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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | 聚辛烯与硫磺交联剂对橡胶沥青性能改善作用研究显示文摘为评价聚辛烯与硫磺双掺对橡胶沥青性能的改善作用,制备不同掺量双掺改性橡胶沥青,采用黏度和DSR等试验测试其使用性能。结果表明:黏度对双掺改性橡胶沥青高温性能区分度较针入度和软化点好;双掺能使橡胶沥青高温性能明显改善,且降低其应力敏感性,但也增强了温度敏感性;聚辛烯与0.1%硫磺双掺能改善橡胶沥青低温性能,同时双掺能增强橡胶沥青弹性恢复和储存稳定性,其中弹性恢复随两者掺量的增加逐渐提高,储存稳定性则在1.0%聚辛烯掺量下效果较好;考虑综合性能,推荐的聚辛烯与硫磺掺量分别为1.0%和0.1%。 | 李平 翟龙 刘豪斌 刘连国 彭卓祥(译) Padhan R K Gupta A A Mohanta C S | 2018 | 中外公路2018，38，5： | 3 |
| 3 | On the GI/M/1/N queue with working vacations-analytic analysis and computation显示文摘 | Banik A D Gupta U C Pathak S S | 2007 | Applied Mathematics Modeling2007，，： | 1 |
| 4 | Short-term outcomes of 23-gauge pars plana vitrectomy显示文摘 | Gupta OP Ho A Kaiser PK Regillo C Chen S Dyer D | 2008 | Am J Ophthalmol2008，146，2： | 1 |
| 5 | Biochemistry and physiology of bioluminescent bacteria显示文摘 | HASTINGS J W POTRIKUS C J GUPTA S C | 1985 | Advances Microbial Physiology1985，26，： | 1 |
| 6 | A role for extrarenal cells in the regeneration following acute renal failure显示文摘 | Gupta S Vedaillie C Chmielewski D | 2002 | Kidney Int2002，62，4： | 1 |
| 7 | Grapefruit juice reduces theoral bioavailability of fexofenadine but not desloratadine显示文摘 | Banfield C Gupta S Marino M | 2002 | ClinPharmacokinet2002，41，： | 1 |
| 8 | An improved response surface method for detemlination of failure probability and imponallee measures显示文摘 | Gupta S Manohar C S | 2004 | Structural Safety2004，26，： | 1 |
| 9 | Isolation and char- acterization of kidney-derived stem cells 显示文摘 | Gupta S Verfaillie C Chmielewski D | 2006 | J Am Soc Nephrol2006，17，11： | 1 |
| 10 | Deposition, exhumation, and paleoclimate of an ancient lake deposit, Gale crater, Mars 显示文摘 | GROTZINGER J P GUPTA S MALIN M C | 2015 | Science2015，350，6257： | 1 |
| 11 | In vitro plantlet development from explants of 25-year-old trees of Populus × euramericana--a hybrid poplar显示文摘 | AGRAWAL V GUPTA S C | 1991 | Plant Science1991，78，1： | 1 |
| 12 | A sharper condition for the solvability of a three-point second order boundary value problem显示文摘 | GUPTA C P Trofimchuk S I | 1997 | J Math Anal Appl1997，205，： | 1 |
| 13 | The design of catalysts for green oxidation processes显示文摘 | GUPTA S C | 2002 | Science2002，296，： | 1 |
| 14 | The tribological properties of AI-CulSiCp metal-matrix composites fabricated using the rheocasting technique 显示文摘 | LIM S C GUPTA M REN L KWOK J K M | 1999 | Journal of Materials Processing Technolog1999，8090，： | 1 |
| 15 | Grapefruit juice reduces theoral bioavailability of fexofenadine but not desloratadine显示文摘 | Banfield C Gupta S Marino M | 2002 | ClinPharmacokinet2002，41，： | 1 |
| 16 | Antibiotic uptake by plants from soil fertilized with animal manure显示文摘 | Kumar K Gupta S C Baidoo S K | 2005 | J Environ Qual2005，34，6： | 1 |
| 17 | Validation of real-time three-dimensional echocardiography for quantifying left ventricular volumes in the presence of a left ventricular aneurysm: in vitro and in vivo studies显示文摘 | Jian Xin Qin Michael Jones Takahiro Shiota Neil L Greenberg Hiroyuki Tsujino Michael S Firstenberg Pankaj C Gupta Arthur D Zetts Yong Xu Jing Ping Sun Lisa A Cardon Jill A Odabashian Scott D Flamm Richard D White Julio A Panza James D Thomas | 2000 | Journal of the American College of Cardiology2000，，3： | 1 |
| 18 | Dysregulated immune system in children with autism:beneficial effects of intravenous immune globulin on autistic characteristics显示文摘 | Gupta S Aggarwal S Heads C | 1996 | J Autism Dev Disord1996，26，4： | 1 |
| 19 | Cognitive impairment following high fat diet consumption is associated with brain inflammation显示文摘 | PISTELL P J MORRISON C D GUPTA S eta | 2010 | J Neuroimmunol2010，219，12： | 1 |
| 20 | What Is a Free Customer Worth显示文摘 | Gupta S Mela C F | 2008 | Harvard Business Review2008，86，11： | 1 |
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