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		题名	作者	年代	出处	被引量
	1	Porcine model characterizing various parameters assessing the outcome after acetaminophen intoxication induced acute liver failure显示文摘AIM To investigate the changes of hemodynamic and laboratory parameters during the course of acute liver failure following acetaminophen overdose.METHODS Eight pigs underwent a midline laparotomy following jejunal catheter placement for further acetaminophen intoxication and positioning of a portal vein Doppler flow-probe. Acute liver failure was realized by intrajejunal acetaminophen administration in six animals, two animals were sham operated. All animals were invasively monitored and received standardized intensive care support throughout the study. Portal blood flow, hemodynamic and ventilation parameters were continuously recorded. Laboratory parameters were analysed every eight hours. Liver biopsies were sampled every 24 h following intoxication and upon autopsy.RESULTS Acute liver failure (ALF) occurred after 28 ± 5 h resulted in multiple organ failure and death despite maximal support after further 21 ± 1 h (study end). Portal blood flow (baseline 1100 ± 156 m L/min) increased to a maximum flow of 1873 ± 175 m L/min at manifestation of ALF, which was significantly elevated(P < 0.01). Immediately after peaking, portal flow declined rapidly to 283 ± 135 m L/min at study end. Thrombocyte values (baseline 307 × 103/μL± 34 × 103/μL) of intoxicated animals declined slowly to values of 145 × 103/μL± 46 × 103/μL when liver failure occurred. Subsequent appearance of severe thrombocytopenia in liver failure resulted in values of 11 × 103/μL± 3 × 103/μL preceding fatality within few hours which was significant(P > 0.01).CONCLUSION Declining portal blood flow and subsequent severe thrombocytopenia after acetaminophen intoxication precede fatality in a porcine acute liver failure model.	Karolin Thiel Wilfried Klingert Kathrin Klingert Matthias H Morgalla Martin U Schuhmann Pamela Leckie Yalda Sharifi Nathan A Davies Rajiv Jalan Andreas Peter Christian Grasshoff Alfred Konigsrainer Martin Schenk Christian Thiel	2017	World Journal of Gastroenterology2017，23，9：	1
	2	Fibroblasts surrounding melanoma express elevated levels of matrix metalloproteinase-1 (MMP-1) and intercellular adhesion molecule-1(ICAM-1) in vitro显示文摘	Wandel E Grasshoff A Mittag M	2000	Exp Dermatol2000，9，1：	1
	3	Fibroblasts surrounding melanoma express elevated levels of matrix metalloproteinase-1 ( MMP-I ) and intercelluar adhesion molecule-1 ( ICAM-1 ) in vitro 显示文摘	Wandel E Grasshoff A Mitta M	2000	Exp Dermatol2000，9，1：	1
	4	Reoperations in anorectal malformations显示文摘	Pena A Grasshoff S Levitt M	2007	J Pediatr Surg2007，42，2：	1
	5	Fibroblasts surrounding melanoma express elevated levels of matrix metalloproteinase-1(MMP-1) and intercellular adhesion molecule-1(ICAM-1) in vitro显示文摘	Wandel E Grasshoff A Mittag M	2000	Exp Dermatol2000，9，1：	1
	6	Reoperations in anorectal malformations显示文摘	Pe(n)a A Grasshoff S Levitt M		0，，02：	1
	7	Fibroblasts surrounding melanoma express elevated levels of matrix metalloproteinase-1 (MMP-1) and intercellular adhesion molecule-1 (ICAM-1) in vitro显示文摘	Wandel E Grasshoff A Mittag M	2000	Exp Dermatol2000，9，1：	1

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