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| 1 | Immunotherapy and immunoescape in colorectal cancer显示文摘Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma. | Guillermo Mazzolini Oihana Murillo Catalina Atorrasagasti Juan Dubrot Iigo Tirapu Miguel Rizzo Ainhoa Arina Carlos Alfaro Arantza Azpilicueta Carmen Berasain José L Perez-Gracia Alvaro Gonzalez Ignacio Melero | 2007 | World Journal of Gastroenterology2007，13，44： | 4 |
| 2 | Mapping aboveground biomass by integrating geospatial and forest inventory data through a k-nearest neighbor strategy in North Central Mexico显示文摘As climate change negotiations progress,monitoring biomass and carbon stocks is becoming an important part of the current forest research.Therefore,national governments are interested in developing forest-monitoring strategies using geospatial technology.Among statistical methods for mapping biomass,there is a nonparametric approach called k-nearest neighbor(kNN).We compared four variations of distance metrics of the kNN for the spatially-explicit estimation of aboveground biomass in a portion of the Mexican north border of the intertropical zone.Satellite derived,climatic,and topographic predictor variables were combined with the Mexican National Forest Inventory(NFI)data to accomplish the purpose.Performance of distance metrics applied into the kNN algorithm was evaluated using a cross validation leave-one-out technique.The results indicate that the Most Similar Neighbor(MSN)approach maximizes the correlation between predictor and response variables(r=0.9).Our results are in agreement with those reported in the literature.These findings confirm the predictive potential of the MSN approach for mapping forest variables at pixel level under the policy of Reducing Emission from Deforestation and Forest Degradation(REDD+). | Carlos A AGUIRRE-SALADO Eduardo J TREVIO-GARZA Oscar A AGUIRRE-CALDERóN Javier JIMNEZ-PREZ Marco A GONZLEZ-TAGLE José R VALDZ-LAZALDE Guillermo SNCHEZ-DíAZ Reija HAAPANEN Alejandro I AGUIRRE-SALADO Liliana MIRANDA-ARAGóN | 2014 | Journal of Arid Land2014，6，1： | 3 |
| 3 | Relation of atrophic gastritis with Helicobacter pylori-CagA^+ and interleukin-1 gene polymorphisms显示文摘AIM: To determine the association of Helicobacter pylori (H pylori) CagA+ infection and pro-inflammatory poly-morphisms of the genes interleukin (IL)-1RN and IL-1B with the risk of gastric atrophy and peptic ulcers in a dyspeptic population in Costa Rica, a country with high incidence and mortality of gastric cancer. METHODS: Seven biopsy specimens, a fasting blood sample and a questionnaire concerning nutritional and sociodemographic factors were obtained from 501 con-secutive patients who had undergone endoscopy for dyspeptic symptoms. A histopathological diagnosis was made. Pepsinogen concentrations were analyzed by enzyme linked immunosorbent assay (ELISA). Infection with H pylori CagA+ was determined by serology and polymerase chain reaction (PCR). IL-1B and IL-1RN polymorphisms genotyping was performed by PCR-restriction fragment length polymorphism (PCR-RFLP)and PCR respectively. RESULTS: In this dyspeptic population, 86% were H pylori positive and of these, 67.8% were positive for CagA. Atrophic antral gastritis (AAG) was associated with CagA+ status [odd ratio (OR) = 4.1; P < 0.000] and fruit consumption (OR = 0.3; P < 0.00). Atrophic body gastritis (ABG) was associated with pepsinogen PGI/PGII < 3.4 (OR = 4.9; P < 0.04) and alcohol consumption (OR = 7.3; P < 0.02). Duodenal ulcer was associated with CagA+ (OR = 2.9; P < 0.04) and smoking (OR = 2.4; P < 0.04). PGI < 60 μg/L as well as PGI/PGII < 3.4 were associated with CagA+. CONCLUSION: In a dyspeptic population in Costa Rica, H pylori CagA+ is not associated with ABG, but it is a risk factor for AAG. The pro-inflammatory cytokine poly-morphisms IL-1B + 3945 and IL-1RN are not associated with the atrophic lesions of this dyspeptic population. | Rafaela Sierra Clas Une Vanessa Ramírez Warner Alpízar-Alpízar María I González José A Ramírez Antoine de Mascarel Patricia Cuenca Guillermo Pérez-Pérez Francis Mégraud | 2008 | World Journal of Gastroenterology2008，14，42： | 2 |
