 9 | Use of Fibrin-Based Sealants and Gelatin-Matrix Hemostats in Laparoscopic Liver Surgery显示文摘 | Rehan Saif Mathew Jacob Stuart Robinson Amien Amer Douglas Kei-Hui Gourab Sen Derek Manas Steve White | 2011 | Surgical Laparoscopy Endoscopy & Percutaneous Techniques2011，，3： | 1 |
| 10 | Operative treatment of cervical spondylotic myelopathy显示文摘 | Rao RD Gourab K David KS | 2006 | J Bone Joint Surg Am2006，88，7： | 1 |
| 11 | Operative treatment of cervical spnndylotic myelopathy 显示文摘 | Rao RD Gourab K David KS | 2006 | J Bone Joint Surg Am2006，88，： | 1 |
| 12 | Operative treatment of cervical spondylotic myelopathy 显示文摘 | Rao RD Gourab K David KS | 2006 | J Bone joint Surg Am2006，88，7： | 1 |
| 13 | Operative Treatment of Cervical Spondylotic Myelopathy显示文摘 | Gourab K David KS | 2006 | Journal of Bone &Joint surgery2006，88，： | 1 |
| 14 | Epidermal neural crest stem cell (EPI-NCSC)-mediated recovery of sensory function in a mouse model of spinal cord injury显示文摘 | Hu Yao Gourab K Wells C | 2010 | Stem Cell Rev2010，6，2： | 1 |
| 15 | Operative treatment of cervical spondylotic myelopathy显示文摘 | Rao RD Gourab K David KS | 2006 | J Bone Joint Surg2006，88，7： | 1 |
| 16 | Design of non-uniform circular antenna arrays using a modi- fied invasive weed optimization algorithm 显示文摘 | Gourab Ghosh Roy Swagatam Das Prithwish Chakraborty | 2011 | IEEE Transacyions on Antennas and Propagation2011，59，1： | 1 |
| 17 | Operative treatment of cervical spondylotic myelopathy显示文摘 | Rao RD Gourab K David KS | | 0，，07： | 1 |
| 18 | Factor Xa Binding to Annexin 2 Mediates Signal Transduction via Protease-Activated Receptor 1 显示文摘 | Gourab Bhattacharjee Jasimuddin Ahamed Rafal Pawlinski | 2008 | Circ Res2008，102，： | 1 |
| 19 | Operative treatment of cervical spondylotic myelopathy显示文摘 | Rao RD Gourab K David KS | 2006 | J Bone Joint Surg Am2006，88，7： | 1 |
| 20 | An improved harmony search algorithm with differ- entiM mutation operator显示文摘 | PRITHWISH C GOURAB G R SWAGATAM D | 2009 | Fundamenta Informa- ticae2009，95，4： | 1 |
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