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| 1 | Pillararene-based supramolecular systems for theranostics and bioapplications显示文摘As an emerging type of important macrocycles for supramolecular chemistry,pillararenes and their derivatives have been widely studied and applied in numerous fields,which intensively promotes the development of chemistry,materials science and biology.Pillararene-based theranostic systems are of special interest in the biological and medical areas as they have shown very promising results.Owing to easy preparation,reliable guest affinity,good biocompatibility and stability,pillararenes are frequently used to construct functional biomaterials.On one hand,pillararenes can either be used individually or form diversiform self-assemblies such as micelles,nanoparticles and vesicles to increase water solubility and biocompatibility of drugs.On the other hand,it is promising to modify solid materials like framework materials,silica nanoparticles and graphene oxides with pillararene derivatives to enhance their functions and controllability.In this review,we summarize recent endeavors of pillararene-based supramolecular systems with theranostics and other biological applications comprising drug delivery/chemotherapy,photodynamic/photothermal therapy,antimicrobials,bioimaging,etc.By introducing several typical examples,the design principles,preparation strategies,identifications and bio-applications of these pillararene-based supramolecular systems are described.Future challenges and directions of this field are also outlined. | Huangtianzhi Zhu Qi Li Laila E.Khalil-Cruz Niveen M.Khashab Guocan Yu Feihe Huang | 2021 | Science China Chemistry2021，64，5： | 4 |
| 2 | A water-soluble pillararene:Synthesis,host-guest chemistry,and its application in dispersion of multiwalled carbon nanotubes in water显示文摘 | Yu Guocan Min Xue Zhang Zibin | 2012 | Journal of the American Chemical Society2012，134，13： | 1 |
| 3 | Lipid nanomaterials-based RNA therapy and cancer treatment显示文摘We summarize the most important advances in RNA delivery and nanomedicine.We describe lipid nanoparticle-based RNA therapeutics and the impacts on the development of novel drugs.The fundamental properties of the key RNA members are described.We introduced recent advances in the nanoparticles to deliver RNA to defined targets,with a focus on lipid nanoparticles(LNPs).We review recent advances in biomedical therapy based on RNA drug delivery and state-of-the-art RNA application platforms,including the treatment of different types of cancer.This review presents an overview of current LNPs based RNA therapies in cancer treatment and provides deep insight into the development of future nanomedicines sophisticatedly combining the unparalleled functions of RNA therapeutics and nanotechnology. | Xingcai Zhang Luo Hai Yibo Gao Guocan Yu Yingli Sun | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 1 |
| 4 | A pillar[5]arene-based molecular grapple of hexafluorophosphate显示文摘A symmetric pillararene-based receptor containing ten triazole units was synthesized.Interestingly,it formed 1:1 complexes instead of 1:2 with different halide anions.This was caused by the cooperative multivalent hydrogen-bond interactions between the triazole protons on one side of the receptor and the halide anion,which changed its structure from pillar to conical.However,by the regulation of the effector F-,it can work like an excavator grapple selectively grasps a PF6-anion. | Zibin Zhang Kechang Sun Shijun Li Guocan Yu | 2019 | Chinese Chemical Letters2019，30，5： | 0 |
| 5 | Numerical Simulation of Flow between Rotating Cylinders显示文摘IntroductionFlowbetweenrotatingcylinderswithsmalh/R(histhegapbetweencylindersandRistheinnercylinderradius)hasbeenwidelystudie... | Chunwei YU and Guocan LING (LNM, Institute of Mechanics, CAS, Beijing, 100080, China) | 1998 | Communications in Nonlinear Science and Numerical Simulation1998，3，1： | 0 |
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