| 4 | Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis显示文摘 | Mary Eapen Vanderson Rocha Guillermo Sanz Andromachi Scaradavou Mei-Jie Zhang William Arcese Anne Sirvent Richard E Champlin Nelson Chao Adrian P Gee Luis Isola Mary J Laughlin David I Marks Samir Nabhan Annalisa Ruggeri Robert Soiffer Mary M Horowitz Eli | 2010 | Lancet Oncology2010，，7： | 2 |
| 5 | Real-time reverse transcription loop-mediated isothermal ampli- fication for rapid detection of west Nile virus显示文摘 | Manmohan P Guillermo P Shingo I | 2004 | J Clin Microbiol2004，42，： | 1 |
| 6 | Purification and characterization of urease from Helicobacter pylori显示文摘 | Bruce E D Campbell G P Guillermo I | 1990 | The J of Biological Chemistry1990，265，： | 1 |
| 7 | Marrow stromal cells, mitosis, and neuronal differentiation: stem cell and precursor functions显示文摘 | Guillermo M E Woodbury D Black I B | 2003 | Stem cells2003，21，3： | 1 |
| 8 | Carbonaceous fillers for shape memory actuation of polyurethane composites by resistive heating显示文摘 | Sedat Gunes I Guillermo A Jimenezl Sadhan C Jana | 2009 | Carbon2009，47，4： | 1 |
| 9 | Spherical Micro Aggregation; Anonymizing Sparse Vector Spaces 显示文摘 | Proceedings of the 30th I EEE Internationa Anonymization Over Big Data Using Map Daniel A Guillermo N Vicen T | 2015 | Computers & Security2015，，3： | 1 |
| 10 | Real-time reverse transcription loop-mediated isothermal amplification for rapid detection of West Nile virus 显示文摘 | Manmohan P Guillermo P Shingo I | 2004 | J Clin Microbial2004，42，1： | 1 |
| 11 | Heat-shock proteins expression in fish central nervous system and its possible relation with water acidosis resistance显示文摘 | MART(I)N Monserrat CELIA Herna'ndez GUILLERMO Bodega l | 1998 | Neuroscience Research1998，31，： | 1 |
| 12 | Highly hydrophobic wood surfaces prepared by treatment with atmospheric pressure dielectric barrier discharges显示文摘 | Toriz Guillermo Guti 8 rrez Milagros G Gonz d lez- Alvarez V i ctor | 2008 | Journal of Adhesion Science and Technology2008，22，16： | 1 |
| 13 | Purification and characterization of urease from Helicobacter pylori显示文摘 | Bruce E Dunn Gail P Campbell Guillermo I | 1990 | The Journal of Biological Chemistry1990，16，265： | 1 |
| 14 | A novel method for simulating smoldering propagation and its application to STAR (Self-sustaining Treatment for Active Remediation)显示文摘 | Macphee Stephanie L Gerhard Jason I Rein Guillermo | 2012 | Environmental Modelling & Software2012，，31： | 1 |
| 15 | Real-time reverse transcription loop-mediated isothermal amplification for rapid detection of West nile virus显示文摘 | Manmohan P Guillermo P Shingo I Futoshi H and Kouichi M | 2004 | Journal of Clinical Microbiology2004，42，1： | 1 |
| 16 | Post-disaster recovery dilemmas:Challenges in balancing short-term and long- term needs for vulnerability reduction 显示文摘 | Jane C I Guillermo F Cfistina R R | 2006 | Environmental Science & Policy2006，9，： | 1 |
| 17 | Molecular diversity of arbuscular mycorrhizal fungi in onion roots from organic and conventional fanning systems in the Netherlands显示文摘 | Guillermo A Galvan I P Karin B | 2009 | Mycorrhiza2009，19，： | 1 |
| 18 | Marrow stromal cells, mitosis, and neuronal differentiation: stem cell and precursor functions 显示文摘 | Guillermo M E Woodbury D Black I B | 2003 | Stem Cells2003，21，3： | 1 |
| 19 | Epidemiology of Helicobacterpylori infection显示文摘 | GUILLERMO I P ROTHENBACHER D BRENNER H | 2004 | Helicobacter2004，9，2： | 1 |
| 20 | Prognostic factors and survival in a prospective cohort of patients with high-grade glioma treated with carmustine wafers or temozolomide on an intention-to-treat basis显示文摘 | Gregorio Catalán-Uribarrena Gaizka Bilbao-Barandica I?igo Pomposo-Gaztelu José Undabeitia-Huertas Edurne Ruiz de Gopegui-Ruiz Lara Galbarriatu-Gutiérrez Manuel Canales-Llantada Jon Aurrecoechea-Obieta Alfonso Igartua-Azkune Guillermo Carbayo-Lozano | 2012 | Acta Neurochirurgica2012，，2： | 1 |
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