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| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | Role of laminin in axonal extension from olfactory receptor cells显示文摘 | Greer C A | 1997 | J Neurobiol1997，32，： | 1 |
| 3 | Considering Diversity: The Positive Effects of Considerate Leadership in Diverse Teams 显示文摘 | Homan A C Greer L L | 2013 | Group Processes & Intergroup Relations2013，16，1： | 1 |
| 4 | Understanding health literacy: an expanded model显示文摘 | ZARCADOOLAS C PLEASANT A GREER DS | 2005 | Health Promot Int2005，20，2： | 1 |
| 5 | Microbial functional potential and community composition in permafrost-affected soils of the NW Canadian Arctic显示文摘 | FRANK-FAHLE B A YERGEAU E GREER C W | 2014 | The Public Library of Science2014，9，84： | 1 |
| 6 | Crystal nucleation in amorphous (Au100-yCuy)77Si9Ge14 alloys显示文摘 | THOMPSON C V GREER A L SPAEPEN F | 1983 | Acta Metall1983，31，： | 1 |
| 7 | Sublaminar organization of the mouse olfactory bulb nerve layer 显示文摘 | AU W W TRELOAR H B GREER C A | 2002 | J Comp Neurol2002，446，1： | 1 |
| 8 | Effect of Nurse Case Management Compared With Usual Care on Controlling Cardiovascular Risk Factors in Patients With Diabetes A randomized controlled triM显示文摘 | Ishani A Greer N Taylor B C | 2011 | Diabetes care2011，54，8： | 1 |
| 9 | First case of ranavirus-asso- ciated morbidity and mortality in natural populations of the South American frog Atelognathus patagonicus 显示文摘 | Fox S F Greer A L Torres C R | 2006 | Dis Aquat Organ2006，72，1： | 1 |
| 10 | Considering diversity: The positive effects of considerate leadership in diverse teams显示文摘 | Homan A C Greer L L | 2013 | Group Processes & Intergroup Relations2013，16，1： | 1 |
| 11 | Grain refinement by A1 Ti B alloys in aluminium melts: A study of the mechanisms of poisoning by zirconium 显示文摘 | BUNN A M SCHUMACHER P KEARNS M A BOOTHROYD C B GREER A L | 1999 | Materials Science and Technology1999，15，： | 1 |
| 12 | Modern manage- ment of complex open abdominal wounds of war: A 5-year experience显示文摘 | Vertrees A Greer L Pickett C | 2008 | J Am Coll Surg2008，207，6： | 1 |
| 13 | Occupational Stress and Perceived Organizational Effectiveness in Formal Groups: An Examination of Stress Level and Stress Type 显示文摘 | Alien D R Hitt M A Greer C R | 1982 | Personnel Psychology1982，35，2： | 1 |
| 14 | NanocrystaUization in M-based amorphous alloys 显示文摘 | Zhong Z C Jiang X Y Greer A L | 1997 | Philosophical Maga- zine Part B1997，76，4： | 1 |
| 15 | Nanocrystallization in Al-based amorphous alloys 显示文摘 | ZHONG Z C JIANG X Y GREER A L | 1997 | Philosophical Magazane B1997，76，4： | 1 |
| 16 | Low-molecular-weight heparins for thromboprop- hylaxis and treatment of venous thromboembolism in pregnancy: a systematic review of safety and efficacy显示文摘 | Greer I A Nelson-Piercy C | 2005 | Blood2005，106，2： | 1 |
| 17 | Human resource management outsourcing: The make or buy decision 显示文摘 | GREER C R YOUNGBLOOD S A GRAY D A | 1999 | Academy of Management Executive1999，，13： | 1 |
| 18 | Structure of mouse calpain small subunit gene显示文摘 | SIMON J ARTHUR C GREER P A | 1998 | Biochimica et Biophysica Acta1998，1388，： | 1 |
| 19 | Olfactory ensheathing cells; bridging the gap in spinal cord injury显示文摘 | Bartolomei J C Greer C A | 2000 | Neurosurgery2000，47，5： | 1 |
| 20 | Epicardial fat vo- lume in patients with left ventricular systolic dysfunction 显示文摘 | Khawaja T Greer C Chokshi A | 2011 | Am J Cardiol2011，108，3： | 1 |
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