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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Renal artery stenosis:prevalenceof,risk factors for,and management of in-stent stenosis显示文摘 | Boateng F K Greco B A | 2013 | Am J Kidney Dis2013，61，1： | 1 |
| 3 | Metabolic syndrome and urinary stone composition: what factors matter most? 显示文摘 | Kadlec AO Greco K Fridirici ZC | 2012 | Urology2012，80，： | 1 |
| 4 | Caesarean scar pregnancy: a review of manage- ment options 显示文摘 | Litwicka K Greco E | 2011 | Curt Opin Obstet Gynecol2011，23，6： | 1 |
| 5 | Rough set approach to multiple criteria classification with imprecise e- valuations and assignments显示文摘 | Dembczynski K Greco S Slowiski R | 2009 | European Journal Operational Research2009，198，2： | 1 |
| 6 | Rough set approach to multiple criteria classification with imprecise evaluations and assignments显示文摘 | Dembczynski K Greco S Slowinski R | 2009 | European J of Operational Research2009，198，2： | 1 |
| 7 | Characterization of a zinc -De- pendent transcriptional activator from Arabidopsis 显示文摘 | PATER S D GRECO V PHAM K | 1996 | Nucleic Acids Re- sareh1996，24，23： | 1 |
| 8 | Caesarean scar pregnancy : a reviewof management options 显示文摘 | Litwicka K Greco E | 2011 | Curr Opin Obstet Gynecol2011，23，6： | 1 |
| 9 | Caesarean scar pregnancy:a review of manangement options显示文摘 | Litwicka K Greco E | 2011 | Curr Opin Obstet Gynecol2011，23，： | 1 |
| 10 | The contribution of water hyacinth ( Eichhornia erassipes) and zooplankton to the internal cycling of Phosphorus in the eutrophic Pampulba Reservoir 显示文摘 | Pinto-Coelho R M Greco M K B | 1999 | Brazil Hydrobiologia1999，411，： | 1 |
| 11 | Current status of PET/CT for tumor volume definition in radiotherapy treat ment planning for non- small cell lung cancer (NSCLC)显示文摘 | Greco C Rosenzweig K Cascini G L | 2007 | Lung Cancer2007，57，2： | 1 |
| 12 | Gene expression analysis in SV-40 immortalized human corneal epithelial cells cultured with an air-liquid interface显示文摘 | Greco D Vellonen K S Turner H C | | 0，，： | 1 |
| 13 | Caesarean scar pregnancy:a review of management options显示文摘 | Litwicka K Greco E | 2013 | Curr Opin Obstet Gynecol2013，25，6： | 1 |
| 14 | Coherent radar targetdetection in heavy-tailed compound-Gaussian clutter 显示文摘 | Sangston K J Gini Fulvio Greco M S | 2012 | IEEETransactions on Aerospace and Electronic Systems2012，48，1： | 1 |
| 15 | Human papillomavirus 16 E5 mod-ulates the expression of host microRNAs显示文摘 | Greco D Kivi N Qian K | 2011 | PLoS One2011，6，21： | 1 |
| 16 | Caesarean scar pregnancy:a review ofmanagement options显示文摘 | LITWICKA K GRECO E | 2011 | Curr Opin Obstet Gynecol2011，23，6： | 1 |
| 17 | Successful management of a triplet heterotopic caesarean scar pregnacy after in vitro fertilization-embryo transfer显示文摘 | Litwicka K Greco E Prefumo F | | 0，，01： | 1 |
| 18 | Caesarean scar pregnancy: a review of manage- ment options显示文摘 | Litwicka K Greco E | 2013 | Curt Opin Obstet Gynecol2013，25，6： | 1 |
| 19 | Exploring univer- sal patterns in human home-work commuting from mobile phone data 显示文摘 | KUNG K S GRECO K SOBOLEVSKY S el al | 2014 | PLoS ONE2014，9，96： | 1 |
| 20 | Caesarean scar pregnancy: a review of management options 显示文摘 | Litwieka K Greco E | 2011 | Curr Opin Obstet Gynecol2011，23，6： | 1 |
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