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| 1 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 2 | Novel variations in the signal peptide region of transforming growth factor beta1 gene in patients with hepatitis: a brief report from India 显示文摘 | Gupta V Arora R Saha A | 2005 | Int J Immunogenet2005，32，2： | 1 |
| 3 | Laparoscopic inguinal hernia repair in the pediatric age group-experience with 437 children 显示文摘 | PARELKAR S V OAK S GUPTA R | 2010 | Pediatr Sur2010，45，4： | 1 |
| 4 | Rapid synthesis of graft co- polymers from natural cellulose fiber 显示文摘 | Thakur V K Thakur M K Gupta R K | 2013 | Carbohydrate Polymers2013，98，： | 1 |
| 5 | Sustainability under combined application of mineral and organic fertilizers in a rained soybean-wheat system of the Indian Himalayas 显示文摘 | Bhattacharyya R Kundu S Prakash V Gupta H S | 2008 | European Journal of Agronomy2008，28，1： | 1 |
| 6 | Development of soft sensor for neural network based control of distillation column显示文摘 | RANI A SINGH V GUPTA J R P | 2013 | ISA Transactions2013，52，3： | 1 |
| 7 | Recent advances on surface engineering of magnetic iron oxide nanoparticles and their biomedical applications 显示文摘 | GUPTA A K NAREGALKAR R R VAIDYA V D | 2007 | Nanornedicine2007，2，1： | 1 |
| 8 | Heterocyclic systems containing bridgehead nitrogen atom: synthesis and anti- hypertensive activity of some 1- { 6-(4-alkoxyphenyl)-3- methyl-5, 6-dihydro-s-triazolo1, 3, 4-thiadiazole-5-yl}- 3-(5-aryl-s-triazole-3-ylthio) propan-2-ols 显示文摘 | Gupta R Sudan S Mengi V | 1996 | Indian J Chem1996，35，： | 1 |
| 9 | Alkaline lipase from a novel strain Burkholderia multivorans: statistical medium optimization and production in a bioreactor显示文摘 | Gupta N Sahai V Gupta R | 2007 | Process Biochemistry2007，42，： | 1 |
| 10 | The estimation of surface temperature over an agricultural area in the state of Haryana and Panjab, India, and its relationship with the normalized difference vegetation index (NDVI), using NOAA AVHRR data显示文摘 | Gupta R K Prasas S Seshasal M V R | 1997 | Int J Remote Sensing1997，18，18： | 1 |
| 11 | Microstructural evolution of A1-Fe powder mixture during high-energy ball milling 显示文摘 | Cardellni F Contini V Gupta R | 1998 | Journal of Materials Science1998，33，10： | 1 |
| 12 | A physically based filter for separating base flow form stream flow times series显示文摘 | Furey P R Gupta V K | 2001 | Water Resources Research2001，37，11： | 1 |
| 13 | The risk factor of domestic violence in India显示文摘 | Mahapatro M R Gupta V Gupta | 2012 | Indian J Community Med2012，37，3： | 1 |
| 14 | Gingival squamous cell carcinoma presenting as periodontal lesion in the mandibular posterior region显示文摘 | Gupta R Debnath N Khandelwal V | 2014 | BMJ Case Rep2014，19，8： | 1 |
| 15 | Debittering of citrus juices - A review显示文摘 | Singh S V Jain R K Gupta A | 2003 | Journal of Food Science and Technology-Mysore2003，40，3： | 1 |
| 16 | Klebsiella pneumoniae carrying bla NDM-1gene in orthopedic practice显示文摘 | Gupta V Bansal N Gupta R | 2014 | Indian J Orthop2014，48，5： | 1 |
| 17 | Kharitonov's theo- rem and routh criterion for stability margin of interval systems 显示文摘 | HOTE Y V GUPTA J R P CHOUDHURY D R | 2010 | In-ternational Journal of Control Automation and Systems2010，8，3： | 1 |
| 18 | A case of ovarian metastasis of gall bladder carcinoma simulating primary ovarian neoplasm:diagnostic pitfalls and review of literature显示文摘 | Jain V Gupta K Kudva R | 2006 | Int J Gynecol Cancer2006，16，1： | 1 |
| 19 | Changes in microbial biomass and organic matter levels during the first year of medi- fled tillage and stubble management practices on a red earth显示文摘 | Gupta V V S R Roper MM Kirkegaard J A | 1994 | Australian Journal of Soil Research1994，32，： | 1 |
| 20 | Effect of pH on zinc adsorption-precipitation reactions in an alkali soil显示文摘 | Gupta R K Elshout S V D Abbol I P | 1987 | Soil Sci1987，143，3： | 1 |
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